Immunology

Piezo1 mechanosensing regulates integrin-dependent chemotactic migration in human T cells

1. Chinky Shiu Chen Liu
2. Tithi Mandal
3. Parijat Biswas
4. Md Asmaul Hoque
5. Purbita Bandopadhyay
6. Bishnu Prasad Sinha
7. Jafar Sarif
8. Ranit D'Rozario
9. Deepak Kumar Sinha
10. Bidisha Sinha
11. Dipyaman Ganguly

• Curated by eLife

  eLife assessment

  This study provides useful insights into the subcellular localization, interaction with integrins, and functional importance of the cell surface receptor Piezo1 in migrating human T-cells. Whether Piezo1 is critically sensing mechano-physical cues during T-cell migration is however not well supported by direct experimental evidence. The data collected is solid otherwise.

Reviewed by eLife

NAD+ prevents septic shock-induced death by non-canonical inflammasome blockade and IL-10 cytokine production in macrophages

1. Jasper Iske
2. Rachid El Fatimy
3. Yeqi Nian
4. Amina Ghouzlani
5. Siawosh K Eskandari
6. Hector Rodriguez Cetina Biefer
7. Anju Vasudevan
8. Abdallah Elkhal

• Curated by eLife

  eLife assessment

  In this valuable contribution, the authors demonstrate that the infusion of NAD+ may prevent death and reduce disease severity from lethal experimental bacterial sepsis, possibly through inflammasome inhibition, without reducing bacterial load. They provide solid evidence for these protective effects of NAD+, though the precise mechanisms involved remain unclear and need further support and elucidation. The core findings may well have clinical implications but, in addition to mechanistic clarifications, contextualised interpretation as metabolic adaptation to sepsis would create wider interest.

Reviewed by eLife

Ym1 protein crystals promote type 2 immunity

1. Ines Heyndrickx
2. Kim Deswarte
3. Kenneth Verstraete
4. Koen HG Verschueren
5. Ursula Smole
6. Helena Aegerter
7. Ann Dansercoer
8. Hamida Hammad
9. Savvas N Savvides
10. Bart N Lambrecht

• Curated by eLife

  eLife assessment

  This is an important and interesting account of the ability of Ym1 crystals to promote type 2 immunity in vivo, in mice. The data presented are compelling, building on and significantly advancing evidence this group has previously published on the type 2 immunogenicity of other protein crystals. The work will be of relevant interest to immunologists and researchers working on type 2 inflammatory disease, in the lung and in others tissues.

Reviewed by eLife

Leucine alleviates cytokine storm syndrome by regulating macrophage polarization via the mTORC1/LXRα signaling pathway

1. Hui Yan
2. Yao Liu
3. Xipeng Li
4. Bing Yu
5. Jun He
6. Xiangbing Mao
7. Jie Yu
8. Zhiqing Huang
9. Yuheng Luo
10. Junqiu Luo
11. Aimin Wu
12. Daiwen Chen

• Curated by eLife

  eLife assessment

  The study has added value to what we have already known in the potential pharmacological immunomodulatory therapies in LPS-induced sepsis, and especially the use of oral leucine might be of great interest to the readers engaged in this field. We believe this study is important and provides solid evidence on the potential use of leucine in sepsis.

Reviewed by eLife

IL-27 maintains cytotoxic Ly6C ⁺ γδ T cells that arise from immature precursors

1. Robert Wiesheu
2. Sarah C. Edwards
3. Ann Hedley
4. Marie Tosolini
5. Marcelo Gregorio Filho Fares da Silva
6. Nital Sumaria
7. Yasmin Optaczy
8. David G. Hill
9. Alan J. Hayes
10. Jodie Hay
11. Anna Kilbey
12. Alison M. Michie
13. Gerard J. Graham
14. Anand Manoharan
15. Christina Halsey
16. Gareth W. Jones
17. Karen Blyth
18. Jean-Jacques Fournie
19. Daniel J. Pennington
20. Vasileios Bekiaris
21. Seth B. Coffelt

Reviewed by Review Commons

Protective non-neutralizing mAbs Ab94 and Ab81 retain high-affinity and potent Fc-mediated function against SARS-CoV-2 variants from Omicron to XBB1.5

1. Arman Izadi
2. Magdalena Godzwon
3. Mats Ohlin
4. Pontus Nordenfelt

Reviewed by Rapid Reviews Infectious Diseases, PREreview

Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection

1. Alexander Lercher
2. Jin-Gyu Cheong
3. Chenyang Jiang
4. Hans-Heinrich Hoffmann
5. Alison W. Ashbrook
6. Yue S. Yin
7. Corrine Quirk
8. Emma J. DeGrace
9. Luis Chiriboga
10. Brad R. Rosenberg
11. Steven Z. Josefowicz
12. Charles M. Rice

Reviewed by PREreview

Secretory leukocyte protease inhibitor protects against severe urinary tract infection in mice

1. Anne L. Rosen
2. Michael A. Lint
3. Dayne H. Voelker
4. Nicole M. Gilbert
5. Christopher P. Tomera
6. Jesús Santiago-Borges
7. Meghan A. Wallace
8. Thomas J. Hannan
9. Carey-Ann D. Burnham
10. Scott J. Hultgren
11. Andrew L. Kau

Reviewed by PREreview, Rapid Reviews Infectious Diseases

DNA damage signaling in Drosophila macrophages modulates systemic cytokine levels in response to oxidative stress

1. Fabian Hersperger
2. Tim Meyring
3. Pia Weber
4. Chintan Chhatbar
5. Gianni Monaco
6. Marc S Dionne
7. Katrin Paeschke
8. Marco Prinz
9. Olaf Groß
10. Anne-Kathrin Classen
11. Katrin Kierdorf

• Curated by eLife

  eLife assessment

  This study elucidates the role of a specific hemocyte subpopulation in oxidative damage response by establishing connections between DNA damage response and the JNK-JAK/STAT axis to regulate energy metabolism. The identification of this distinct hemocyte subpopulation through single-cell RNA sequencing analysis and the finding of hemocytes that respond to oxidative stress are important. The method for single-cell RNA sequencing and related analyses are convincing and experiments linking oxidative stress to DNA damage and energy expenditure are solid. The finding of stress-responsive immune cells capable of influencing whole-body metabolism adds insights for cell biologists and developmental biologists in the fields of immunology and metabolism.

Reviewed by eLife

Commensal bacteria maintain a Qa-1b-restricted unconventional CD8+ T population in gut epithelium

1. Jian Guan
2. J David Peske
3. Michael Manoharan Valerio
4. Chansu Park
5. Ellen A Robey
6. Scheherazade Sadegh-Nasseri

• Curated by eLife

  eLife assessment

  This is an important study that investigates the role of commensal microbes and molecules in the antigen presentation pathway affecting the development and phenotype of an unusual population of T lymphocytes. The authors provide compelling evidence to identify a population of unconventional T cells that exist in the small intestinal epithelium, which appear to depend on commensal microbes, and show that a single commensal microbe (that encodes an antigen capable of weakly stimulating these cells) is sufficient to maintain this T cell population.

Reviewed by eLife