Genetics

eLife Assessment

This study offers important insight into the pathogenic basis of intragenic frameshift deletions in the carboxy-terminal domain of MECP2, which account for some Rett syndrome cases, yet similar variants also appear in unaffected individuals. Using base editing and mouse models, the authors present convincing evidence supporting the pathogenicity of select deletion variants, with potential implications for therapeutic development.

eLife Assessment

This important study presents convincing evidence that uncovers a novel signaling axis impacting the post-mating response in females of the brown planthopper. The findings open several avenues for testing the molecular and neurobiological mechanisms of mating behavior in insects, and in the revised version the authors provide further evidence supporting their conclusions.

eLife Assessment

This study presents a valuable finding on the condition dependence of autophagy-mediated lifespan regulation in C. elegans. The evidence is solid, as the data broadly support the main claims, although variability between biological replicates and limited mechanistic exploration leave some conclusions less firmly established. The work will be of interest to researchers studying autophagy, ageing, and intracellular trafficking.

eLife Assessment

This useful study analyzes demographic history and selection using whole-genome sequencing data from 40 Faroese individuals, generating results of value beyond the study region. The analyses are convincing, and revisions have satisfactorily addressed prior concerns, including clarification of selection analyses and expanded discussion of population structure and admixture timing. While a more fine-scale reconstruction of demographic history could still yield more insights, and access restrictions on individual-level data continue to limit broader reuse, the provision of summary statistics partially mitigates this constraint.