Immunology

Shared Immune and Epigenetic Pathways in Systemic Lupus Erythematosus and Melanoma Immunotherapy: A Cross-Disease Analysis with Prognostic and Therapeutic Implications

1. Basma Shabana
2. Nouraldeen Ali Ramadan
3. Manar Mosad Marey
4. Mervat Mohamed Shaban

Reviewed by PREreview

Male-Biased Cyp17a2 Governs Antiviral Sexual Dimorphism in Fish via STING Stabilization and Viral Protein Degradation

1. Long-Feng Lu
2. Bao-jie Cui
3. Sheng-Chi Shi
4. Yang-Yang Wang
5. Can Zhang
6. Xiao Xu
7. Meng-Ze Tian
8. Zhen-Qi Li
9. Na Xu
10. Zhuo-Cong Li
11. Dan-Dan Chen
12. Li Zhou
13. Gang Zhai
14. Zhan Yin
15. Shun Li

• Curated by eLife

  eLife Assessment

  This manuscript describes a useful study describing an interesting infection phenotype that differs between adult male and female zebrafish. The authors argue that male-biased expression of Cyp17a2 is implicated in mediating infection levels through STING and USP8 activity regulation. Thus, this study highlights an unexpected factor involved in antiviral immunity that could open new avenues of investigation for infection, metabolism, and other contexts. Although the manuscript presents some evidence supporting its main claims, the evidence for the main argument made in the study on sex dimorphism remains incomplete at this stage.

Reviewed by eLife

Type I and type III interferon receptor knockout chickens: Novel models for unraveling interferon dynamics in influenza infection

1. Mohanned Naif Alhussien
2. Hanna-Kaisa Vikkula
3. Romina Klinger
4. Christian Zenner
5. Simon P Früh
6. Rashi Negi
7. Theresa von Heyl
8. Sabrina Schleibinger
9. Milena Brunner
10. Tom VL Berghof
11. Leora Avolio
12. Arne Reich
13. Benjamin Schade
14. Bassel A Abukhadra
15. Silke Rautenschlein
16. Rudolf Preisinger
17. Hicham Sid
18. Benjamin Schusser

• Curated by eLife

  eLife Assessment

  This study reports on the development and characterization of chickens with genetic deficiencies in type I or type III interferon receptors, which is an important contribution to the field of avian immunology. The data reflecting the development of the new interferon-receptor-deficient chickens is compelling. However, the characterization of IFN biology and infection responses in these knockout chickens is somewhat incomplete and could be improved by addressing the noted weaknesses.

Reviewed by eLife

Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis

1. Peter Georgiev
2. Sheila Johnson
3. Kiran Kurmi
4. Song-Hua Hu
5. SeongJun Han
6. Dillon Patterson
7. Thao H. Nguyen
8. Linglin Huang
9. Dan Liang
10. Naomi Goldman
11. Thomas Conway
12. Hannah Creasey
13. Jared Rowe
14. Marcia C. Haigis
15. Arlene H. Sharpe

• Curated by eLife

  eLife Assessment

  Non-essential amino acids such as glutamine have been known to be required for T cell general activation through sustaining basic biosynthetic processes, including nucleotide biosynthesis, ATP generation, and protein synthesis. In this important study, the authors found that extracellular asparagine (Asn) is required not only for T cells to generally refuel metabolic reprogramming, but to produce helper T cell lineage-specific cytokine, for instance, IL17. In particular, the importance of Asn in IL17 production was convincingly demonstrated in the mouse experimental autoimmune encephalomyelitei (EAE) model, mimicking human multiple sclerosis disease.

Reviewed by eLife

Tolerance to Lung Infection in TWIK2 K+ Efflux Mediated Macrophage Trained Immunity

1. Josh Thompson
2. Yufan Li
3. Yuanling Song
4. Ki-Wook Kim
5. Asrar B Malik
6. Jingsong Xu

• Curated by eLife

  eLife Assessment

  This study presents valuable data suggesting that ATP-induced modulation of alveolar macrophage (AM) functions is associated with NLRP3 inflammasome activation and enhanced phagocytic capacity. While the in vivo and in vitro data reveal an interesting phenotype, the evidence provided is incomplete and does not fully support the paper's conclusions. Additional investigations would be of value in complementing the data and strengthening the interpretation of the results. This study should be of interest to immunologists and the mucosal immunity community.

