Evaluated articles

Single molecule imaging of transcription dynamics, RNA localization and fate in human T cells

1. M. Valeria Lattanzio
2. Nikolina Šoštarić
3. Nandhini Kanagasabesan
4. Branka Popović
5. Antonia Bradarić
6. Leyma Wardak
7. Aurélie Guislain
8. Philipp Savakis
9. Evelina Tutucci
10. Monika C. Wolkers

Reviewed by Review Commons

Amyloid-β fibrils accumulated in preeclamptic placentas suppress syncytialization of cytotrophoblasts

1. Kaho Nishioka
2. Midori Ikezaki
3. Naoyuki Iwahashi
4. Miyu Arakawa
5. Momo Fukushima
6. Noa Mori
7. Mika Mizoguchi
8. Yuko Horiuchi-Tanizaki
9. Megumi Fujino
10. Takami Tomiyama
11. Yoshito Ihara
12. Kenji Uchimura
13. Kazuhiko Ino
14. Kazuchika Nishitsuji

Reviewed by Review Commons

A Drosophila screen of schizophrenia-related genes highlights the requirement of neural and glial matrix metalloproteinases for neuronal remodeling

1. Shir Keret
2. Hagar Meltzer
3. Neta Marmor-Kollet
4. Oren Schuldiner

Reviewed by Review Commons

Identifying regulators of associative learning using a protein-labelling approach in C. elegans

1. Aelon Rahmani
2. Anna McMillen
3. Ericka Allen
4. Radwan Ansaar
5. Renee Green
6. Michaela Johnson
7. Anne Poljak
8. Yee Lian Chew

• Curated by eLife

  eLife Assessment

  This valuable work defines a "learning proteome" for a C. elegans gustatory associative learning paradigm. These results provide the field with a new set of genes to further explore their roles in learning and memory, provide new tools for other labs to employ in their investigations of behavior, and molecular pathways revelant for C. elegans learning and memory. The methodological evidence and the quality of the dataset are convincing. The results will be of interest to neuroscientists and developmental biologists seeking to understand the self-assembly and operation of neural circuits for learning and memory.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

A conserved RNA switch for acetylcholine receptor clustering at neuromuscular junctions in chordates

1. Md. Faruk Hossain
2. Sydney Popsuj
3. Burcu Vitrinel
4. Nicole A. Kaplan
5. Alberto Stolfi
6. Lionel Christiaen
7. Matteo Ruggiu

Reviewed by Review Commons

Key roles of the zona pellucida and perivitelline space in promoting gamete fusion and fast block to polyspermy inferred from the choreography of spermatozoa in mice oocytes

1. Yaëlle Dubois
2. Sophie Favier
3. Nathan Martin-Fornier
4. Mohyeddine Omrane
5. David Stroebel
6. Eric Perez
7. Sandrine Barbaux
8. Ahmed Ziyyat
9. Nicolas Rodriguez
10. Christine Gourier

Reviewed by Review Commons

Lipid packing contributes to the confinement of caveolae to the plasma membrane

1. Elin Larsson
2. Aleksei Kabedev
3. Hudson Pace
4. Jakob Lindwall
5. Fouzia Bano
6. Robert G Parton
7. Christel AS Bergström
8. Ingela Parmryd
9. Marta Bally
10. Richard Lundmark

• Curated by eLife

  eLife Assessment

  This study reports the important finding that the dynamin inhibitor Dyngo-4a broadly affects lipid packing and plasma membrane dynamics, independently of its action on dynamin. While solid computational, biophysical, and cell-based evidence supports this conclusion, there is incomplete support for the authors' main claim on the role of lipid packing in caveolae internalization, as the causal relationship remains unclear and direct analyses are lacking. With stronger evidence, this work would be of significant interest to cell biologists, biophysicists, and chemists interested in membrane remodeling and drug-membrane interactions.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

TORC2-regulated sterol redistribution mediates recovery from membrane perturbation by small amphipathic molecules.

1. Maria G. Tettamanti
2. Paulina Nowak
3. Beata Kusmider
4. Jennifer M Kefauver
5. Vincent Mercier
6. Aurelien Roux
7. Robbie Loewith

Reviewed by Review Commons

Engineering fluorescent reporters in human pluripotent cells and strategies for live imaging human neurogenesis

1. Alwyn Dady
2. Lindsay Davidson
3. Nicolas Loyer
4. Sophie Rappich
5. Greg Findlay
6. Timothy Sanders
7. Jens Januschke
8. Kate G. Storey

Reviewed by Review Commons

Antigen flexibility supports the avidity of hemagglutinin-specific antibodies at low antigen densities

