eLife

Latest preprint reviews

1. Decoding molecular mechanisms for loss-of-function variants in the human proteome

   This article has 3 authors:

   1. Matteo Cagiada
   2. Nicolas Jonsson
   3. Kresten Lindorff-Larsen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work introduces FunC-ESMs, a proteome-scale framework to classify loss-of-function missense variants into distinct mechanistic groups by combining two complementary state-of-the-art machine learning models. The strength of evidence is convincing, supported by solid benchmarking, integration with experimental datasets, and careful methodological design. The significance of the findings is valuable, providing a resource of clear interest to researchers and diagnostic laboratories working on variant interpretation.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2023.04.06.535943

3. We couldn't get details of this article at this time:
   10.1101/2025.08.21.671501

4. Blocking Osteoprotegerin Reprograms Cancer Associated Fibroblast to Promotes Immune Infiltration into the Tumor Microenvironment

   This article has 12 authors:

   1. Yao Wang
   2. Hara Apostolopoulou
   3. Im Hong Sun
   4. Arjan Bains
   5. David Gibbs
   6. Sui Huang
   7. Tamara Alliston
   8. Ajay Maker
   9. Thea Tlsty
   10. Vasilis Ntranos
   11. James M Gardner
   12. Anil Bhushan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents an important finding by identifying OPG as a novel stromal checkpoint influencing T-cell anti-tumor responses, thereby shedding new light on the complex interplay between the tumor microenvironment and immune regulation. The data are robust and the experimental approaches are sound, providing solid support for the study's conclusions; however, there are a number of additional questions raised by the data. Of particular note are the questions raised on the mechanistic effects of TRAIL versus RANKL. In addition, it would broaden the interest in this study to include more translational human data to complement the work presented.

   Reviewed by eLife

5. We couldn't get details of this article at this time:
   10.1101/2024.12.16.628649

6. We couldn't get details of this article at this time:
   10.1101/2025.04.26.650775

7. A recursive pathway for isoleucine biosynthesis arises from enzyme promiscuity

   This article has 4 authors:

   1. Vittorio Rainaldi
   2. Stefano Donati
   3. Sarah D’Adamo
   4. Nico J Claassens

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study reports a potential pathway for isoleucine biosynthesis mediated by the underground activity of AHASII, which converts glyoxylate and pyruvate to 2-ketobutyrate. While the findings are valuable in revealing a possible alternative route for isoleucine production, the evidence presented remains incomplete. More comprehensive biochemical experiments are required to substantiate the physiological feasibility of this pathway.

   Reviewed by eLife

8. We couldn't get details of this article at this time:
   10.1101/2023.11.10.566531

9. We couldn't get details of this article at this time:
   10.1101/2025.08.26.672402

10. We couldn't get details of this article at this time:
    10.1101/2025.08.01.668170