Microbiology

Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions

1. Eric S. Pringle
2. Brett A. Duguay
3. Maxwell P. Bui-Marinos
4. Rory P. Mulloy
5. Shelby L. Landreth
6. Krishna Swaroop Desireddy
7. Stacia M. Dolliver
8. Shan Ying
9. Taylor Caddell
10. Trinity H. Tooley
11. Patrick D. Slaine
12. Stephen L. Bearne
13. Darryl Falzarano
14. Jennifer A. Corcoran
15. Denys A. Khaperskyy
16. Craig McCormick

Reviewed by ScreenIT

Dissecting the role of the human microbiome in COVID-19 via metagenome-assembled genomes

1. Shanlin Ke
2. Scott T. Weiss
3. Yang-Yu Liu

Reviewed by ScreenIT

Reorganization of F-actin nanostructures is required for the late phases of SARS-CoV-2 replication in pulmonary cells

1. Jitendriya Swain
2. Peggy Merida
3. Karla Rubio
4. David Bracquemond
5. Israel Aguilar-Ordoñez
6. Stefan Günther
7. Guillermo Barreto
8. Delphine Muriaux

Reviewed by Review Commons, ScreenIT

SARS-CoV-2 Omicron variant is more stable than the ancestral strain on various surfaces

1. Alex Wing Hong Chin
2. Alison Man Yuk Lai
3. Malik Peiris
4. Leo Lit Man Poon

Reviewed by ScreenIT

Extensive neutralization against SARS-CoV-2 variants elicited by Omicron-specific subunit vaccine booster

1. Pai Peng
2. Chengqian Feng
3. Jie Hu
4. Chang-long He
5. Hai-jun Deng
6. Qinghong Fan
7. Jin Xiang
8. Guofang Tang
9. Mengling Jiang
10. Fengyu Hu
11. Feng Li
12. Kai Wang
13. Ni Tang
14. Xiaoping Tang
15. Ai-long Huang

Reviewed by ScreenIT

Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq

1. Liselot Dewachter
2. Julien Dénéréaz
3. Xue Liu
4. Vincent de Bakker
5. Charlotte Costa
6. Mara Baldry
7. Jean-Claude Sirard
8. Jan-Willem Veening

• Curated by eLife

  Evaluation Summary:

  Three experts in the field reviewed this manuscript from slightly different perspectives. All three reviewers are generally positive about this interesting, well-presented paper and think that it leads to several advances in the field. However, the reviewers also think changes can be made that would considerably strengthen the current version and its impact. Specific modifications have been requested to improve analysis of the screening data, to discuss hits besides the mevalonate pathway that increase Streptococcus pneumoniae cell length and shape, to clarify some issues about how mevalonate depletion changes pneumococcal cell shape and peptidoglycan synthesis, and to provide more context for clomiphene potentiation of amoxicillin killing of Streptococcus pneumoniae in comparison to previously published results in Staphylococcus aureus.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Geneticin shows selective antiviral activity against SARS-CoV-2 by interfering with programmed −1 ribosomal frameshifting

1. Carmine Varricchio
2. Gregory Mathez
3. Trestan Pillonel
4. Claire Bertelli
5. Laurent Kaiser
6. Caroline Tapparel
7. Andrea Brancale
8. Valeria Cagno

Reviewed by ScreenIT

SARS-CoV-2 Spike evolution influences GBP and IFITM sensitivity

1. Dejan Mesner
2. Ann-Kathrin Reuschl
3. Matthew V.X Whelan
4. Taylor Bronzovich
5. Tafhima Haider
6. Lucy G. Thorne
7. Greg J. Towers
8. Clare Jolly

Reviewed by ScreenIT

Crippled Coronavirus: 5’-PolyU targeted Oligo prevents development of infectious Virions

1. Hemayet Ullah
2. Saadyah Averick
3. Qiyi Tang

Reviewed by ScreenIT

A mechanistic understanding of the modes of Ca ion binding to the SARS-CoV-1 fusion peptide and their role in the dynamics of host membrane penetration

1. Juliana Debrito Carten
2. George Khelashvili
3. Miya K. Bidon
4. Marco R. Straus
5. Tiffany Tang
6. Javier A. Jaimes
7. Harel Weinstein
8. Gary R. Whittaker
9. Susan Daniel

Reviewed by ScreenIT