Immunology

SARS-CoV-2 spike protein interacts with and activates TLR41

1. Yingchi Zhao
2. Ming Kuang
3. Junhong Li
4. Ling Zhu
5. Zijing Jia
6. Xuefei Guo
7. Yaling Hu
8. Jun Kong
9. Hang Yin
10. Xiangxi Wang
11. Fuping You

Reviewed by ScreenIT

Seroprevalence of SARS-CoV-2 specific IgG antibodies in District Srinagar, northern India – A cross-sectional study

1. S. Muhammad Salim Khan
2. Mariya Amin Qurieshi
3. Inaamul Haq
4. Sabhiya Majid
5. Arif Akbar Bhat
6. Sahila Nabi
7. Nisar Ahmad Ganai
8. Nazia Zahoor
9. Auqfeen Nisar
10. Iqra Nisar Chowdri
11. Tanzeela Bashir Qazi
12. Rafiya Kousar
13. Abdul Aziz Lone
14. Iram Sabah
15. Shahroz Nabi
16. Ishtiyaq Ahmad Sumji
17. Misbah Ferooz Kawoosa
18. Shifana Ayoub

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TCR meta-clonotypes for biomarker discovery with tcrdist3 enabled identification of public, HLA-restricted clusters of SARS-CoV-2 TCRs

1. Koshlan Mayer-Blackwell
2. Stefan Schattgen
3. Liel Cohen-Lavi
4. Jeremy C Crawford
5. Aisha Souquette
6. Jessica A Gaevert
7. Tomer Hertz
8. Paul G Thomas
9. Philip Bradley
10. Andrew Fiore-Gartland

• Curated by eLife

  Evaluation Summary:

  The paper by Mayer-Blackwell et al. builds on the idea that TCRs to the same antigen often share sequence similarities, which they quantify using a bespoke tool TCRdist3. Using this tool they develop the idea of a metaclone, a set of TCRs sharing similarities and potentially recognising the same antigen. They further show that such clonotypes show increased sharing between HLA-related individuals, and explore the use of such clonotypes in characterising antigen-specific immune response across cohorts of individuals. The paper is novel and of interest to a broad range of immunologists interested in repertoire. However, as raised in a series of detailed comments by the reviewers, the message of the paper needs to be sharpened and clearly focused on the development of the metaclone concept (with less emphasis on SARS-Cov-2. The concept of the metaclone itself, which is the main message of the paper, needs to be clarified, and characterised.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife, ScreenIT

Gamma-irradiated SARS-CoV-2 vaccine candidate, OZG-38.61.3, confers protection from SARS-CoV-2 challenge in human ACEII-transgenic mice

1. Raife Dilek Turan
2. Cihan Tastan
3. Derya Dilek Kancagi
4. Bulut Yurtsever
5. Gozde Sir Karakus
6. Samed Ozer
7. Selen Abanuz
8. Didem Cakirsoy
9. Gamze Tumentemur
10. Sevda Demir
11. Utku Seyis
12. Recai Kuzay
13. Muhammer Elek
14. Miyase Ezgi Kocaoglu
15. Gurcan Ertop
16. Serap Arbak
17. Merve Acikel Elmas
18. Cansu Hemsinlioglu
19. Ozden Hatirnaz Ng
20. Sezer Akyoney
21. Ilayda Sahin
22. Cavit Kerem Kayhan
23. Fatma Tokat
24. Gurler Akpinar
25. Murat Kasap
26. Ayse Sesin Kocagoz
27. Ugur Ozbek
28. Dilek Telci
29. Fikrettin Sahin
30. Koray Yalcin
31. Siret Ratip
32. Umit Ince
33. Ercument Ovali

Reviewed by ScreenIT

Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

1. Naveenchandra Suryadevara
2. Swathi Shrihari
3. Pavlo Gilchuk
4. Laura A. VanBlargan
5. Elad Binshtein
6. Seth J. Zost
7. Rachel S. Nargi
8. Rachel E. Sutton
9. Emma S. Winkler
10. Elaine C. Chen
11. Mallorie E. Fouch
12. Edgar Davidson
13. Benjamin J. Doranz
14. Rita E. Chen
15. Pei-Yong Shi
16. Robert H. Carnahan
17. Larissa B. Thackray
18. Michael S. Diamond
19. James E. Crowe

Reviewed by ScreenIT

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling

1. Yi Zheng
2. Meng-Wei Zhuang
3. Lulu Han
4. Jing Zhang
5. Mei-Ling Nan
6. Peng Zhan
7. Dongwei Kang
8. Xinyong Liu
9. Chengjiang Gao
10. Pei-Hui Wang

Reviewed by ScreenIT

Reference ontology and database annotation of the COVID-19 Open Research Dataset (CORD-19)

1. Oliver Giles
2. Rachael Huntley
3. Anneli Karlsson
4. Jane Lomax
5. James Malone

Reviewed by ScreenIT

A distinct innate immune signature marks progression from mild to severe COVID-19

1. Stéphane Chevrier
2. Yves Zurbuchen
3. Carlo Cervia
4. Sarah Adamo
5. Miro E. Raeber
6. Natalie de Souza
7. Sujana Sivapatham
8. Andrea Jacobs
9. Esther Bachli
10. Alain Rudiger
11. Melina Stüssi-Helbling
12. Lars C. Huber
13. Dominik J. Schaer
14. Jakob Nilsson
15. Onur Boyman
16. Bernd Bodenmiller

Reviewed by ScreenIT

Anti-CoVid19 plasmid DNA vaccine induces a potent immune response in rodents by Pyro-drive Jet Injector intradermal inoculation

1. Tomoyuki Nishikawa
2. Chin Yang Chang
3. Jiayu A Tai
4. Hiroki Hayashi
5. Jiao Sun
6. Shiho Torii
7. Chikako Ono
8. Yoshiharu Matsuura
9. Ryoko Ide
10. Junichi Mineno
11. Miwa Sasai
12. Masahiro Yamamoto
13. Hironori Nakagami
14. Kunihiko Yamashita

Reviewed by ScreenIT

SARS-CoV-2 escapes CD8 T cell surveillance via mutations in MHC-I restricted epitopes

1. Benedikt Agerer
2. Maximilian Koblischke
3. Venugopal Gudipati
4. Mark Smyth
5. Alexandra Popa
6. Jakob-Wendelin Genger
7. Lukas Endler
8. David M. Florian
9. Vanessa Mühlgrabner
10. Alexander Lercher
11. Pia Gattinger
12. Ricard Torralba-Gombau
13. Thomas Penz
14. Ingrid Fae
15. Sabine Wenda
16. Marianna Traungott
17. Gernot Walder
18. Gottfried Fischer
19. Wolfgang Hoepler
20. Erich Pawelka
21. Alexander Zoufaly
22. Rudolf Valenta
23. Christoph Bock
24. Johannes B. Huppa
25. Judith H. Aberle
26. Andreas Bergthaler

Reviewed by ScreenIT