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  1. PYCR1 Levels Track with Premature and Chronological Skin Aging

    This article has 20 authors:
    1. Kortessa Sotiropoulou
    2. Saniye Yumlu
    3. Tomoko Hirano
    4. Michael Maier
    5. Abigail Loh
    6. Peh Fern Ong
    7. Onn Siong Yim
    8. Chunping Liu
    9. Emmanuel Vial
    10. Umut Altunoğlu
    11. Sheela Nampoothiri
    12. Deepthi de Silva
    13. Björn Fischer-Zirnsak
    14. Hülya Kayserili
    15. Poh San Lai
    16. Oliver Dreesen
    17. Kenji Kabashima
    18. Uwe Kornak
    19. Nathalie Escande-Beillard
    20. Bruno Reversade
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript uses genetic mouse modeling to delve deeper into a rare human disease of aging. The targeted approaches employed lend greater pathophysiologic insight and makes this paper valuable to the field art large. Additionally, the approaches used are rigorous and solid in supporting their conclusions. Some minor weaknesses were noted along with suggestions to add greater clarity.

    Reviewed by eLife, preLights

    This article has 4 evaluationsAppears in 4 listsLatest version Latest activity
  2. The unique synaptic circuitry of specialized olfactory glomeruli in Drosophila melanogaster

    This article has 7 authors:
    1. Lydia Gruber
    2. Rafael Cantera
    3. Markus William Pleijzier
    4. Michael Steinert
    5. Thomas Pertsch
    6. Bill S. Hansson
    7. Jürgen Rybak
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study seeks to determine how synaptic relationships between principal cell types in the olfactory system vary with glomerulus selectivity and is therefore valuable to the sub-field. The methodology is solid, but technical limitations require that claims regarding local interneurons be tempered as they were grouped with other neuron types for analyses, and with only one sample from each glomerulus, it is difficult to assess the import of differences between glomeruli without measures of inter-animal variability.

    Reviewed by eLife, preLights

    This article has 4 evaluationsAppears in 4 listsLatest version Latest activity
  3. Multisensory gaze stabilization in response to subchronic alteration of vestibular type I hair cells

    This article has 9 authors:
    1. Louise Schenberg
    2. Aïda Palou
    3. François Simon
    4. Tess Bonnard
    5. Charles-Elliot Barton
    6. Desdemona Fricker
    7. Michele Tagliabue
    8. Jordi Llorens
    9. Mathieu Beraneck
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This paper provides a fundamental expansion of vestibular compensation into transient and partial dysfunction, as well as insights into the adaptation of visual reflexes in this process. The conclusions are convincingly supported with paired histological and behavioral measurements, which are additionally modeled for further interpretation. This work would be of interest to neuroscientists working in multisensory integration and recovery mechanisms.

    Reviewed by eLife, preLights

    This article has 8 evaluationsAppears in 4 listsLatest version Latest activity
  4. Anti-inflammatory therapy with nebulised dornase alfa for severe COVID-19 pneumonia

    This article has 25 authors:
    1. Joanna C. Porter
    2. Jamie Inshaw
    3. Vincente Joel Solis
    4. Emma Denneny
    5. Rebecca Evans
    6. Mia I. Temkin
    7. Nathalia De Vasconcelos
    8. Iker Valle Aramburu
    9. Dennis Hoving
    10. Donna Basire
    11. Tracey Crissell
    12. Jesusa Guinto
    13. Alison Webb
    14. Hanif Esmail
    15. Victoria Johnston
    16. Anna Last
    17. Thomas Rampling
    18. Elisa Theresa Helbig
    19. Lena Lippert
    20. Florian Kurth
    21. Bryan Williams
    22. Aiden Flynn
    23. Pauline T Lukey
    24. Veronique Birault
    25. Venizelos Papayannopoulos
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This small-sized clinical trial comparing nebulized dornase-alfa to the best available care in patients hospitalized with COVID-19 pneumonia is valuable, but in its present form the paper is incomplete.

