Evaluated articles

Global molecular landscape of early MASLD progression in obesity

1. Qing Zhao
2. William De Nardo
3. Ruoyu Wang
4. Yi Zhong
5. Umur Keles
6. Gabrielé Sakalauskaite
7. Li Na Zhao
8. Huiyi Tay
9. Sonia Youhanna
10. Mengchao Yan
11. Ye Xie
12. Youngrae Kim
13. Sungdong Lee
14. Rachel Liyu Lim
15. Guoshou Teo
16. Pradeep Narayanaswamy
17. Paul R Burton
18. Volker M Lauschke
19. Hyungwon Choi
20. Matthew J Watt
21. Philipp Kaldis

• Curated by eLife

  eLife Assessment

  The authors provide a useful integrated analytical approach to investigating MASLD focused on diverse multiomic integration methods. The strength of evidence for this new resource is solid, as analyses highlight the importance of previously-described pathophysiologic processes, as well as unveil several new mechanisms as key features of MASLD in obese patients.

Reviewed by eLife, Review Commons

Assessing target genes for homing suppression gene drive

1. Xuejiao Xu
2. Jialing Fang
3. Jingheng Chen
4. Jie Yang
5. Xiaozhen Yang
6. Shibo Hou
7. Weitang Sun
8. Jackson Champer

Reviewed by Review Commons

E4BP4 Safeguards Brown Fat Mitochondria from Obesity-Induced Fragmentation via Ceramide Repression

1. Fernando Valdivieso-Rivera
2. Vanessa O. Furino
3. Carlos E. Leher
4. Ariane M. Zanesco
5. Monara Kaélle Cruz
6. Flavia C. Gan
7. Adriana Leandra Santoro
8. Lara Regina-Ferreira
9. Giovanna Leite Santos
10. Tiago Gonçalves
11. Luiz Osório Leiria
12. Pedro M. Moraes-Vieira
13. Roger Frigério Castilho
14. Shingo Kajimura
15. Marcelo A. Mori
16. Licio A. Velloso
17. Carlos H. Sponton

Reviewed by Review Commons

Provision of Preferred Nutrients to Macrophages Enables Salmonella to Replicate Intracellularly Without Relying on Type III Secretion Systems

1. Francisco-Javier Garcia-Rodriguez
2. Camila Valenzuela
3. Joaquin Bernal-Bayard
4. Pedro Escoll

Reviewed by Review Commons

Multi-omics analysis of endothelial cells reveals the metabolic diversity that underlies endothelial cell functions

1. Stephan Durot
2. Peter F. Doubleday
3. Lydia Schulla
4. Amélie Sabine
5. Tatiana V. Petrova
6. Nicola Zamboni

Reviewed by Review Commons

Spatial control of secretory vesicle targeting by the Ync13–Rga7– Rng10 complex during cytokinesis

1. Sha Zhang
2. Davinder Singh
3. Yi-Hua Zhu
4. Katherine J. Zhang
5. Alejandro Melero
6. Sophie G. Martin
7. Jian-Qiu Wu

Reviewed by Review Commons

Multiciliated cells adapt the mechanochemical Piezo1-Erk1/2-Yap1 cell proliferation axis to fine-tune centriole number

1. Vani Narayanan
2. Venkatramanan G Rao
3. Angelo Arrigo
4. Saurabh S Kulkarni

Reviewed by Review Commons

Neural crest induction requires SALL4-mediated BAF recruitment to lineage specific enhancers

1. Martina Demurtas
2. Samantha M. Barnada
3. Emma van Domselaar
4. Zoe H. Mitchell
5. Laura Deelen
6. Marco Trizzino

Reviewed by Review Commons

Local synthesis of Reticulon-1C lessens the outgrowth of injured axons and Spastin activity

1. Alejandro Luarte
2. Javiera Gallardo
3. Daniela Corvalán
4. Ankush Chakraborty
5. Cláudio Gouveia-Roque
6. Francisca Bertin
7. Carlos Contreras
8. Juan Pablo Ramírez
9. André Weber
10. Waldo Acevedo
11. Werner Zuschratter
12. Rodrigo Herrera-Molina
13. Úrsula Wyneken
14. Andrea Paula-Lima
15. Tatiana Adasme-Rocha
16. Jorge Toledo
17. Rodrigo Vergara
18. Antonia Figueroa
19. Carolina González
20. Christian González-Billault
21. Ulrich Hengst
22. Andrés Couve

Reviewed by Review Commons

Codon-specific ribosome stalling reshapes translational dynamics during branched-chain amino acid starvation

