Microbiology

Pneumococcal genetic variability in age-dependent bacterial carriage

1. Philip HC Kremer
2. Bart Ferwerda
3. Hester J Bootsma
4. Nienke Y Rots
5. Alienke J Wijmenga-Monsuur
6. Elisabeth AM Sanders
7. Krzysztof Trzciński
8. Anne L Wyllie
9. Paul Turner
10. Arie van der Ende
11. Matthijs C Brouwer
12. Stephen D Bentley
13. Diederik van de Beek
14. John A Lees

• Curated by eLife

  Evaluation Summary:

  Strain variability in bacterial infections is a confounding factor in the treatment and prevention of the associated diseases. Pneumococcal disease is widespread, and the current vaccine targets only a subset of circulating strains, with disease and vaccine efficacy likely varying with the age of the host. Using two large databases of pneumococcal genomes, this study explores the associations between genomic factors and the age of the human host. Ultimately, these data and related studies will establish whether and how vaccines should be differentially designed for children and the elderly. This work will be of interest to those working in bacterial infections and host-pathogen genomics.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Impact of temperature on the affinity of SARS-CoV-2 Spike for ACE2

1. Jérémie Prévost
2. Jonathan Richard
3. Romain Gasser
4. Shilei Ding
5. Clément Fage
6. Sai Priya Anand
7. Damien Adam
8. Natasha Gupta Vergara
9. Alexandra Tauzin
10. Mehdi Benlarbi
11. Shang Yu Gong
12. Guillaume Goyette
13. Anik Privé
14. Sandrine Moreira
15. Hugues Charest
16. Michel Roger
17. Walther Mothes
18. Marzena Pazgier
19. Emmanuelle Brochiero
20. Guy Boivin
21. Cameron F. Abrams
22. Arne Schön
23. Andrés Finzi

Reviewed by ScreenIT

Reduced neutralization of SARS-CoV-2 B.1.617 variant by inactivated and RBD-subunit vaccine

1. Jie Hu
2. Xiao-yu Wei
3. Jin Xiang
4. Pai Peng
5. Feng-li Xu
6. Kang Wu
7. Fei-yang Luo
8. Ai-shun Jin
9. Liang Fang
10. Bei-zhong Liu
11. Kai Wang
12. Ni Tang
13. Ai-Long Huang

Reviewed by ScreenIT

A CTP-dependent gating mechanism enables ParB spreading on DNA

1. Adam SB Jalal
2. Ngat T Tran
3. Clare EM Stevenson
4. Afroze Chimthanawala
5. Anjana Badrinarayanan
6. David M Lawson
7. Tung BK Le

• Curated by eLife

  Evaluation Summary:

  Bacterial ParB partition proteins have the novel property that they employ an unusual nucleotide cofactor for complex assembly at their specific DNA binding site, parS. The impact of this study is on our general understanding of this novel class of nucleotide-dependent processes, and the role that nucleotide-protein interactions play in DNA binding and bacterial physiology.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection

1. Pasquale Laise
2. Megan L. Stanifer
3. Gideon Bosker
4. Xiaoyun Sun
5. Sergio Triana
6. Patricio Doldan
7. Federico La Manna
8. Marta De Menna
9. Ronald B. Realubit
10. Sergey Pampou
11. Charles Karan
12. Theodore Alexandrov
13. Marianna Kruithof-de Julio
14. Andrea Califano
15. Steeve Boulant
16. Mariano J. Alvarez

Reviewed by ScreenIT

Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice

1. Sandrine Belouzard
2. Arnaud Machelart
3. Valentin Sencio
4. Thibaut Vausselin
5. Eik Hoffmann
6. Nathalie Deboosere
7. Yves Rouillé
8. Lowiese Desmarets
9. Karin Séron
10. Adeline Danneels
11. Cyril Robil
12. Loïc Belloy
13. Camille Moreau
14. Catherine Piveteau
15. Alexandre Biela
16. Alexandre Vandeputte
17. Séverine Heumel
18. Lucie Deruyter
19. Julie Dumont
20. Florence Leroux
21. Ilka Engelmann
22. Enagnon Kazali Alidjinou
23. Didier Hober
24. Priscille Brodin
25. Terence Beghyn
26. François Trottein
27. Benoît Déprez
28. Jean Dubuisson

Reviewed by ScreenIT

Early detection of SARS-CoV-2 in circulating immune cells in a mouse model

1. Tingting Geng
2. Spencer Keilich
3. Triantafyllos Tafas
4. Penghua Wang

Reviewed by ScreenIT

Neutralization of Delta variant with sera of Covishield™ vaccinees and COVID-19-recovered vaccinated individuals

1. Gajanan N Sapkal
2. Pragya D Yadav
3. Rima R Sahay
4. Gururaj Deshpande
5. Nivedita Gupta
6. Dimpal A Nyayanit
7. Deepak Y Patil
8. Anita M Shete
9. Sanjay Kumar
10. Priya Abraham
11. Samiran Panda
12. Balram Bhargava

Reviewed by ScreenIT

Spike protein cleavage-activation mediated by the SARS-CoV-2 P681R mutation: a case-study from its first appearance in variant of interest (VOI) A.23.1 identified in Uganda

1. Bailey Lubinski
2. Laura Frazier
3. My Phan
4. Daniel Bugumbe
5. Jessie L Cunningham
6. Tiffany Tang
7. Susan Daniel
8. Matthew Cotten
9. Javier A. Jaimes
10. Gary Whittaker

Reviewed by ScreenIT

Thiol-based chemical probes exhibit antiviral activity against SARS-CoV-2 via allosteric disulfide disruption in the spike glycoprotein

1. Yunlong Shi
2. Ari Zeida
3. Caitlin E. Edwards
4. Michael L. Mallory
5. Santiago Sastre
6. Matías R. Machado
7. Raymond J. Pickles
8. Ling Fu
9. Keke Liu
10. Jing Yang
11. Ralph S. Baric
12. Richard C. Boucher
13. Rafael Radi
14. Kate S. Carroll

Reviewed by ScreenIT