Evaluated articles

Transcriptional Repression of reaper by Stand Still Safeguards Female Germline Development in Drosophila

1. Masaya Matsui
2. Shinichi Kawaguchi
3. Toshie Kai

Reviewed by Review Commons

Molecular and Neural Circuit Mechanisms Underlying Sexual Experience-dependent Long-Term Memory in Drosophila.

1. Dongyu Sun
2. Xiaoli Zhang
3. Hongyu Miao
4. Tianmu Zhang
5. Woo Jae Kim

Reviewed by Review Commons

Bora Bridges Aurora-A Activation and Substrate Recognition of PLK1

1. Jennifer A Miles
2. Matthew Batchelor
3. Martin Walko
4. Vanda Gunning
5. Andrew J Wilson
6. Megan H Wright
7. Richard Bayliss

Reviewed by Review Commons

TRF2 Non-Telomeric Function is Indispensable for Neural stemness

1. Soujanya Vinayagamurthy
2. Amit Kumar Bhatt
3. Sulochana Bagri
4. Supratim Ghosh
5. Arpan Parichha
6. Arindam Maitra
7. Shantanu Chowdhury

Reviewed by Review Commons

Deep learning predicts tissue outcomes in retinal organoids

1. Cassian Afting
2. Norin Bhatti
3. Christina Schlagheck
4. Encarnación Sánchez Salvador
5. Laura Herrera-Astorga
6. Rashi Agarwal
7. Risa Suzuki
8. Nicolaj Hackert
9. Hanns-Martin Lorenz
10. Lucie Zilova
11. Joachim Wittbrodt
12. Tarik Exner

Reviewed by Review Commons

THE FAM53C/DYRK1A axis regulates the G1/S transition of the cell cycle

1. Taylar Hammond
2. Jong Bin Choi
3. Miles W Membreño
4. Janos Demeter
5. Roy Ng
6. Debadrita Bhattacharya
7. Thuyen N Nguyen
8. Griffin G Hartmann
9. Caterina I Colón
10. Carine Bossard
11. Jan M Skotheim
12. Peter K Jackson
13. Anca Pasca
14. Seth M Rubin
15. Julien Sage

• Curated by eLife

  eLife Assessment

  This study identifies the uncharacterised protein FAM53C as a novel, potential regulator of the G1/S cell cycle transition, linking its function to the DYRK1A kinase and the RB/p53 pathways. The work is valuable and of interest to the cell cycle field, leveraging a strong computational screen to identify a new candidate. The findings are solid, although confidence in the siRNA depletion phenotypes would have been higher with rescue experiments using an siRNA-resistant cDNA and more robust quantification of some immunoassay data.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Compromised DNA replication in gut cells underlies tardigrade sensitivity to genotoxic stress

1. Gonzalo Quiroga-Artigas
2. Pauline Fontanié
3. Benjamin Lacroix
4. Maria Dolores Molina
5. María Moriel-Carretero

Reviewed by Review Commons

MAVISp: A Modular Structure-Based Framework for Protein Variant Effects

1. Matteo Arnaudi
2. Mattia Utichi
3. Kristine Degn
4. Matteo Tiberti
5. Ludovica Beltrame
6. Karolina Krzesińska
7. Pablo Sánchez-Izquierdo Besora
8. Eleni Kiachaki
9. Simone Scrima
10. Laura Bauer
11. Katrine Meldgård
12. Anna Melidi
13. Lorenzo Favaro
14. Anu Oswal
15. Guglielmo Tedeschi
16. Terézia Dorčaková
17. Alberte Heering Estad
18. Joachim Breitenstein
19. Jordan Safer
20. Paraskevi Saridaki
21. Valentina Sora
22. Francesca Maselli
23. Philipp Becker
24. Jérémy Vinhas
25. Alberto Pettenella
26. Matteo Lambrughi
27. Claudia Cava
28. Anna Rohlin
29. Mef Nilbert
30. Sumaiya Iqbal
31. Peter Wad Sackett
32. Burcu Aykac Fas
33. Elena Papaleo

Reviewed by Review Commons

Importin α Characterizes a Micronuclear Environment Associated with Genomic Instability in Human Cancer Cells

1. Yoichi Miyamoto
2. Reo Kisanuki
3. Rieko Oshima
4. Shige H Yoshimura
5. Mutsumi Yokota
6. Kazumitsu Maehara
7. Chiaki Hata
8. Taro Tachibana
9. Hiroshi Kimura
10. Masato Koike
11. Yasuyuki Ohkawa
12. Toyomasa Katagiri
13. Yoshihiro Yoneda
14. Masahiro Oka
15. Hisato Saitoh

Reviewed by Review Commons

Beyond the transcript: chromatin implications in trans-splicing in Trypanosomatids

