Microbiology

  1. Evolutionary rescue of spherical mreB deletion mutants of the rod-shape bacterium Pseudomonas fluorescens SBW25

    1. Paul Richard Yulo
    2. Nicolas Desprat
    3. Monica L. Gerth
    4. Barbara Ritzl-Rinkenberger
    5. Andrew D Farr
    6. Yunhao Liu
    7. Xue-Xian Zhang
    8. Michael Miller
    9. Felipe Cava
    10. Paul B. Rainey
    11. Heather L Hendrickson

    • Curated by eLife

      eLife assessment

      This valuable study combines evolution experiments with molecular and genetic techniques to study how a genetic lesion in MreB that causes rod-shape cells to become spherical, with concomitant deleterious fitness effects, can be rescued by natural selection. The results are convincing, although the statistical analyses and figure presentation could be improved, and the concrete contribution of the paper and how it relates to previous literature clarified.

    Reviewed by eLife, Arcadia Science

    7 evaluationsAppears in 2 listsLatest version Latest activity

  2. Essential Roles of RodA Peptidoglycan Polymerase and PBP2 Transpeptidase in Expression of Cell Wall-Spanning Supramolecular Organelles and Modulating Salmonella Virulence

    1. Anne C. Doble
    2. Bethany C Gollan
    3. John Clark-Corrigall
    4. David M. Bulmer
    5. Richard A Daniel
    6. Pietro Mastroeni
    7. C. M. Anjam Khan

    Reviewed by Arcadia Science

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Released bacterial ATP shapes local and systemic inflammation during abdominal sepsis

    1. Daniel Spari
    2. Annina Schmid
    3. Daniel Sanchez-Taltavull
    4. Shaira Murugan
    5. Keely Keller
    6. Nadia Ennaciri
    7. Lilian Salm
    8. Deborah Stroka
    9. Guido Beldi

    • Curated by eLife

      eLife assessment

      This fundamental study advances our understanding of the role of bacterial-derived extracellular ATP in the pathogenesis of sepsis. The evidence supporting the conclusions is compelling, although not all concerns from a previous round of reviews were adequately addressed. The work will be of broad interest to researchers on microbiology and infectious diseases.

    Reviewed by eLife

    8 evaluationsAppears in 1 listLatest version Latest activity

  4. Induction of Hepatitis B Core Protein Aggregation Targeting an Unconventional Binding Site

    1. Vladimir Khayenko
    2. Cihan Makbul
    3. Clemens Schulte
    4. Naomi Hemmelmann
    5. Sonja Kachler
    6. Bettina Böttcher
    7. Hans M Maric

    • Curated by eLife

      eLife assessment

      This valuable work presents an interesting strategy to interfere with the HBV infectious cycle as it identifies two previously unexplored HBc-Ag binding pockets. The experimental data is solid; however, the cryo-EM data is not properly explained, the structural and mechanistic details could be explained in greater detail, and the conclusions need to be supported by evaluating the effect of these molecules on viral infectivity.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  5. Structure of the Pseudomonas aeruginosa PAO1 Type IV pilus

    1. Hannah Ochner
    2. Jan Böhning
    3. Zhexin Wang
    4. Abul K. Tarafder
    5. Ido Caspy
    6. Tanmay A. M. Bharat

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  6. SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection

    1. Alexsia Richards
    2. Andrew Khalil
    3. Max Friesen
    4. Troy W. Whitfield
    5. Tenzin Lungjangwa
    6. Lee Gehrke
    7. David Mooney
    8. Rudolf Jaenisch

    Reviewed by Rapid Reviews Infectious Diseases

    2 evaluationsAppears in 1 listLatest version Latest activity

  7. Characterization of an EG.5.1 clinical isolate in vitro and in vivo

    1. Ryuta Uraki
    2. Maki Kiso
    3. Kiyoko Iwatsuki-Horimoto
    4. Seiya Yamayoshi
    5. Mutsumi Ito
    6. Shiho Chiba
    7. Yuko Sakai-Tagawa
    8. Masaki Imai
    9. Yukie Kashima
    10. Michiko Koga
    11. Noriko Fuwa
    12. Nobumasa Okumura
    13. Masayuki Hojo
    14. Noriko Iwamoto
    15. Hideaki Kato
    16. Hideaki Nakajima
    17. Norio Ohmagari
    18. Hiroshi Yotsuyanagi
    19. Yutaka Suzuki
    20. Yoshihiro Kawaoka

    Reviewed by Rapid Reviews Infectious Diseases

    2 evaluationsAppears in 1 listLatest version Latest activity

  8. Caspase cleavage of Influenza A virus M2 disrupts M2-LC3 interaction and regulates virion production

    1. Carmen Figueras-Novoa
    2. Masato Akutsu
    3. Daichi Murata
    4. Ming Jiang
    5. Beatriz Montaner
    6. Christelle Dubois
    7. Avinash Shenoy
    8. Rupert Beale

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  9. Interferons and tuft cell numbers are bottlenecks for persistent murine norovirus infection

    1. Somya Aggarwal
    2. Forrest C. Walker
    3. James S. Weagley
    4. Broc T. McCune
    5. Xiaofen Wu
    6. Lawrence A. Schriefer
    7. Heyde Makimaa
    8. Dylan Lawrence
    9. Pratyush Sridhar
    10. Megan T. Baldridge

    Reviewed by Rapid Reviews Infectious Diseases

    2 evaluationsAppears in 1 listLatest version Latest activity

  10. SARS-CoV-2 infects neurons, astrocytes, choroid plexus epithelial cells and pericytes of the human central nervous system

    1. Ruth Haverty
    2. Janet McCormack
    3. Christopher Evans
    4. Kevin Purves
    5. Sophie O’Reilly
    6. Virginie Gautier
    7. Keith Rochfort
    8. Aurelie Fabre
    9. Nicola F. Fletcher

    Reviewed by Rapid Reviews Infectious Diseases

    2 evaluationsAppears in 1 listLatest version Latest activity
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