Microbiology

Pathogenic and transcriptomic differences of emerging SARS-CoV-2 variants in the Syrian golden hamster model

1. Kyle L. O'Donnell
2. Amanda N. Pinski
3. Chad S. Clancy
4. Tylisha Gourdine
5. Kyle Shifflett
6. Paige Fletcher
7. Ilhem Messaoudi
8. Andrea Marzi

Reviewed by ScreenIT

A mouse-adapted SARS-CoV-2 strain replicating in standard laboratory mice

1. Xavier Montagutelli
2. Matthieu Prot
3. Grégory Jouvion
4. Laurine Levillayer
5. Laurine Conquet
6. Edouard Reyes-Gomez
7. Flora Donati
8. Melanie Albert
9. Sylvie van der Werf
10. Jean Jaubert
11. Etienne Simon-Lorière

Reviewed by ScreenIT

Host Cellular RNA Helicases Regulate SARS-CoV-2 Infection

1. Yasuo Ariumi

Reviewed by ScreenIT

Loss of N1-methylation of G37 in tRNA induces ribosome stalling and reprograms gene expression

1. Isao Masuda
2. Jae-Yeon Hwang
3. Thomas Christian
4. Sunita Maharjan
5. Fuad Mohammad
6. Howard Gamper
7. Allen R Buskirk
8. Ya-Ming Hou

• Curated by eLife

  Evaluation Summary:

  This manuscript provides evidence that loss of N1-methylation of G37 of tRNAs in bacteria on depletion of TrmD results in defects in aminoacylation and peptidyl-transfer, leading to ribosome stalling and phenotypes indicating activation of the stringent response.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Therapeutic efficacy of CT-P59 against P.1 variant of SARS-CoV-2

1. Dong-Kyun Ryu
2. Bobin Kang
3. Sun-Je Woo
4. Min-Ho Lee
5. Aloys SL Tijsma
6. Hanmi Noh
7. Jong-In Kim
8. Ji-Min Seo
9. Cheolmin Kim
10. Minsoo Kim
11. Eunji Yang
12. Gippeum Lim
13. Seong-Gyu Kim
14. Su-Kyeong Eo
15. Jung-ah Choi
16. Sang-Seok Oh
17. Patricia M Nuijten
18. Manki Song
19. Hyo-Young Chung
20. Carel A van Baalen
21. Ki-Sung Kwon
22. Soo-Young Lee

Reviewed by ScreenIT

A Photoactivable Natural Product with Broad Antiviral Activity against Enveloped Viruses, Including Highly Pathogenic Coronaviruses

1. Thomas Meunier
2. Lowiese Desmarets
3. Simon Bordage
4. Moussa Bamba
5. Kévin Hervouet
6. Yves Rouillé
7. Nathan François
8. Marion Decossas
9. Valentin Sencio
10. François Trottein
11. Fézan Honora Tra Bi
12. Olivier Lambert
13. Jean Dubuisson
14. Sandrine Belouzard
15. Sevser Sahpaz
16. Karin Séron

Reviewed by ScreenIT

Immunogenicity of Low-Dose Prime-Boost Vaccination of mRNA Vaccine CV07050101 in Non-Human Primates

1. Neeltje van Doremalen
2. Robert J. Fischer
3. Jonathan E. Schulz
4. Myndi G. Holbrook
5. Brian J. Smith
6. Jamie Lovaglio
7. Benjamin Petsch
8. Vincent J. Munster

Reviewed by ScreenIT

Pneumococcal genetic variability in age-dependent bacterial carriage

1. Philip HC Kremer
2. Bart Ferwerda
3. Hester J Bootsma
4. Nienke Y Rots
5. Alienke J Wijmenga-Monsuur
6. Elisabeth AM Sanders
7. Krzysztof Trzciński
8. Anne L Wyllie
9. Paul Turner
10. Arie van der Ende
11. Matthijs C Brouwer
12. Stephen D Bentley
13. Diederik van de Beek
14. John A Lees

• Curated by eLife

  Evaluation Summary:

  Strain variability in bacterial infections is a confounding factor in the treatment and prevention of the associated diseases. Pneumococcal disease is widespread, and the current vaccine targets only a subset of circulating strains, with disease and vaccine efficacy likely varying with the age of the host. Using two large databases of pneumococcal genomes, this study explores the associations between genomic factors and the age of the human host. Ultimately, these data and related studies will establish whether and how vaccines should be differentially designed for children and the elderly. This work will be of interest to those working in bacterial infections and host-pathogen genomics.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Impact of temperature on the affinity of SARS-CoV-2 Spike for ACE2

1. Jérémie Prévost
2. Jonathan Richard
3. Romain Gasser
4. Shilei Ding
5. Clément Fage
6. Sai Priya Anand
7. Damien Adam
8. Natasha Gupta Vergara
9. Alexandra Tauzin
10. Mehdi Benlarbi
11. Shang Yu Gong
12. Guillaume Goyette
13. Anik Privé
14. Sandrine Moreira
15. Hugues Charest
16. Michel Roger
17. Walther Mothes
18. Marzena Pazgier
19. Emmanuelle Brochiero
20. Guy Boivin
21. Cameron F. Abrams
22. Arne Schön
23. Andrés Finzi

Reviewed by ScreenIT

Reduced neutralization of SARS-CoV-2 B.1.617 variant by inactivated and RBD-subunit vaccine

1. Jie Hu
2. Xiao-yu Wei
3. Jin Xiang
4. Pai Peng
5. Feng-li Xu
6. Kang Wu
7. Fei-yang Luo
8. Ai-shun Jin
9. Liang Fang
10. Bei-zhong Liu
11. Kai Wang
12. Ni Tang
13. Ai-Long Huang

Reviewed by ScreenIT