Immunology

Use of eVLP-based vaccine candidates to broaden immunity against SARS-CoV-2 variants

1. Jasminka Bozic
2. Tanvir Ahmed
3. Barthelemy Ontsouka
4. Anne-Catherine Fluckiger
5. Abebaw Diress
6. Tamara Berthoud
7. Xiaoyang Yuan
8. Lanjian Yang
9. Francisco Diaz-Mitoma
10. David E. Anderson
11. Catalina Soare

Reviewed by ScreenIT

A combination of two human neutralizing antibodies prevents SARS-CoV-2 infection in rhesus macaques

1. Ronald R. Cobb
2. Joseph Nkolola
3. Pavlo Gilchuk
4. Abishek Chandrashekar
5. Robert V. House
6. Christopher G. Earnhart
7. Nicole M. Dorsey
8. Svetlana A. Hopkins
9. Doris M. Snow
10. Rita E. Chen
11. Laura A. VanBlargan
12. Manuel Hechenblaikner
13. Brian Hoppe
14. Laura Collins
15. Milan T. Tomic
16. Genevieve H. Nonet
17. Kyal Hackett
18. James C. Slaughter
19. Michael S. Diamond
20. Robert H. Carnahan
21. Dan H. Barouch
22. James E. Crowe

Reviewed by ScreenIT

BNT162b2 vaccination induces durable SARS-CoV-2–specific T cells with a stem cell memory phenotype

1. Gisella Guerrera
2. Mario Picozza
3. Silvia D’Orso
4. Roberta Placido
5. Marta Pirronello
6. Alice Verdiani
7. Andrea Termine
8. Carlo Fabrizio
9. Flavia Giannessi
10. Manolo Sambucci
11. Maria Pia Balice
12. Carlo Caltagirone
13. Antonino Salvia
14. Angelo Rossini
15. Luca Battistini
16. Giovanna Borsellino

Reviewed by ScreenIT

ChAdOx1 nCoV-19 vaccine elicits monoclonal antibodies with cross-neutralizing activity against SARS-CoV-2 viral variants

1. Jeffrey Seow
2. Carl Graham
3. Sadie R. Hallett
4. Thomas Lechmere
5. Thomas J.A. Maguire
6. Isabella Huettner
7. Daniel Cox
8. Hataf Khan
9. Suzanne Pickering
10. Rebekah Roberts
11. Anele Waters
12. Christopher C. Ward
13. Christine Mant
14. Michael J. Pitcher
15. Jo Spencer
16. Julie Fox
17. Michael H. Malim
18. Katie J. Doores

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Inflammasome activation in infected macrophages drives COVID-19 pathology

1. Esen Sefik
2. Rihao Qu
3. Caroline Junqueira
4. Eleanna Kaffe
5. Haris Mirza
6. Jun Zhao
7. J. Richard Brewer
8. Ailin Han
9. Holly R. Steach
10. Benjamin Israelow
11. Holly N. Blackburn
12. Sofia E. Velazquez
13. Y. Grace Chen
14. Stephanie Halene
15. Akiko Iwasaki
16. Eric Meffre
17. Michel Nussenzweig
18. Judy Lieberman
19. Craig B. Wilen
20. Yuval Kluger
21. Richard A. Flavell

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SARS-CoV-2 spike-specific memory B cells express higher levels of T-bet and FcRL5 after non-severe COVID-19 as compared to severe disease

1. Raphael A. Reyes
2. Kathleen Clarke
3. S. Jake Gonzales
4. Angelene M. Cantwell
5. Rolando Garza
6. Gabriel Catano
7. Robin E. Tragus
8. Thomas F. Patterson
9. Sebastiaan Bol
10. Evelien M. Bunnik

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IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay

1. Kotaro Akaki
2. Kosuke Ogata
3. Yuhei Yamauchi
4. Noriki Iwai
5. Ka Man Tse
6. Fabian Hia
7. Atsushi Mochizuki
8. Yasushi Ishihama
9. Takashi Mino
10. Osamu Takeuchi

• Curated by eLife

  Evaluation Summary:

  This is an important study that describes a new mechanism by which Regnase-1 is inhibited upon immune activation, which mediates the efficient synthesis of inflammatory mediators whose mRNAs are normally degraded by Regnase-1. The interaction with 14-3-3 presented here was not known before. This provides an alternative mechanism by which inflammatory mRNAs are upregulated by inhibiting degradation via Regnase-1.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

A Recombinant Subunit Vaccine Induces a Potent, Broadly Neutralizing, and Durable Antibody Response in Macaques against the SARS-CoV-2 P.1 (Gamma) Variant

1. Albert To
2. Teri Ann S. Wong
3. Michael M. Lieberman
4. Karen Thompson
5. Aquena H. Ball
6. Laurent Pessaint
7. Jack Greenhouse
8. Nisrine Daham
9. Anthony Cook
10. Brandon Narvaez
11. Zack Flinchbaugh
12. Alex Van Ry
13. Jake Yalley-Ogunro
14. Hanne Andersen Elyard
15. Chih-Yun Lai
16. Oreola Donini
17. Axel T. Lehrer

Reviewed by ScreenIT

Caspase-4/11 exacerbates disease severity in SARS–CoV-2 infection by promoting inflammation and immunothrombosis

1. Mostafa M. Eltobgy
2. Ashley Zani
3. Adam D. Kenney
4. Shady Estfanous
5. Eunsoo Kim
6. Asmaa Badr
7. Cierra Carafice
8. Kylene Daily
9. Owen Whitham
10. Maciej Pietrzak
11. Amy Webb
12. Jeffrey Kawahara
13. Adrian C. Eddy
14. Parker Denz
15. Mijia Lu
16. Mahesh KC
17. Mark E. Peeples
18. Jianrong Li
19. Jian Zhu
20. Jianwen Que
21. Richard Robinson
22. Oscar Rosas Mejia
23. Rachael E. Rayner
24. Luanne Hall-Stoodley
25. Stephanie Seveau
26. Mikhail A. Gavrilin
27. Xiaoli Zhang
28. Jeronay Thomas
29. Jacob E. Kohlmeier
30. Mehul S. Suthar
31. Eugene Oltz
32. Andrea Tedeschi
33. Frank H. Robledo-Avila
34. Santiago Partida-Sanchez
35. Emily A. Hemann
36. Eman Abdelrazik
37. Adriana Forero
38. Shahid M. Nimjee
39. Prosper N. Boyaka
40. Estelle Cormet-Boyaka
41. Jacob S. Yount
42. Amal O. Amer

Reviewed by ScreenIT

SARS-CoV-2 preS dTM vaccine booster candidates increase functional antibody responses and cross-neutralization against SARS-CoV-2 variants of concern in non-human primates

1. Vincent Pavot
2. Catherine Berry
3. Michael Kishko
4. Natalie G. Anosova
5. Dean Huang
6. Tim Tibbitts
7. Alice Raillard
8. Sylviane Gautheron
9. Cindy Gutzeit
10. Marguerite Koutsoukos
11. Roman Chicz
12. Valerie Lecouturier

Reviewed by ScreenIT