eLife

Latest preprint reviews

1. A neuromorphic model of active vision shows how spatiotemporal encoding in lobula neurons can aid pattern recognition in bees

   This article has 6 authors:

   1. HaDi MaBouDi
   2. Mark Roper
   3. Marie-Geneviève Guiraud
   4. Mikko Juusola
   5. Lars Chittka
   6. James AR Marshall

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Inspired by bee's visual behavior, the goal of the manuscript is to develop a model of visual scanning, visual processing and learning to recognize visual patterns. In this model, pre-training with natural images leads to the formation of spatiotemporal receptive fields that can support associative learning. Due to an incomplete test of the necessity and sufficiency of the features included in the model, it cannot be concluded that the model is either the "minimal circuit" or the most biologically plausible circuit of this system. With a more in-depth analysis, the work has the potential of being important and very valuable to both experimental and computational neurobiologists.

   Reviewed by eLife

2. The oocyte zinc transporter Slc39a10/Zip10 is a regulator of zinc sparks during fertilization in mice

   This article has 12 authors:

   1. Atsuko Kageyama
   2. Narumi Ogonuki
   3. Takuya Wakai
   4. Takafumi Namiki
   5. Yui Kawata
   6. Manabu Ozawa
   7. Yasuhiro Yamada
   8. Toshiyuki Fukada
   9. Atsuo Ogura
   10. Rafael Fissore
   11. Naomi Kashiwazaki
   12. Junya Ito

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents significant and novel insights into the roles of zinc in mammalian meiosis/fertilization events. These findings are useful to our understanding of these processes. The evidence presented is solid, with experiments being well-designed, carefully described, and interpreted with appropriate rigor. The authors acknowledge the lack of mechanistic insight which represents the main limitation of the study.

   Reviewed by eLife

3. Occupancy of the HbYX hydrophobic pocket is sufficient to induce gate opening in the archaeal 20S proteasomes

   This article has 3 authors:

   1. Janelle JY Chuah
   2. Madalena R Daugherty
   3. David M Smith

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable manuscript describes cryo-EM structures of archaeal proteasomes that reveal insights into how occupancy of binding pockets on the 20S proteasome regulates proteasome gating. The evidence supporting these claims is convincing, although the extrapolation of these findings to the more complex eukaryotic proteasome may prove challenging. This work will be of high interest to researchers interested in proteasome structure and regulation.

   Reviewed by eLife

4. Dorsoventral-mediated Shh induction is required for axolotl limb regeneration

   This article has 5 authors:

   1. Sakiya Yamamoto
   2. Saya Furukawa
   3. Ayaka Ohashi
   4. Mayuko Hamada
   5. Akira Satoh

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental work by Yamamoto and colleagues advances our understanding of how positional information is coordinated between axes during limb outgrowth and patterning. They provide convincing evidence that the dorsal-ventral axis feeds into anterior-posterior signaling, and identify the responsible molecules by combining transplantations with molecular manipulations. This work will be of broad interest to regeneration, tissue engineering, and evolutionary biologists.

   Reviewed by eLife

5. Lineage priming and cell type proportioning depends on the interplay between stochastic and deterministic factors

   This article has 7 authors:

   1. William M Salvidge
   2. Chris Brimson
   3. Nicole Gruenheit
   4. Li-Yao Huang
   5. Catherine J Pears
   6. Jason B Wolf
   7. Christopher RL Thompson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study shows how stochastic and deterministic factors are integrated in Dictyostelium discoideum to reliably drive determination of distinct cell types despite exposure to nearly identical environmental conditions. The authors present convincing evidence that gene expression variability contributes to the robustness of cell fate decisions, which reveals an unexpected role of stochasticity during cell differentiation.

