Immunology

  1. Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to Plasmodium infection

    1. Kely Catarine Matteucci
    2. Nathalia PS Leite
    3. Patricia A Assis
    4. Isabella Cristina Hirako
    5. Franciele Pioto
    6. Ogooluwa Ojelabi
    7. Juliana E Toller-Kawahisa
    8. Leonardo Gomes Vaz
    9. Diego Luis Costa
    10. João S da Silva
    11. José C Alves-Filho
    12. Ricardo T Gazzinelli

    • Curated by eLife

      eLife Assessment

      This important study examines the role of TNF in modulating energy metabolism during parasite infection. The authors perform an elegant set of studies combining genetics, small molecule perturbation, and phenotypic experiments to highlight a role for glycolysis and glucose transport in control of parasitemia. This solid work integrates an interesting set of observations that will be of interest to the Plasmodium and pathogenesis communities with an expanded set of experiments.

    Reviewed by eLife

    9 evaluationsAppears in 1 listLatest version Latest activity

  2. Deubiquitinase USP-14 controls intestinal distension-induced immune activation in Caenorhabditis elegans via Wnt/β-catenin signaling

    1. Annesha Ghosh
    2. Jogender Singh

    Reviewed by Review Commons

    6 evaluationsAppears in 1 listLatest version Latest activity

  3. TGF-β drives the conversion of conventional NK cells into uterine tissue-resident NK cells to support murine pregnancy

    1. Josselyn D Barahona
    2. Liping Yang
    3. D Michael Nelson
    4. Wayne M Yokoyama

    • Curated by eLife

      eLife Assessment

      The importance of uterine natural killer (NK) cells in reproductive success has been demonstrated in mice and humans; however, it is still unclear how uterine NK cells are developed. In this important manuscript, the authors provide convincing evidence that TGF-b signaling in NK cells supports normal pregnancy in mice by the conversion of conventional NK cells into uterine tissue-resident NK cells. Previous concerns have been addressed in this revised version.

    Reviewed by eLife

    7 evaluationsAppears in 1 listLatest version Latest activity

  4. Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis

    1. Peter Georgiev
    2. Sheila Johnson
    3. Kiran Kurmi
    4. Song-Hua Hu
    5. SeongJun Han
    6. Dillon Patterson
    7. Thao H Nguyen
    8. Linglin Huang
    9. Dan Liang
    10. Naomi Goldman
    11. Thomas Conway
    12. Hannah Creasey
    13. Jared Rowe
    14. Marcia C Haigis
    15. Arlene H Sharpe

    • Curated by eLife

      eLife Assessment

      Non-essential amino acids such as glutamine have been known to be required for T cell general activation through sustaining basic biosynthetic processes, including nucleotide biosynthesis, ATP generation, and protein synthesis. In this important study, the authors found that extracellular asparagine (Asn) is required not only for T cells to generally refuel metabolic reprogramming, but to produce helper T cell lineage-specific cytokine, for instance, IL17. In particular, the importance of Asn in IL17 production was convincingly demonstrated in the mouse experimental autoimmune encephalomyelitei (EAE) model, mimicking human multiple sclerosis disease.

    Reviewed by eLife

    7 evaluationsAppears in 1 listLatest version Latest activity

  5. Constitutive interferon epsilon expression shapes antiviral epithelial states in the female reproductive tract and intestine

    1. Rebecca L. Casazza
    2. Samantha Skavicus
    3. David Hare
    4. Kaila A. Cooley
    5. Nicholas S. Heaton
    6. Carolyn B. Coyne

    Reviewed by PREreview

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Deciphering interferon functions in avian influenza using receptor knockout models in the natural host

    1. Mohanned Naif Alhussien
    2. Hanna Kaisa Vikkula
    3. Romina Klinger
    4. Christian Zenner
    5. Simon P Früh
    6. Rashi Negi
    7. Theresa von Heyl
    8. Sabrina Schleibinger
    9. Milena Brunner
    10. Tom VL Berghof
    11. Leora Avolio
    12. Arne Reich
    13. Benjamin Schade
    14. Bassel Aboukhadra
    15. Silke Rautenschlein
    16. Rudolf Preisinger
    17. Hicham Sid
    18. Benjamin Schusser

    • Curated by eLife

      eLife Assessment

      This study reports on the development and characterization of chickens with genetic deficiencies in type I or type III interferon receptors, which is an important contribution to the field of avian immunology. The data reflecting the development of the new interferon-receptor-deficient chickens is compelling. The initial characterization of IFN biology and infection responses in these knockout chickens provides a solid foundation for future studies on the distinct contributions of type I and type III interferon signaling to antiviral responses.