    Reviewed by eLife, Rapid Reviews Infectious Diseases, ScreenIT

    This article has 8 evaluationsAppears in 5 listsLatest version Latest activity
  5. Tetherin antagonism by SARS-CoV-2 enhances virus release: multiple mechanisms including ORF3a-mediated defective retrograde traffic

    This article has 15 authors:
    1. Hazel Stewart
    2. Roberta Palmulli
    3. Kristoffer H. Johansen
    4. Naomi McGovern
    5. Ola M. Shehata
    6. George W. Carnell
    7. Hannah K. Jackson
    8. Jin S. Lee
    9. Jonathan C. Brown
    10. Thomas Burgoyne
    11. Jonathan L. Heeney
    12. Klaus Okkenhaug
    13. Andrew E. Firth
    14. Andrew A. Peden
    15. James R. Edgar

    Reviewed by Review Commons, Rapid Reviews Infectious Diseases, ScreenIT

    This article has 8 evaluationsAppears in 4 listsLatest version Latest activity
  6. Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial

    This article has 24 authors:
    1. Sanjay Ramakrishnan
    2. Dan V Nicolau
    3. Beverly Langford
    4. Mahdi Mahdi
    5. Helen Jeffers
    6. Christine Mwasuku
    7. Karolina Krassowska
    8. Robin Fox
    9. Ian Binnian
    10. Victoria Glover
    11. Stephen Bright
    12. Christopher Butler
    13. Jennifer L Cane
    14. Andreas Halner
    15. Philippa C Matthews
    16. Louise E Donnelly
    17. Jodie L Simpson
    18. Jonathan R Baker
    19. Nabil T Fadai
    20. Stefan Peterson
    21. Thomas Bengtsson
    22. Peter J Barnes
    23. Richard E K Russell
    24. Mona Bafadhel

    Reviewed by Rapid Reviews Infectious Diseases, PREreview, ScreenIT

    This article has 5 evaluationsAppears in 5 listsLatest version Latest activity
  7. Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2-mRNA-vaccinated individuals

    This article has 29 authors:
    1. Talia Kustin
    2. Noam Harel
    3. Uriah Finkel
    4. Shay Perchik
    5. Sheri Harari
    6. Maayan Tahor
    7. Itamar Caspi
    8. Rachel Levy
    9. Michael Leshchinsky
    10. Shifra Ken Dror
    11. Galit Bergerzon
    12. Hala Gadban
    13. Faten Gadban
    14. Eti Eliassian
    15. Orit Shimron
    16. Loulou Saleh
    17. Haim Ben-Zvi
    18. Elena Keren Taraday
    19. Doron Amichay
    20. Anat Ben-Dor
    21. Dana Sagas
    22. Merav Strauss
    23. Yonat Shemer Avni
    24. Amit Huppert
    25. Eldad Kepten
    26. Ran D. Balicer
    27. Doron Netzer
    28. Shay Ben-Shachar
    29. Adi Stern

    Reviewed by NCRC, Rapid Reviews Infectious Diseases, ScreenIT

    This article has 6 evaluationsAppears in 5 listsLatest version Latest activity
  8. Transferred mitochondria accumulate reactive oxygen species, promoting proliferation

    This article has 14 authors:
    1. Chelsea U Kidwell
    2. Joseph R Casalini
    3. Soorya Pradeep
    4. Sandra D Scherer
    5. Daniel Greiner
    6. Defne Bayik
    7. Dionysios C Watson
    8. Gregory S Olson
    9. Justin D Lathia
    10. Jarrod S Johnson
    11. Jared Rutter
    12. Alana L Welm
    13. Thomas A Zangle
    14. Minna Roh-Johnson
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript provides compelling evidence that macrophages transfer mitochondria to cancer cells and that transferred mitochondria stimulate proliferation in recipient cells. The usage an array of clever cell biology-based tools provides compelling evidence for these claims despite the difficulties associated with studying a relatively low probability event. Solid evidence supports the proposed model that transferred mitochondria induce proliferation by stimulating ERK signaling in a ROS dependent manner, although at present some aspects of the proposed model are incomplete. The work has broad significance for both mitochondrial biology and cancer biology as the authors show clear evidence of mitochondrial transfer in mouse models of human tumors.

