Cell Biology

A Ctnnb1 enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epithelia

1. Xiaojiao Hua
2. Chen Zhao
3. Jianbo Tian
4. Junbao Wang
5. Xiaoping Miao
6. Gen Zheng
7. Min Wu
8. Mei Ye
9. Ying Liu
10. Yan Zhou

• Curated by eLife

  eLife assessment

  Ctnnb1 encodes β-catenin, an essential component of the canonical Wnt signaling pathway. In this important study, the authors identify an upstream enhancer of Ctnnb1 responsible for the specific expression level of β-catenin in the gastrointestinal track. Deletion of this enhancer in mice and analyses of its association with human colorectal tumors provide compelling support that it controls the dosage of Wnt signaling critical to the homeostasis in intestinal epithelia and colorectal cancers.

Reviewed by eLife

Significantly reduced, but balanced, rates of mitochondrial fission and fusion are sufficient to maintain the integrity of yeast mitochondrial DNA

1. Brett T. Wisniewski
2. Jason C. Casler
3. Laura L. Lackner

Reviewed by preLights

STAG3 promotes exit from pluripotency through post-transcriptional mRNA regulation in the cytoplasm

1. Sam Weeks
2. Dubravka Pezic
3. Martin Dodel
4. Kunal Shah
5. Amandeep Bhamra
6. Stephen Henderson
7. Silvia Surinova
8. Tyson Sharp
9. Faraz Mardakheh
10. Suzana Hadjur

• Curated by eLife

  eLife assessment

  This potentially valuable study reports new and unexpected roles of STAG3 in regulating exit from pluripotency in mouse embryonic stem cells (mESCs). However, the evidence for the proposed role of STAG3 in the post-transcriptional regulation of gene expression is viewed as yet incomplete. The work will be of interest to colleagues studying stem cells, early steps in differentiation, and gene regulation.

Reviewed by eLife

PP2A-B56 regulates Mid1 protein levels for proper cytokinesis in fission yeast

1. Madeline L. Chrupcala
2. James B. Moseley

Reviewed by Review Commons

Nuclear basket proteins regulate the distribution and mobility of nuclear pore complexes in budding yeast

1. Janka Zsok
2. Francois Simon
3. Göksu Bayrak
4. Luljeta Isaki
5. Nina Kerff
6. Yoana Kicheva
7. Amy Wolstenholme
8. Lucien E. Weiss
9. Elisa Dultz

Reviewed by Review Commons

TMX5/TXNDC15, a natural trapping mutant of the PDI family is a client of the proteostatic factor ERp44

1. Tatiana Soldà
2. Carmela Galli
3. Concetta Guerra
4. Carolin Hoefner
5. Maurizio Molinari

Reviewed by Review Commons

Triglyceride metabolism controls inflammation and APOE4 -associated disease states in microglia

1. Roxan A. Stephenson
2. Kory R. Johnson
3. Linling Cheng
4. Linda G. Yang
5. Jessica T. Root
6. Jaanam Gopalakrishnan
7. Han-Yu Shih
8. Priyanka S. Narayan

Reviewed by preLights

Formation of multinucleated osteoclasts depends on an oxidized species of cell surface-associated La protein

1. Evgenia Leikina
2. Jarred M Whitlock
3. Kamran Melikov
4. Wendy Zhang
5. Michael P Bachmann
6. Leonid Chernomordik

• Curated by eLife

  eLife assessment

  This manuscript provides an important advance in our understanding of the molecular events that promote osteoclast fusion. Compelling data support the conclusion that an oxidized form of the ubiquitous protein La promotes osteoclast fusion following enrichment at the cell surface of osteoclast progenitors. These data improve our understanding of the processes that regulate bone resorption and will be of broad interest to researchers in the fields of cell biology and musculoskeletal physiology.

Reviewed by eLife

Circular RNA HMGCS1 sponges MIR4521 to aggravate type 2 diabetes-induced vascular endothelial dysfunction

1. Ming Zhang
2. Guangyi Du
3. Lianghua Xie
4. Yang Xu
5. Wei Chen

• Curated by eLife

  eLife assessment

  This study presents important findings linking circHMGCS1 and miR-4521 in diabetes-induced vascular endothelial dysfunction. Overall, the evidence supporting the claims of the authors is convincing. The work will be of interest to biomedical scientists working with cardiovascular and/or RNA biology, particularly those studying diabetes.

Reviewed by eLife

S-acylation of NLRP3 provides a nigericin sensitive gating mechanism that controls access to the Golgi

1. Daniel M Williams
2. Andrew A Peden

• Curated by eLife

  eLife assessment

  This important paper implicates S-acylation of Cys-130 in recruitment of the inflammasome receptor NLRP3 to the Golgi, and it provides convincing evidence that S-acylation plays a key role in response to the stress induced by nigericin treatment. While Cys-130 does seem to play a previously unappreciated role in membrane association of NLRP3, further work will be needed to clarify the details of the mechanism.

Reviewed by eLife