Immunology

  1. Serratia marcescens Outer Membrane Vesicles rapidly paralyze Drosophila melanogaster through triggering apoptosis in the nervous system

    1. Bechara Sina Rahme
    2. Roberto E Bruna
    3. Marion Draheim
    4. Chuping Cai
    5. Maria Victoria Molino
    6. Yaotang Wu
    7. Miriam Wennida Yamba
    8. Gisela Di Venanzio
    9. Matthieu Lestradet
    10. Eleonora García Véscovi
    11. Dominique Ferrandon

    • Curated by eLife

      eLife Assessment

      This study offers important insights into how outer membrane vesicles (OMVs) secreted by Serratia marcescens, which carry various virulence factors, contribute to pathogenicity. The experiments provide solid preliminary support for OMV-mediated pathogenic effects, with a critical role for the metalloprotease virulence factor PrtA. However, the evidence remains incomplete, and the current level of validation limits confidence in the strength of the conclusions.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  2. Citrobacter rodentium infection activates colonic lamina propria group 2 innate lymphoid cells

    1. Rita Berkachy
    2. Vishwas Mishra
    3. Priyanka Biswas
    4. Gad Frankel

    Reviewed by preLights

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Epigenetic Adaptation Drives Monocyte Differentiation into Microglia-Like Cells Upon Engraftment into the Central Nervous System

    1. Jie Liu
    2. Fengyang Lei
    3. Bin Yan
    4. Tian Cao
    5. Naiwen Cui
    6. Jyoti Sharma
    7. Victor Correa
    8. Lara Roach
    9. Savvas Nicolaou
    10. Kristen Pitts
    11. James Chodosh
    12. Daniel E Maidana
    13. Demetrios Vavvas
    14. Milica A Margeta
    15. Huidan Zhang
    16. David Weitz
    17. Raul Mostoslavsky
    18. Eleftherios I Paschalis

    • Curated by eLife

      eLife Assessment

      The authors investigated the epigenetic mechanisms regulating the differentiation of circulating monocytes that infiltrate the CNS and adopt microglia-like characteristics. The work is useful to the field, as the contribution of circulating myeloid cell-derived microglia remains controversial. However, the evidence presented is inadequate as the analyses are based on a very limited set of genes, which does not sufficiently support the authors' central claims.

    Reviewed by PREreview, eLife

    4 evaluationsAppears in 2 listsLatest version Latest activity

  4. Gut microbial composition modulates food-specific CD4 + T cells in food allergy

    1. Alexa R Weingarden
    2. Flannery S Dahlberg
    3. Caroline N Broude
    4. Xiandong Meng
    5. Sunit Jain
    6. Allison M Weakley
    7. Ashley V Cabrera
    8. Thamotharampillai Dileepan
    9. Michael A Fischbach
    10. Marc K Jenkins

    Reviewed by preLights

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response

    1. Long-Feng Lu
    2. Can Zhang
    3. Zhuo-Cong Li
    4. Bao-Jie Cui
    5. Yang-Yang Wang
    6. Ke-Jia Han
    7. Xiao Xu
    8. Chu-Jing Zhou
    9. Xiao-Yu Zhou
    10. Yue Wu
    11. Na Xu
    12. Xiao-Li Yang
    13. Dan-Dan Chen
    14. Xi-Yin Li
    15. Li Zhou
    16. Shun Li

    • Curated by eLife

      eLife Assessment

      This valuable study uses zebrafish as a model to reveal a role for the cell cycle protein kinase CDK2 as a negative regulator of type I interferon signaling. The evidence supporting the authors' claims is convincing, including both in vivo and in vitro investigative approaches that corroborate a role for CDK2 in regulating TBK1 degradation. In this latest version, the authors included data addressing a concern raised by the reviewer in the previous peer review round. This work will interest cell biologists, immunologists, and virologists.