Reviewed by eLife

The metabolic cofactor Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling

1. Anthony E. Jones
2. Amy Rios
3. Neira Ibrahimovic
4. Carolina Chavez
5. Nicholas A. Bayley
6. Andréa B. Ball
7. Wei Yuan Hsieh
8. Alessandro Sammarco
9. Amber R. Bianchi
10. Angel A. Cortez
11. Thomas G. Graeber
12. Alexander Hoffmann
13. Steven J. Bensinger
14. Ajit S. Divakaruni

Reviewed by Review Commons

Label-Free In-Line Characterization of Immune Cell Culture using Quantitative Phase Imaging

1. Caroline E. Serafini
2. Viswanath Gorti
3. Paloma Casteleiro Costa
4. Aaron D. Silva Trenkle
5. Bharat Kanwar
6. Bryan Wang
7. Brian Wicker
8. Linda E. Kippner
9. Isaac LeCompte
10. Rui Qi Chen
11. Benjamin Joffe
12. Ye Li
13. Annie C. Bowles-Welch
14. Jing Li
15. Christine E. Brown
16. Gabriel A. Kwong
17. Stephen Balakirsky
18. Krishnendu Roy
19. Francisco E. Robles

Reviewed by Arcadia Science

The synovial lining macrophage layer develops in the first weeks of life in a CSF1- and TGFβ-dependent but monocyte-independent process

1. Marlene Magalhaes Pinto
2. Bert Malengier-Devlies
3. Guillaume Seuzaret
4. Anna Ahlback
5. Solvig Becker
6. Katelyn Patatsos
7. Georgios Drakoulis
8. Julia Karjalainen
9. Christiane Ruedl
10. David Voehringer
11. Calum C Bain
12. Elaine Emmerson
13. Barbora Schonfeldova
14. Kristina Zec
15. Irina Udalova
16. Theodoros Simakou
17. Lucy MacDonald
18. Mariola Kurowska-Stolarska
19. Jadwiga Zarebska
20. Tonia Vincent
21. Romeo Ricci
22. Eric Erbs
23. Jack Barrington
24. Barry W McColl
25. Georgiana Neag
26. Samuel Kemble
27. Christopher Mahony
28. Adam Croft
29. Louis Boon
30. Nicole Migotsky
31. Megan L Killian
32. Oumaima Ben Brahim
33. Stefan Uderhardt
34. Alexandre Gallerand
35. Stoyan Ivanov
36. Rebecca Gentek

Reviewed by Review Commons

Inhibition of the UFD-1-NPL-4 complex triggers an aberrant immune response in Caenorhabditis elegans

1. Rajneesh Rao
2. Alejandro Aballay
3. Jogender Singh

• Curated by eLife

  eLife Assessment

  In this valuable manuscript, Rao and colleagues investigate the UFD-1/NPL-4 complex, which is involved in extracting misfolded proteins in the plasma membrane and the accumulation of pathogenic bacteria in the intestine. Using convincing methods, the authors find that knockdown of the ufd-1 and npl-4 genes leads to shortened lifespan of the nematode C. elegans and reduced accumulation of the bacterial pathogen P. aeruginosa in the intestine.

Reviewed by eLife

IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion

1. Daniel L Aldridge
2. Zachary Lanzar
3. Anthony T Phan
4. David A Christian
5. Ryan Pardy
6. Booki Min
7. Ross M Kedl
8. Christopher A Hunter

• Curated by eLife

  eLife Assessment

  The article presents important findings describing the role of IL27 in maintaining HSCs at steady state, and in emergency haematopoiesis in response to T. goodii by limiting the inflammatory monocyte outcomes. The evidence provided are solid and support that IL27 acts at the level of HSCs and not downstream. This study will be of interest to immunologists and hematologists, as well as infectious disease researchers.

Reviewed by eLife