Genetics

Microbiota impact Drosophila ageing via Acetobacter, Tachykinin, and TkR99D

1. Diana Marcu
2. David R Sannino
3. Anthony J Dornan
4. Rita Ibrahim
5. Atharv Kapoor
6. Miriam Wood
7. Adam J Dobson

• Curated by eLife

  eLife Assessment

  This important study demonstrates that in Drosophila melanogaster, tachykinin (Tk) expression is regulated by the microbiota. The authors present convincing evidence that axenic flies raised with no microbiota are longer-lived than conventionally reared animals, and that Tk expression and Tk receptors in the nervous system are required for this effect. They further test individual bacterial strains for their role in these effects and connect the effect to loss of lipid stores and suggest that FOXO may be involved in the phenotype, results that are of interest to the fields of environmental perception, host microbiome interactions, and geroscience.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Differential functions of upstream and intronic HOT regions shape dlg-1 transcription and C. elegans development

1. Cristina Tocchini
2. Fanny Eggeler
3. Palmer Bassett
4. Susan E. Mango

Reviewed by Review Commons

Nucleosome positioning shapes cryptic antisense transcription

1. Jian Yi Kok
2. Zachary H. Harvey
3. Elin Axelsson
4. Frédéric Berger

Reviewed by Review Commons

Redox Dyshomeostasis Links Renal and Neuronal Dysfunction in Drosophila Models of Gaucher and Parkinson’s Disease

1. Alexander J Hull
2. Magda L Atilano
3. Kerri J Kinghorn

• Curated by eLife

  eLife Assessment

  This is a valuable manuscript that reframes Gaucher's disease pathology through the analysis of renal health, using a Drosophila model mutant for glucocerebrosidase (GBA1). The authors provide physiological and cellular data showing that renal dysfunction may be a critical disease-modifying feature. This work broadens the field's focus beyond the nervous system to include systemic ionic regulation as a potential contributor to disease initiation and progression. The genetic and experimental approaches are solid and offer a rationale for investigating analogous dysfunction in human tissues; however, several claims extend beyond the presented evidence and would benefit from additional experimental support to fully support the conclusions.

Reviewed by eLife

Assessing target genes for homing suppression gene drive

1. Xuejiao Xu
2. Jialing Fang
3. Jingheng Chen
4. Jie Yang
5. Xiaozhen Yang
6. Shibo Hou
7. Weitang Sun
8. Jackson Champer

Reviewed by Review Commons

Genetic Modifiers Influencing the Acute and Long-Term Responses to Traumatic Brain Injury in Drosophila

1. Brandon Molina
2. Jesse Jacob Rojas
3. Nadja El-Mecharrafie
4. Eric P Ratliff
5. Marta Lipinski
6. Kim Diane Finley

Reviewed by PREreview