    Reviewed by eLife

    11 evaluationsAppears in 1 listLatest version Latest activity

  6. Glycosylated IgG antibodies contribute to the recovery of haemorrhagic fever with renal syndrome patients

    1. Chuansong Quan
    2. Lu Wang
    3. Jiming Gao
    4. Yaoni Li
    5. Xiaoyu Xu
    6. Houqiang Li
    7. Zixuan Gao
    8. Wenxu Ruan
    9. Hongzhi Liu
    10. Qian Li
    11. Weijia Xing
    12. Liqiong Zhao
    13. Michael J Carr
    14. Weifeng Shi
    15. Haifeng Hou

    • Curated by eLife

      eLife Assessment

      The authors investigated the potential role of IgG N-glycosylation in Haemorrhagic Fever with Renal Syndrome (HFRS), which may offer significant insights for understanding molecular mechanisms and for the development of therapeutic strategies for this infectious disease. The findings are valuable to the field and the strength of evidence to support the findings is solid.

    Reviewed by eLife

    11 evaluationsAppears in 1 listLatest version Latest activity

  7. Phospholipid scramblase 1 (PLSCR1) regulates interferon-lambda receptor 1 (IFN-λR1) and IFN-λ signaling in influenza A virus (IAV) infection

    1. Alina Xiaoyu Yang
    2. Lisa Ramos-Rodriguez
    3. Parand Sorkhdini
    4. Dongqin Yang
    5. Carmelissa Norbrun
    6. Sonoor Majid
    7. Sanghyun Lee
    8. Yong Zhang
    9. Michael Holtzman
    10. David F Boyd
    11. Yang Zhou

    • Curated by eLife

      eLife Assessment

      This valuable manuscript presents a potentially novel mechanism by which the phospholipid scramblase, PLSCR1, defends against influenza A virus infection. The strength of the paper rests on solid findings involving knockout and lung specific over-expressing Plscr1 mice, airway tissue expression and mechanistic studies to show Plscr1 enhances type III interferon-mediated viral clearance.

    Reviewed by eLife

    7 evaluationsAppears in 1 listLatest version Latest activity

  8. SARS-CoV-2 spike antibodies cross-react with dengue virus and enhance infection in vitro and in vivo

    1. Kamini Jakhar
    2. Sudipta Sonar
    3. Gagandeep Singh
    4. Tejeswara Rao Asuru
    5. Garima Joshi
    6. Nisha Beniwal
    7. Tania Sarkar
    8. Mahima Tiwari
    9. Jaskaran Kaur
    10. Deepak Kumar Rathore
    11. Banwari Lal
    12. Sandeep Kumar
    13. Puneet Srivastav
    14. Satendra Kumar
    15. Vikas Phagna
    16. Sushma Mithina
    17. Lokesh Kumar
    18. Vishal Gupta
    19. Pallavi Kshetrapal
    20. Savita Singh
    21. Nitya Wadhwa
    22. Ramachandran Thiruvengadam
    23. Sreevatsan Raghavan
    24. Mudita Gosain
    25. Tripti Shrivastava
    26. Sankar Bhattacharyya
    27. Shailendra Asthana
    28. Prasenjit Guchhait
    29. Shailendra Mani

    Reviewed by Rapid Reviews Infectious Diseases

    4 evaluationsAppears in 1 listLatest version Latest activity

  9. Universal protection against SARS-CoV-2 viruses by multivalent mRNA vaccine in mice

    1. Zhengyang Lei
    2. Shiyao Zhai
    3. Xi Yuan
    4. Runming Wang
    5. Yunpeng Wang
    6. Vijay Pandey
    7. Can Yang Zhang
    8. Jiansong Ji
    9. Dongmei Yu
    10. Zhenglin Chen
    11. Sumin Bian
    12. Peiwu Qin

    Reviewed by Rapid Reviews Infectious Diseases

    3 evaluationsAppears in 1 listLatest version Latest activity

  10. Protective non-neutralizing mAbs Ab94 and Ab81 retain high-affinity and potent Fc-mediated function against SARS-CoV-2 variants from Omicron to XBB1.5

    1. Arman Izadi
    2. Magdalena Godzwon
    3. Mats Ohlin
    4. Pontus Nordenfelt

    Reviewed by Rapid Reviews Infectious Diseases, PREreview

    5 evaluationsAppears in 2 listsLatest version Latest activity
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