Immunology

Integrin-deficient T cell leukemia accumulates in the central nervous system

1. Samantha Y Lux
2. Cynthia Chen
3. Bibi S Subhan
4. Hyunsoo Chung
5. Martyna Okuniewska
6. Asha Y Caslin
7. Kathleen A Martin
8. Jennifer K Schiavo
9. Jonah B Vernejoul
10. Robert C Froemke
11. Michael Cammer
12. Susan R Schwab

• Curated by eLife

  eLife Assessment

  This study presents an important finding that loss or blockade of key integrins unexpectedly enhances central nervous system accumulation of T-cell acute lymphoblastic leukemia cells and may increase their sensitivity to chemotherapy. The evidence is convincing, supported by well-designed in vivo models, CRISPR-based perturbations, competitive assays, imaging, and complementary therapeutic experiments. However, the mechanistic basis linking integrin loss, altered spatial distribution, and increased proliferation remains incompletely defined, and the translational implications would be strengthened by additional survival studies and validation in more clinically relevant models.

Reviewed by eLife

The serine protease homolog Skanda modulates Toll-Phenoloxidase-mediated immunity in Drosophila

1. Sanjana Vasanth
2. Yang Wang
3. Nathan Klotz
4. Anzer Khan
5. Chao Xiong
6. Jean-Philippe Boquete
7. Tisheng Shan
8. Prince Kumar Sah
9. Haobo Jiang
10. Bruno Lemaitre

Reviewed by Review Commons

Uncovering the Heterogeneity and Ontogeny of Mouse Thymic Macrophages Reveals an Unexpected Early Checkpoint Role

1. Helen Wang
2. Vinothkumar Rajan
3. Anthony Wong
4. Slava Epelman
5. Juan Carlos Zúñiga-Pflücker

• Curated by eLife

  eLife Assessment

  This study characterizes the heterogeneity and developmental origins of macrophages in the thymus and offers tantalizing evidence of their potential involvement in the first step of T cell selection. The macrophage characterisation is interesting, although the evidence for the specific involvement of macrophages in beta-selection is incomplete, as alternative explanations have not been ruled out. These results provide an important advance that further our understanding of thymus biology, especially in view of the contribution of heterogenous thymic macrophage subpopulations.

Reviewed by eLife

Deubiquitinase USP-14 controls intestinal distension-induced immune activation in Caenorhabditis elegans via Wnt/β-catenin signaling

1. Annesha Ghosh
2. Jogender Singh

Reviewed by Review Commons

Constitutive interferon epsilon expression shapes antiviral epithelial states in the female reproductive tract and intestine

1. Rebecca L. Casazza
2. Samantha Skavicus
3. David Hare
4. Kaila A. Cooley
5. Nicholas S. Heaton
6. Carolyn B. Coyne

Reviewed by PREreview