1. Ananya Benegal
2. Yuanyuan He
3. Katilyn Ho
4. Giselle Groff
5. Zijian Guo
6. Michael D. Vahey

Reviewed by Review Commons

The microcephaly protein WDR62 regulates cellular purine metabolism through the HSP70/HSP90 chaperone machinery

1. Matthew J. Morris
2. Yvonne Y. Yeap
3. Chi Chen
4. S. Sean Millard
5. Julia K. Pagan
6. Dominic C. H. Ng

Reviewed by Review Commons

Recurrent cancer-associated ERBB4 mutations are transforming and confer resistance to targeted therapies

1. Veera K. Ojala
2. Sini Ahonen
3. Aura Tuohisto-Kokko
4. Olaya Esparta
5. Peppi Suominen
6. Anne Jokilammi
7. Iman Farahani
8. Deepankar Chakroborty
9. Nikol Dibus
10. Steffen Boettcher
11. Tomi T. Airenne
12. Mark S. Johnson
13. Lisa D. Eli
14. Klaus Elenius
15. Kari J. Kurppa

Reviewed by Review Commons

The Arp2/3 complex maintains genome integrity and survival of epidermal Langerhans cells

1. Maria-Graciela Delgado
2. Ann-Kathrin Burkhart
3. Javiera Villar
4. Roberto Amadio
5. Vanessa S. Racz
6. Doriane Sanséau
7. Nilushi De Silva
8. Livia Lacerda Mariano
9. Anna Shmakova
10. Anna Chipont
11. Mabel San Roman
12. Giulia Bracchetti
13. Vincent Calmettes
14. Zahraa Alraies
15. Mathieu Maurin
16. Aurelien Dauphin
17. Coralie Guerin
18. Florent Ginhoux
19. Nicolas Manel
20. Daniele Fachinetti
21. Federica Benvenuti
22. Sandra Iden
23. Ana-Maria Lennon-Duménil

Reviewed by Review Commons

Identification of Wnt regulated genes that are repressed by, or independent of, β-catenin

1. Shiyang Liu
2. Sara Haghani
3. Enrico Petretto
4. Babita Madan
5. Nathan Harmston
6. David M Virshup

Reviewed by Review Commons

Sulfation affects apical extracellular matrix organization during development of the Drosophila embryonic salivary gland tube

1. J Luke Woodward
2. Jeffrey Matthew
3. Rutuparna Joshi
4. Vishakha Vishwakarma
5. Ying Xiao
6. SeYeon Chung

• Curated by eLife

  eLife Assessment

  This paper is important in demonstrating a requirement for sulfation in organizing apical extracellular matrix (aECM) during tubulogenesis in Drosophila melanogaster. The authors identify and characterize the organization of some of the first known components of the non-chitinous aECM in the Drosophila salivary gland tube, and these findings are supported by convincing data. This study would be of interest to developmental and cell biologists.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Disruption of the mRNA m ⁶ A writer complex triggers autoimmunity in Arabidopsis

1. Carey L Metheringham
2. Anjil K Srivastava
3. Peter Thorpe
4. Ankita Maji
5. Matthew T Parker
6. Geoffrey J Barton
7. Gordon G Simpson

Reviewed by Review Commons

Flexibility and modulation of translation initiation in enterovirus genomes

1. Rhian L. O’Connor
2. Georgia M. Cook
3. Jacqueline Hankinson
4. Ksenia Fominykh
5. Samantha H. Cheng
6. Daniel A. Nash
7. Aurélie Cenier
8. Komal M. Nayak
9. Stephen C. Graham
10. Janet E. Deane
11. Matthias Zilbauer
12. Andrew E. Firth
13. Valeria Lulla

Reviewed by Review Commons

PRC1 resists microtubule sliding in two distinct resistive modes due to variations in the separation between overlapping microtubules

1. Daniel Steckhahn
2. Shane A. Fiorenza
3. Ellinor Tai
4. Scott Forth
5. Peter R. Kramer
6. Meredith Betterton

Reviewed by Review Commons

Mitochondrial fission during mitophagy requires both inner and outer mitofissins

1. Kentaro Furukawa
2. Tatsuro Maruyama
3. Shun-ichi Yamashita
4. Keiichi Inoue
5. Tomoyuki Fukuda
6. Nobuo N. Noda
7. Tomotake Kanki

Reviewed by Review Commons

Functional Role for Cas Cytoplasmic Adaptor Proteins During Cortical Axon Pathfinding

1. Jason A. Estep
2. Alyssa M. Treptow
3. Payton A. Rao
4. Patrick Williamson
5. Wenny Wong
6. Martin M. Riccomagno

Reviewed by Review Commons