Immunology

Layilin Regulates Treg Motility and Suppressive Capacity in Skin

1. Victoire Gouirand
2. Sean Clancy
3. Courtney Macon
4. Jose Valle
5. Mariela Pauli
6. Hong-An Troung
7. Jarish Cohen
8. Maxime Kinet
9. Margaret M Lowe
10. Samuel J Lord
11. Kristen Skruber
12. Hobart Harris
13. Esther Kim
14. Isaac Neuhaus
15. Karin Reif
16. Ali A Zarrin
17. Dyche R Mullins
18. Michael D Rosenblum

• Curated by eLife

  eLife Assessment

  This study reports valuable findings on the role of Layilin in the motility and suppressive capacity of clonal expanded regulatory T cells (Tregs) in the skin. Although the strength of the study is utilizing conditional knock-out mice and human skin samples, the analysis of the molecular mechanism by which Layilin affects Treg function is incomplete. The study will be of interest to medical scientists working on skin immunology.

Reviewed by eLife, Arcadia Science

Malnutrition drives infection susceptibility and dysregulated myelopoiesis that persists after refeeding intervention

1. Alisa Sukhina
2. Clemence Queriault
3. Saptarshi Roy
4. Elise Hall
5. Kelly Rome
6. Muskaan Aggarwal
7. Elizabeth Nunn
8. Ashley Weiss
9. Janet Nguyen
10. F Chris Bennett
11. Will Bailis

• Curated by eLife

  eLife Assessment

  This important work advances our understanding of the impact of malnutrition on hematopoiesis and subsequently infection susceptibility. Support for the overall claims is convincing in some respects and incomplete in terms of identifying mechanism as highlighted by reviewers. This work will be of general interest to those in the fields of hematopoiesis, malnutrition, and dietary influence on immunity.

Reviewed by eLife

Epidermal Resident Memory T Cell Fitness Requires Antigen Encounter in the Skin

1. Eric S Weiss
2. Toshiro Hirai
3. Haiyue Li
4. Andrew Liu
5. Shannon Baker
6. Ian Magill
7. Jacob Gillis
8. Youran R Zhang
9. Torben Ramcke
10. Kazuo Kurihara
11. The ImmGen Consortium OpenSource T cell Project
12. David Masopust
13. Niroshana Anandasabapathy
14. Harinder Singh
15. David Zemmour
16. Laura K Mackay
17. Daniel H Kaplan

• Curated by eLife

  eLife Assessment

  Weiss et al. provide important new insights and convincing evidence to further our mechanistic understanding of how antigen presentation shapes skin persistence of CD8+ TRM. Using a mouse model for inducible genetic ablation of transforming growth factor beta receptor 3 (TGFBR3) in CD8+ T cells, they demonstrate TGFBR3's role in regulating CD8+ TRM persistence in skin. Furthermore, they show that the strength of T cell receptor (TCR) engagement upon initial CD8+ TRM skin seeding has a positive influence on subsequent TRM expansion following a secondary antigen-reencounter. Together, these mechanisms add to our understanding of how the skin CD8+ T cell repertoire is dynamically responsive to topical antigen.

Reviewed by eLife

HIV-specific CD8+ T-cell responses soon after treatment initiation during acute HIV infection are associated with viral reservoir decline

1. Pien M van Paassen
2. Alexander O Pasternak
3. Karel A van Dort
4. Ad C van Nuenen
5. Irma Maurer
6. Brigitte Boeser-Nunnink
7. Ninée VEJ Buchholtz
8. Tokameh Mahmoudi
9. Cynthia Lungu
10. Reinout van Crevel
11. Casper Rokx
12. Jori Symons
13. Monique Nijhuis
14. Annelou van der Veen
15. Liffert Vogt
16. Michelle J Klouwens
17. Jan M Prins
18. Neeltje A Kootstra
19. Godelieve J de Bree

• Curated by eLife

  eLife Assessment

  This valuable paper used a longitudinal cohort of individuals initiating ART to suggest that CD8+ T cells may contribute to the clearance of intact HIV DNA during long-term antiretroviral therapy (ART) for HIV, which is relevant to our understanding of the mechanisms driving reservoir persistence in people living with HIV. The reviewers concluded that the evidence presented is incomplete to fully support these claims, as the cohort sampling is relatively infrequent, and the association direction could be bi-directional or due to other confounding variables.

