Cell Biology

Interferon-Induced PARP14-Mediated ADP-Ribosylation in p62 Bodies Requires an Active Ubiquitin-Proteasome System

1. Rameez Raja
2. Banhi Biswas
3. Rachy Abraham
4. Hongrui Liu
5. Che-Yuan Chang
6. Hien Vu
7. Anthony K. L. Leung

Reviewed by PREreview, Review Commons

Chromokinesin Klp-19 regulates microtubule overlap and dynamics during anaphase in C. elegans

1. Vitaly Zimyanin
2. Magdalena Magaj
3. Nadia Ingabire Manzi
4. Che-Hang Yu
5. Theresa Gibney
6. Yu-Zen Chen
7. Mustafa Basaran
8. Xavier Horton
9. Karsten Siller
10. Ariel Pani
11. Daniel Needleman
12. Daniel J. Dickinson
13. Stefanie Redemann

Reviewed by Review Commons

Macromolecular condensation is unlikely to buffer intracellular osmolality

1. Alan R. Kay
2. Zahra Aminzare

• Curated by Biophysics Colab

  Evaluation Statement (30 January 2025)

  Kay and Aminzare discuss a claim made in a prior publication that macromolecular condensation acts as a water buffering mechanism in cells to compensate for the effects of osmotic shock. The authors argue that, although such a buffer could temporarily maintain a transmembrane osmolality differential, this differential would drive water across the membrane to reach a steady-state in which osmolality within the cell equals osmolality outside the cell. Using the well-established pump-leak model for osmotic water transport, they further show that the timescale at which a water buffer could maintain a modest 10% osmolality differential across the membrane is at most one minute for a typical animal cell.

  Biophysics Colab recommends this study to researchers working on membrane transport, intracellular water buffering, and condensate biology.

  Biophysics Colab has evaluated this study as one that meets the following criteria:

  • Rigorous methodology
  • Transparent reporting
  • Appropriate interpretation

Reviewed by Biophysics Colab

TXNIP mediates LAT1/SLC7A5 endocytosis to reduce amino acid uptake in cells entering quiescence

1. Jennifer Kahlhofer
2. Nikolas Marchet
3. Brigitta Seifert
4. Kristian Zubak
5. Madlen Hotze
6. Anna-Sophia Egger
7. Claudia Manzl
8. Yannick Weyer
9. Sabine Weys
10. Martin Offterdinger
11. Sebastian Herzog
12. Veronika Reiterer
13. Marcel Kwiatkowski
14. Saskia B. Wortmann
15. Siamak Nemati
16. Johannes A. Mayr
17. Johannes Zschocke
18. Bernhard Radlinger
19. Kathrin Thedieck
20. Lukas A. Huber
21. Hesso Farhan
22. Mariana E.G. de Araujo
23. Susanne Kaser
24. Sabine Scholl-Bürgi
25. Daniela Karall
26. David Teis

Reviewed by Review Commons

Albendazole specifically disrupts microtubules and protein turnover in the tegument of the cestode Mesocestoides corti

1. Inés Guarnaschelli
2. Uriel Koziol

Reviewed by Arcadia Science