1. Romina Trinidad Zambrano Siri
2. Paula Beati
3. Lucas Inchausti
4. Pablo Smircich
5. Guillermo Daniel Alonso
6. Josefina Ocampo

Reviewed by Review Commons

Opposing roles for lipocalins and a CD36 family scavenger receptor in apical extracellular matrix-dependent protection of narrow tube integrity

1. Alexandra C. Belfi
2. Sage G. Aviles
3. Rachel Forman-Rubinsky
4. Hasreet K. Gill
5. Jennifer D. Cohen
6. Aleksandra Nawrocka
7. Axelle Bourez
8. Pierre van Antwerpen
9. Patrick Laurent
10. Meera V. Sundaram

Reviewed by Review Commons

Translational buffering tunes gene expression in mice and humans

1. Shilpa Rao
2. Aden Y Le
3. Logan Persyn
4. Can Cenik

Reviewed by Review Commons

Trisomy 21 impairs synchronized activity and connectivity in developing human down syndrome cortical excitatory neuron networks

1. Manuel Peter
2. Raquel Real
3. Alessio Strano
4. Hugh P. C. Robinson
5. Mark A. Smith
6. Samuel J. Barnes
7. Vincenzo de Paola
8. Frederick J. Livesey

Reviewed by Review Commons

Microbiota impact Drosophila ageing via Acetobacter, Tachykinin, and TkR99D

1. Diana Marcu
2. David R Sannino
3. Anthony J Dornan
4. Rita Ibrahim
5. Atharv Kapoor
6. Miriam Wood
7. Adam J Dobson

• Curated by eLife

  eLife Assessment

  This important study demonstrates that in Drosophila melanogaster, tachykinin (Tk) expression is regulated by the microbiota. The authors present convincing evidence that axenic flies raised with no microbiota are longer-lived than conventionally reared animals, and that Tk expression and Tk receptors in the nervous system are required for this effect. They further test individual bacterial strains for their role in these effects and connect the effect to loss of lipid stores and suggest that FOXO may be involved in the phenotype, results that are of interest to the fields of environmental perception, host microbiome interactions, and geroscience.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Chronic replication stress-mediated genomic instability disrupts placenta development in mice

1. Mumingjiang Munisha
2. Rui Huang
3. Jordan Khan
4. John C. Schimenti

Reviewed by Review Commons

miR-184 modulates dilp8 to control developmental timing during normal growth conditions and in response to developmental perturbations

1. Jervis Fernandes
2. Muhammed Naseem
3. Ayisha Marwa MP
4. Jishy Varghese

Reviewed by Review Commons

The Ketogenic Diet Metabolite β-Hydroxybutyrate Promotes Mitochondrial Elongation via Deacetylation and Improves Autism-like Behavior in Zebrafish

1. Golam M. Uddin
2. Rachel Lacroix
3. Mashiat Zaman
4. Iman Al Khatib
5. Amit Jaiswal
6. Jong M. Rho
7. Deborah M. Kurrasch
8. Timothy E. Shutt

Reviewed by Review Commons

When mitochondria fall apart: Unbalanced mitochondrial segregation triggers loss of mtDNA in the absence of mitochondrial fusion

1. Lisa Dengler
2. Francesco Padovani
3. Bianca Lemke
4. Rebecca Brugger
5. Benedikt Westermann
6. Boris Maček
7. Kurt M. Schmoller
8. Jennifer C. Ewald

Reviewed by Review Commons

Interferon-β induction heterogeneity during KSHV infection is correlated to levels and activation of the transcription factors ATF2 and RelA, and not IRF3

1. Machika Kaku
2. Marta Maria Gaglia

Reviewed by Review Commons

Global molecular landscape of early MASLD progression in obesity

1. Qing Zhao
2. William De Nardo
3. Ruoyu Wang
4. Yi Zhong
5. Umur Keles
6. Gabrielé Sakalauskaite
7. Li Na Zhao
8. Huiyi Tay
9. Sonia Youhanna
10. Mengchao Yan
11. Ye Xie
12. Youngrae Kim
13. Sungdong Lee
14. Rachel Liyu Lim
15. Guoshou Teo
16. Pradeep Narayanaswamy
17. Paul R Burton
18. Volker M Lauschke
19. Hyungwon Choi
20. Matthew J Watt
21. Philipp Kaldis

• Curated by eLife

  eLife Assessment

  The authors provide a useful integrated analytical approach to investigating MASLD focused on diverse multiomic integration methods. The strength of evidence for this new resource is solid, as analyses highlight the importance of previously-described pathophysiologic processes, as well as unveil several new mechanisms as key features of MASLD in obese patients.

Reviewed by eLife, Review Commons