Microbiology

Relative infectivity of the SARS-CoV-2 Omicron variant in human alveolar cells

1. Taewoo Kim
2. Kyoung Il Min
3. Jeong-Sun Yang
4. Jun Won Kim
5. Junhyung Cho
6. Yun Ho Kim
7. Jeong Seok Lee
8. Young Tae Kim
9. Kyung-Chang Kim
10. Jeong Yeon Kim
11. Kwon Joong Na
12. Joo-Yeon Lee
13. Young Seok Ju

Reviewed by ScreenIT

SARS-CoV-2 Delta breakthrough infections in vaccinated patients

1. Jing Zou
2. Xuping Xie
3. Mingru Liu
4. Pei-Yong Shi
5. Ping Ren

Reviewed by ScreenIT

Markers of Fungal Translocation Are Elevated During Post-Acute Sequelae of SARS-CoV-2 Infection and Induce NF-κB Triggered Inflammation

1. Leila B. Giron
2. Michael J. Peluso
3. Jianyi Ding
4. Grace Kenny
5. Netanel F Zilberstein
6. Jane Koshy
7. Kai Ying Hong
8. Heather Rasmussen
9. Greg Miller
10. Faraz Bishehsari
11. Robert A. Balk
12. James N. Moy
13. Rebecca Hoh
14. Scott Lu
15. Aaron R. Goldman
16. Hsin-Yao Tang
17. Brandon C. Yee
18. Ahmed Chenna
19. John W. Winslow
20. Christos J. Petropoulos
21. J. Daniel Kelly
22. Haimanot Wasse
23. Jeffrey N. Martin
24. Qin Liu
25. Ali Keshavarzian
26. Alan Landay
27. Steven G. Deeks
28. Timothy J. Henrich
29. Mohamed Abdel-Mohsen

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Discrimination of SARS-CoV-2 Omicron sub-lineages BA.1 and BA.2 using a high-resolution melting-based assay: A pilot study

1. Akira Aoki
2. Hirokazu Adachi
3. Yoko Mori
4. Miyabi Ito
5. Katsuhiko Sato
6. Kenji Okuda
7. Toru Sakakibara
8. Yoshinori Okamoto
9. Hideto Jinno

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Key mutations on spike protein altering ACE2 receptor utilization and potentially expanding host range of emerging SARS‐CoV‐2 variants

1. Qiong Wang
2. Sheng‐Bao Ye
3. Zhi‐Jian Zhou
4. Jin‐Yan Li
5. Ji‐Zhou Lv
6. Bodan Hu
7. Shuofeng Yuan
8. Ye Qiu
9. Xing‐Yi Ge

Reviewed by ScreenIT

SARS-ANI: a global open access dataset of reported SARS-CoV-2 events in animals

1. Afra Nerpel
2. Liuhuaying Yang
3. Johannes Sorger
4. Annemarie Käsbohrer
5. Chris Walzer
6. Amélie Desvars-Larrive

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The interferon-inducible GTPase MxB promotes capsid disassembly and genome release of herpesviruses

1. Manutea C Serrero
2. Virginie Girault
3. Sebastian Weigang
4. Todd M Greco
5. Ana Ramos-Nascimento
6. Fenja Anderson
7. Antonio Piras
8. Ana Hickford Martinez
9. Jonny Hertzog
10. Anne Binz
11. Anja Pohlmann
12. Ute Prank
13. Jan Rehwinkel
14. Rudolf Bauerfeind
15. Ileana M Cristea
16. Andreas Pichlmair
17. Georg Kochs
18. Beate Sodeik

• Curated by eLife

  Evaluation Summary:

  This paper uses an innovative cell-free system to identify antiviral factors that interact with HSV-1 in cells. In addition to cataloging many capsid-interacting factors, the paper probes the antiviral mechanism of one of these, MxB. The data provide strong support for an intriguing model in which MxB "punches" holes in HSV-1 capsids, releasing viral DNA and potentially triggering host DNA sensors. However, the binding of a variety of factors to the capsid appears able to bind to and shield the capsids from MxB attack, suggesting a new perspective on how viruses might evade some host defenses.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Phosphoregulation accommodates Type III secretion and assembly of a tether of ER-Chlamydia inclusion membrane contact sites

1. Rachel J Ende
2. Rebecca L Murray
3. Samantha K D'Spain
4. Isabelle Coppens
5. Isabelle Derré

• Curated by eLife

  Evaluation Summary:

  This manuscript will be of interest to readers in the field of infection and cell biology. The authors follow up their previous study to further deepen our understanding of host-pathogen interactions that contribute to transkingdom contact sites. The authors show that the Chlamydia effector protein IncV tethers ER to the bacterial vacuole in a manner dependent on the phosphorylation of its C-terminus by the host kinase CK2. In addition, the authors show that IncV recruits the host kinase CK2 to the bacterial vacuole in manner required for its phosphorylation and ER tethering. Overall, the data justify most of the key claims put forward by the authors. Nonetheless, clarification is required concerning the chain of events and the phosphorylation events required for VAP binding.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

The Delta variant SARS-CoV-2 spike protein uniquely promotes aggregation of pseudotyped viral particles

1. Jennifer D. Petersen
2. Jianming Lu
3. Wendy Fitzgerald
4. Fei Zhou
5. Paul S. Blank
6. Doreen Matthies
7. Joshua Zimmerberg

Reviewed by ScreenIT

Hippo signaling pathway activation during SARS-CoV-2 infection contributes to host antiviral response

1. Gustavo Garcia
2. Arjit Vijey Jeyachandran
3. Yijie Wang
4. Joseph Ignatius Irudayam
5. Sebastian Castillo Cario
6. Chandani Sen
7. Shen Li
8. Yunfeng Li
9. Ashok Kumar
10. Karin Nielsen-Saines
11. Samuel W. French
12. Priya S. Shah
13. Kouki Morizono
14. Brigitte N. Gomperts
15. Arjun Deb
16. Arunachalam Ramaiah
17. Vaithilingaraja Arumugaswami

Reviewed by ScreenIT