Evaluated articles

A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia

1. Sven M. Lange
2. Jeremy A. Bennett
3. Robyn J. Eisert
4. Alan Brown

Reviewed by Arcadia Science

TRPV1+ neurons promote cutaneous immunity against Schistosoma mansoni

1. Juan M Inclan-Rico
2. Adriana Stephenson
3. Camila M Napuri
4. Heather L Rossi
5. Li-Yin Hung
6. Christopher F Pastore
7. Wenqin Luo
8. De’Broski R Herbert

Reviewed by Arcadia Science

A low-cost FPGA-based approach for pile-up corrected high-speed in vivo FLIM imaging

1. Felipe Velasquez Moros
2. Dorian Amiet
3. Rachel Meister
4. Alexandra von Faber-Castell
5. Matthias Wyss
6. Aiman S. Saab
7. Paul Zbinden
8. Bruno Weber
9. Luca Ravotto

Reviewed by Arcadia Science

Interleukin-27 is antiviral at the maternal-fetal interface

1. Madeline S. Merlino
2. Briah Barksdale
3. Seble G. Negatu
4. Rebecca L. Clements
5. Taylor Miller-Ensminger
6. Alexandra H. Lopez
7. Sneha Mani
8. Monica N. Mainigi
9. Christopher A. Hunter
10. Kellie A. Jurado

Reviewed by Arcadia Science

A Cross-Species Generative Cell Atlas Across 1.5 Billion Years of Evolution: The TranscriptFormer Single-cell Model

1. James D Pearce
2. Sara E Simmonds
3. Gita Mahmoudabadi
4. Lakshmi Krishnan
5. Giovanni Palla
6. Ana-Maria Istrate
7. Alexander Tarashansky
8. Benjamin Nelson
9. Omar Valenzuela
10. Donghui Li
11. Stephen R Quake
12. Theofanis Karaletsos

Reviewed by Arcadia Science

Antibody affinity engineering using antibody repertoire data and machine learning

1. Lena Erlach
2. Simon Friedensohn
3. Daniel Neumeier
4. Derek M. Mason
5. Sai T. Reddy

Reviewed by Arcadia Science

Random UV Mutagenesis for the production of Chlorella vulgaris mutants with low chlorophyll content for the food industry

1. Ivan N. Ivanov
2. Jiří Kopecký
3. Karolína Štěrbová
4. Pavel Hrouzek
5. Martin Lukeš
6. Kateřina Bišová
7. Setyo Budi Kurniawan

Reviewed by Arcadia Science

Antifungal and other bioactive properties of the volatilome of Streptomyces scabiei

1. Nudzejma Stulanovic
2. Djulia Bensaada
3. Loïc Belde
4. Delphine Adam
5. Marc Hanikenne
6. Jean-François Focant
7. Pierre-Hugues Stefanuto
8. Sébastien Rigali

Reviewed by Arcadia Science

Eukaryotes’ closest relatives are internally simple syntrophic archaea

1. Hiroyuki Imachi
2. Masaru K. Nobu
3. Shun’ichi Ishii
4. Yuga Hirakata
5. Tetsuro Ikuta
6. Yuta Isaji
7. Makoto Miyata
8. Masayuki Miyazaki
9. Yuki Morono
10. Kazuyoshi Murata
11. Satoshi Nakagawa
12. Miyuki Ogawara
13. Satoshi Okada
14. Yumi Saito
15. Sanae Sakai
16. Shigeru Shimamura
17. Yuhei O. Tahara
18. Yoshihiro Takaki
19. Yoshinori Takano
20. Eiji Tasumi
21. Katsuyuki Uematsu
22. Toshihiro Yoshimura
23. Ken Takai

Reviewed by Arcadia Science

Balancing stability and flexibility when reshaping archaeal membranes

1. Miguel Amaral
2. Felix Frey
3. Xiuyun Jiang
4. Buzz Baum
5. Anđela Šarić

• Curated by eLife

  eLife Assessment

  This fundamental study characterizes the mechanics and stability of bolalipids from archaeal membranes using a minimalist, physics-based computational model. The authors present a robust mesoscale model of bolalipids-containing membranes, systematically evaluating it across diverse membrane configurations. The results are compelling, demonstrating that the incorporation of bolalipids and regular bilayer lipids in archaeal membranes significantly enhances membrane fluidity and structural stability.

