Immunology

WASP facilitates tumor mechanosensitivity in T lymphocytes

1. Srishti Mandal
2. Mariane Melo
3. Pavlo Gordiichuk
4. Sayanti Acharya
5. Yeh-Chuin Poh
6. Na Li
7. Aereas Aung
8. Eric L. Dane
9. Darrell J. Irvine
10. Sudha Kumari

• Curated by eLife

  eLife assessment

  This valuable study employs a diverse array of techniques encompassing cell biological manipulations, biophysical measurements, and mouse models to elucidate the impact of target cell stiffness on CD8+ cytotoxic T cell activation, with a particular focus on the actin nucleator protein WASP. The finding that WASP is essential for the stiffness-dependent phosphorylation of ZAP70 in CD8 T cells is convincing. However, the data regarding the role of WASP in mechanosensing within CD8 T cell-mediated anti-tumor immunity is incomplete and would benefit from a more rigorous study design. This work would be of interest to cell biologists and investigators studying mechanosensing within the immune system.

Reviewed by eLife

Pulsed ultrasound promotes secretion of anti-inflammatory extracellular vesicles from skeletal myotubes via elevation of intracellular calcium level

1. Atomu Yamaguchi
2. Noriaki Maeshige
3. Hikari Noguchi
4. Jiawei Yan
5. Xiaoqi Ma
6. Mikiko Uemura
7. Dongming Su
8. Hiroyo Kondo
9. Kristopher Sarosiek
10. Hidemi Fujino

• Curated by eLife

  eLife assessment

  This study illuminates the effects of ultrasound-induced extracellular vesicle interactions with macrophages. It provides solid data offering insights that will be potentially useful in exploring therapeutic approaches to inflammation modulation, by suggesting that ultrasound-treated myotube vesicles can suppress macrophage inflammatory responses.

Reviewed by eLife

Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors

1. Xiaozheng Xu
2. Takeya Masubuchi
3. Qixu Cai
4. Yunlong Zhao
5. Enfu Hui

Reviewed by Review Commons

Catalytic activity and autoprocessing of murine caspase-11 mediate noncanonical inflammasome assembly in response to cytosolic LPS

1. Daniel C Akuma
2. Kimberly A Wodzanowski
3. Ronit Schwartz Wertman
4. Patrick M Exconde
5. Víctor R Vázquez Marrero
6. Chukwuma E Odunze
7. Daniel Grubaugh
8. Sunny Shin
9. Cornelius Taabazuing
10. Igor E Brodsky

• Curated by eLife

  eLife assessment

  Brodsky and colleagues report here an unexpected cis-activation mechanism of caspase-11. The authors use cellular imaging methods and cleavage site mutants to show that the LPS-induced speck formation by caspase-11 depends on the autoprocessing between two subdomains. This new finding opens multiple doors for further investigating how this non-canonical inflammasome is regulated and activated at the molecular level.

Reviewed by eLife

Fatty acid synthesis promotes inflammasome activation through NLRP3 palmitoylation

1. Stuart Leishman
2. Najd M. Aljadeed
3. Liyunhe Qian
4. Shamshad Cockcroft
5. Jacques Behmoaras
6. Paras K. Anand

Reviewed by Arcadia Science

Concurrent Administration of COVID-19 and Influenza Vaccines Enhances Spike-Specific Antibody Responses

1. Susanna E Barouch
2. Taras M Chicz
3. Ross Blanc
4. Domenic R Barbati
5. Lily J Parker
6. Xin Tong
7. Wenjun Li
8. Ryan P McNamara

Reviewed by PREreview

Sustained store-operated calcium entry utilizing activated chromatin state leads to instability in iTregs

1. Huiyun Lyu
2. Guohua Yuan
3. Xinyi Liu
4. Xiaobo Wang
5. Shuang Geng
6. Tie Xia
7. Xuyu Zhou
8. Yinqing Li
9. Xiaoyu Hu
10. Yan Shi

• Curated by eLife

  eLife assessment

  This study presents the valuable finding that sustained calcium signaling in induced-Treg (iTreg) cells can lead to the loss of Foxp3 expression and iTreg identity by altering the chromatin landscape. The evidence supporting the claims of the authors is convincing. The work will be of interest to immunologists working on Treg cell therapy.

Reviewed by eLife

Apoptotic signaling clears engineered Salmonella in an organ-specific manner

1. Taylor J Abele
2. Zachary P Billman
3. Lupeng Li
4. Carissa K Harvest
5. Alexia K Bryan
6. Gabrielle R Magalski
7. Joseph P Lopez
8. Heather N Larson
9. Xiao-Ming Yin
10. Edward A Miao

• Curated by eLife

  eLife assessment

  Host cell death is an effective strategy to protect against infection, and is believed to function primarily by the elimination of the intracellular niche for pathogen replication. Abele and colleagues address an important question: does the mode of cell death affect its effectiveness in pathogen clearance? Consistent with prior observations, the authors provide compelling new evidence that the answer can depend on the cell type and/or tissue involved.

Reviewed by eLife

CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment

1. Musleh M Muthana
2. Xuexiang Du
3. Mingyue Liu
4. Xu Wang
5. Wei Wu
6. Chunxia Ai
7. Lishan Su
8. Pan Zheng
9. Yang Liu

• Curated by eLife

  eLife assessment

  This valuable study presents presents solid evidence that an anti-CTLA-4 antibody drug conjugate transiently depletes circulating B cells in a mouse model, showing how dysregulation of the T cell immune system can impact B cell homeostasis. The work will be of broad interest to immunologists and medical biologists, but a major limitation is that the mechanism of B-cell reduction remains unclear, as evidence of killing of B-cells by T-cells is not presented.

Reviewed by eLife

Germline-targeting chimpanzee SIV Envelopes induce V2-apex broadly neutralizing-like B cell precursors in a rhesus macaque infection model

1. Rami Musharrafieh
2. Yana Safonova
3. Ge Song
4. Ryan S. Roark
5. Fang-Hua Lee
6. Shiyu Zhang
7. Jonathan Hurtado
8. Peter Yong
9. Shuyi Wang
10. Ronnie M. Russell
11. Wenge Ding
12. Yingying Li
13. Juliette Rando
14. Alexander I. Murphy
15. Emily Lindemuth
16. Chengyan Zhao
17. Andrew Jesse Connell
18. Wen-Hsin Lee
19. Nitesh Mishra
20. Gabriel Avillion
21. Wanting He
22. Sean Callaghan
23. Katharina Dueker
24. Anh L. Vo
25. Xuduo Li
26. Tazio Capozzola
27. Collin Joyce
28. Fangzhu Zhao
29. Fabio Anzanello
30. Weimin Liu
31. Frederic Bibollet-Ruche
32. Alejandra Ramos
33. Hui Li
34. Mark G. Lewis
35. Gabriel Ozorowski
36. Elise Landais
37. Brian T. Foley
38. Kshitij Wagh
39. Devin Sok
40. Bryan Briney
41. Andrew B. Ward
42. Beatrice H. Hahn
43. Dennis R. Burton
44. George M. Shaw
45. Raiees Andrabi

Reviewed by Rapid Reviews Infectious Diseases