eLife

Latest preprint reviews

1. PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation

   This article has 17 authors:

   1. Shiyi Wang
   2. Ryan Baumert
   3. Gabrielle Séjourné
   4. Dhanesh Sivadasan Bindu
   5. Kylie Dimond
   6. Kristina Sakers
   7. Leslie Vazquez
   8. Jessica L Moore
   9. Christabel Xin Tan
   10. Tetsuya Takano
   11. Maria Pia Rodriguez
   12. Nick Brose
   13. Luke Bradley
   14. Reed Lessing
   15. Scott H Soderling
   16. Albert R La Spada
   17. Cagla Eroglu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study identifies astrocyte-intrinsic mechanisms by which the LRRK2 G2019S, a mutation linked to familial Parkinson's disease, disrupts synaptic integrity in the anterior cingulate cortex. The findings are convincing, as they rely on a comprehensive set of in vivo and in vitro genetic, biochemical, proteomic, and electrophysiological approaches. They are important because of their translational value, being validated in both mouse models and post-mortem human samples.

   Reviewed by eLife

2. Humans underestimate their body mass in microgravity: evidence from reaching movements during spaceflight

   This article has 8 authors:

   1. Zhaoran Zhang
   2. Yu Tian
   3. Chunhui Wang
   4. Changhua Jiang
   5. Bo Wang
   6. Hongqiang Yu
   7. Rui Zhao
   8. Kunlin Wei

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper undertakes an important investigation to determine whether movement slowing in microgravity is due to a strategic conservative approach or rather due to an underestimation of the mass of the arm. The experimental dataset is unique, the coupled experimental and computational analyses comprehensive, and the effect is strong. However, the authors present incomplete results to support the claim that movement slowing is due to mass underestimation. Further analysis is needed to rule out alternative explanations.

   Reviewed by eLife

3. Development of Auditory and Spontaneous Movement Responses to Music over the First Postnatal Year

   This article has 8 authors:

   1. Trinh Nguyen
   2. Félix Bigand
   3. Susanne Reisner
   4. Atesh Koul
   5. Roberta Bianco
   6. Gabriela Markova
   7. Stefanie Hoehl
   8. Giacomo Novembre

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This well-designed study offers important insights into the development of infants' responses to music based on the exploration of EEG neural auditory responses and video-based movement analysis. The compelling results revealed that evoked responses emerge between 3 and 12 months of age, but no age group demonstrated evidence of coordinated movements to music. This study will be of significant interest to developmental psychologists and neuroscientists, as well as researchers interested in music processing and in the translation of perception into action.

   Reviewed by eLife

4. Hippocampal single-cell RNA Atlas of chronic methamphetamine abuse-induced cognitive decline in mice

   This article has 6 authors:

   1. Hai Qiu
   2. Xia Yue
   3. Yuebing Huang
   4. Ziling Meng
   5. Jiahong Wang
   6. Dongfang Qiao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors proposed two hypotheses: first, that methamphetamine induces neuroinflammation, and second, that it alters neuronal stem cell differentiation. These are valuable hypotheses, and the authors provided in vivo observations of the methamphetamine response in mice. However, concerns remain regarding the interpretation of the data, and the current evidence is incomplete, requiring substantial experimental validation.

   Reviewed by eLife

5. A cortical–hippocampal communication undergoes rebalancing after new learning

   This article has 2 authors:

   1. Arron F Hall
   2. Dong V Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study investigates the neural basis of bidirectional communication between the cortex and hippocampus during learning. The evidence supporting the identification of specific circuits and functional cell types involved is convincing. However, certain aspects of the behavioral analysis and statistical interpretation remain incomplete. Overall, the work will be of interest to neuroscientists studying learning and memory.

