Immunology

Circular RNA vaccines against SARS-CoV-2 and emerging variants

1. Liang Qu
2. Zongyi Yi
3. Yong Shen
4. Liangru Lin
5. Feng Chen
6. Yiyuan Xu
7. Zeguang Wu
8. Huixian Tang
9. Xiaoxue Zhang
10. Feng Tian
11. Chunhui Wang
12. Xia Xiao
13. Xiaojing Dong
14. Li Guo
15. Shuaiyao Lu
16. Chengyun Yang
17. Cong Tang
18. Yun Yang
19. Wenhai Yu
20. Junbin Wang
21. Yanan Zhou
22. Qing Huang
23. Ayijiang Yisimayi
24. Shuo Liu
25. Weijin Huang
26. Yunlong Cao
27. Youchun Wang
28. Zhuo Zhou
29. Xiaozhong Peng
30. Jianwei Wang
31. Xiaoliang Sunney Xie
32. Wensheng Wei

Reviewed by ScreenIT

Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7

1. Pengfei Wang
2. Manoj S. Nair
3. Lihong Liu
4. Sho Iketani
5. Yang Luo
6. Yicheng Guo
7. Maple Wang
8. Jian Yu
9. Baoshan Zhang
10. Peter D. Kwong
11. Barney S. Graham
12. John R. Mascola
13. Jennifer Y. Chang
14. Michael T. Yin
15. Magdalena Sobieszczyk
16. Christos A. Kyratsous
17. Lawrence Shapiro
18. Zizhang Sheng
19. Yaoxing Huang
20. David D. Ho

Reviewed by ScreenIT

An AI-guided signature reveals the nature of the shared proximal pathways of host immune response in MIS-C and Kawasaki disease

1. Debashis Sahoo
2. Gajanan D. Katkar
3. Chisato Shimizu
4. Jihoon Kim
5. Soni Khandelwal
6. Adriana H. Tremoulet
7. John Kanegaye
8. Pediatric Emergency Medicine Kawasaki Disease Research Group
9. Joseph Bocchini
10. Soumita Das
11. Jane C. Burns
12. Pradipta Ghosh

Reviewed by ScreenIT

Immunogenicity and protective efficacy of an intranasal live-attenuated vaccine against SARS-CoV-2

1. Jun-Gyu Park
2. Fatai S. Oladunni
3. Mohammed A. Rohaim
4. Jayde Whittingham-Dowd
5. James Tollitt
6. Matthew D.J. Hodges
7. Nadin Fathallah
8. Muhsref Bakri Assas
9. Wafaa Alhazmi
10. Abdullah Almilaibary
11. Munir Iqbal
12. Pengxiang Chang
13. Renee Escalona
14. Vinay Shivanna
15. Jordi B. Torrelles
16. John J. Worthington
17. Lucy H. Jackson-Jones
18. Luis Martinez-Sobrido
19. Muhammad Munir

Reviewed by ScreenIT

Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19

1. Sarthak Sinha
2. Nicole L. Rosin
3. Rohit Arora
4. Elodie Labit
5. Arzina Jaffer
6. Leslie Cao
7. Raquel Farias
8. Angela P. Nguyen
9. Luiz G. N. de Almeida
10. Antoine Dufour
11. Amy Bromley
12. Braedon McDonald
13. Mark R. Gillrie
14. Marvin J. Fritzler
15. Bryan G. Yipp
16. Jeff Biernaskie

Reviewed by ScreenIT

SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway

1. Shahanshah Khan
2. Mahnoush S Shafiei
3. Christopher Longoria
4. John W Schoggins
5. Rashmin C Savani
6. Hasan Zaki

• Curated by eLife

  Evaluation Summary:

  The identification of a novel role of the spike protein expressed on SARS-CoV-2 in directly evoking the host inflammatory responses has a substantial impact in understanding the molecular mechanism of COVID-19 pathogenesis, which may have implication for development of new therapeutics. The elegant analytic approach conducted herein justifies the major conclusions of this work though several additional steps can be made to validate these claims.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife, ScreenIT

Recovery from Acute SARS-CoV-2 Infection and Development of Anamnestic Immune Responses in T Cell-Depleted Rhesus Macaques

1. Kim J. Hasenkrug
2. Friederike Feldmann
3. Lara Myers
4. Mario L. Santiago
5. Kejun Guo
6. Bradley S. Barrett
7. Kaylee L. Mickens
8. Aaron Carmody
9. Atsushi Okumura
10. Deepashri Rao
11. Madison M. Collins
12. Ronald J. Messer
13. Jamie Lovaglio
14. Carl Shaia
15. Rebecca Rosenke
16. Neeltje van Doremalen
17. Chad Clancy
18. Greg Saturday
19. Patrick Hanley
20. Brian J. Smith
21. Kimberly Meade-White
22. W. Lesley Shupert
23. David W. Hawman
24. Heinz Feldmann

Reviewed by ScreenIT

Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection

1. Nina Le Bert
2. Hannah E. Clapham
3. Anthony T. Tan
4. Wan Ni Chia
5. Christine Y.L. Tham
6. Jane M. Lim
7. Kamini Kunasegaran
8. Linda Wei Lin Tan
9. Charles-Antoine Dutertre
10. Nivedita Shankar
11. Joey M.E. Lim
12. Louisa Jin Sun
13. Marina Zahari
14. Zaw Myo Tun
15. Vishakha Kumar
16. Beng Lee Lim
17. Siew Hoon Lim
18. Adeline Chia
19. Yee-Joo Tan
20. Paul Anantharajah Tambyah
21. Shirin Kalimuddin
22. David Lye
23. Jenny G.H. Low
24. Lin-Fa Wang
25. Wei Yee Wan
26. Li Yang Hsu
27. Antonio Bertoletti
28. Clarence C. Tam

Reviewed by ScreenIT

A Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2. HLA-DR4. Rag1 KO.IL-2Rγc KO. NOD) for COVID-19

1. Teodor-D. Brumeanu
2. Pooja Vir
3. Ahmad Faisal Karim
4. Swagata Kar
5. Dalia Benetiene
6. Megan Lok
7. Jack Greenhouse
8. Tammy Putmon-Taylor
9. Christopher Kitajewski
10. Kevin K. Chung
11. Kathleen P. Pratt
12. Sofia A. Casares

Reviewed by ScreenIT

Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell epitope mapping

1. Felix Schreibing
2. Monica Hannani
3. Fabio Ticconi
4. Eleanor Fewings
5. James S Nagai
6. Matthias Begemann
7. Christoph Kuppe
8. Ingo Kurth
9. Jennifer Kranz
10. Dario Frank
11. Teresa M Anslinger
12. Patrick Ziegler
13. Thomas Kraus
14. Jürgen Enczmann
15. Vera Balz
16. Frank Windhofer
17. Paul Balfanz
18. Christian Kurts
19. Gernot Marx
20. Nikolaus Marx
21. Michael Dreher
22. Rebekka K Schneider
23. Julio Saez-Rodriguez
24. Ivan Costa
25. Rafael Kramann

Reviewed by ScreenIT