Immunology

Mycobacterium tuberculosis suppresses protective Th17 responses during infection

1. Alex Zilinskas
2. Amir Balakhmet
3. Douglas Fox
4. Heyuan Michael Ni
5. Carolina Agudelo
6. Helia Samani
7. Sarah A Stanley

• Curated by eLife

  eLife Assessment

  This important study investigates the mechanisms by which Mycobacterium tuberculosis suppresses protective Th17 differentiation during infection. Using ESX-1- and PDIM-deficient mutants of M. tuberculosis, which lack functional eccC1 and fadD28 respectively, the authors demonstrate that these virulence factors actively restrict IL-17 responses via a T-bet-dependent pathway, independent of overall bacterial attenuation or infection duration. While the precise molecular interactions by which ESX-1 and PDIM modulate Th17 differentiation warrant further elucidation, the experiments are rigorously designed, the findings are clearly presented, and the evidence is solid for a specific role for these factors in limiting protective IL-17 immunity in M. tuberculosis infection.

Reviewed by eLife

BATF controls IFN I production via DC-SCRIPT in plasmacytoid dendritic cells

1. Shafaqat Ali
2. Ritu Mann-Nüttel
3. Marcel Marson
4. Ben Leiser
5. Jasmina Hoffe
6. Regine J. Dress
7. Mahamudul Hasan Bhuyan
8. Patrick Petzsch
9. Karl Köhrer
10. Haifeng C. Xu
11. Philipp A. Lang
12. Shengbo Zhang
13. Michaël Chopin
14. Stephen L. Nutt
15. Judith Alferink
16. Stefanie Scheu

Reviewed by PREreview

Integrin-deficient T cell leukemia accumulates in the central nervous system

1. Samantha Y Lux
2. Cynthia Chen
3. Bibi S Subhan
4. Hyunsoo Chung
5. Martyna Okuniewska
6. Asha Y Caslin
7. Kathleen A Martin
8. Jennifer K Schiavo
9. Jonah B Vernejoul
10. Robert C Froemke
11. Michael Cammer
12. Susan R Schwab

• Curated by eLife

  eLife Assessment

  This study presents an important finding that loss or blockade of key integrins unexpectedly enhances central nervous system accumulation of T-cell acute lymphoblastic leukemia cells and may increase their sensitivity to chemotherapy. The evidence is convincing, supported by well-designed in vivo models, CRISPR-based perturbations, competitive assays, imaging, and complementary therapeutic experiments. However, the mechanistic basis linking integrin loss, altered spatial distribution, and increased proliferation remains incompletely defined, and the translational implications would be strengthened by additional survival studies and validation in more clinically relevant models.

Reviewed by eLife

The serine protease homolog Skanda modulates Toll-Phenoloxidase-mediated immunity in Drosophila

1. Sanjana Vasanth
2. Yang Wang
3. Nathan Klotz
4. Anzer Khan
5. Chao Xiong
6. Jean-Philippe Boquete
7. Tisheng Shan
8. Prince Kumar Sah
9. Haobo Jiang
10. Bruno Lemaitre

Reviewed by Review Commons

Deubiquitinase USP-14 controls intestinal distension-induced immune activation in Caenorhabditis elegans via Wnt/β-catenin signaling

1. Annesha Ghosh
2. Jogender Singh

Reviewed by Review Commons

Constitutive interferon epsilon expression shapes antiviral epithelial states in the female reproductive tract and intestine

1. Rebecca L. Casazza
2. Samantha Skavicus
3. David Hare
4. Kaila A. Cooley
5. Nicholas S. Heaton
6. Carolyn B. Coyne

Reviewed by PREreview