Microbiology

The SARS-CoV-2 spike S375F mutation characterizes the Omicron BA.1 variant

1. Izumi Kimura
2. Daichi Yamasoba
3. Hesham Nasser
4. Jiri Zahradnik
5. Yusuke Kosugi
6. Jiaqi Wu
7. Kayoko Nagata
8. Keiya Uriu
9. Yuri L. Tanaka
10. Jumpei Ito
11. Ryo Shimizu
12. Toong Seng Tan
13. Erika P. Butlertanaka
14. Hiroyuki Asakura
15. Kenji Sadamasu
16. Kazuhisa Yoshimura
17. Takamasa Ueno
18. Akifumi Takaori-Kondo
19. Gideon Schreiber
20. Mako Toyoda
21. Kotaro Shirakawa
22. Takashi Irie
23. Akatsuki Saito
24. So Nakagawa
25. Terumasa Ikeda
26. Kei Sato

Reviewed by ScreenIT

Evolution of the Quorum Sensing Regulon in Cooperating Populations of Pseudomonas aeruginosa

1. Nicole E. Smalley
2. Amy L. Schaefer
3. Kyle L. Asfahl
4. Crystal Perez
5. E. Peter Greenberg
6. Ajai A. Dandekar

• Curated by eLife

  Evaluation Summary:

  Pseudomonas aeruginosa regulates the production of many cooperative traits through quorum sensing cell-cell signaling. The authors carried out transcriptomic studies of experimental evolved populations of P. aeruginosa and observed that the size of the quorum sensing regulon decreases when only a few but not all the cooperative processes regulated quorum sensing are required for growth. Their findings are consistent with the hypothesis that quorum sensing regulated genes can be counter selected rapidly when not beneficial. This study is of interest for microbiologists studying quorum-sensing, and evolutionary biologists studying the evolution of cooperative behavior.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

SARS-CoV-2 Omicron is specifically restricted in its replication in human lung tissue, compared to other variants of concern

1. Or Alfi
2. Marah Hamdan
3. Ori Wald
4. Arkadi Yakirevitch
5. Ori Wandel
6. Esther Oiknine-Djian
7. Ben Gvili
8. Hadas Knoller
9. Noa Rozendorn
10. Hadar Golan
11. Sheera Adar
12. Olesya Vorontsov
13. Michal Mandelboim
14. Zichria Zakay-Rones
15. Menachem Oberbaum
16. Amos Panet
17. Dana G. Wolf

Reviewed by ScreenIT

Brequinar and dipyridamole in combination exhibits synergistic antiviral activity against SARS-CoV-2 in vitro: Rationale for a host-acting antiviral treatment strategy for COVID-19

1. James F. Demarest
2. Maryline Kienle
3. RuthMabel Boytz
4. Mary Ayres
5. Eun Jung Kim
6. J.J. Patten
7. Donghoon Chung
8. Varsha Gandhi
9. Robert A. Davey
10. David B. Sykes
11. Nadim Shohdy
12. John C. Pottage
13. Vikram S. Kumar

Reviewed by ScreenIT

Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2

1. Jing Zou
2. Chaitanya Kurhade
3. Hongjie Xia
4. Mingru Liu
5. Xuping Xie
6. Ping Ren
7. Pei-Yong Shi

Reviewed by ScreenIT

Methylene blue, Mycophenolic acid, Posaconazole, and Niclosamide inhibit SARS-CoV-2Omicron variant BA.1 infection of human airway epithelial explant cultures

1. Romain Volle
2. Luca Murer
3. Anthony Petkidis
4. Vardan Andriasyan
5. Alessandro Savi
6. Cornelia Bircher
7. Nicole Meili
8. Lucy Fischer
9. Daniela Policarpo Sequeira
10. Daniela Katharina Mark
11. Alfonso Gomez-Gonzalez
12. Urs F. Greber

Reviewed by ScreenIT

Neutralization of Omicron BA.1, BA.2, and BA.3 SARS-CoV-2 by 3 doses of BNT162b2 vaccine

1. Chaitanya Kurhade
2. Jing Zou
3. Hongjie Xia
4. Hui Cai
5. Qi Yang
6. Mark Cutler
7. David Cooper
8. Alexander Muik
9. Kathrin U. Jansen
10. Xuping Xie
11. Kena A. Swanson
12. Pei‑Yong Shi

Reviewed by ScreenIT

Mosaic RBD nanoparticles protect against multiple sarbecovirus challenges in animal models

1. Alexander A. Cohen
2. Neeltje van Doremalen
3. Allison J. Greaney
4. Hanne Andersen
5. Ankur Sharma
6. Tyler N. Starr
7. Jennifer R. Keeffe
8. Chengcheng Fan
9. Jonathan E. Schulz
10. Priyanthi N.P. Gnanapragasam
11. Leesa M. Kakutani
12. Anthony P West
13. Greg Saturday
14. Yu E. Lee
15. Han Gao
16. Claudia A. Jette
17. Mark G. Lewis
18. Tiong K. Tan
19. Alain R. Townsend
20. Jesse D. Bloom
21. Vincent J. Munster
22. Pamela J. Bjorkman

Reviewed by ScreenIT

A rapid, high-throughput, viral infectivity assay using automated brightfield microscopy with machine learning

1. Rupert Dodkins
2. John R. Delaney
3. Tess Overton
4. Frank Scholle
5. Alba Frias-De-Diego
6. Elisa Crisci
7. Nafisa Huq
8. Ingo Jordan
9. Jason T. Kimata
10. Teresa Findley
11. Ilya G. Goldberg

Reviewed by ScreenIT

An engineered ACE2 decoy receptor can be administered by inhalation and potently targets the BA.1 and BA.2 omicron variants of SARS-CoV-2

1. Lianghui Zhang
2. Krishna K. Narayanan
3. Laura Cooper
4. Kui K. Chan
5. Christine A. Devlin
6. Aaron Aguhob
7. Kristie Shirley
8. Lijun Rong
9. Jalees Rehman
10. Asrar B. Malik
11. Erik Procko

Reviewed by ScreenIT