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  1. Thank you for sharing this interesting data in such an open and accessible way. The preprint was an absolute pleasure to read and the LampreyDB easy to navigate and explore. I liked that you chose to carry out metabolomics on both the buccal tissue and the feeding site to demonstrate use and enrichment of sucking-associated metabolites at the site. While reading became particularly interested in the shared blood-sucking strategies (with respect to metabolites) that Lamprey may share with other species of bloodsuckers and I think you could further strengthen this study by elaborating on this a little more in the discussion. A comparative table summarizing this across a few parasites may be very helpful. Overall thank you for a great study! I truly appreciate how accessible all of it is.

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