1. Lina Worpenberg
2. Cédric Gobet
3. Felix Naef

Reviewed by Review Commons

The metabolic cofactor Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling

1. Anthony E. Jones
2. Amy Rios
3. Neira Ibrahimovic
4. Carolina Chavez
5. Nicholas A. Bayley
6. Andréa B. Ball
7. Wei Yuan Hsieh
8. Alessandro Sammarco
9. Amber R. Bianchi
10. Angel A. Cortez
11. Thomas G. Graeber
12. Alexander Hoffmann
13. Steven J. Bensinger
14. Ajit S. Divakaruni

Reviewed by Review Commons

Single molecule counting detects low-copy glycine receptors in hippocampal and striatal synapses

1. Serena Camuso
2. Yana Vella
3. Souad Youjil Abadi
4. Clémence Mille
5. Bert Brône
6. Christian G Specht

• Curated by eLife

  eLife Assessment

  The study presents convincing quantitative evidence, supported by appropriate negative controls, for the presence of low-abundance glycine receptors (GlyRs) within inhibitory synapses in telencephalic regions of the mouse brain. Using sensitive single-molecule localization microscopy of endogenously tagged GlyRs, the authors reveal previously undetected populations of these receptors. Although the functional significance of these low-abundance GlyRs remains to be established, the findings offer valuable insights and methodologies that will be of interest to neuroscientists studying inhibitory synapse biology.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Xrp1 drives damage-induced cellular plasticity of enteroendocrine cells in the adult Drosophila midgut

1. Qingyin Qian
2. Hiroki Nagai
3. Yuya Sanaki
4. Makoto Hayashi
5. Kenichi Kimura
6. Yu-ichiro Nakajima
7. Ryusuke Niwa

Reviewed by Review Commons

The nanos ^d integral gene drive enables population modification of the malaria vector Anopheles gambiae

1. Pei-Shi Yen
2. Sebald ANR Verkuijl
3. Paolo Capriotti
4. Giuseppe Del Corsano
5. Astrid Hoermann
6. Maria Grazia Inghilterra
7. Irati Aramburu-Gonzalez
8. Moeez A Khan
9. Dina Vlachou
10. George K Christophides
11. Nikolai Windbichler

Reviewed by Review Commons

A conserved Arf-GEF modulates axonal integrity through RAB-35 by altering neuron-epidermal attachment

1. Igor Bonacossa-Pereira
2. Sean Coakley
3. Massimo A. Hilliard

Reviewed by Review Commons

High resolution mapping of the actin fusion focus reveals myosin V-dependent transport of formin for actin aster compaction

1. Valentine Thomas
2. Hikari Mase
3. Laetitia Michon
4. Andrea Picco
5. Marko Kaksonen
6. Sophie G Martin

Reviewed by Review Commons

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

1. Kamila J Bienkowska
2. Stephany Gallardo Y
3. Nur S Zainal
4. Matthew Ellis
5. Maria-Antoinette Lopez
6. Judith Austine
7. Sai Pittla
8. Serena J Chee
9. Aiman Alzetani
10. Emily C Shaw
11. Christian H Ottensmeier
12. Gareth J Thomas
13. Christopher J Hanley

Reviewed by Review Commons

MRTF-dependent cytoskeletal dynamics drive efficient cell cycle progression

1. Julie C. Nielsen
2. Maria Benito-Jardon
3. Noel Christo Petrela
4. Jessica Diring
5. Sofie Bellamy
6. Richard Treisman

Reviewed by Review Commons

The synovial lining macrophage layer develops in the first weeks of life in a CSF1- and TGFβ-dependent but monocyte-independent process

1. Marlene Magalhaes Pinto
2. Bert Malengier-Devlies
3. Guillaume Seuzaret
4. Anna Ahlback
5. Solvig Becker
6. Katelyn Patatsos
7. Georgios Drakoulis
8. Julia Karjalainen
9. Christiane Ruedl
10. David Voehringer
11. Calum C Bain
12. Elaine Emmerson
13. Barbora Schonfeldova
14. Kristina Zec
15. Irina Udalova
16. Theodoros Simakou
17. Lucy MacDonald
18. Mariola Kurowska-Stolarska
19. Jadwiga Zarebska
20. Tonia Vincent
21. Romeo Ricci
22. Eric Erbs
23. Jack Barrington
24. Barry W McColl
25. Georgiana Neag
26. Samuel Kemble
27. Christopher Mahony
28. Adam Croft
29. Louis Boon
30. Nicole Migotsky
31. Megan L Killian
32. Oumaima Ben Brahim
33. Stefan Uderhardt
34. Alexandre Gallerand
35. Stoyan Ivanov
36. Rebecca Gentek

Reviewed by Review Commons

Dicer accumulates in cytoplasmic foci upon alphavirus infection and plays a proviral role in Myotis myotis bat cells

1. Léa Gaucherand
2. Hugo Marie
3. Julie Cremaschi
4. Sébastien Pfeffer

Reviewed by Review Commons