Cell Biology

ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin

1. Cristina Cacho-Navas
2. Carmen López-Pujante
3. Natalia Reglero-Real
4. Natalia Colás-Algora
5. Ana Cuervo
6. Jose Javier Conesa
7. Susana Barroso
8. Gema de Rivas
9. Sergio Ciordia
10. Alberto Paradela
11. Gianluca D'Agostino
12. Carlo Manzo
13. Jorge Feito
14. Germán Andrés
15. Francisca Molina-Jiménez
16. Pedro Majano
17. Isabel Correas
18. José-Maria Carazo
19. Sussan Nourshargh
20. Meritxell Huch
21. Jaime Millán

• Curated by eLife

  eLife assessment

  The authors report useful findings on novel function of apical ICAM1 in regulating bile duct homeostasis in the liver. The strength of evidence is solid using appropriate methodolgy with only minor weakness. The findings will be of interest to researchers in hepatology and membrane traffic biology.

Reviewed by eLife

Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis

1. Joan Chang
2. Adam Pickard
3. Jeremy A. Herrera
4. Sarah O’Keefe
5. Richa Garva
6. John Knox
7. Thomas A. Jowitt
8. Matthew Hartshorn
9. Anna Hoyle
10. Lewis Dingle
11. Madeleine Coy
12. Cédric Zeltz
13. Jason Wong
14. Adam Reid
15. Rajamiyer V. Venkateswaran
16. Yinhui Lu
17. Patrick Caswell
18. Stephen High
19. Donald Gullberg
20. Karl E. Kadler

• Curated by eLife

  eLife assessment

  This important work substantially advances our understanding of how collagen fibrils are built and maintained in a manner regulated by circadian rhythms in intracellular secretory trafficking pathways. The evidence supporting the data are solid, although further data regarding the molecular mechanisms regulating endocytic recycling of collagen would have strengthened the study. The work will be of considerable interest to those who study extracellular matrix assembly or collagen homeostasis.

Reviewed by eLife

The novel bacterial effector protein Cb EPF1 mediates ER-LD membrane contacts to regulate host lipid droplet metabolism

1. Rajendra Kumar Angara
2. Arif Sadi
3. Stacey D. Gilk

Reviewed by Review Commons

Aurora B controls microtubule stability to regulate abscission dynamics in stem cells

1. Snježana Kodba
2. Amber Öztop
3. Eri van Berkum
4. Malina K. Iwanski
5. Wilco Nijenhuis
6. Lukas C. Kapitein
7. Agathe Chaigne

Reviewed by preLights

Myotubularin-related proteins regulate KRAS function by controlling plasma membrane levels of polyphosphoinositides and phosphatidylserine

1. Karen M. Henkels
2. Taylor E. Miller
3. Ali Naji
4. Ransome van der Hoeven
5. Hong Liang
6. Yong Zhou
7. Gerald R.V. Hammond
8. John F. Hancock
9. Kwang-jin Cho

Reviewed by Review Commons

Dynamic localization of the chromosomal passenger complex in trypanosomes is controlled by the orphan kinesins KIN-A and KIN-B

1. Daniel Ballmer
2. Bungo Akiyoshi

• Curated by eLife

  eLife assessment

  This important study identifies the mitotic localization mechanism for Aurora B and INCENP (parts of the chromosomal passenger complex, CPC) in Trypanosoma brucei. The mechanism differs from that in the more commonly studied opisthokonts and is supported by compelling RNAi and imaging experiments, targeted mutations, immunoprecipitations with crosslinking/mass spec, and AlphaFold interaction predictions. The findings will be of interest to cell biologists working on cell division, parasitologists, and those interested in the evolution of mitotic mechanisms.

Reviewed by eLife

KIF1C, an RNA transporting kinesin-3, undergoes liquid-liquid phase separation through its C-terminal disordered domain

1. Qi Geng
2. Jakia Jannat Keya
3. Takashi Hotta
4. Kristen J Verhey

Reviewed by Review Commons

Reduction of cortical pulling at mitotic entry facilitates aster centration

1. Anne Rosfelter
2. Ghislain de Labbey
3. Janet Chenevert
4. Rémi Dumollard
5. Sebastien Schaub
6. Zoltan Machaty
7. Lydia Besnardeau
8. Daniel Gonzalez Suarez
9. Céline Hebras
10. Hervé Turlier
11. David R. Burgess
12. Alex McDougall

Reviewed by Review Commons

Identification of plants’ functional counterpart of the metazoan mediator of DNA Damage checkpoint 1

1. Zdravko J Lorković
2. Michael Klingenbrunner
3. Chung Hyun Cho
4. Frédéric Berger

Reviewed by Review Commons

Mammalian glial protrusion transcriptomes predict localization of Drosophila glial transcripts required for synaptic plasticity

1. Dalia S. Gala
2. Jeffrey Y. Lee
3. Maria Kiourlappou
4. Joshua S. Titlow
5. Rita O. Teodoro
6. Ilan Davis

Reviewed by Review Commons, Arcadia Science