Cell Biology

  1. Restoring mechanophenotype reverts malignant properties of ECM-enriched vocal fold cancer

    1. Jasmin Kaivola
    2. Karolina Punovuori
    3. Megan R. Chastney
    4. Yekaterina A. Miroshnikova
    5. Hind Abdo
    6. Fabien Bertillot
    7. Fabian Krautgasser
    8. Jasmin Di Franco
    9. James R.W. Conway
    10. Gautier Follain
    11. Jaana Hagström
    12. Antti Mäkitie
    13. Heikki Irjala
    14. Sami Ventelä
    15. Hellyeh Hamidi
    16. Giorgio Scita
    17. Roberto Cerbino
    18. Sara A. Wickström
    19. Johanna Ivaska

    Reviewed by preLights

    1 evaluationAppears in 1 listLatest version Latest activity

  2. A FUCCI sensor reveals complex cell cycle organization of Toxoplasma endodyogeny

    1. Mrinalini Batra
    2. Clem Marsilia
    3. Danya Awshah
    4. Lauren M. Hawkins
    5. Chengqi Wang
    6. Dale Chaput
    7. Daria A. Naumova
    8. Elena S. Suvorova

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  3. Defective Neurogenesis in Lowe Syndrome is Caused by Mitochondria Loss and Cilia-related Sonic Hedgehog Defects

    1. Chien-Hui Lo
    2. Siyu Chen
    3. Jingyu Zhao
    4. Zhiquan Liu
    5. Biao Wang
    6. Qing Wang
    7. Tia J Kowal
    8. Yang Sun

    • Curated by eLife

      eLife Assessment

      This study investigated mitochondrial dysfunction and the impairment of the ciliary Sonic Hedgehog signaling in Lowe syndrome (LS), a timely topic given the limited research in this area. The data from patient iPSC-derived neurons and a mouse model were collected using solid methods, but the evidence supporting key claims is incomplete, and some technical aspects fall short of expectations. Despite these limitations, the study provides a useful foundation for exploring the relationship between mitochondrial defects and primary cilia in neural development.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  4. Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis

    1. Joan Chang
    2. Adam Pickard
    3. Jeremy A Herrera
    4. Sarah O'Keefe
    5. Richa Garva
    6. Matthew Hartshorn
    7. Anna Hoyle
    8. Lewis Dingle
    9. John Knox
    10. Thomas A Jowitt
    11. Madeleine Coy
    12. Jason Wong
    13. Adam Reid
    14. Yinhui Lu
    15. Cédric Zeltz
    16. Rajamiyer V Venkateswaran
    17. Patrick T Caswell
    18. Stephen High
    19. Donald Gullberg
    20. Karl E Kadler

    • Curated by eLife

      eLife Assessment

      This study describes a novel mechanism for how collagen fibrils are formed. The authors present compelling evidence that collagen-I fibrillogenesis relies on a functional endocytic system for recycling collagen-I, with circadian-regulated VPS33b and integrin-α11 being critical for fibril assembly. This is an important study for the understanding of the pathophysiology of collagen fibrillogenesis.

    Reviewed by eLife

    8 evaluationsAppears in 1 listLatest version Latest activity

  5. Progesterone induces meiosis through two obligate co-receptors with PLA2 activity

    1. Nancy Nader
    2. Lama Assaf
    3. Lubna Zarif
    4. Anna Halama
    5. Sharan Yadav
    6. Maya Dib
    7. Nabeel Attarwala
    8. Qiuying Chen
    9. Karsten Suhre
    10. Steven Gross
    11. Khaled Machaca

    • Curated by eLife

      eLife Assessment

      This important study provides solid evidence for a non-genomic action of progesterone in Xenopus oocyte activation. The findings demonstrate that two non-genomic progesterone receptors, ABHD2 and mPRb, function as a novel progesterone-stimulated phospholipase A2. The findings will be of broad interest to reproductive endocrinologists and physiologists.

