Microbiology

  1. Dual roles of a novel oncolytic viral vector-based SARS-CoV-2 vaccine: preventing COVID-19 and treating tumor progression

    1. Yaping Sun
    2. Wenjuan Dong
    3. Lei Tian
    4. Youliang Rao
    5. Chao Qin
    6. Sierra A. Jaramillo
    7. Erik W. Settles
    8. Shoubao Ma
    9. Jianying Zhang
    10. Kang Yu
    11. Bo Xu
    12. Jiazhuo Yan
    13. Rui Ma
    14. Zhuo Li
    15. Sanjeet S. Dadwal
    16. Bridget M. Barker
    17. Paul S. Keim
    18. Pinghui Feng
    19. Michael A. Caligiuri
    20. Jianhua Yu

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  2. Targeting Conserved Sequences Circumvents the Evolution of Resistance in a Viral Gene Drive against Human Cytomegalovirus

    1. Marius Walter
    2. Rosalba Perrone
    3. Eric Verdin

    • Curated by eLife

      Evaluation Summary:

      This paper will be of interest to experimental virologists and others following the development of "gene drive" technology to promote the rapid spread of specific mutations through a population. The authors first nicely confirm their prior finding that a gene drive virus can be used to transfer mutations into a normal virus when both are infecting the same cell. They then evaluate a strategy with potential to ameliorate the undesirable but expected emergence of viruses that acquire resistance to the gene transfer. Although the experiments are well done, the data are mostly convincing and accurately interpreted, and the presentation is clear, the studies provide a relatively minor advance in fundamental understanding of this potentially innovative therapy.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  3. The local anaesthetic procaine prodrugs ProcCluster ® and Procaine-hydrochloride impair SARS-CoV-2 replication in vitro

    1. Clio Häring
    2. Josefine Schroeder
    3. Bettina Löffler
    4. Beatrice Engert
    5. Christina Ehrhardt

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. FXR inhibition reduces ACE2 expression, SARS-CoV-2 infection and may improve COVID-19 outcome

    1. Teresa Brevini
    2. Mailis Maes
    3. Gwilym J. Webb
    4. William T. H. Gelson
    5. Sally Forrest
    6. Petra Mlcochova
    7. Scott Dillon
    8. Sagar Varankar
    9. Mahnaz Darvish-Damavandi
    10. Victoria L. Mulcahy
    11. Rhoda E. Kuc
    12. Thomas L. Williams
    13. Vasileios Galanakis
    14. Marta Vila-Gonzalez
    15. Olivia C. Tysoe
    16. Daniele Muraro
    17. Thomas W. M. Crozier
    18. Johannes Bargehr
    19. Sanjay Sinha
    20. Sara S. Upponi
    21. Lisa Swift
    22. Kourosh Saeb-Parsy
    23. Susan E. Davies
    24. Thomas Marjot
    25. Eleanor Barnes
    26. Ansgar W. Lohse
    27. Andrew M. Moon
    28. A. Sidney Barritt
    29. Ravindra K. Gupta
    30. Stephen Baker
    31. Anthony P. Davenport
    32. Gareth Corbett
    33. Simon J. A. Buczacki
    34. Joo-Hyeon Lee
    35. Paul Gibbs
    36. Andrew J. Butler
    37. Christopher J. E. Watson
    38. George F. Mells
    39. Gordon Dougan
    40. Ludovic Vallier
    41. Fotios Sampaziotis

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Niche partitioning facilitates coexistence of closely related honey bee gut bacteria

    1. Silvia Brochet
    2. Andrew Quinn
    3. Ruben AT Mars
    4. Nicolas Neuschwander
    5. Uwe Sauer
    6. Philipp Engel

    • Curated by eLife

      Evaluation Summary:

      Brochet et al. address an outstanding ecological question related to how closely related microbial symbionts co-exist in the gut as stable communities. To tackle this question, the authors use an elegant model relying on honeybees colonized with a defined bacterial community. They provide compelling empirical evidence that a nutritionally complex diet together with microbial metabolic diversity play a key role in enabling co-existence of closely-related honeybee gut microbiota.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  6. Unifying the known and unknown microbial coding sequence space

    1. Chiara Vanni
    2. Matthew S Schechter
    3. Silvia G Acinas
    4. Albert Barberán
    5. Pier Luigi Buttigieg
    6. Emilio O Casamayor
    7. Tom O Delmont
    8. Carlos M Duarte
    9. A Murat Eren
    10. Robert D Finn
    11. Renzo Kottmann
    12. Alex Mitchell
    13. Pablo Sánchez
    14. Kimmo Siren
    15. Martin Steinegger
    16. Frank Oliver Gloeckner
    17. Antonio Fernàndez-Guerra

    • Curated by eLife

      Evaluation Summary:

      This paper tackles perhaps THE central question in metagenomics: what are all these unknown genes and genomes doing!? The authors use recent advances in high-throughput sequencing clustering and homology detection algorithms to systematically integrate unannotated genes into discovery workflows. The paper's exploration results in a wide array of highly informative summative statistics, together with a simple example of how powerful the provided resource can be in generating hypotheses about the function of unknown genes.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  7. Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant

    1. Lucy G Thorne
    2. Mehdi Bouhaddou
    3. Ann-Kathrin Reuschl
    4. Lorena Zuliani-Alvarez
    5. Ben Polacco
    6. Adrian Pelin
    7. Jyoti Batra
    8. Matthew V.X. Whelan
    9. Manisha Ummadi
    10. Ajda Rojc
    11. Jane Turner
    12. Kirsten Obernier
    13. Hannes Braberg
    14. Margaret Soucheray
    15. Alicia Richards
    16. Kuei-Ho Chen
    17. Bhavya Harjai
    18. Danish Memon
    19. Myra Hosmillo
    20. Joseph Hiatt
    21. Aminu Jahun
    22. Ian G. Goodfellow
    23. Jacqueline M. Fabius
    24. Kevan Shokat
    25. Natalia Jura
    26. Klim Verba
    27. Mahdad Noursadeghi
    28. Pedro Beltrao
    29. Danielle L. Swaney
    30. Adolfo Garcia-Sastre
    31. Clare Jolly
    32. Greg J. Towers
    33. Nevan J. Krogan

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Screening of Botanical Drugs against SARS-CoV-2 Entry

    1. Junyuan Cao
    2. Yang Liu
    3. Minmin Zhou
    4. Siqi Dong
    5. Xiaoying Jia
    6. Xiaohao Lan
    7. Yueli Zhang
    8. Jiao Guo
    9. Gengfu Xiao
    10. Wei Wang

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. Visualization of SARS-CoV-2 infection dynamic

    1. Chengjin Ye
    2. Kevin Chiem
    3. Jun-Gyu Park
    4. Jesus A. Silvas
    5. Desarey Morales Vasquez
    6. Jordi B. Torrelles
    7. James J. Kobie
    8. Mark R. Walter
    9. Juan Carlos de la Torre
    10. Luis Martinez-Sobrido

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

    1. Marco Grodzki
    2. Andrew P. Bluhm
    3. Moritz Schaefer
    4. Abderrahmane Tagmount
    5. Max Russo
    6. Amin Sobh
    7. Roya Rafiee
    8. Chris D. Vulpe
    9. Stephanie M. Karst
    10. Michael H. Norris

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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