Immunology

Identification of HLA-A*24:02-restricted CTL candidate epitopes derived from the non-structural polyprotein 1a of SARS-CoV-2 and analysis of their conservation using the mutation database of SARS-CoV-2 variants

1. Akira Takagi
2. Masanori Matsui

Reviewed by ScreenIT

Design of Peptide Vaccine for COVID19: CD8+ and CD4+ T cell epitopes from SARS-CoV-2 open-reading-frame protein variants

1. Simone Parn
2. Gabriel Jabbour
3. Vincent Nguyenkhoa
4. Sivanesan Dakshanamurthy

Reviewed by ScreenIT

Anti-SARS-CoV-2 IgG and IgA antibodies in COVID-19 convalescent plasma do not facilitate antibody-dependent enhance of viral infection

1. Natasha M Clark
2. Sanath Kumar Janaka
3. William Hartman
4. Susan Stramer
5. Erin Goodhue
6. John Weiss
7. David T. Evans
8. Joseph P. Connor

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Neutralizing antibody-independent immunity to SARS-CoV-2 in hamsters and hACE-2 transgenic mice immunized with a RBD/Nucleocapsid fusion protein

1. Julia T. Castro
2. Marcílio J. Fumagalli
3. Natalia S. Hojo-Souza
4. Patrick Azevedo
5. Natalia Salazar
6. Bruna Rattis
7. Simone G. Ramos
8. Lídia Faustino
9. Gregório G. Almeida
10. Livia I. Oliveira
11. Tomas G. Marçal
12. Marconi Augusto
13. Rubens Magalhães
14. Bruno Cassaro
15. Gabriela Burle
16. Daniel Doro
17. Jorge Kalil
18. Edson Durigon
19. Andrés Salazar
20. Otávia Caballero
21. Alexandre Machado
22. João S. Silva
23. Flávio da Fonseca
24. Ana Paula Fernandes
25. Santuza R. Teixeira
26. Ricardo T. Gazzinelli

Reviewed by ScreenIT

Synthetic multiantigen MVA vaccine COH04S1 protects against SARS-CoV-2 in Syrian hamsters and non-human primates

1. Flavia Chiuppesi
2. Vu H. Nguyen
3. Yoonsuh Park
4. Heidi Contreras
5. Veronica Karpinski
6. Katelyn Faircloth
7. Jenny Nguyen
8. Mindy Kha
9. Daisy Johnson
10. Joy Martinez
11. Angelina Iniguez
12. Qiao Zhou
13. Teodora Kaltcheva
14. Paul Frankel
15. Swagata Kar
16. Ankur Sharma
17. Hanne Andersen
18. Mark G. Lewis
19. Yuriy Shostak
20. Felix Wussow
21. Don J. Diamond

Reviewed by ScreenIT

Rapid identification of neutralizing antibodies against SARS-CoV-2 variants by mRNA display

1. Shiho Tanaka
2. C. Anders Olson
3. Christopher O. Barnes
4. Wendy Higashide
5. Marcos Gonzalez
6. Justin Taft
7. Ashley Richardson
8. Marta Martin-Fernandez
9. Dusan Bogunovic
10. Priyanthi N.P. Gnanapragasam
11. Pamela J. Bjorkman
12. Patricia Spilman
13. Kayvan Niazi
14. Shahrooz Rabizadeh
15. Patrick Soon-Shiong

Reviewed by ScreenIT

A model of preferential pairing between epithelial and dendritic cells in thymic antigen transfer

1. Matouš Vobořil
2. Jiří Březina
3. Tomáš Brabec
4. Jan Dobeš
5. Ondřej Ballek
6. Martina Dobešová
7. Jasper Manning
8. Richard S Blumberg
9. Dominik Filipp

• Curated by eLife

  Evaluation Summary:

  This manuscript will be of interest to immunologists studying mechanisms of thymic central tolerance. The study elegantly makes use of multiple genetic mouse models to generate data supporting the conclusion that different dendritic cell subsets in the thymus capture self-antigens from distinct subsets of thymic epithelial cells. However, some key conclusions are not entirely novel, and the final model, as currently presented, draws from only selective analyses and thus may not accurately reflect the antigen transfer between thymic epithelial cell and dendritic cell subsets that promote central tolerance.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Design of T cell epitope-based vaccine candidate for SARS-CoV-2 targeting nucleocapsid and spike protein escape variants

1. Gabriel Jabbour
2. Samantha Rego
3. Vincent Nguyenkhoa
4. Sivanesan Dakshanamurthy

Reviewed by ScreenIT

Immune recall improves antibody durability and breadth to SARS-CoV-2 variants

1. Yuezhou Chen
2. Pei Tong
3. Noah Whiteman
4. Ali Sanjari Moghaddam
5. Mehrdad Zarghami
6. Adam Zuiani
7. Shaghayegh Habibi
8. Avneesh Gautam
9. Keerti
10. Caihong Bi
11. Tianshu Xiao
12. Yongfei Cai
13. Bing Chen
14. Donna Neuberg
15. Duane R. Wesemann

Reviewed by ScreenIT

Intranasal administration of a VLP-based vaccine against COVID-19 induces neutralizing antibodies against SARS-CoV-2 and Variants of Concerns

1. Dominik A. Rothen
2. Pascal S. Krenger
3. Aleksandra Nonic
4. Ina Balke
5. Anne-Cathrine S. Vogt
6. Xinyue Chang
7. Alessandro Manenti
8. Fabio Vedovi
9. Gunta Resevica
10. Senta M. Walton
11. Andris Zeltins
12. Emanuele Montomoli
13. Monique Vogel
14. Martin F. Bachmann
15. Mona O. Mohsen

Reviewed by ScreenIT