Latest preprint reviews

  1. A stretching mechanism evokes mechano-electrical transduction in auditory chordotonal neurons

    This article has 4 authors:
    1. Atitheb Chaiyasitdhi
    2. Manuela Nowotny
    3. Marcel Van der Heijden
    4. Benjamin Warren
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study uses a sophisticated array of techniques to investigate the mechanisms through which the chordotonal receptors in the locust ear (Müller's organ) sense auditory signals. Ultrastructural reconstruction of the sensory organ provides convincing evidence of the organization of the scolopidial structure that wraps the sensory neuron cilium. However, the recordings of sound-evoked motion and electrophysiological activity from the chordotonal sensory neurons provide incomplete evidence for the proposed axial stretch model of mechanotransduction.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  2. Cataloguing the postnatal small intestinal transcriptome during the first postnatal month

    This article has 11 authors:
    1. Luiz Fernando Silva Oliveira
    2. Radhika S Khetani
    3. Yu-Syuan Wu
    4. Venkata Siva Dasuri
    5. Amanda W Harrington
    6. Oluwabunmi Olaloye
    7. Jeffrey Goldsmith
    8. David T Breault
    9. Liza Konnikova
    10. Shannan J Ho Sui
    11. Amy E O’Connell
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents a useful inventory of genes that are up- and down-regulated in the mouse small intestine (duodenum and ileum) during the first postnatal month; the data were collected and analyzed using solid and validated methodology and can be used as a starting point for additional validation of specific markers and for follow-up functional studies. Some aspects of the study were incomplete, with claims being only partially supported by the data, and it is suggested that additional validation be performed. The authors attempted to correlate gene expression changes with periods of high and low NEC susceptibility, but these correlations are speculative and not supported by functional follow-up studies. Discussion of gene expression changes with NEC susceptibility would be more appropriate to include in the Discussion section and to be tempered in the results section.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Time-adaptive modulation of evidence evaluation in rat posterior parietal cortex

    This article has 6 authors:
    1. Preetham Ganupuru
    2. Adam B Goldring
    3. Tanner Stevenson
    4. Kendall Stewart
    5. Rishidev Chaudhuri
    6. Timothy D Hanks
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study examined the roles of the posterior parietal cortex in rats performing an auditory change-detection decision task. It provided solid evidence for two subpopulations with opposing modulation patterns during decision formation and for a correspondence between neural and behavioral measures of the short timescale used for evidence evaluation.

    Reviewed by eLife

    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
  4. Twice as nice: Boosts in adolescent reinforcement learning from Pavlovian bias and age-related prioritization of reward-motivated incidental memory

    This article has 2 authors:
    1. Haley Hegefeld
    2. Juliet Y Davidow
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable developmental study provides intriguing but incomplete evidence suggesting that, relative to adults, the enhancement of instrumental learning by Pavlovian bias is most pronounced in adolescence, while reward-induced memory enhancements are strongest in childhood. Although the authors tackle a key aspect of learning and motivation with rigorous experimental methods and sophisticated modeling techniques, there are substantial concerns about the absence of relevant analyses, the lack of accord between model-based and exploratory analyses, and the lack of an explanation for how the results cohere with inconsistent findings in the literature.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  5. Subtle methodological variations substantially impact correlation test results in ecological time series

    This article has 4 authors:
    1. Caroline Cannistra
    2. Linh Hoang
    3. Alex E Yuan
    4. Wenying Shou
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents a valuable in-depth comparison of statistical methods for the analysis of ecological time series data, and shows that different analyses can generate different conclusions, emphasizing the importance of carefully choosing methods and of reporting methodological details. The evidence supporting the claims, based on simulated data for a two-species ecosystem, is solid, although testing on more complex datasets could be of further benefit. This paper should be of broad interest to researchers in ecology.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
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