Genetics

Drosophila melanogaster model of RVCL-S demonstrates age dependent disease progression

1. Elena Gracheva
2. Abigail Matt
3. Fei Wang
4. Raymond Hsin
5. Hongwu Liang
6. Xiangping Ouyang
7. Jimin Ding
8. Jonathan J Miner
9. Chao Zhou

• Curated by eLife

  eLife Assessment

  This manuscript describing the phenotypes associated with loss and gain of RVCL-S documents important findings that have practical implications. Although the data and methods are solid and support many claims, there remain some concerns about mechanisms.

Reviewed by eLife

Sickle cell status skews malaria parasite genotype at infection

1. Helena D. Hopson
2. Alejandra Herbert-Mainero
3. Aline Gaelle Bouopda-Tuedom
4. Charlène Tina Nanssong-Vomo
5. Brigitte Tumamo Fotso
6. Belinda Claire Kiam
7. Ibrahima Ibrahima
8. Clément Onguene
9. Luc Abate
10. Radoslaw Igor Omelianczyk
11. Heather D. Evans
12. Lyra E. Horton
13. Gavin Band
14. Tracey J. Lamb
15. Lawrence S. Ayong
16. Sandrine E. Nsango
17. Ellen M. Leffler

Reviewed by Rapid Reviews Infectious Diseases

Visible traits demonstrate that crispant founder mice can be used for phenotypic assessment

1. Rebekah Tillotson
2. Marina Gertsenstein
3. Li-Hsin Chang
4. Julie Ruston
5. Fernando Bellido Molías
6. Lauri G Lintott
7. Christine Taylor
8. Philippe Gautier
9. Lauryl MJ Nutter
10. Monica J Justice

• Curated by eLife

  eLife Assessment

  This study offers important methodological advances for CRISPR-based mutagenesis in mice, highlighting the potential of founder animals for early phenotypic characterization. The authors present convincing evidence, supported by rigorous experimental design, that "crispant" (F0) analysis in mice, despite prior concerns about genetic mosaicism, can be utilized to assess protein function.

Reviewed by eLife

Functional Profiling of 2,193 ASS1 Missense Variants: Insights into Variant Pathogenicity and Epistatic Interactions in Citrullinemia Type I

1. Russell S. Lo
2. Gareth A. Cromie
3. Michelle Tang
4. Amy Sirr
5. Ljubica Caldovic
6. Hiroki Morizono
7. Nicholas Ah Mew
8. Andrea Gropman
9. Aimée M. Dudley

Reviewed by Review Commons

Genetic and environmental determinants of multicellular-like phenotypes in fission yeast

1. Bence Kӧvér
2. Céleste E Cohen
3. Ladislav Seres
4. Saniya Raut
5. Markus Ralser
6. Benjamin M Heineike
7. Jürg Bähler

Reviewed by Review Commons