Latest preprint reviews

  1. Spatiotemporal WNT and BMP gradients orchestrate regional enteroendocrine cell diversity along the Drosophila midgut

    This article has 3 authors:
    1. Jiaying Lv
    2. Xingting Guo
    3. Rongwen Xi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study is a comprehensive investigation into the regulatory mechanisms and regional distribution of enteroendocrine cell subtypes in the Drosophila midgut, significantly advancing the understanding of how WNT and BMP gradients contribute to EE diversity. The methodological foundation and robust genetic evidence are solid in supporting the key roles of compartment boundary signals, particularly WNT and BMP, in specifying EE subtypes and division modes. However, there is a lack of full mechanistic insight regarding Notch pathway involvement, incomplete quantification of phenotype data, and insufficient global pattern analysis, which detracts from fully supporting some proposed models. Overall, the study provides a platform for future work but would benefit from stronger data integration and expanded mechanistic exploration.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  2. Mediator Subunit MED16 Collaborates with UBP1-TFCP2 to Control Transcriptional Activation or Repression via Promoter Positional Specificity

    This article has 8 authors:
    1. Yuanming Zheng
    2. Xiaying Zhao
    3. Ming Yang
    4. Xinyi Yang
    5. Huanzhang Zhu
    6. Xiaofei Yu
    7. Qiang Zhou
    8. Gang Wang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The characterization of a dissociable Mediator subunit implicated in cellular pathways, particularly lung alveolar function and HIV latency, would be conceptually interesting. The authors have preliminary evidence for a stable Med16 subcomplex that may regulate specific genes. This work is useful in that it points to interactions between Med16 and UBP1, but the evidence is preliminary and incomplete.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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