Immunology

Characteristics and Functions of Infection-enhancing Antibodies to the N-terminal Domain of SARS-CoV-2

1. Ruth Connor
2. Mrunal Sakharkar
3. Garrett Rappazzo
4. Chengzi Kaku
5. Nicholas Curtis
6. Seungmin Shin
7. Wendy Wieland-Alter
8. Jordan Wentworth
9. Daniel Mielcarz
10. Joshua Weiner
11. Margaret Ackerman
12. Laura Walker
13. Jiwon Lee
14. Peter Wright

Reviewed by Rapid Reviews Infectious Diseases

CD4 T cells and CD8α+ lymphocytes are necessary for intravenous BCG-induced protection against tuberculosis in macaques

1. Andrew W. Simonson
2. Joseph J. Zeppa
3. Allison N. Bucsan
4. Michael C. Chao
5. Supriya Pokkali
6. Forrest Hopkins
7. Michael R. Chase
8. Andrew J. Vickers
9. Matthew S. Sutton
10. Caylin G. Winchell
11. Amy J. Myers
12. Cassaundra L. Ameel
13. Ryan Kelly
14. Ben Krouse
15. Luke E. Hood
16. Jiaxiang Li
17. Chelsea C. Lehman
18. Megha Kamath
19. Jaime Tomko
20. Mark A. Rodgers
21. Rachel Donlan
22. Harris Chishti
23. H. Jacob Borish
24. Edwin Klein
25. Charles A. Scanga
26. Sarah Fortune
27. Philana Ling Lin
28. Pauline Maiello
29. Mario Roederer
30. Patricia A. Darrah
31. Robert A. Seder
32. JoAnne L. Flynn

Reviewed by Rapid Reviews Infectious Diseases

Heterologous booster with a novel formulation containing glycosylated trimeric S protein is effective against Omicron

1. Daniela Bottero
2. Erika Rudi
3. Pablo Martin Aispuro
4. Eugenia Zurita
5. Emilia Gaillard
6. Maria M. Gonzalez Lopez Ledesma
7. Juan Malito
8. Matthew Stuible
9. Nicolas Ambrosis
10. Yves Durocher
11. Andrea V. Gamarnik
12. Andrés Wigdorovitz
13. Daniela Hozbor

Reviewed by Rapid Reviews Infectious Diseases

Pneumocystis murina Promotes Inflammasome Formation and NETosis during Pneumocystis Pneumonia

1. Steven G. Sayson
2. Alan Ashbaugh
3. Aleksey Porollo
4. Melanie T. Cushion

Reviewed by Rapid Reviews Infectious Diseases

Germline-targeting chimpanzee SIV Envelopes induce V2-apex broadly neutralizing-like B cell precursors in a rhesus macaque infection model

1. Rami Musharrafieh
2. Yana Safonova
3. Ge Song
4. Ryan S. Roark
5. Fang-Hua Lee
6. Shiyu Zhang
7. Jonathan Hurtado
8. Peter Yong
9. Shuyi Wang
10. Ronnie M. Russell
11. Wenge Ding
12. Yingying Li
13. Juliette Rando
14. Alexander I. Murphy
15. Emily Lindemuth
16. Chengyan Zhao
17. Andrew Jesse Connell
18. Wen-Hsin Lee
19. Nitesh Mishra
20. Gabriel Avillion
21. Wanting He
22. Sean Callaghan
23. Katharina Dueker
24. Anh L. Vo
25. Xuduo Li
26. Tazio Capozzola
27. Collin Joyce
28. Fangzhu Zhao
29. Fabio Anzanello
30. Weimin Liu
31. Frederic Bibollet-Ruche
32. Alejandra Ramos
33. Hui Li
34. Mark G. Lewis
35. Gabriel Ozorowski
36. Elise Landais
37. Brian T. Foley
38. Kshitij Wagh
39. Devin Sok
40. Bryan Briney
41. Andrew B. Ward
42. Beatrice H. Hahn
43. Dennis R. Burton
44. George M. Shaw
45. Raiees Andrabi

Reviewed by Rapid Reviews Infectious Diseases

Therapeutic DNA Vaccine Targeting Mycobacterium tuberculosis Persisters Shortens Curative Tuberculosis Treatment

