Multiple group peer review and curation

PYCR1 Levels Track with Premature and Chronological Skin Aging

1. Kortessa Sotiropoulou
2. Saniye Yumlu
3. Tomoko Hirano
4. Michael Maier
5. Abigail Loh
6. Peh Fern Ong
7. Onn Siong Yim
8. Chunping Liu
9. Emmanuel Vial
10. Umut Altunoğlu
11. Sheela Nampoothiri
12. Deepthi de Silva
13. Björn Fischer-Zirnsak
14. Hülya Kayserili
15. Poh San Lai
16. Oliver Dreesen
17. Kenji Kabashima
18. Uwe Kornak
19. Nathalie Escande-Beillard
20. Bruno Reversade

• Curated by eLife

  eLife assessment

  This manuscript uses genetic mouse modeling to delve deeper into a rare human disease of aging. The targeted approaches employed lend greater pathophysiologic insight and makes this paper valuable to the field art large. Additionally, the approaches used are rigorous and solid in supporting their conclusions. Some minor weaknesses were noted along with suggestions to add greater clarity.

Reviewed by eLife, preLights

The unique synaptic circuitry of specialized olfactory glomeruli in Drosophila melanogaster

1. Lydia Gruber
2. Rafael Cantera
3. Markus William Pleijzier
4. Michael Steinert
5. Thomas Pertsch
6. Bill S. Hansson
7. Jürgen Rybak

• Curated by eLife

  eLife assessment

  This study seeks to determine how synaptic relationships between principal cell types in the olfactory system vary with glomerulus selectivity and is therefore valuable to the sub-field. The methodology is solid, but technical limitations require that claims regarding local interneurons be tempered as they were grouped with other neuron types for analyses, and with only one sample from each glomerulus, it is difficult to assess the import of differences between glomeruli without measures of inter-animal variability.

Reviewed by eLife, preLights

Multisensory gaze stabilization in response to subchronic alteration of vestibular type I hair cells

1. Louise Schenberg
2. Aïda Palou
3. François Simon
4. Tess Bonnard
5. Charles-Elliot Barton
6. Desdemona Fricker
7. Michele Tagliabue
8. Jordi Llorens
9. Mathieu Beraneck

• Curated by eLife

  eLife assessment

  This paper provides a fundamental expansion of vestibular compensation into transient and partial dysfunction, as well as insights into the adaptation of visual reflexes in this process. The conclusions are convincingly supported with paired histological and behavioral measurements, which are additionally modeled for further interpretation. This work would be of interest to neuroscientists working in multisensory integration and recovery mechanisms.

Reviewed by eLife, preLights

Anti-inflammatory therapy with nebulised dornase alfa for severe COVID-19 pneumonia

1. Joanna C. Porter
2. Jamie Inshaw
3. Vincente Joel Solis
4. Emma Denneny
5. Rebecca Evans
6. Mia I. Temkin
7. Nathalia De Vasconcelos
8. Iker Valle Aramburu
9. Dennis Hoving
10. Donna Basire
11. Tracey Crissell
12. Jesusa Guinto
13. Alison Webb
14. Hanif Esmail
15. Victoria Johnston
16. Anna Last
17. Thomas Rampling
18. Elisa Theresa Helbig
19. Lena Lippert
20. Florian Kurth
21. Bryan Williams
22. Aiden Flynn
23. Pauline T Lukey
24. Veronique Birault
25. Venizelos Papayannopoulos

• Curated by eLife

  eLife assessment

  This small-sized clinical trial comparing nebulized dornase-alfa to the best available care in patients hospitalized with COVID-19 pneumonia is valuable, but in its present form the paper is incomplete.

Reviewed by eLife, Rapid Reviews Infectious Diseases, ScreenIT

Citation needed? Wikipedia bibliometrics during the first wave of the COVID-19 pandemic

1. Omer Benjakob
2. Rona Aviram
3. Jonathan Aryeh Sobel

Reviewed by GigaScience, preLights, ScreenIT

Engineered RNA biosensors enable ultrasensitive SARS-CoV-2 detection in a simple color and luminescence assay

1. Anirudh Chakravarthy
2. Anirudh Nandakumar
3. Geen George
4. Shyamsundar Ranganathan
5. Suchitta Umashankar
6. Nishan Shettigar
7. Dasaradhi Palakodeti
8. Akash Gulyani
9. Arati Ramesh

Reviewed by Review Commons, ScreenIT, preLights

Implication of backward contact tracing in the presence of overdispersed transmission in COVID-19 outbreaks

1. Akira Endo
2. Centre for the Mathematical Modelling of Infectious Diseases COVID-19 Working Group
3. Quentin J. Leclerc
4. Gwenan M. Knight
5. Graham F. Medley
6. Katherine E. Atkins
7. Sebastian Funk
8. Adam J. Kucharski

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT, NCRC

A human coronavirus evolves antigenically to escape antibody immunity

1. Rachel T. Eguia
2. Katharine H. D. Crawford
3. Terry Stevens-Ayers
4. Laurel Kelnhofer-Millevolte
5. Alexander L. Greninger
6. Janet A. Englund
7. Michael J. Boeckh
8. Jesse D. Bloom

