Evaluated articles

Targeted disruption of phage liquid crystalline droplets abolishes antibiotic tolerance of bacterial biofilms

1. Abul K. Tarafder
2. Miles Graham
3. Luke K. Davis
4. Shawna Pratt
5. Jan Böhning
6. Pavithra Manivannan
7. Zhexin Wang
8. Camila M. Clemente
9. Raymond J Owens
10. George A. O’Toole
11. Philip Pearce
12. Tanmay A.M. Bharat

Reviewed by Review Commons

VAMP8 function reveals tight linkage between endocytic recycling and endocytosis

1. Ailing Liu
2. Yueping Li
3. Zheng Huang
4. Wen Chen
5. Peiliu Xu
6. Xiangying Wei
7. Guosheng Hu
8. Shuangquan Liu
9. Xiaoxia Liu
10. Yaohui He
11. Danling Wang
12. Sandra L. Schmid
13. Zhiming Chen

Reviewed by Review Commons

Ubiquitination regulates granulostasis and DRiP accumulation in SGs under heat stress via the E3 ligase MKRN2

1. Emmanuel Amzallag
2. Yehuda M. Danino
3. Valentina Secco
4. Serena Carra
5. Eran Hornstein

Reviewed by Review Commons

LGL-1 and the RhoGAP protein PAC-1 redundantly polarize the C. elegans embryonic epidermis

1. Olga D. Jarosińska
2. Amalia Riga
3. Hala Zahreddine Fahs
4. Joren M. Woeltjes
5. Ruben Schmidt
6. Fathima S. Refai
7. Suma Gopinadhan
8. Kristin C. Gunsalus
9. Mike Boxem

Reviewed by Review Commons

HIV-1 envelope glycoprotein modulates CXCR4 clustering and dynamics on the T cell membrane

1. Adriana Quijada-Freire
2. César A Santiago
3. Eva M García-Cuesta
4. Blanca Soler Palacios
5. Rosa Ayala-Bueno
6. Sofia R Gardeta
7. Enara San Sebastian
8. Eva Armendariz-Burgoa
9. Maria Carmen Puertas
10. Ricardo Villares
11. Urtzi Garaigorta
12. Luis Ignacio González-Granado
13. Jose Miguel Rodriguez Frade
14. Jakub Chojnacki
15. Javier Martinez-Picado
16. Mario Mellado

• Curated by eLife

  eLife Assessment

  This study provides valuable insights into how HIV-1 Env modulates the nanoscale organization and dynamics of the CXCR4 co-receptor on T cells, using quantitative imaging and functional approaches, the authors present convincing evidence that gp120 engagement promotes CD4-dependent clustering and altered mobility of CXCR4, distinct from the effects of the natural ligand CXCL12. Some concerns were raised regarding the interpretation of the single-particle tracking analyses, and additional clarification or analysis may help strengthen the conclusions. The physiological relevance of the findings could be further enhanced by validation with infectious virus and by more clearly integrating the CXCR4R334X mutant observations into the central mechanistic narrative. The work will be of interest to researchers studying HIV entry and membrane receptor organization.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

From Noise to Models to Numbers: Evaluating Negative Binomial Models and Parameter Estimations in Single-Cell RNA-seq

1. Yiling Wang
2. Zhanpeng Shu
3. Zhixing Cao
4. Ramon Grima

Reviewed by Review Commons

Cell type specific allometry controls sex-differences in Drosophila body size

1. Soumitra Pal
2. Jerome Avellaneda
3. Celena M. Cherian
4. Puja Biswas
5. Georg Vogler
6. Elizabeth J. Rideout
7. Frank Schnorrer
8. Teresa M. Przytycka
9. Brian Oliver

Reviewed by Review Commons

Orphan nuclear receptors recruit TRIM28 to promote telomeric H3K9me3 for the alternative lengthening of telomeres pathway

1. Chia-Tsen Tsai
2. Venus Marie Gaela
3. Hsuan-Yu Hsia
4. Yu-Chen Huang
5. Liuh-Yow Chen

Reviewed by Review Commons

The Rho effector ARHGAP18 coordinates a Hippo pathway feedback loop through YAP and Merlin to regulate the cytoskeleton and epithelial cell polarity

1. Emma C. Murray
2. Gillian M. Hodge
3. Khanh Pham
4. Leighton S. Lee
5. Cameron A.R. Mitchell
6. Yongho Bae
7. Andrew T. Lombardo