1. Styliani Karanika
2. Tianyin Wang
3. Addis Yilma
4. Jennie Ruelas Castillo
5. James T. Gordy
6. Hannah Bailey
7. Darla Quijada
8. Kaitlyn Fessler
9. Rokeya Tasneen
10. Elisa M. Rouse Salcido
11. Harley T. Harris
12. Rowan E. Bates
13. Heemee Ton
14. Jacob Meza
15. Yangchen Li
16. Alannah D. Taylor
17. Jean J. Zheng
18. Jiaqi Zhang
19. J David Peske
20. Theodoros Karantanos
21. Amanda R. Maxwell
22. Eric Nuermberger
23. Richard B. Markham
24. Petros C. Karakousis

Reviewed by Rapid Reviews Infectious Diseases

Semi-synthetic glycoconjugate vaccine candidate against Cryptococcus neoformans

1. Conor J. Crawford
2. Livia Liporagi-Lopes
3. Carolina Coelho
4. Samuel R. Santos Junior
5. André Moraes Nicola
6. Maggie P. Wear
7. Raghav Vij
8. Stefan Oscarson
9. Arturo Casadevall

Reviewed by Rapid Reviews Infectious Diseases

Broadly inhibitory antibodies to severe malaria virulence proteins

1. Raphael A. Reyes
2. Sai Sundar Rajan Raghavan
3. Nicholas K. Hurlburt
4. Viola Introini
5. Sebastiaan Bol
6. Ikhlaq Hussain Kana
7. Rasmus W. Jensen
8. Elizabeth Martinez-Scholze
9. María Gestal-Mato
10. Borja López-Gutiérrez
11. Silvia Sanz
12. Cristina Bancells
13. Monica Lisa Fernández-Quintero
14. Johannes R. Loeffler
15. James Alexander Ferguson
16. Wen-Hsin Lee
17. Greg Michael Martin
18. Thor G. Theander
19. John P. A. Lusingu
20. Daniel T. R. Minja
21. Isaac Ssewanyana
22. Margaret E. Feeney
23. Bryan Greenhouse
24. Andrew B. Ward
25. Maria Bernabeu
26. Marie Pancera
27. Louise Turner
28. Evelien M. Bunnik
29. Thomas Lavstsen

Reviewed by Rapid Reviews Infectious Diseases

Mast cells promote pathology and susceptibility in tuberculosis

1. Ananya Gupta
2. Vibha Taneja
3. Javier Rangel Moreno
4. Nilofer Naqvi
5. Abhimanyu
6. Yun Tao
7. Mushtaq Ahmed
8. Kuldeep S Chauhan
9. Daniela Trejo-Ponce de León
10. Gustavo Ramírez-Martínez
11. Luis Jiménez-Alvarez
12. Cesar Luna-Rivero
13. Joaquin Zuniga
14. Deepak Kaushal
15. Shabaana A Khader

• Curated by eLife

  eLife Assessment

  In this useful study, the authors utilize published scRNA-seq data to highlight the potential importance of mast cells (MCs) in TB granulomas, presenting a solid comparative assessment of chymase- and tryptase-expressing MCs in the lungs of Mycobacterium tuberculosis-infected individuals and non-human primates. While the authors appropriately discussed the inconsistencies across models, adoptive transfer experiments in MC-deficient mice would substantially strengthen the causal link between MCs and TB outcomes, providing more direct functional validation of the proposed role of MCs in TB pathogenesis.

Reviewed by eLife, Arcadia Science

Ly6G+Granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

1. Priya Sharma
2. Raman Deep Sharma
3. Binayak Sarkar
4. Varnika Panwar
5. Mrinmoy Das
6. Lakshyaveer Singh
7. Neharika Jain
8. Shivam Chaturvedi
9. Lalita Mehra
10. Aditya Rathee
11. Shilpa Sharma
12. Shihui Foo
13. Andrea Lee
14. N Pavan Kumar
15. Prasenjit Das
16. Vijay Viswanathan
17. Hardy Kornfeld
18. Shanshan W Howland
19. Subash Babu
20. Vinay Nandicoori
21. Amit Singhal
22. Dhiraj Kumar

• Curated by eLife

  eLife Assessment

  This valuable study examines the role of IL17-producing Ly6G PMNs as a reservoir for Mycobacterium tuberculosis to evade host killing activated by BCG immunisation. The authors provide solid data reporting that IL17-producing polymorphonuclear neutrophils harbour a significant bacterial load in both wild-type and IFNg-/- mice and that targeting IL17 and Cox2 improved disease outcomes whilst enhancing BCG efficacy. The specific contribution of neutrophil-derived IL-17 to disease pathogenesis remains to be definitively established through direct demonstration of IL-17 production by neutrophils and targeted depletion studies.

Reviewed by eLife