Showing page 39 of 41 pages of list content

  1. Unsupervised reference-free inference reveals unrecognized regulated transcriptomic complexity in human single cells

    This article has 7 authors:
    1. Roozbeh Dehghannasiri
    2. George Henderson
    3. Rob Bierman
    4. Tavor Baharav
    5. Kaitlin Chaung
    6. Peter Wang
    7. Julia Salzman
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents a valuable advance for the analysis of gene expression variation at the level of individual cells by introducing a novel reference-free framework that can detect splicing, fusion, editing, immune-receptor diversity and repeated elements in sequencing data. The evidence supporting these claims is solid, with rigorous validation on simulated datasets and extensive analysis of full-length single-cell sequencing data demonstrating improved performance over existing methods. This work will be of particular interest to researchers developing methods for high-resolution transcriptome analysis and to those studying cellular heterogeneity in health and disease.

    Reviewed by eLife, Arcadia Science

    This article has 6 evaluationsAppears in 2 listsLatest version Latest activity
  2. ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin polymerization

    This article has 6 authors:
    1. Katarzyna Bogucka-Janczi
    2. Gregory Harms
    3. Marie-May Coissieux
    4. Mohamed Bentires-Alj
    5. Bernd Thiede
    6. Krishnaraj Rajalingam
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The manuscript describes a fundamental study of the atypical MAPK, ERK3, in the activation of RhoGTPase Cdc42 and the formation of actin-rich protrusions and cell migration. The results show that ERK3 is required for the motility of tumor cells in vivo, providing a new target for fighting metastasis.

    Reviewed by Arcadia Science, eLife

    This article has 24 evaluationsAppears in 2 listsLatest version Latest activity
  3. Disparate patterns of genetic divergence in three widespread corals across a pan-Pacific environmental gradient highlights species-specific adaptation trajectories

    This article has 38 authors:
    1. Benjamin C C Hume
    2. Christian R Voolstra
    3. Eric Armstrong
    4. Guinther Mitushasi
    5. Barbara Porro
    6. Nicolas Oury
    7. Sylvain Agostini
    8. Emilie Boissin
    9. Julie Poulain
    10. Quentin Carradec
    11. David A. Paz-GarcĂ­a
    12. Didier Zoccola
    13. Hélène Magalon
    14. Clémentine Moulin
    15. Guillaume Bourdin
    16. Guillaume Iwankow
    17. Sarah Romac
    18. Bernard Banaigs
    19. Emmanuel Boss
    20. Chris Bowler
    21. Colomban de Vargas
    22. Eric Douville
    23. Michel Flores
    24. Paola Furla
    25. Pierre E Galand
    26. Eric Gilson
    27. Fabien Lombard
    28. Stéphane Pesant
    29. Stéphanie Reynaud
    30. Matthew B. Sullivan
    31. Shinichi Sunagawa
    32. Olivier Thomas
    33. Romain Troublé
    34. Rebecca Vega Thurber
    35. Patrick Wincker
    36. Serge Planes
    37. Denis Allemand
    38. Didier Forcioli

    Reviewed by Arcadia Science

    This article has 22 evaluationsAppears in 1 listLatest version Latest activity
  4. How do Vampires Suck Blood?

    This article has 7 authors:
    1. Meng Gou
    2. Xuyuan Duan
    3. Jun Li
    4. Yaocen Wang
    5. Qingwei Li
    6. Yue Pang
    7. Yonghui Dong

    Reviewed by Arcadia Science

    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
  5. High-throughput library transgenesis in Caenorhabditis elegans via Transgenic Arrays Resulting in Diversity of Integrated Sequences (TARDIS)

    This article has 6 authors:
    1. Zachary C Stevenson
    2. Megan J Moerdyk-Schauwecker
    3. Stephen A Banse
    4. Dhaval S Patel
    5. Hang Lu
    6. Patrick C Phillips
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript provides a description of an approach for efficiently integrating diverse libraries into the C. elegans genome and tools that enable researchers to use the method. It is a valuable contribution for researchers carrying out experiments that would benefit from easy generation of such libraries, and the data for the effectiveness of the method is solid. The advantages of this approach in terms of ease and effectiveness relative to others with similar aims will emerge as they are put to more general use in addressing biological problems.

    Reviewed by eLife, Arcadia Science

    This article has 13 evaluationsAppears in 2 listsLatest version Latest activity
  6. Microbial community interactions on a chip

    This article has 11 authors:
    1. Duane S. Juang
    2. Wren E. Wightman
    3. Gabriel L. Lozano
    4. Terry D. Juang
    5. Layla J. Barkal
    6. Jiaquan Yu
    7. Manuel F. Garavito
    8. Amanda Hurley
    9. Ophelia S. Venturelli
    10. Jo Handelsman
    11. David J. Beebe

    Reviewed by Arcadia Science

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. Recommendations for Uniform Variant Calling of SARS-CoV-2 Genome Sequence across Bioinformatic Workflows

    This article has 26 authors:
    1. Ryan Connor
    2. Migun Shakya
    3. David A. Yarmosh
    4. Wolfgang Maier
    5. Ross Martin
    6. Rebecca Bradford
    7. J. Rodney Brister
    8. Patrick S. G. Chain
    9. Courtney A. Copeland
    10. Julia di Iulio
    11. Bin Hu
    12. Philip Ebert
    13. Jonathan Gunti
    14. Yumi Jin
    15. Kenneth S. Katz
    16. Andrey Kochergin
    17. Tré LaRosa
    18. Jiani Li
    19. Po-E Li
    20. Chien-Chi Lo
    21. Sujatha Rashid
    22. Evguenia S. Maiorova
    23. Chunlin Xiao
    24. Vadim Zalunin
    25. Lisa Purcell
    26. Kim D. Pruitt

    Reviewed by Arcadia Science

    This article has 1 evaluationAppears in 1 listLatest version Latest activity