   Reviewed by eLife

6. Uev1A counteracts oncogenic Ras stimuli in both polyploid and diploid cells

   This article has 13 authors:

   1. Qi Zhang
   2. Yunfeng Wang
   3. Xueli Fu
   4. Ziguang Wang
   5. Yang Zhang
   6. Lizhong Yan
   7. Yuejia Wang
   8. Muhan Yang
   9. Dongze Song
   10. Ruixing Zhang
   11. Hongru Zhang
   12. Shian Wu
   13. Shaowei Zhao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study examines the role of E2 ubiquitin enzyme, Uev1a in tissue resistance to oncogenic RasV12 in Drosophila melanogaster polyploid germline cells and human cancer cell lines. The solid evidence suggests that Uev1a works with the E3 ligase APC/C to degrade Cyclin A. This work would be of interest to researchers in germline biology and cancer.

   Reviewed by eLife

7. Structure of an oxygen-induced tubular nanocompartment in Pyrococcus furiosus

   This article has 11 authors:

   1. Wenfei Song
   2. Jan Fiala
   3. Ioannis Skalidis
   4. Pascal Albanese
   5. Constantinos Patinios
   6. Marten L Chaillet
   7. Servé WM Kengen
   8. Richard A Scheltema
   9. Stuart C Howes
   10. Albert JR Heck
   11. Friedrich Förster

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Using advanced CryoEM and mass spectrometry, the authors provide compelling evidence of how tubule formation occurs in an oxygen-dependent manner. These fundamental findings offer a novel mechanism by which rubrerythrin tubules encapsulate encapsulin to prevent oxidative stress in Pyrococcus furiosus. However, there are a few reasonable concerns about biochemical validations and the lack of adequate description of results and methodology.

   Reviewed by eLife

8. The denitrosylase SCoR2 controls cardioprotective metabolic reprogramming

   This article has 12 authors:

   1. Zachary W Grimmett
   2. Rongli Zhang
   3. Hua-Lin Zhou
   4. Qiuying Chen
   5. Dawson Miller
   6. Zhaoxia Qian
   7. Justin Lin
   8. Riti Kalra
   9. Steven S Gross
   10. Walter J Koch
   11. Richard T Premont
   12. Jonathan S Stamler

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides new and interesting findings that SCoR2 acts as a denitrosylase to control cardioprotective metabolic reprogramming and prevent injury following ischemia/reperfusion. The compelling evidence is supported by a novel multi-omics approach, but questions remain regarding the stability and human relevance of BDH1 as well as the sufficiency of SCoR2. Overall, the work will be of interest to cardiovascular researchers and provides valuable information to the field, though some mechanistic aspects require further clarification.

   Reviewed by eLife

9. SVEP1 enables efficient binding of Angiopoietin-2 to the TIE1 receptor, allowing receptor phosphorylation and downstream signaling

   This article has 9 authors:

   1. Katharina Uphoff
   2. Melina Hußmann
   3. Dörte Schulte-Ostermann
   4. Yvonne Huisman
   5. Matthias Mörgelin
   6. Fabian Metzen
   7. J Fernando Bazan
   8. Manuel Koch
   9. Stefan Schulte-Merker

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript focuses on developing a structural model of how the multidomain ECM protein SVEP1 enables Angiopoietin (ANG) binding to the orphan receptor TIE1, resulting in downstream receptor phosphorylation and signaling. This is a potentially important study, however, it currently lacks key controls and is therefore incomplete. The data will be of interest to scientists working in vascular biology and RTK signaling.

   Reviewed by eLife

10. High-throughput neutralization measurements correlate strongly with evolutionary success of human influenza strains

    This article has 13 authors:

    1. Caroline Kikawa
    2. Andrea N Loes
    3. John Huddleston
    4. Marlin D Figgins
    5. Philippa Steinberg
    6. Tachianna Griffiths
    7. Elizabeth M Drapeau
    8. Heidi Peck
    9. Ian Barr
    10. Janet A Englund
    11. Scott E Hensley
    12. Trevor Bedford
    13. Jesse D Bloom

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This fundamental study advances our understanding of population-level immune responses to influenza in both children and adults. The strength of the evidence supporting the conclusions is compelling, with high-throughput profiling assays and mathematical modeling. The work will be of interest to immunologists, virologists, vaccine developers, and those working on mathematical modeling of infectious diseases.

    Reviewed by eLife