    Reviewed by eLife, ASAPbio crowd review

    This article has 6 evaluationsAppears in 6 listsLatest version Latest activity
  9. DNMT3B PWWP mutations cause hypermethylation of heterochromatin

    This article has 16 authors:
    1. Francesca Taglini
    2. Ioannis Kafetzopoulos
    3. Kamila Irena Musialik
    4. Heng Yang Lee
    5. Yujie Zhang
    6. Mattia Marenda
    7. Lyndsay Kerr
    8. Hannah Finan
    9. Cristina Rubio-Ramon
    10. Hannah Wapenaar
    11. Hazel Davidson-Smith
    12. Jimi Wills
    13. Laura C. Murphy
    14. Ann Wheeler
    15. Marcus D. Wilson
    16. Duncan Sproul

    Reviewed by Review Commons, PREreview

    This article has 6 evaluationsAppears in 4 listsLatest version Latest activity
  10. Atlas of Plasmodium falciparum intraerythrocytic development using expansion microscopy

    This article has 9 authors:
    1. Benjamin Liffner
    2. Ana Karla Cepeda Diaz
    3. James Blauwkamp
    4. David Anaguano
    5. Sonja Frolich
    6. Vasant Muralidharan
    7. Danny W Wilson
    8. Jeffrey D Dvorin
    9. Sabrina Absalon
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study provides an unprecedented overview of the subcellular organization of proliferative blood stage malaria parasites using expansion microscopy. The localization of multiple parasite organelles is comprehensively probed using three-dimensional super-resolution microscopy throughout the entire intraerythrocytic development cycle. This work provides a compelling framework to investigate in future more deeply the unconventional cell biology of malaria-causing parasites.

    Reviewed by eLife, preLights, Life Science Editors

    This article has 11 evaluationsAppears in 6 listsLatest version Latest activity
  11. Dynamic allosteric networks drive adenosine A1 receptor activation and G-protein coupling

    This article has 2 authors:
    1. Miguel A Maria-Solano
    2. Sun Choi
    This article has been curated by 2 groups:
    • Curated by eLife

      eLife assessment

      The authors describe the dynamics underlying allostery of the adenosine A1 receptor, providing valuable insights into the receptor's activation pathway. The enhanced sampling molecular dynamics simulations of available structural data, followed by network analysis, reveal transient conformational states and communication between functional regions. The authors carefully state the limitations of their work, including the restricted convergence of the free energy landscape and missing water-mediated hydrogen bond coordination. Collectively, they provide a convincing framework for advancing rational design strategies of specific modulators with desired modes of action.

      [Editors' note: this was originally reviewed and assessed by Biophysics Colab]

    • Curated by Biophysics Colab

      Evaluation statement (16 June 2023)

      Maria-Solano and Choi present the dynamics underlying allostery of the adenosine A1 receptor, providing valuable insights into the receptor's activation pathway. The enhanced sampling molecular dynamics simulations of available structural data, followed by network analysis, reveal transient conformational states and communication between functional regions. The authors carefully state the limitations of their work, including the restricted convergence of the free energy landscape and missing water-mediated hydrogen bond coordination. Collectively, the findings provide a convincing framework to advance rational design strategies of specific modulators with desired modes of action.

      Biophysics Colab considers this to be a convincing study and recommends it to scientists interested in the structural dynamics, allosteric pathway activations, and free energy landscapes of GPCRs.

      (This evaluation by Biophysics Colab refers to version 5 of this preprint, which has been revised in response to peer review of versions 3 and 4.)

    Reviewed by eLife, Biophysics Colab

    This article has 5 evaluationsAppears in 7 listsLatest version Latest activity
  12. lncRNA H19/Let7b/EZH2 axis regulates somatic cell senescence

    This article has 5 authors:
    1. Manali Potnis
    2. Justin Do
    3. Olivia El Naggar
    4. Eishi Noguchi
    5. Christian Sell
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this manuscript, Sell et al., investigate the role of the long non-coding RNA H19 in regulating cellular senescence. Using several cell models they identify upstream and downstream effectors of H19 including let-7 and EZH2. The advances in this work include the identification of a specific cascade of factors connecting H19, senescence and the actions of rapamycin.

    Reviewed by eLife, ASAPbio crowd review

    This article has 4 evaluationsAppears in 5 listsLatest version Latest activity