Immunology

Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response

1. Long-Feng Lu
2. Can Zhang
3. Zhuo-Cong Li
4. Bao-Jie Cui
5. Yang-Yang Wang
6. Ke-Jia Han
7. Xiao Xu
8. Chu-Jing Zhou
9. Xiao-Yu Zhou
10. Yue Wu
11. Na Xu
12. Xiao-Li Yang
13. Dan-Dan Chen
14. Xi-Yin Li
15. Li Zhou
16. Shun Li

• Curated by eLife

  eLife Assessment

  This valuable study uses zebrafish as a model to reveal a role for the cell cycle protein kinase CDK2 as a negative regulator of type I interferon signaling. The evidence supporting the authors' claims is convincing, including both in vivo and in vitro investigative approaches that corroborate a role for CDK2 in regulating TBK1 degradation. In this latest version, the authors included data addressing a concern raised by the reviewer in the previous peer review round. This work will interest cell biologists, immunologists, and virologists.

Reviewed by eLife

Glycosylated IgG antibodies contribute to the recovery of haemorrhagic fever with renal syndrome patients

1. Chuansong Quan
2. Lu Wang
3. Jiming Gao
4. Yaoni Li
5. Xiaoyu Xu
6. Houqiang Li
7. Zixuan Gao
8. Wenxu Ruan
9. Hongzhi Liu
10. Qian Li
11. Weijia Xing
12. Liqiong Zhao
13. Michael J Carr
14. Weifeng Shi
15. Haifeng Hou

• Curated by eLife

  eLife Assessment

  The authors investigated the potential role of IgG N-glycosylation in Haemorrhagic Fever with Renal Syndrome (HFRS), which may offer significant insights for understanding molecular mechanisms and for the development of therapeutic strategies for this infectious disease. The findings are valuable to the field and the strength of evidence to support the findings is solid.

Reviewed by eLife

Phospholipid Scramblase 1 (PLSCR1) Regulates Interferon-Lambda Receptor 1 (IFN-λR1) and IFN-λ Signaling in Influenza A Virus (IAV) Infection

1. Alina X Yang
2. Lisa Ramos-Rodriguez
3. Parand Sorkhdini
4. Dongqin Yang
5. Carmelissa Norbrun
6. Sonoor Majid
7. Sanghyun Lee
8. Yong Zhang
9. Michael J Holtzman
10. David F Boyd
11. Yang Zhou

• Curated by eLife

  eLife Assessment

  This valuable manuscript presents a potentially novel mechanism by which the phospholipid scramblase, PLSCR1, defends against influenza A virus infection. The strength of the paper rests on solid findings involving knockout and lung specific over-expressing Plscr1 mice, airway tissue expression and mechanistic studies to show Plscr1 enhances type III interferon-mediated viral clearance.

Reviewed by eLife

SARS-CoV-2 spike antibodies cross-react with dengue virus and enhance infection in vitro and in vivo

1. Kamini Jakhar
2. Sudipta Sonar
3. Gagandeep Singh
4. Tejeswara Rao Asuru
5. Garima Joshi
6. Nisha Beniwal
7. Tania Sarkar
8. Mahima Tiwari
9. Jaskaran Kaur
10. Deepak Kumar Rathore
11. Banwari Lal
12. Sandeep Kumar
13. Puneet Srivastav
14. Satendra Kumar
15. Vikas Phagna
16. Sushma Mithina
17. Lokesh Kumar
18. Vishal Gupta
19. Pallavi Kshetrapal
20. Savita Singh
21. Nitya Wadhwa
22. Ramachandran Thiruvengadam
23. Sreevatsan Raghavan
24. Mudita Gosain
25. Tripti Shrivastava
26. Sankar Bhattacharyya
27. Shailendra Asthana
28. Prasenjit Guchhait
29. Shailendra Mani

Reviewed by Rapid Reviews Infectious Diseases

Universal protection against SARS-CoV-2 viruses by multivalent mRNA vaccine in mice

1. Zhengyang Lei
2. Shiyao Zhai
3. Xi Yuan
4. Runming Wang
5. Yunpeng Wang
6. Vijay Pandey
7. Can Yang Zhang
8. Jiansong Ji
9. Dongmei Yu
10. Zhenglin Chen
11. Sumin Bian
12. Peiwu Qin

Reviewed by Rapid Reviews Infectious Diseases

Protective non-neutralizing mAbs Ab94 and Ab81 retain high-affinity and potent Fc-mediated function against SARS-CoV-2 variants from Omicron to XBB1.5

1. Arman Izadi
2. Magdalena Godzwon
3. Mats Ohlin
4. Pontus Nordenfelt

Reviewed by Rapid Reviews Infectious Diseases, PREreview

XBB.1.5 monovalent mRNA vaccine booster elicits robust neutralizing antibodies against emerging SARS-CoV-2 variants

1. Qian Wang
2. Yicheng Guo
3. Anthony Bowen
4. Ian A. Mellis
5. Riccardo Valdez
6. Carmen Gherasim
7. Aubree Gordon
8. Lihong Liu
9. David D. Ho

Reviewed by Rapid Reviews Infectious Diseases

Secretory leukocyte protease inhibitor protects against severe urinary tract infection in mice

1. Anne L. Rosen
2. Michael A. Lint
3. Dayne H. Voelker
4. Nicole M. Gilbert
5. Christopher P. Tomera
6. Jesús Santiago-Borges
7. Meghan A. Wallace
8. Thomas J. Hannan
9. Carey-Ann D. Burnham
10. Scott J. Hultgren
11. Andrew L. Kau

Reviewed by PREreview, Rapid Reviews Infectious Diseases

Characteristics and Functions of Infection-enhancing Antibodies to the N-terminal Domain of SARS-CoV-2

1. Ruth Connor
2. Mrunal Sakharkar
3. Garrett Rappazzo
4. Chengzi Kaku
5. Nicholas Curtis
6. Seungmin Shin
7. Wendy Wieland-Alter
8. Jordan Wentworth
9. Daniel Mielcarz
10. Joshua Weiner
11. Margaret Ackerman
12. Laura Walker
13. Jiwon Lee
14. Peter Wright

Reviewed by Rapid Reviews Infectious Diseases

CD4 T cells and CD8α+ lymphocytes are necessary for intravenous BCG-induced protection against tuberculosis in macaques

1. Andrew W. Simonson
2. Joseph J. Zeppa
3. Allison N. Bucsan
4. Michael C. Chao
5. Supriya Pokkali
6. Forrest Hopkins
7. Michael R. Chase
8. Andrew J. Vickers
9. Matthew S. Sutton
10. Caylin G. Winchell
11. Amy J. Myers
12. Cassaundra L. Ameel
13. Ryan Kelly
14. Ben Krouse
15. Luke E. Hood
16. Jiaxiang Li
17. Chelsea C. Lehman
18. Megha Kamath
19. Jaime Tomko
20. Mark A. Rodgers
21. Rachel Donlan
22. Harris Chishti
23. H. Jacob Borish
24. Edwin Klein
25. Charles A. Scanga
26. Sarah Fortune
27. Philana Ling Lin
28. Pauline Maiello
29. Mario Roederer
30. Patricia A. Darrah
31. Robert A. Seder
32. JoAnne L. Flynn

Reviewed by Rapid Reviews Infectious Diseases