Reviewed by eLife

Coenzyme A governs proinflammatory macrophage metabolism

1. Greg. A. Timblin
2. Kevin. M. Tharp
3. Johanna ten Hoeve
4. Daniel S. Kantner
5. Ilayda Baydemir
6. Eric A. Noel
7. Chandra Khantwal
8. Pankaj K. Singh
9. Joshua N. Farahzad
10. Jorge Domínguez-Andrés
11. Russell E. Vance
12. Nathaniel W. Snyder
13. Valerie M. Weaver

• Curated by eLife

  eLife Assessment

  This important study looks into the effect of exogenous CoA on the response of TLR4-activated macrophages. Specifically, CoA enhances the LPS response by examining metabolomics, 13C tracing, and assessments of transcription and acetylation. Together, these provide a compelling series of findings that show exogenous CoA is taken up by macrophages, and this facilitates histone acetylation and transcription associated with activation and antimicrobial activity.

Reviewed by eLife

Susceptibility of Kit-mutant mice to sepsis caused by enteral dysbiosis, not mast cell deficiency

1. Thorsten B Feyerabend
2. Fabienne Schochter
3. Alpaslan Tasdogan
4. Hans-Reimer Rodewald

• Curated by eLife

  eLife Assessment

  This study presents a useful finding showing that the high susceptibility to sepsis of Kit-mutant mice is due to dysbiosis. However, the data provided is incomplete and would benefit from more rigorous approaches. With the mechanism part strengthened, this paper would be of interest to researchers on mast cell biology and mucosal immunology.

Reviewed by eLife

Layers of immunity: Deconstructing the Drosophila effector response

1. Faustine Ryckebusch
2. Yao Tian
3. Mylene Rapin
4. Fanny Schüpfer
5. Mark A Hanson
6. Bruno Lemaitre

• Curated by eLife

  eLife Assessment

  This work provides one of the first important attempts to look at Drosophila immune responses against bacterial, viral, and fungal pathogens in a way that combines the roles of four major arms in immunity (Imd signaling, Toll signaling, phagocytosis, and melanization) rather than studying them separately. The findings are convincing, and the tools provided can be used as they are, or built upon, in various contexts.

Reviewed by eLife

Opposing Regulation of TNF Responses by IFN-γ and a PGE2-cAMP Axis that is Apparent in Rheumatoid and Immune Checkpoint Inhibitor-induced Arthritis IL-1β+ Macrophages

1. Upneet K Sokhi
2. Ruoxi Yuan
3. Bikash Mishra
4. Yuri Chinenov
5. Anvita Singaraju
6. Karmela K Chan
7. Anne R Bass
8. Richard D Bell
9. Laura Donlin
10. Lionel B Ivashkiv

• Curated by eLife

  eLife Assessment

  The manuscript contains important findings regarding inflammatory macrophage subsets that have theoretical and/or practical applications beyond the field of rheumatology. The authors demonstrate with compelling evidence the effects of PGE2 on TNF signaling. This work will be of broad interest to immunologists and cell biologists.

Reviewed by eLife

Class A Scavenger Receptor MARCO negatively regulates Ace expression and aldosterone production

1. Conan JO O’Brien
2. Giorgio Ratti
3. Hellen Veida-Silva
4. Emma Haberman
5. Charles Sweeney
6. Siamon Gordon
7. Ana I Domingos

• Curated by eLife

  eLife Assessment

  O'Brien and co-authors addressed how statins reduce levels of aldosterone in humans and provide important data demonstrating that tissue-resident macrophages can exert physiological functions and influence endocrine systems. However, the strength of evidence, as of now, is incomplete, as the sole description of the phenotype of MARCO-deficient mice is insufficient to claim that MARCO in alveolar macrophages can negatively regulate ACE expression and aldosterone production at steady-state. The work will be of broad interest to cell biologists and immunologists.

Reviewed by eLife

Contrasting Effects of SARS-CoV-2 Vaccination vs. Infection on Antibody and TCR Repertoires

1. Jasper Braun
2. Elliot D. Hill
3. Elisa Contreras
4. Michie Yasuda
5. Alexandra Morgan
6. Sarah Ditelberg
7. Ethan Winter
8. Cody Callahan
9. Gabrielle Mazzoni
10. Andrea Kirmaier
11. Hamid Mirebrahim
12. Hosseinali Asgharian
13. Dilduz Telman
14. Ai-Ris Y. Collier
15. Dan H. Barouch
16. Stefan Riedel
17. Sanjucta Dutta
18. Florian Rubelt
19. Ramy Arnaout

Reviewed by Review Commons