eLife

Latest preprint reviews

1. Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma

   This article has 14 authors:

   1. Olivia G Waltner
   2. April A Apfelbaum
   3. Emma D Wrenn
   4. Shruti S Bhise
   5. Sami B Kanaan
   6. Rula Green Gladden
   7. Mark A Mendoza
   8. Roger Volden
   9. Zev Kronenberg
   10. Anand Patel
   11. Michael Dyer
   12. Jay F Sarthy
   13. Elizabeth R Lawlor
   14. Scott N Furlan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study presents an analysis of the gene regulatory networks that contribute to tumour heterogeneity and tumor plasticity in Ewing sarcoma, with key implications for other fusion-driven sarcomas. The authors employed compelling orthogonal approaches, including single-cell sequencing and xenografts, to reveal the existence and plasticity of specific gene regulatory networks (e.g., TGF-beta signaling) within Ewing sarcoma, as well as significant differences that exist between cell lines and patient tumors.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2025.07.14.664740

3. Hepatic Transthyretin knockdown alleviates NAFLD by enhancing SERCA2 function and inhibiting endoplasmic reticulum stress

   This article has 7 authors:

   1. Yingzi He
   2. Tian Yang
   3. Ruojun Qiu
   4. Bingyang Liu
   5. Shuo Wang
   6. Jianan Wang
   7. Fenping Zheng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This potentially important study examines the consequences of manipulating the expression of thyroxine-binding and amyloidogenic hepatocyte secretory protein transthyretin (TTR). Solid in vivo evidence from two dietary models supports that TTR production exacerbates liver injury, whereas the evidence for a link between TTR production, uptake, and calcium dysregulation is incomplete. If the findings are confirmed, they would provide evidence for a novel cell biological pathway of liver injury.

   Reviewed by eLife

4. Cholinergic blockade reveals a role for human hippocampal theta in memory encoding but not retrieval

   This article has 6 authors:

   1. Tamara Gedankien
   2. Jennifer Kriegel
   3. Erfan Zabeh
   4. David McDonagh
   5. Bradley Lega
   6. Joshua Jacobs

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental work advances our understanding of the role of human hippocampal theta oscillations in memory encoding and retrieval. The evidence supporting the conclusions is convincing, using both scopolamine administration and intracranial EEG recordings. This work will be of broad interest to neuroscientists and has translational implications.

   Reviewed by eLife

5. We couldn't get details of this article at this time:
   10.1101/2024.12.03.626629

6. We couldn't get details of this article at this time:
   10.1101/2024.06.01.596932

7. We couldn't get details of this article at this time:
   10.1101/2025.10.15.682734

8. Evolutionary remodeling of non-canonical ORF translation in mammals

   This article has 7 authors:

   1. Yue Chang
   2. Tianyu Lei
   3. Feng Zhou
   4. Jiawen Jiang
   5. Yu Huang
   6. Ziyang Zhu
   7. Hong Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a large, systematically curated catalog of non-canonical open reading frames (ncORFs) in human and mouse through the reanalysis of nearly 400 Ribo-seq datasets using a standardized pipeline; the resulting atlas consolidates ncORF annotations across tissues and provides a valuable resource for investigating non-canonical translation and ORF emergence. The main conclusions are supported by consistent data processing and multiple computational measures of translation and conservation. While the pipeline is transparent and technically robust, some analytical criteria and dataset limitations could be described more explicitly, and several downstream conclusions would benefit from more cautious interpretation, some evolutionary inferences are primarily correlative; dataset heterogeneity, uneven tissue representation, and limited experimental validation also constrain the strength of a subset of the findings. Overall, the evidence is solid, and the resource is likely to be broadly beneficial to the community.

   Reviewed by eLife, Arcadia Science

9. Distinct brain mechanisms support trust violations, belief integration, and bias in human-AI teams

   This article has 5 authors:

   1. Luisa Roeder
   2. Pamela Hoyte
   3. Graham Kerr
   4. Peter Bruza
   5. Johan N van der Meer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a useful investigation of human-AI interaction and decision-making, using both behavioral and electrophysiological measures. However, the theoretical framework and experimental design are incomplete, with an unclear task structure and feedback implementation limiting interpretability. With these issues addressed, the work could make a significant contribution to understanding human-AI collaboration.

   Reviewed by eLife

10. We couldn't get details of this article at this time:
    10.1101/2023.10.26.564294