Microbiology

  1. Unifying the known and unknown microbial coding sequence space

    1. Chiara Vanni
    2. Matthew S Schechter
    3. Silvia G Acinas
    4. Albert Barberán
    5. Pier Luigi Buttigieg
    6. Emilio O Casamayor
    7. Tom O Delmont
    8. Carlos M Duarte
    9. A Murat Eren
    10. Robert D Finn
    11. Renzo Kottmann
    12. Alex Mitchell
    13. Pablo Sánchez
    14. Kimmo Siren
    15. Martin Steinegger
    16. Frank Oliver Gloeckner
    17. Antonio Fernàndez-Guerra

    • Curated by eLife

      Evaluation Summary:

      This paper tackles perhaps THE central question in metagenomics: what are all these unknown genes and genomes doing!? The authors use recent advances in high-throughput sequencing clustering and homology detection algorithms to systematically integrate unannotated genes into discovery workflows. The paper's exploration results in a wide array of highly informative summative statistics, together with a simple example of how powerful the provided resource can be in generating hypotheses about the function of unknown genes.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  2. Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant

    1. Lucy G Thorne
    2. Mehdi Bouhaddou
    3. Ann-Kathrin Reuschl
    4. Lorena Zuliani-Alvarez
    5. Ben Polacco
    6. Adrian Pelin
    7. Jyoti Batra
    8. Matthew V.X. Whelan
    9. Manisha Ummadi
    10. Ajda Rojc
    11. Jane Turner
    12. Kirsten Obernier
    13. Hannes Braberg
    14. Margaret Soucheray
    15. Alicia Richards
    16. Kuei-Ho Chen
    17. Bhavya Harjai
    18. Danish Memon
    19. Myra Hosmillo
    20. Joseph Hiatt
    21. Aminu Jahun
    22. Ian G. Goodfellow
    23. Jacqueline M. Fabius
    24. Kevan Shokat
    25. Natalia Jura
    26. Klim Verba
    27. Mahdad Noursadeghi
    28. Pedro Beltrao
    29. Danielle L. Swaney
    30. Adolfo Garcia-Sastre
    31. Clare Jolly
    32. Greg J. Towers
    33. Nevan J. Krogan

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Screening of Botanical Drugs against SARS-CoV-2 Entry

    1. Junyuan Cao
    2. Yang Liu
    3. Minmin Zhou
    4. Siqi Dong
    5. Xiaoying Jia
    6. Xiaohao Lan
    7. Yueli Zhang
    8. Jiao Guo
    9. Gengfu Xiao
    10. Wei Wang

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Visualization of SARS-CoV-2 infection dynamic

    1. Chengjin Ye
    2. Kevin Chiem
    3. Jun-Gyu Park
    4. Jesus A. Silvas
    5. Desarey Morales Vasquez
    6. Jordi B. Torrelles
    7. James J. Kobie
    8. Mark R. Walter
    9. Juan Carlos de la Torre
    10. Luis Martinez-Sobrido

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

    1. Marco Grodzki
    2. Andrew P. Bluhm
    3. Moritz Schaefer
    4. Abderrahmane Tagmount
    5. Max Russo
    6. Amin Sobh
    7. Roya Rafiee
    8. Chris D. Vulpe
    9. Stephanie M. Karst
    10. Michael H. Norris

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator

    1. Lisiena Hysenaj
    2. Samantha Little
    3. Kayla Kulhanek
    4. Oghenekevwe M. Gbenedio
    5. Lauren Rodriguez
    6. Alan Shen
    7. Jean-Christophe Lone
    8. Leonard C. Lupin-Jimenez
    9. Luke R. Bonser
    10. Nina K. Serwas
    11. Kriti Bahl
    12. Eran Mick
    13. Jack Z. Li
    14. Vivianne W. Ding
    15. Shotaro Matsumoto
    16. Mazharul Maishan
    17. Camille Simoneau
    18. Gabriela Fragiadakis
    19. David M. Jablons
    20. Charles R. Langelier
    21. Michael Matthay
    22. Melanie Ott
    23. Matthew Krummel
    24. Alexis J. Combes
    25. Anita Sil
    26. David J. Erle
    27. Johannes R. Kratz
    28. Jeroen P. Roose

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Synergistic Block of SARS-CoV-2 Infection by Combined Drug Inhibition of the Host Entry Factors PIKfyve Kinase and TMPRSS2 Protease

    1. Alex J. B. Kreutzberger
    2. Anwesha Sanyal
    3. Ravi Ojha
    4. Jesse D. Pyle
    5. Olli Vapalahti
    6. Giuseppe Balistreri
    7. Tom Kirchhausen

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Virucidal activity of a proprietary blend of plant-based oils (Viruxal) against SARS-CoV-2 and influenza viruses – an in vitro study

    1. Jón Magnús Kristjánsson
    2. Óttar Rolfsson

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. SARS-CoV-2 cell-to-cell spread occurs rapidly and is insensitive to antibody neutralization

    1. Laurelle Jackson
    2. Hylton Rodel
    3. Shi-Hsia Hwa
    4. Sandile Cele
    5. Yashica Ganga
    6. Houriiyah Tegally
    7. Mallory Bernstein
    8. Jennifer Giandhari
    9. COMMIT-KZN Team
    10. Bernadett I. Gosnell
    11. Khadija Khan
    12. Willem Hanekom
    13. Farina Karim
    14. Tulio de Oliveira
    15. Mahomed-Yunus S. Moosa
    16. Alex Sigal

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

    1. Ruochen Zang
    2. Maria Florencia Gomez Castro
    3. Broc T. McCune
    4. Qiru Zeng
    5. Paul W. Rothlauf
    6. Naomi M. Sonnek
    7. Zhuoming Liu
    8. Kevin F. Brulois
    9. Xin Wang
    10. Harry B. Greenberg
    11. Michael S. Diamond
    12. Matthew A. Ciorba
    13. Sean P. J. Whelan
    14. Siyuan Ding

    Reviewed by ScreenIT, preLights

    2 evaluationsAppears in 2 listsLatest version Latest activity
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