Reviewed by eLife, Arcadia Science

Programmable design of functional proteins from natural language

1. Fengyuan Dai
2. Shiyang You
3. Yudian Zhu
4. Yuan Gao
5. Lihao Fu
6. Xibin Zhou
7. Jin Su
8. Chentong Wang
9. Yuliang Fan
10. Qingsong Tan
11. Xiaoxiao Ma
12. Xianjun Deng
13. Letong Yu
14. Hui Qian
15. Yan He
16. Yitao Ke
17. Zhe Zhang
18. Chenchen Han
19. Xing Chang
20. Liangzhen Zheng
21. Sheng Wang
22. Yuan Ji
23. Kexin Hao
24. Longxing Cao
25. Yajie Wang
26. Anping Zeng
27. Shunzhi Wang
28. Chunjun Zhan
29. Jing Zhao
30. Tong Si
31. Jianming Liu
32. Hongyuan Lu
33. Fajie Yuan

Reviewed by Arcadia Science

Varicose-projection astrocytes: a reactive phenotype associated with neuropathology

1. Caterina Ciani
2. Giulio Pistorio
3. Simona Giancola
4. Marika Mearelli
5. Francesca Emma Mongelli
6. Delaram Forouzeh
7. Luca Mio
8. Paula Ramos-Gonzalez
9. Carlos Matute
10. Ugne Kuliesiute
11. Sari Elena Dötterer
12. Gediminas Luksys
13. Saulius Rocka
14. Urte Neniskyte
15. Marya Ayub
16. Jean-Marie Graïc
17. Francesco Petrelli
18. Alexei Verkhratsky
19. Nunzio Iraci
20. Fabio Cavaliere
21. Carmen Falcone

Reviewed by Arcadia Science

Self-Organizing Neural Networks in Novel Moving Bodies: Anatomical, Behavioral, and Transcriptional Characterization of a Living Construct with a Nervous System

1. Haleh Fotowat
2. Laurie O’Neill
3. Léo Pio-Lopez
4. Megan Sperry
5. Patrick Erickson
6. Tiffany Lin
7. Michael Levin

Reviewed by Arcadia Science

Inferring genotype–phenotype maps using attention models

1. Krishna Rijal
2. Caroline M Holmes
3. Samantha Petti
4. Gautam Reddy
5. Michael M Desai
6. Pankaj Mehta

Reviewed by Arcadia Science

Free‐Form Microfluidic Microneedle Array Patches

1. Ian A. Coates
2. Madison M. Driskill
3. Netra U. Rajesh
4. Gabriel Lipkowitz
5. Dan Ilyn
6. Yue Xu
7. Maria T. Dulay
8. Gunilla B. Jacobson
9. John R. Tumbleston
10. Jillian L. Perry
11. Shaomin Tian
12. Joseph M. DeSimone

Reviewed by Arcadia Science

Life as a Function: Why Transformer Architectures Struggle to Gain Genome-Level Foundational Capabilities

1. Hassan Hassan
2. Kyle Puhger
3. Ali Saadat
4. Johannes Mayer
5. Maximilian Sprang

Reviewed by Arcadia Science

Evolution of gene order in prokaryotes is driven primarily by gene gain and loss

1. Shelly Brezner
2. Sofya K. Garushyants
3. Yuri I. Wolf
4. Eugene V. Koonin
5. Sagi Snir

Reviewed by Arcadia Science

The visual system of the longest-living vertebrate, the Greenland shark

1. Lily G. Fogg
2. Emily Tom
3. Maxime Policarpo
4. William Cho
5. Fangyuan Gao
6. Doreen Hii
7. Aaron E. Fawcett
8. Nicolas Boileau
9. Amalie Bech-Poulsen
10. Kirstine F. Steffensen
11. Cherlyn J. Ng
12. Peter G. Bushnell
13. John Fleng Steffensen
14. Richard Brill
15. Walter Salzburger
16. Dorota Skowronska-Krawczyk

Reviewed by Arcadia Science

Low-dimensional genotype-fitness mapping across divergent environments suggests a limiting functions model of fitness

1. Olivia M. Ghosh
2. Grant Kinsler
3. Benjamin H. Good
4. Dmitri A. Petrov

Reviewed by Arcadia Science

Evolutionary adaptations of TRPA1 thermosensitivity and skin thermoregulation in vertebrates

1. Gabriel E. Bertolesi
2. Neda Heshami
3. Sarah McFarlane

Reviewed by Arcadia Science