Microbiology

Whole Genome Sequencing Reveals Enterobacter hormaechei as a Key Bloodstream Pathogen in Six Tertiary Care Hospitals in Southwestern Nigeria

1. Faith I. Oni
2. Ayorinde O. Afolayan
3. Anderson O. Oaikhena
4. Erkison Ewomazino Odih
5. Odion O. Ikhimiukor
6. Veronica O. Ogunleye
7. Aaron O. Aboderin
8. Olatunde F. Olabisi
9. Adewale A. Amupitan
10. Abayomi Fadeyi
11. Rasaki A. Raheem
12. Bashirat A. Olanipekun
13. Charles J. Elikwu
14. Oluwadamilola A. Sadare
15. Phillip O. Oshun
16. Oyinlola O. Oduyebo
17. Folashade Ojo
18. Abolaji T. Adeyemo
19. Ifeanyi E Mba
20. Abiodun Egwuenu
21. Tochi Okwor
22. Anthony Underwood
23. Silvia Argimón
24. Chikwe Ihekweazu
25. David M. Aanensen
26. Iruka N. Okeke

Reviewed by Rapid Reviews Infectious Diseases

Discovery of antibiotics in the archaeome using deep learning

1. Marcelo D. T. Torres
2. Fangping Wan
3. Cesar de la Fuente-Nunez

Reviewed by Arcadia Science

A functional interleukin-4 homolog is encoded in the genome of infectious laryngotracheitis virus: unveiling a novel virulence factor

1. Jeremy D. Volkening
2. Stephen J. Spatz
3. Maricarmen García
4. Teresa A. Ross
5. Daniel A. Maekawa
6. Kenneth S. Rosenthal
7. Ana C. Zamora
8. April Skipper
9. Julia Blakey
10. Roshan Paudel

Reviewed by Arcadia Science

Morphology-dependent entry kinetics and spread of influenza A virus

1. Sarah Peterl
2. Carmen M. Lahr
3. Carl N. Schneider
4. Janis Meyer
5. Xenia Podlipensky
6. Vera Lechner
7. Maria Villiou
8. Larissa Eis
9. Steffen Klein
10. Charlotta Funaya
11. Elisabetta Ada Cavalcanti-Adam
12. Frederik Graw
13. Christine Selhuber-Unkel
14. Karl Rohr
15. Petr Chlanda

Reviewed by Review Commons, PREreview

Effects of parental care on skin microbial community composition in poison frogs

1. Marie-Therese Fischer
2. Katherine S. Xue
3. Elizabeth K. Costello
4. Mai Dvorak
5. Gaëlle Raboisson
6. Anna Robaczewska
7. Stephanie N. Caty
8. David A. Relman
9. Lauren A. O’Connell

• Curated by eLife

  eLife Assessment

  This study provides an important first look at the influence of vertical transmission in the establishment of the amphibian microbiome, with a specific focus on the potential role of parental care. Through a combination of cross-fostering experimental work, comparative analysis across species that show variable levels of care, and developmental time series, the authors provide convincing evidence that vertical transmission through care is possible, but incomplete evidence that it plays a significant role in shaping frog skin microbiomes in nature or across time. This work will be of interest to researchers studying the evolution of parental care and microbiomes in vertebrates.

Reviewed by eLife

Neutralizing human monoclonal antibodies that target the PcrV component of the Type III Secretion System of Pseudomonas aeruginosa act through distinct mechanisms

1. Jean-Mathieu Desveaux
2. Eric Faudry
3. Carlos Contreras-Martel
4. François Cretin
5. Leonardo Sebastian Dergan-Dylon
6. Axelle Amen
7. Isabelle Bally
8. Victor TardivyCasemajor
9. Fabien Chenavier
10. Delphine Fouquenet
11. Yvan Caspar
12. Ina Attrée
13. Andréa Dessen
14. Pascal Poignard

• Curated by eLife

  eLife Assessment

  This useful study identifies new monoclonal antibodies produced by cystic fibrosis patients against the Pseudomonas aeruginosa type three secretion system. The evidence supporting the authors' claim is solid. However, in the current version of the manuscript, it is unclear what the benefits of the newly isolated antibodies are with respect to antibodies previously identified using a similar approach. The study will be of interest to those working on developing mAbs against Pseudomonas aeruginosa and also against other pathogens that harbor the T3SS.

Reviewed by eLife

Alveolar metabolite availability facilitates secondary infection by Pseudomonas aeruginosa in acutely injured lungs

1. Jennifer M. Baker
2. Thomas L. Flott
3. Laura A. McLellan
4. Ingrid G. Bustos
5. Jose L. Guerrero
6. Lina M. Mendez
7. Annastasia M. Petouhoff
8. Piyush Ranjan
9. Joseph D. Metcalf
10. Roderick A. McDonald
11. Nicole R. Falkowski
12. Ying He
13. Mónica P. Cala
14. Gary B. Huffnagle
15. Michael W. Sjoding
16. Luis F. Reyes
17. Kathleen A. Stringer
18. Robert P. Dickson

Reviewed by PREreview

Oxidative stress drives potent bactericidal activity of pyrazinamide against Mycobacterium tuberculosis

1. Nicholas A Dillon
2. Elise A Lamont
3. Muzafar A Rather
4. Anthony D Baughn

• Curated by eLife

  eLife Assessment

  This study reports important advances in understanding how pyrazinamide, a first-line antibiotic for tuberculosis treatment, is effective in vivo. The experimental design and data provide solid evidence that the production of reactive oxygen species by host cells contributes to how pyrazinamide is more potent in the host than in culture conditions; however, additional experiments and controls would strengthen these conclusions. This work is of interest to the antibiotic drug development field.

Reviewed by eLife

Temperature modulates the dissemination potential of Microsporidia MB, a malaria-blocking endosymbiont of Anopheles mosquitoes

1. Fidel Gabriel Otieno
2. Priscille Barreaux
3. Affognon Steeven Belvinos
4. Edward Edmond Makhulu
5. Thomas Ogao Onchuru
6. Anne Wambui Wairimu
7. Stancy Mandere Omboye
8. Cynthia Nyambura King’ori
9. Sokame Bonoukpoè Mawuko
10. Anthony Nyamache Kebira
11. Jeremy Keith Herren

Reviewed by Rapid Reviews Infectious Diseases

Linalool combats Saprolegnia parasitica infections through direct killing of microbes and modulation of host immune system

1. Tao Tang
2. Weiming Zhong
3. Puyu Tang
4. Rongsi Dai
5. Jiajing Guo
6. Zhipeng Gao

• Curated by eLife

  eLife Assessment

  This useful study presents findings on the efficacy and mechanisms of linalool protection against Saprolegnia parasitica oomycetes in the grass carp model. The evidence presented is solid since the methods, data and analyses broadly support the claims with only minor weaknesses. This work will be of great interest to scientists within the fields of aquaculture, ichthyology, microbiology, and drug discovery.

Reviewed by eLife