Reviewed by PREreview, ScreenIT, Review Commons

Tetherin antagonism by SARS‐CoV ‐2 ORF3a and spike protein enhances virus release

1. Hazel Stewart
2. Roberta Palmulli
3. Kristoffer H Johansen
4. Naomi McGovern
5. Ola M Shehata
6. George W Carnell
7. Hannah K Jackson
8. Jin S Lee
9. Jonathan C Brown
10. Thomas Burgoyne
11. Jonathan L Heeney
12. Klaus Okkenhaug
13. Andrew E Firth
14. Andrew A Peden
15. James R Edgar

Reviewed by Review Commons, Rapid Reviews Infectious Diseases, ScreenIT

Insights into household transmission of SARS-CoV-2 from a population-based serological survey

1. Qifang Bi
2. Justin Lessler
3. Isabella Eckerle
4. Stephen A. Lauer
5. Laurent Kaiser
6. Nicolas Vuilleumier
7. Derek A. T. Cummings
8. Antoine Flahault
9. Dusan Petrovic
10. Idris Guessous
11. Silvia Stringhini
12. Andrew S. Azman
13. SEROCoV-POP Study Group
14. Silvia Stringhini
15. Idris Guessous
16. Hélène Baysson
17. Prune Collombet
18. David De Ridder
19. Paola d’Ippolito
20. Matilde D’asaro-Aglieri Rinella
21. Yaron Dibner
22. Nacira El Merjani
23. Natalie Francioli
24. Marion Frangville
25. Kailing Marcus
26. Chantal Martinez
27. Natacha Noel
28. Francesco Pennacchio
29. Javier Perez-Saez
30. Dusan Petrovic
31. Attilio Picazio
32. Alborz Pishkenari
33. Giovanni Piumatti
34. Jane Portier
35. Caroline Pugin
36. Barinjaka Rakotomiaramanana
37. Aude Richard
38. Lilas Salzmann-Bellard
39. Stephanie Schrempft
40. Maria-Eugenia Zaballa
41. Zoé Waldmann
42. Ania Wisniak
43. Alioucha Davidovic
44. Joséphine Duc
45. Julie Guérin
46. Fanny Lombard
47. Manon Will
48. Antoine Flahault
49. Isabelle Arm Vernez
50. Olivia Keiser
51. Loan Mattera
52. Magdalena Schellongova
53. Laurent Kaiser
54. Isabella Eckerle
55. Pierre Lescuyer
56. Benjamin Meyer
57. Géraldine Poulain
58. Nicolas Vuilleumier
59. Sabine Yerly
60. François Chappuis
61. Sylvie Welker
62. Delphine Courvoisier
63. Laurent Gétaz
64. Mayssam Nehme
65. Febronio Pardo
66. Guillemette Violot
67. Samia Hurst
68. Philippe Matute
69. Jean-Michel Maugey
70. Didier Pittet
71. Arnaud G. L’Huillier
72. Klara M. Posfay-Barbe
73. Jean-François Pradeau
74. Michel Tacchino
75. Didier Trono

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT, NCRC

Structure of the complete, membrane-assembled COPII coat reveals a complex interaction network

1. Joshua Hutchings
2. Viktoriya G. Stancheva
3. Nick R. Brown
4. Alan C. M. Cheung
5. Elizabeth A. Miller
6. Giulia Zanetti

Reviewed by eLife, preLights

Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial

1. Sanjay Ramakrishnan
2. Dan V Nicolau
3. Beverly Langford
4. Mahdi Mahdi
5. Helen Jeffers
6. Christine Mwasuku
7. Karolina Krassowska
8. Robin Fox
9. Ian Binnian
10. Victoria Glover
11. Stephen Bright
12. Christopher Butler
13. Jennifer L Cane
14. Andreas Halner
15. Philippa C Matthews
16. Louise E Donnelly
17. Jodie L Simpson
18. Jonathan R Baker
19. Nabil T Fadai
20. Stefan Peterson
21. Thomas Bengtsson
22. Peter J Barnes
23. Richard E K Russell
24. Mona Bafadhel

Reviewed by Rapid Reviews Infectious Diseases, PREreview, ScreenIT

Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2-mRNA-vaccinated individuals

1. Talia Kustin
2. Noam Harel
3. Uriah Finkel
4. Shay Perchik
5. Sheri Harari
6. Maayan Tahor
7. Itamar Caspi
8. Rachel Levy
9. Michael Leshchinsky
10. Shifra Ken Dror
11. Galit Bergerzon
12. Hala Gadban
13. Faten Gadban
14. Eti Eliassian
15. Orit Shimron
16. Loulou Saleh
17. Haim Ben-Zvi
18. Elena Keren Taraday
19. Doron Amichay
20. Anat Ben-Dor
21. Dana Sagas
22. Merav Strauss
23. Yonat Shemer Avni
24. Amit Huppert
25. Eldad Kepten
26. Ran D. Balicer
27. Doron Netzer
28. Shay Ben-Shachar
29. Adi Stern

