Cell Biology

Impact of maximal overexpression of a non-toxic protein on yeast cell physiology

1. Yuri Fujita
2. Shotaro Namba
3. Yoshiaki Kamada
4. Hisao Moriya

• Curated by eLife

  eLife assessment

  This convincing study advances our understanding of the physiological consequences of the strong overexpression of non-toxic proteins in baker's yeast. The findings suggest that a massive protein burden results in nitrogen starvation and a shift in metabolism likely regulated via the TORC1 pathway, as well as defects in ribosome biogenesis in the nucleolus. The study presents findings and tools that are important for the cell biology and protein homeostasis fields.

Reviewed by eLife

C-terminal tagging, transmembrane domain hydrophobicity, and an ER retention motif influence the secretory trafficking of the inner nuclear membrane protein emerin

1. Jessica Mella
2. Regan F Volk
3. Balyn W Zaro
4. Abigail Buchwalter

• Curated by eLife

  eLife Assessment

  This study presents a valuable finding on the delivery of a nuclear envelop protein to lysosomes and the impact of C-terminal tagging on its traffic. The authors provide solid evidence for the potential artifacts introduced by large terminal tags, particularly in the context of membrane protein localization and stability.

Reviewed by eLife

Novel Fatigue Profiling Approach Highlights Temporal Dynamics of Human Sperm Motility

1. Athanasia Sergounioti
2. Efstathios Alonaris
3. Dimitrios Rigas

Reviewed by PREreview

Tmbim5 and Slc8b1 cooperate in tissue-specific mitochondrial calcium regulation in zebrafish

1. Iga Wasilewska
2. Łukasz Majewski
3. Dobrochna Adamek-Urbańska
4. Sofiia Baranykova
5. Matylda Macias
6. Aleksandra Szybińska
7. Axel Methner

Reviewed by Review Commons

Key roles of the zona pellucida and perivitelline space in promoting gamete fusion and fast block to polyspermy inferred from the choreography of spermatozoa in mice oocytes

1. Yaëlle Dubois
2. Sophie Favier
3. Nathan Martin-Fornier
4. Mohyeddine Omrane
5. David Stroebel
6. Eric Perez
7. Sandrine Barbaux
8. Ahmed Ziyyat
9. Nicolas Rodriguez
10. Christine Gourier

Reviewed by Review Commons

CellBinDB: a large-scale multimodal annotated dataset for cell segmentation with benchmarking of universal models

1. Can Shi
2. Jinghong Fan
3. Zhonghan Deng
4. Huanlin Liu
5. Qiang Kang
6. Yumei Li
7. Jing Guo
8. Jingwen Wang
9. Jinjiang Gong
10. Sha Liao
11. Ao Chen
12. Ying Zhang
13. Mei Li

Reviewed by GigaScience

TORC2-regulated sterol redistribution mediates recovery from membrane perturbation by small amphipathic molecules.

1. Maria G. Tettamanti
2. Paulina Nowak
3. Beata Kusmider
4. Jennifer M Kefauver
5. Vincent Mercier
6. Aurelien Roux
7. Robbie Loewith

Reviewed by Review Commons

Mycobacterium tuberculosis -infected macrophages accumulate more nanoparticles

1. Amine Pochet
2. Tom Bourguignon
3. Axelle Grandé
4. Jesus Alfredo Godinez-Leon
5. Joan Fine
6. Priscille Brodin
7. Arnaud Machelart
8. Ruxandra Gref

Reviewed by Rapid Reviews Infectious Diseases

The microcephaly protein WDR62 regulates cellular purine metabolism through the HSP70/HSP90 chaperone machinery

1. Matthew J. Morris
2. Yvonne Y. Yeap
3. Chi Chen
4. S. Sean Millard
5. Julia K. Pagan
6. Dominic C. H. Ng

Reviewed by Review Commons

Identification of Wnt regulated genes that are repressed by, or independent of, β-catenin

1. Shiyang Liu
2. Sara Haghani
3. Enrico Petretto
4. Babita Madan
5. Nathan Harmston
6. David M Virshup

Reviewed by Review Commons