   Reviewed by eLife

6. Unreliable homeostatic action potential broadening in cultured dissociated neurons

   This article has 16 authors:

   1. Andreas Ritzau-Jost
   2. Salil Rajayer
   3. Jana Nerlich
   4. Filip Maciag
   5. Alexandra John
   6. Michael Russier
   7. Victoria Gonzalez Sabater
   8. Luke J Steiger
   9. Jacques-Olivier Coq
   10. Jens Eilers
   11. Maren Engelhardt
   12. Juan Burrone
   13. Dominique Debanne
   14. Martin Heine
   15. Stephen M Smith
   16. Stefan Hallermann

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides compelling evidence that action potential (AP) broadening is not a universal feature of homeostatic plasticity in response to chronic activity deprivation. By leveraging state-of-the-art methods across multiple brain regions and laboratories, the authors demonstrate that AP half-width remains largely stable, challenging previous assumptions in the field. These important findings help resolve longstanding inconsistencies in the literature and significantly advance our understanding of neuronal network homeostasis.

   Reviewed by eLife

7. Glycosylated IgG antibodies contribute to the recovery of haemorrhagic fever with renal syndrome patients

   This article has 15 authors:

   1. Chuansong Quan
   2. Lu Wang
   3. Jiming Gao
   4. Yaoni Li
   5. Xiaoyu Xu
   6. Houqiang Li
   7. Zixuan Gao
   8. Wenxu Ruan
   9. Hongzhi Liu
   10. Qian Li
   11. Weijia Xing
   12. Liqiong Zhao
   13. Michael J Carr
   14. Weifeng Shi
   15. Haifeng Hou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors investigated the potential role of IgG N-glycosylation in Haemorrhagic Fever with Renal Syndrome (HFRS), which may offer significant insights for understanding molecular mechanisms and for the development of therapeutic strategies for this infectious disease. The findings are valuable to the field and the strength of evidence to support the findings is solid.

   Reviewed by eLife

8. C. elegans food choice exhibits effort discounting-like behavior

   This article has 6 authors:

   1. Jonathan RM Millet
   2. Serge Faumont
   3. Aaron B Schatz
   4. Amanda M White
   5. Kathy D Chicas-Cruz
   6. Shawn R Lockery

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work develops the C. elegans as a model organism for studying effort-based discounting by asking the worms to choose between patches of easy and hard to digest bacteria. The authors provide convincing evidence that the nematodes are effort discounting. They also provide solid evidence of involvement of dopamine in the food preference and that the finding is not restricted to lab-acclimated strains.

   Reviewed by eLife

9. The self-interest of adolescents overrules cooperation in social dilemmas

   This article has 7 authors:

   1. Xiaoyan Wu
   2. Hongyu Fu
   3. Gökhan Aydogan
   4. Chunliang Feng
   5. Shaozheng Qin
   6. Yi Zeng
   7. Chao Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work investigates cooperative behaviors in adolescents using a repeated Prisoner's Dilemma game. The approach used in the study is solid. The impact of this work could be further enhanced with more rigorous modelling procedures and more modeling selection/comparison details, as well as by framing the findings in terms of the specific game-theoretic context, rather than general cooperation. Findings from this study will be of interest to developmental psychologists, economists, and social psychologists.

   Reviewed by eLife

10. Inducible, virus-free direct lineage reprogramming enhances scalable generation of human inner ear hair cell-like cells

    This article has 11 authors:

    1. Robert N Rainey
    2. Sam D Houman
    3. Louise Menendez
    4. Ryan Chang
    5. Litao Tao
    6. Helena Bugacov
    7. Andrew P McMahon
    8. Radha Kalluri
    9. John S Oghalai
    10. Andrew K Groves
    11. Neil Segil

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      The findings of this important study substantially advance our understanding of the transcription factors that can induce hair cell-like cells from human pluripotent stem cells. The presented evidence supporting these findings is compelling, including rigorous characterization of the effects of hair cell induction using both single-cell RNA sequencing and electrophysiological assessments.

    Reviewed by eLife