    Reviewed by eLife

    9 evaluationsAppears in 1 listLatest version Latest activity

  6. Noncanonical roles of ATG5 and membrane atg8ylation in retromer assembly and function

    1. Masroor Ahmad Paddar
    2. Fulong Wang
    3. Einar S Trosdal
    4. Emily Hendrix
    5. Yi He
    6. Michelle R Salemi
    7. Michal Mudd
    8. Jingyue Jia
    9. Thabata Duque
    10. Ruheena Javed
    11. Brett S Phinney
    12. Vojo Deretic

    • Curated by eLife

      eLife Assessment

      Masroor Ahmad Paddar and colleagues reveal noncanonical roles of ATG5 and membrane ATG8ylation in regulating retromer assembly and function. They identify ATG5's unique non-autophagic role and show that CASM partially contributes to these phenotypes. Although the mechanism by which ATG8ylation regulates the retromer remains unclear, the findings provide important insights with solid supporting evidence.

    Reviewed by eLife

    10 evaluationsAppears in 1 listLatest version Latest activity

  7. Rejuvenating aged osteoprogenitors for bone repair

    1. Joshua Reeves
    2. Pierre Tournier
    3. Pierre Becquart
    4. Robert Carton
    5. Yin Tang
    6. Alessandra Vigilante
    7. Dong Fang
    8. Shukry J Habib

    • Curated by eLife

      eLife Assessment

      Aging reduces tissue regeneration capacity, posing challenges for an aging population. In this fundamental study, Reeves et al. show that by combining Wnt-mediated osteoprogenitor expansion (using a special bandage) with intermittent fasting, calvarial bone healing can be restored in aged animals. Intermitted fasting improves osteoprogenitor function by rescuing aging-related mitochondrial dysfunction, which can also be achieved by nicotinamide mononucleotide (NMN) supplementation or by modulating the gut microbiome. By employing rigorous histological, transcriptomic, and imaging analyses in a clinically relevant model, the authors provide compelling evidence supporting the conclusions. The therapeutic approach presented in this study shows promise for rejuvenating tissue repair, not only in bones but potentially across other tissues.

    Reviewed by eLife

    9 evaluationsAppears in 1 listLatest version Latest activity

  8. Leukocytes use endothelial membrane tunnels to extravasate the vasculature

    1. Werner J. van der Meer
    2. Abraham C.I. van Steen
    3. Eike Mahlandt
    4. Loïc Rolas
    5. Haitao Wang
    6. Janine J.G. Arts
    7. Lanette Kempers
    8. Max L.B. Grönloh
    9. Rianne M. Schoon
    10. Amber Driessen
    11. Jos van Rijssel
    12. Ingeborg Klaassen
    13. Reinier O. Schlingemann
    14. Yosif Manavski
    15. Mark Hoogenboezem
    16. Reinier A. Boon
    17. Satya Khuon
    18. Eric Wait
    19. John Heddleston
    20. Teng-Leong Chew
    21. Martijn A. Nolte
    22. Sussan Nourshargh
    23. Joachim Goedhart
    24. Jaap D. van Buul

    Reviewed by preLights

    1 evaluationAppears in 1 listLatest version Latest activity

  9. SpotMAX: a generalist framework for multi-dimensional automatic spot detection and quantification

    1. Francesco Padovani
    2. Ivana Čavka
    3. Ana Rita Rodrigues Neves
    4. Cristina Piñeiro López
    5. Nada Al-Refaie
    6. Leonardo Bolcato
    7. Dimitra Chatzitheodoridou
    8. Yagya Chadha
    9. Xiaofeng A. Su
    10. Jette Lengefeld
    11. Daphne S. Cabianca
    12. Simone Köhler
    13. Kurt M. Schmoller

    Reviewed by Arcadia Science

    7 evaluationsAppears in 1 listLatest version Latest activity

  10. Genome-wide analysis of anterior-posterior mRNA regionalization in Stentor coeruleus reveals a role for the microtubule cytoskeleton

    1. Ashley R. Albright
    2. Connie Yan
    3. David Angeles-Albores
    4. Yina Hudnall
    5. Tatyana Makushok
    6. Jamarc Allen-Henderson
    7. Wallace F. Marshall

    Reviewed by Arcadia Science

    5 evaluationsAppears in 1 listLatest version Latest activity
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