Genetics

Trans- acting mutations reveal non-nuclear modulators of both intrinsic and extrinsic gene expression noise in a eukaryote

1. Nena Martin
2. Julie Kleine-Schultjann
3. Elena Paris
4. Quentin Boussau
5. Agnès Dumont
6. Hélène Duplus-Bottin
7. Margaux Prieux
8. Adelme Bazin
9. Laurent Modolo
10. Gaël Yvert
11. Patricia J. Wittkopp
12. Fabien Duveau

Reviewed by Review Commons

Effects of knockdown of autophagy pathway genes on C. elegans longevity are highly condition dependent

1. Kuei Ching Hsiung
2. Hannah Chapman
3. Xiaoya Wei
4. Xiaoyu Sun
5. Isadora Rawlinson
6. David Gems

• Curated by eLife

  eLife Assessment

  This study presents a valuable finding on the condition dependence of autophagy-mediated lifespan regulation in C. elegans. The evidence is solid, as the data broadly support the main claims, although variability between biological replicates and limited mechanistic exploration leave some conclusions less firmly established. The work will be of interest to researchers studying autophagy, ageing, and intracellular trafficking.

Reviewed by eLife