Microbiology

Two Vibrio species co-colonize a morphologically complex symbiotic light organ

1. Clotilde Bongrand
2. Raphaël Lami
3. Marcelino T Suzuki
4. Eric J Koch

Reviewed by Arcadia Science

The PPE2 protein of Mycobacterium tuberculosis is responsible for the development of hyperglycemia and insulin resistance during tuberculosis

1. Manoj Kumar Bisht
2. Vandana Maurya
3. Priyanka Dahiya
4. Vijaya Lakshmi Valluri
5. Sudip Ghosh
6. Sangita Mukhopadhyay

• Curated by eLife

  eLife Assessment

  This valuable work demonstrates that M. tuberculosis protein PPE2 perturbs adipose tissue biology by modulating adipogenesis, lipolysis, and inflammatory remodeling, thereby contributing to fat loss and insulin resistance during TB. Using M. smegmatis overexpression strains, PPE2-deficient Mtb mutants, and mouse models, the study links PPE2 to downregulation of PPAR-γ, C/EBP-α, adiponectin, and broader transcriptional changes in host fatty acid metabolism. These findings convincingly highlight, for the first time, a direct role for a bacterial virulence factor in TB-associated wasting. However, despite strong associative evidence, the mechanistic basis of PPE2-mediated regulation remains unresolved.

Reviewed by eLife

Targeted disruption of phage liquid crystalline droplets abolishes antibiotic tolerance of bacterial biofilms

1. Abul K. Tarafder
2. Miles Graham
3. Luke K. Davis
4. Shawna Pratt
5. Jan Böhning
6. Pavithra Manivannan
7. Zhexin Wang
8. Camila M. Clemente
9. Raymond J Owens
10. George A. O’Toole
11. Philip Pearce
12. Tanmay A.M. Bharat

Reviewed by Review Commons

Microbial Feast or Famine: dietary carbohydrate composition and gut microbiota metabolic function

1. Blake Dirks
2. Alex E. Mohr
3. Karen D. Corbin
4. Elvis A. Carnero
5. Steven R. Smith
6. Corrie M. Whisner
7. Bruce E. Rittmann
8. Rosa Krajmalnik-Brown

Reviewed by preLights

Dynamic protrusions mediate unique crawling motility in Asgard Archaea (Promethearchaeota)

1. Philipp Radler
2. Tobias Viehboeck
3. Zhen-Hao Luo
4. Nevena Maslać
5. Katharina Schmidt
6. Robert Hauschild
7. Masaru Nobu
8. Silvia Bulgheresi
9. Theresia E.B. Stradal
10. Klemens Rottner
11. Hiroyuki Imachi
12. Michael Sixt
13. Christa Schleper

Reviewed by Arcadia Science

Loss of the s2U tRNA modification induces antibiotic tolerance and is linked to changes in ribosomal protein expression

1. Katherine L Cotten
2. Abigail McShane
3. Peter C Dedon
4. Thomas J Begley
5. Kimberly M Davis

• Curated by eLife

  eLife Assessment

  This fundamental work examines how tRNA modifications influence antibiotic tolerance, providing novel insights that may have therapeutic uses. The evidence supporting the conclusions is convincing. Strengths of the manuscript include the mechanism of tRNA modification influencing antibiotic tolerance and the precise measurement techniques used throughout. Further analysis of growth rate impacts and specific identification of the proteins responsible for the effect would further strengthen the manuscript.

Reviewed by eLife