Microbiology

A SARS-CoV-2 Spike Ferritin Nanoparticle Vaccine Is Protective and Promotes a Strong Immunological Response in the Cynomolgus Macaque Coronavirus Disease 2019 (COVID-19) Model

1. Sara C. Johnston
2. Keersten M. Ricks
3. Ines Lakhal-Naouar
4. Alexandra Jay
5. Caroline Subra
6. Jo Lynne Raymond
7. Hannah A. D. King
8. Franco Rossi
9. Tamara L. Clements
10. David Fetterer
11. Samantha Tostenson
12. Camila Macedo Cincotta
13. Holly R. Hack
14. Caitlin Kuklis
15. Sandrine Soman
16. Jocelyn King
17. Kristina K. Peachman
18. Dohoon Kim
19. Wei-Hung Chen
20. Rajeshwer S. Sankhala
21. Elizabeth J. Martinez
22. Agnes Hajduczki
23. William C. Chang
24. Misook Choe
25. Paul V. Thomas
26. Caroline E. Peterson
27. Alexander Anderson
28. Isabella Swafford
29. Jeffrey R. Currier
30. Dominic Paquin-Proulx
31. Linda L. Jagodzinski
32. Gary R. Matyas
33. Mangala Rao
34. Gregory D. Gromowski
35. Sheila A. Peel
36. Lauren White
37. Jeffrey M. Smith
38. Jay W. Hooper
39. Nelson L. Michael
40. Kayvon Modjarrad
41. M. Gordon Joyce
42. Aysegul Nalca
43. Diane L. Bolton
44. Margaret L. M. Pitt

Reviewed by ScreenIT

The Envelope Protein of SARS-CoV-2 Inhibits Viral Protein Synthesis and Infectivity of Human Immunodeficiency Virus type 1 (HIV-1)

1. Wyatt Henke
2. Hope Waisner
3. Sachith Polpitiya Arachchige
4. Maria Kalamvoki
5. Edward Stephens

Reviewed by ScreenIT

Antiviral roles of interferon regulatory factor (IRF)-1, 3 and 7 against human coronavirus infection

1. Danyang Xu
2. Joseph K. Sampson Duncan
3. Maria Licursi
4. Jin Gohda
5. Yasushi Kawaguchi
6. Kensuke Hirasawa

Reviewed by ScreenIT

Optimized production and fluorescent labelling of SARS-CoV-2 Virus-Like-Particles to study virus assembly and entry

1. Manon Gourdelier
2. Jitendriya Swain
3. Coline Arone
4. Anita Mouttou
5. David Bracquemond
6. Peggy Merida
7. Saveez Saffarian
8. Sébastien Lyonnais
9. Cyril Favard
10. Delphine Muriaux

Reviewed by ScreenIT

Engineering a Vaccine Platform using Rotavirus A to Express SARS-CoV-2 Spike Epitopes

1. Ola Diebold
2. Victoria Gonzalez
3. Luca Venditti
4. Colin Sharp
5. Rosemary A. Blake
6. Joanne Stevens
7. Sarah Caddy
8. Paul Digard
9. Alexander Borodavka
10. Eleanor Gaunt

Reviewed by ScreenIT

SARS-CoV-2 Harnesses Host Translational Shutoff and Autophagy To Optimize Virus Yields: the Role of the Envelope (E) Protein

1. Hope Waisner
2. Brandon Grieshaber
3. Rabina Saud
4. Wyatt Henke
5. Edward B. Stephens
6. Maria Kalamvoki

Reviewed by ScreenIT

Differences in neuroinflammation in the olfactory bulb between D614G, Delta and Omicron BA.1 SARS-CoV-2 variants in the hamster model

1. Lisa Bauer
2. Melanie Rissmann
3. Feline F. W. Benavides
4. Lonneke Leijten
5. Lineke Begeman
6. Edwin Veldhuis Kroeze
7. Peter van Run
8. Marion P. G. Koopmans
9. Barry Rockx
10. Debby van Riel

Reviewed by ScreenIT

The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence

1. Pramod K Jangir
2. Lois Ogunlana
3. Petra Szili
4. Marton Czikkely
5. Liam P Shaw
6. Emily J Stevens
7. Yang Yu
8. Qiue Yang
9. Yang Wang
10. Csaba Pál
11. Timothy R Walsh
12. Craig R MacLean

• Curated by eLife

  eLife assessment

  Antimicrobial peptides (AMP) are a class of antibiotics that are inspired by natural components of innate immunity, which raises the specter of bacteria becoming resistant to both. The author this important study test this idea and find compelling evidence that a plasmid that encodes resistance to the AMP colistin also increases resistance to AMPS produced by humans, pigs, and chickens, enables the bacteria to grow better in low levels of AMP, and increases bacterial virulence in an insect model of infection. The study will be of interest to both evolutionary biologists and microbiologists focused on antimicrobial therapy and suggests that the evolution of resistance to these compounds can have collateral effects on immune evasion as well.

Reviewed by eLife, PREreview

Cellulosic copper nanoparticles and a hydrogen peroxide-based disinfectant protect Vero E6 cells against infection by viral pseudotyped particles expressing SARS-CoV-2, SARS-CoV or MERS-CoV Spike protein

1. Ariane Brault
2. Raphael Néré
3. Jérôme Prados
4. Simon Boudreault
5. Martin Bisaillon
6. Patrick Marchand
7. Patrick Couture
8. Simon Labbé

Reviewed by ScreenIT

An Archaea-specific c-type cytochrome maturation machinery is crucial for methanogenesis in Methanosarcina acetivorans

1. Dinesh Gupta
2. Katie E Shalvarjian
3. Dipti D Nayak

• Curated by eLife

  Evaluation Summary:

  This paper will be of interest to scientists interested in archaea and the field of bioenergetics. Using a series of elegant experiments the authors show that that archaea have a streamlined and functional cytochrome c biogenesis machinery.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

Reviewed by eLife