Reviewed by Review Commons

Centrosome Loss in Embryonic Development Disrupts Axonal Pathfinding and Muscle Integrity

1. Beatriz González
2. Júlia Sellés-Altés
3. Jèrica Pla-Parron
4. Judith Castro-Ribera
5. Sofia J. Araújo

Reviewed by Review Commons

Unravelling the progression of the zebrafish primary body axis with reconstructed spatiotemporal transcriptomics

1. Yang Dong
2. Tao Cheng
3. Xiang Liu
4. Xin-Xin Fu
5. Yang Hu
6. Xian-Fa Yang
7. Ling-En Yang
8. Hao-Ran Li
9. Zhi-Wen Bian
10. Naihe Jing
11. Jie Liao
12. Xiaohui Fan
13. Peng-Fei Xu

Reviewed by Review Commons

Hic2 fast-tracks iPS cell generation by suppressing KLF4-dependent epidermal detour

1. Meryam Beniazza
2. Masahito Yoshihara
3. Daniel F Kaemena
4. James Ashmore
5. Suling Zhao
6. Michael O’Dwyer
7. Emil Andersson
8. Victor Olariu
9. Shintaro Katayama
10. Abdenour Soufi
11. Kosuke Yusa
12. Keisuke Kaji

Reviewed by Review Commons

Opposing CTCF and GATA4 activities set the pace of chromatin topology remodeling during cardiomyogenesis

1. Silvia Becca
2. Sara Bianchi
3. Elisa M. Hahn
4. Kirsten E. Snijders
5. Lukasz Truszkowski
6. Anna Krepelova
7. Francesco Neri
8. Davide Cacchiarelli
9. Sasha Mendjan
10. Elisa Balmas
11. Alessandro Bertero

Reviewed by Review Commons

Skin-derived G-CSF activates pathological granulopoiesis upon psoriasis

1. Tomson Kosasih
2. Tatsuya Morishima
3. Sohyeon Lee
4. Jungyeon Yoon
5. Kanako Wakahashi
6. Pilhan Kim
7. Aiko Sada
8. Hitoshi Takizawa

Reviewed by Review Commons

Mechanistic dissection of GRHL2 and PR transcriptional co-regulation in breast cells

1. M.T. Aarts
2. A. Nordin
3. C. Cantù
4. A.L. van Boxtel
5. R. van Amerongen

Reviewed by Review Commons

MAP7-driven microtubule remodeling builds the Sertoli apical domain that supports timely meiotic progression

1. Koji Kikuchi
2. Toshihiko Fujimori
3. Mami Nakagawa
4. Keisuke Ohta
5. Ryuki Shimada
6. Sayoko Fujimura
7. Kei-ichiro Yasunaga
8. Shingo Usuki
9. Naoki Tani
10. Akira Nakamura
11. Kimi Araki
12. Kei-ichiro Ishiguro

Reviewed by Review Commons

Brachyury expression levels predict lineage potential and axis-forming ability of in vitro derived neuromesodermal progenitors

1. Anahí Binagui-Casas
2. Anna Granés
3. Alberto Ceccarelli
4. Filip J. Wymeersch
5. Matthew French
6. Rosa Portero
7. Jen Annoh
8. Yali Huang
9. Eleni Karagianni
10. Frederick C.K. Wong
11. A. Sophie Brumm
12. Daniel Lopez Ramajo
13. Minoru Takasato
14. Sally Lowell
15. Osvaldo Chara
16. Valerie Wilson

Reviewed by Review Commons

Differential functions of upstream and intronic HOT regions shape dlg-1 transcription and C. elegans development

1. Cristina Tocchini
2. Fanny Eggeler
3. Palmer Bassett
4. Susan E. Mango

Reviewed by Review Commons

Identification of optimal fluorophores for use in the Drosophila embryo

1. Bernardo Chapa-y-Lazo
2. Thamarailingam Athilingam
3. Prabhat Tiwari
4. Prachi Pathak
5. Shaobo Zhang
6. Sophie Theis
7. Timothy E Saunders

Reviewed by Review Commons

SoxB1-Mediated Chromatin Remodeling Promotes Sensory Neuron Differentiation in Planarians

1. Mallory L. Cathell
2. Mohamad A. Auwal
3. Sarai Alvarez Zepeda
4. Kelly G. Ross
5. Ricardo M. Zayas

Reviewed by Review Commons