Immunology

Contrasting roles for IKK regulated inflammatory signalling pathways for development and maintenance of type 1 and adaptive 𝛄δ T cells

1. Farjana Islam
2. Cayman Williams
3. Thea Hogan
4. Louise Webb
5. Ines Boal-Carvalho
6. Benedict Seddon

• Curated by eLife

  eLife Assessment

  This study reports important findings regarding the role of the NF-kB signaling pathway in the development and long-term survival of gamma delta T cells. The authors report disparate roles of IKK-dependent NF-kB activation in the development and long-term survival of gamma delta T cell subsets. The approach and methodology employed is convincing. This work will be of great interest to immunologists interested in innate-like T cell biology and in T cell development.

Reviewed by eLife

Synaptotagmin 1 and Synaptotagmin 7 promote MR1-mediated presentation of Mycobacterium tuberculosis antigens

1. Se-Jin Kim
2. Jessie C Peterson
3. Andrew J Olive
4. Fikadu G Tafesse
5. Corinna A Kulicke
6. Elham Karamooz
7. David M Lewinsohn

• Curated by eLife

  eLife Assessment

  This useful study examines the contribution of synaptotagmin 1 and synaptotagmin 7 to metabolite antigen presentation to mucosal-associated invariant T (MAIT) cells; it begins to address a critical gap in our understanding of the antigen presentation mechanisms of these cells. Strengths of the study include the use of Mtb to study the dynamics of antigen presentation to MAIT cells instead of a synthetic antigen. The strength of the evidence to support the conclusion is solid.

Reviewed by eLife

Ex vivo and in vivo CRISPR/Cas9 screenings identify the roles of protein N-glycosylation in regulating T-cell activation and functions

1. Yu Hong
2. Xiaofang Si
3. Wenjing Liu
4. Xueying Mai
5. Yu Zhang

• Curated by eLife

  eLife Assessment

  The important study uses genome-wide CRISPR/Cas9 screenings to identify a novel target B4GALTZ1 that is implicated in modulating CD8+ T cell function in the context of anti-tumor immunity. The strength of evidence is solid but could benefit from more detail, particularly to verify the efficiency of knockout in their single gene KO lines and identification of N-glycosylation sites of TCR and CD8s. This work highlights the role of protein N-glycosylation, particularly B4GALT1 deficiency, in regulating CD8 function and anti-tumor immunity.

Reviewed by eLife

Daytime variation in SARS-CoV-2 infection and cytokine production

1. Aïssatou Bailo Diallo
2. Laetitia Gay
3. Benjamin Coiffard
4. Marc Leone
5. Soraya Mezouar
6. Jean-Louis Mege

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

Pre-existing YFV-17D immunity mediates T cell cross-protection against DENV-2 infection

1. Prince Baffour Tonto
2. Sebastian Gallon
3. Reem Alatrash
4. Wei-Kung Wang
5. Bobby Brooke Herrera

Reviewed by Rapid Reviews Infectious Diseases, PREreview

High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages

1. Willianne Hoepel
2. Hung-Jen Chen
3. Chiara E. Geyer
4. Sona Allahverdiyeva
5. Xue D. Manz
6. Steven W. de Taeye
7. Jurjan Aman
8. Lynn Mes
9. Maurice Steenhuis
10. Guillermo R. Griffith
11. Peter I. Bonta
12. Philip J.M. Brouwer
13. Tom G. Caniels
14. Karlijn van der Straten
15. Korneliusz Golebski
16. René E. Jonkers
17. Mads D. Larsen
18. Federica Linty
19. Jan Nouta
20. Cindy P.A.A. van Roomen
21. Frank E.H.P. van Baarle
22. Cornelis M. van Drunen
23. Gertjan Wolbink
24. Alexander P.J. Vlaar
25. Godelieve J. de Bree
26. Rogier W. Sanders
27. Lisa Willemsen
28. Annette E. Neele
29. Diederik van de Beek
30. Theo Rispens
31. Manfred Wuhrer
32. Harm Jan Bogaard
33. Marit J. van Gils
34. Gestur Vidarsson
35. Menno de Winther
36. Jeroen den Dunnen

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT, preLights

A conserved immune dysregulation is associated with infection severity, risk factors prior to infection, and treatment response

1. Ananthakrishnan Ganesan
2. Andrew R. Moore
3. Hong Zheng
4. Jiaying Toh
5. Michael Freedman
6. Andrew T. Magis
7. James R. Heath
8. Purvesh Khatri

Reviewed by Rapid Reviews Infectious Diseases

Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators

1. Suelen da Silva Gomes Dias
2. Vinicius Cardoso Soares
3. André C. Ferreira
4. Carolina Q. Sacramento
5. Natalia Fintelman-Rodrigues
6. Jairo R. Temerozo
7. Lívia Teixeira
8. Ester Barreto
9. Mayara Mattos
10. Caroline S. de Freitas
11. Isaclaudia G. Azevedo-Quintanilha
12. Pedro Paulo A. Manso
13. Eugenio D. Hottz
14. Camila R. R. Pão
15. Dumith C. Bou-Habib
16. Fernando A. Bozza
17. Thiago M. L. Souza
18. Patrícia T. Bozza

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

Dual Role of Glycosylation in Resistance to CD4-binding Site Broadly Neutralizing Antibodies

1. Teresa Murphy
2. Meagan Kelly
3. Kai S. Shimagaki
4. Thomas DeStefanis
5. Gabriel Galeotos
6. Myungjin Lee
7. Qing Wei
8. Jan Novak
9. Katharine J. Bar
10. John P. Barton
11. Rebecca M. Lynch

Reviewed by Rapid Reviews Infectious Diseases

Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV-1 V2 apex broadly neutralizing antibody development

1. Rumi Habib
2. Ryan S. Roark
3. Hui Li
4. Andrew Jesse Connell
5. Michael P. Hogarty
6. Kshitij Wagh
7. Shuyi Wang
8. Lorie Marchitto
9. Ashwin N. Skelly
10. John W. Carey
11. Kirsten J. Sowers
12. Kasirajan Ayyanathan
13. Samantha J. Plante
14. Frederic Bibollet-Ruche
15. Younghoon Park
16. Colby J. Agostino
17. Ajay Singh
18. Christian L. Martella
19. Emily Lewis
20. Juliette M. Rando
21. Neha Chohan
22. Jinery Lora
23. Wenge Ding
24. Mary S. Campion
25. Chengyan Zhao
26. Weimin Liu
27. Yingying Li
28. Xuduo Li
29. Bo Liang
30. Rohan Roy Chowdhury
31. Khaled Amereh
32. Elizabeth Van Itallie
33. Zizhang Sheng
34. Amrit R. Ghosh
35. Katharine J. Bar
36. Wilton B. Williams
37. Kevin Wiehe
38. Kevin O. Saunders
39. Robert J. Edwards
40. Derek W. Cain
41. Mark Lewis
42. Facundo D. Batista
43. Dennis R. Burton
44. Raiees Andrabi
45. Daniel W. Kulp
46. Barton F. Haynes
47. Bette Korber
48. Lawrence Shapiro
49. Peter D. Kwong
50. Beatrice H. Hahn
51. George M. Shaw

Reviewed by Rapid Reviews Infectious Diseases