    Reviewed by eLife

    6 evaluationsAppears in 1 listLatest version Latest activity

  7. CD4 T cells and CD8α+ lymphocytes are necessary for intravenous BCG-induced protection against tuberculosis in macaques

    1. Andrew W. Simonson
    2. Joseph J. Zeppa
    3. Allison N. Bucsan
    4. Michael C. Chao
    5. Supriya Pokkali
    6. Forrest Hopkins
    7. Michael R. Chase
    8. Andrew J. Vickers
    9. Matthew S. Sutton
    10. Caylin G. Winchell
    11. Amy J. Myers
    12. Cassaundra L. Ameel
    13. Ryan Kelly
    14. Ben Krouse
    15. Luke E. Hood
    16. Jiaxiang Li
    17. Chelsea C. Lehman
    18. Megha Kamath
    19. Jaime Tomko
    20. Mark A. Rodgers
    21. Rachel Donlan
    22. Harris Chishti
    23. H. Jacob Borish
    24. Edwin Klein
    25. Charles A. Scanga
    26. Sarah Fortune
    27. Philana Ling Lin
    28. Pauline Maiello
    29. Mario Roederer
    30. Patricia A. Darrah
    31. Robert A. Seder
    32. JoAnne L. Flynn

    Reviewed by Rapid Reviews Infectious Diseases

    5 evaluationsAppears in 1 listLatest version Latest activity

  8. Broadly inhibitory antibodies to severe malaria virulence proteins

    1. Raphael A. Reyes
    2. Sai Sundar Rajan Raghavan
    3. Nicholas K. Hurlburt
    4. Viola Introini
    5. Sebastiaan Bol
    6. Ikhlaq Hussain Kana
    7. Rasmus W. Jensen
    8. Elizabeth Martinez-Scholze
    9. María Gestal-Mato
    10. Borja López-Gutiérrez
    11. Silvia Sanz
    12. Cristina Bancells
    13. Monica Lisa Fernández-Quintero
    14. Johannes R. Loeffler
    15. James Alexander Ferguson
    16. Wen-Hsin Lee
    17. Greg Michael Martin
    18. Thor G. Theander
    19. John P. A. Lusingu
    20. Daniel T. R. Minja
    21. Isaac Ssewanyana
    22. Margaret E. Feeney
    23. Bryan Greenhouse
    24. Andrew B. Ward
    25. Maria Bernabeu
    26. Marie Pancera
    27. Louise Turner
    28. Evelien M. Bunnik
    29. Thomas Lavstsen

    Reviewed by Rapid Reviews Infectious Diseases

    6 evaluationsAppears in 1 listLatest version Latest activity

  9. Pneumocystis murina Promotes Inflammasome Formation and NETosis during Pneumocystis Pneumonia

    1. Steven G. Sayson
    2. Alan Ashbaugh
    3. Aleksey Porollo
    4. Melanie T. Cushion

    Reviewed by Rapid Reviews Infectious Diseases

    5 evaluationsAppears in 1 listLatest version Latest activity

  10. Secretory leukocyte protease inhibitor protects against severe urinary tract infection in mice

    1. Anne L. Rosen
    2. Michael A. Lint
    3. Dayne H. Voelker
    4. Nicole M. Gilbert
    5. Christopher P. Tomera
    6. Jesús Santiago-Borges
    7. Meghan A. Wallace
    8. Thomas J. Hannan
    9. Carey-Ann D. Burnham
    10. Scott J. Hultgren
    11. Andrew L. Kau

    Reviewed by PREreview, Rapid Reviews Infectious Diseases

    6 evaluationsAppears in 2 listsLatest version Latest activity
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