Reviewed by NCRC, Rapid Reviews Infectious Diseases, ScreenIT

BNT162b2 Vaccine‐Associated Myo/Pericarditis in Adolescents: A Stratified Risk‐Benefit Analysis

1. Allison Krug
2. Josh Stevenson
3. Tracy Beth Høeg

Reviewed by NCRC, ScreenIT

Transferred mitochondria accumulate reactive oxygen species, promoting proliferation

1. Chelsea U Kidwell
2. Joseph R Casalini
3. Soorya Pradeep
4. Sandra D Scherer
5. Daniel Greiner
6. Defne Bayik
7. Dionysios C Watson
8. Gregory S Olson
9. Justin D Lathia
10. Jarrod S Johnson
11. Jared Rutter
12. Alana L Welm
13. Thomas A Zangle
14. Minna Roh-Johnson

• Curated by eLife

  eLife assessment

  This manuscript provides compelling evidence that macrophages transfer mitochondria to cancer cells and that transferred mitochondria stimulate proliferation in recipient cells. The usage an array of clever cell biology-based tools provides compelling evidence for these claims despite the difficulties associated with studying a relatively low probability event. Solid evidence supports the proposed model that transferred mitochondria induce proliferation by stimulating ERK signaling in a ROS dependent manner, although at present some aspects of the proposed model are incomplete. The work has broad significance for both mitochondrial biology and cancer biology as the authors show clear evidence of mitochondrial transfer in mouse models of human tumors.

Reviewed by eLife, ASAPbio crowd review

DNMT3B PWWP mutations cause hypermethylation of heterochromatin

1. Francesca Taglini
2. Ioannis Kafetzopoulos
3. Kamila Irena Musialik
4. Heng Yang Lee
5. Yujie Zhang
6. Mattia Marenda
7. Lyndsay Kerr
8. Hannah Finan
9. Cristina Rubio-Ramon
10. Hannah Wapenaar
11. Hazel Davidson-Smith
12. Jimi Wills
13. Laura C. Murphy
14. Ann Wheeler
15. Marcus D. Wilson
16. Duncan Sproul

Reviewed by Review Commons, PREreview

Atlas of Plasmodium falciparum intraerythrocytic development using expansion microscopy

1. Benjamin Liffner
2. Ana Karla Cepeda Diaz
3. James Blauwkamp
4. David Anaguano
5. Sonja Frolich
6. Vasant Muralidharan
7. Danny W Wilson
8. Jeffrey D Dvorin
9. Sabrina Absalon

• Curated by eLife

  eLife assessment

  This important study provides an unprecedented overview of the subcellular organization of proliferative blood stage malaria parasites using expansion microscopy. The localization of multiple parasite organelles is comprehensively probed using three-dimensional super-resolution microscopy throughout the entire intraerythrocytic development cycle. This work provides a compelling framework to investigate in future more deeply the unconventional cell biology of malaria-causing parasites.

Reviewed by eLife, preLights, Life Science Editors

Dynamic allosteric networks drive adenosine A1 receptor activation and G-protein coupling

1. Miguel A Maria-Solano
2. Sun Choi

• Curated by eLife

  eLife assessment

  The authors describe the dynamics underlying allostery of the adenosine A1 receptor, providing valuable insights into the receptor's activation pathway. The enhanced sampling molecular dynamics simulations of available structural data, followed by network analysis, reveal transient conformational states and communication between functional regions. The authors carefully state the limitations of their work, including the restricted convergence of the free energy landscape and missing water-mediated hydrogen bond coordination. Collectively, they provide a convincing framework for advancing rational design strategies of specific modulators with desired modes of action.

  [Editors' note: this was originally reviewed and assessed by Biophysics Colab]

• Curated by Biophysics Colab

  Evaluation statement (16 June 2023)

  Maria-Solano and Choi present the dynamics underlying allostery of the adenosine A1 receptor, providing valuable insights into the receptor's activation pathway. The enhanced sampling molecular dynamics simulations of available structural data, followed by network analysis, reveal transient conformational states and communication between functional regions. The authors carefully state the limitations of their work, including the restricted convergence of the free energy landscape and missing water-mediated hydrogen bond coordination. Collectively, the findings provide a convincing framework to advance rational design strategies of specific modulators with desired modes of action.

  Biophysics Colab considers this to be a convincing study and recommends it to scientists interested in the structural dynamics, allosteric pathway activations, and free energy landscapes of GPCRs.

  (This evaluation by Biophysics Colab refers to version 5 of this preprint, which has been revised in response to peer review of versions 3 and 4.)

Reviewed by eLife, Biophysics Colab

lncRNA H19/Let7b/EZH2 axis regulates somatic cell senescence

1. Manali Potnis
2. Justin Do
3. Olivia El Naggar
4. Eishi Noguchi
5. Christian Sell

• Curated by eLife

  eLife Assessment

  In this manuscript, Sell et al., investigate the role of the long non-coding RNA H19 in regulating cellular senescence. Using several cell models they identify upstream and downstream effectors of H19 including let-7 and EZH2. The advances in this work include the identification of a specific cascade of factors connecting H19, senescence and the actions of rapamycin.

Reviewed by eLife, ASAPbio crowd review