Microbiology

  1. A CTP-dependent gating mechanism enables ParB spreading on DNA

    1. Adam SB Jalal
    2. Ngat T Tran
    3. Clare EM Stevenson
    4. Afroze Chimthanawala
    5. Anjana Badrinarayanan
    6. David M Lawson
    7. Tung BK Le

    • Curated by eLife

      Evaluation Summary:

      Bacterial ParB partition proteins have the novel property that they employ an unusual nucleotide cofactor for complex assembly at their specific DNA binding site, parS. The impact of this study is on our general understanding of this novel class of nucleotide-dependent processes, and the role that nucleotide-protein interactions play in DNA binding and bacterial physiology.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  2. A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection

    1. Pasquale Laise
    2. Megan L. Stanifer
    3. Gideon Bosker
    4. Xiaoyun Sun
    5. Sergio Triana
    6. Patricio Doldan
    7. Federico La Manna
    8. Marta De Menna
    9. Ronald B. Realubit
    10. Sergey Pampou
    11. Charles Karan
    12. Theodore Alexandrov
    13. Marianna Kruithof-de Julio
    14. Andrea Califano
    15. Steeve Boulant
    16. Mariano J. Alvarez

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice

    1. Sandrine Belouzard
    2. Arnaud Machelart
    3. Valentin Sencio
    4. Thibaut Vausselin
    5. Eik Hoffmann
    6. Nathalie Deboosere
    7. Yves Rouillé
    8. Lowiese Desmarets
    9. Karin Séron
    10. Adeline Danneels
    11. Cyril Robil
    12. Loïc Belloy
    13. Camille Moreau
    14. Catherine Piveteau
    15. Alexandre Biela
    16. Alexandre Vandeputte
    17. Séverine Heumel
    18. Lucie Deruyter
    19. Julie Dumont
    20. Florence Leroux
    21. Ilka Engelmann
    22. Enagnon Kazali Alidjinou
    23. Didier Hober
    24. Priscille Brodin
    25. Terence Beghyn
    26. François Trottein
    27. Benoît Déprez
    28. Jean Dubuisson

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Early detection of SARS-CoV-2 in circulating immune cells in a mouse model

    1. Tingting Geng
    2. Spencer Keilich
    3. Triantafyllos Tafas
    4. Penghua Wang

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Neutralization of Delta variant with sera of Covishield™ vaccinees and COVID-19-recovered vaccinated individuals

    1. Gajanan N Sapkal
    2. Pragya D Yadav
    3. Rima R Sahay
    4. Gururaj Deshpande
    5. Nivedita Gupta
    6. Dimpal A Nyayanit
    7. Deepak Y Patil
    8. Anita M Shete
    9. Sanjay Kumar
    10. Priya Abraham
    11. Samiran Panda
    12. Balram Bhargava

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Spike protein cleavage-activation mediated by the SARS-CoV-2 P681R mutation: a case-study from its first appearance in variant of interest (VOI) A.23.1 identified in Uganda

    1. Bailey Lubinski
    2. Laura Frazier
    3. My Phan
    4. Daniel Bugumbe
    5. Jessie L Cunningham
    6. Tiffany Tang
    7. Susan Daniel
    8. Matthew Cotten
    9. Javier A. Jaimes
    10. Gary Whittaker

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Thiol-based chemical probes exhibit antiviral activity against SARS-CoV-2 via allosteric disulfide disruption in the spike glycoprotein

    1. Yunlong Shi
    2. Ari Zeida
    3. Caitlin E. Edwards
    4. Michael L. Mallory
    5. Santiago Sastre
    6. Matías R. Machado
    7. Raymond J. Pickles
    8. Ling Fu
    9. Keke Liu
    10. Jing Yang
    11. Ralph S. Baric
    12. Richard C. Boucher
    13. Rafael Radi
    14. Kate S. Carroll

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Natural infection of SARS-CoV-2 delta variant in Asiatic lions ( Panthera leo persica ) in India

    1. Anamika Mishra
    2. Naveen Kumar
    3. Sandeep Bhatia
    4. Ashutosh Aasdev
    5. Sridhar Kanniappan
    6. A. Thayasekhar
    7. Aparna Gopinadhan
    8. R. Silambarasan
    9. C. Sreekumar
    10. Chandan Kumar Dubey
    11. Meghna Tripathi
    12. Ashwin Ashok Raut
    13. Vijendra Pal Singh

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. Pathology and Immunity After SARS-CoV-2 Infection in Male Ferrets Is Affected by Age and Inoculation Route

    1. Koen van de Ven
    2. Harry van Dijken
    3. Lisa Wijsman
    4. Angéla Gomersbach
    5. Tanja Schouten
    6. Jolanda Kool
    7. Stefanie Lenz
    8. Paul Roholl
    9. Adam Meijer
    10. Puck B. van Kasteren
    11. Jørgen de Jonge

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Highly Neutralizing COVID-19 Convalescent Plasmas Potently Block SARS-CoV-2 Replication and Pneumonia in Syrian Hamsters

    1. Yuki Takamatsu
    2. Masaki Imai
    3. Kenji Maeda
    4. Noriko Nakajima
    5. Nobuyo Higashi-Kuwata
    6. Kiyoko Iwatsuki-Horimoto
    7. Mutsumi Ito
    8. Maki Kiso
    9. Tadashi Maemura
    10. Yuichiro Takeda
    11. Kazumi Omata
    12. Tadaki Suzuki
    13. Yoshihiro Kawaoka
    14. Hiroaki Mitsuya

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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