eLife

Latest preprint reviews

1. E(spl)m4 Directly Antagonizes Traf4 to Inhibit JNK Signaling in Drosophila

   This article has 6 authors:

   1. Katrin Strobel
   2. Jennifer Falconi
   3. Cédric Leyrat
   4. Rémi Logeay
   5. Sarah J Bray
   6. Alexandre Djiane

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors identify the Bearded-type small protein E(spl)m4 as a physical and genetic interactor of TRAF4 in the Drosophila wing disc. These valuable findings with potential biomedical relevance are, however, supported by incomplete evidence based largely on overexpression studies that lack quantification, limited molecular support for their model, and issues with Bearded family protein specificity. The work could be of interest to researchers in the fields of cell signaling and developmental biology.

   Reviewed by eLife

2. Determining fragility and robustness to missing data in binary outcome meta-analyses, illustrated with conflicting associations between vitamin D and cancer mortality

   This article has 1 author:

   1. David Robert Grimes

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript makes a valuable contribution to the concept of fragility of meta-analyses via the so-called 'ellipse of insignificance for meta-analyses' (EOIMETA). The strength of evidence is convincing, supported primarily by an example of the fragility of meta-analyses in the association between Vitamin D supplementation and cancer mortality, but the approach could be applied in other meta-analytic contexts. The significance of the work could be enhanced with a more thorough assessment of the impact of between-study heterogeneity, additional case studies, and improved contextualization of the proposed approach in relation to other methods.

   Reviewed by eLife

3. Dark matter of an orchid: metagenome of the microbiome associated with the rhizosphere of Dactylorhiza traunsteineri

   This article has 8 authors:

   1. Gabriel A Vignolle
   2. Leopold Zehetner
   3. Christian Zimmerman
   4. Domenico F Savio
   5. Ovidiu Paun
   6. Robert L Mach
   7. Astrid R Mach-Aigner
   8. Julien Charest

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a useful overview of the taxonomic composition of the microbiome associated with Dactylorhiza traunsteineri, a widely distributed orchid species in Central Europe. The evidence supporting the claims of the authors is incomplete, especially when it comes to the (secondary) metabolic pathways found in the metagenome assembled genomes, and requires more substantial analysis to be able to claim that these pathways play a key role in microbiome-orchid symbiosis.

   Reviewed by eLife

4. We couldn't get details of this article at this time:
   10.1101/2025.09.26.678483

5. An interneuronal CRH and CRHBP circuit stabilizes birdsong performance

   This article has 2 authors:

   1. Bradley M Colquitt
   2. Michael S Brainard

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a useful study that examines the relationship between neuropeptide signaling and the precision of vocal motor output using the songbird as a model system. The study presents evidence based on differential expression patterns and genetic or pharmacological inhibition of various neuropeptide genes for a causal role in song performance; however, this evidence is incomplete.

   Reviewed by eLife

6. Candida albicans drives colorectal cancer progression by inducing hypoxia signaling

   This article has 11 authors:

   1. Wanqiu Wang
   2. Mengqi Yang
   3. Fanglei Gong
   4. Zhenyu Zhang
   5. Yanping Ma
   6. Haihuang Li
   7. Yu Zhao
   8. Changzheng Du
   9. Ningning Li
   10. Guiwei He
   11. Kun Sun

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study examines the role of the fungal pathogen Candida albicans in the progression of colorectal cancer, a relevant and urgent topic given the global incidence of colon cancer. While the findings are useful and provide solid experimental work and insight into how Candida may contribute to tumor progression, the small patient sample size, reliance on in vitro models, and absence of in vivo validation may limit its impact. This work will interest scientists studying cancer progression and the role played by pathogens.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2025.10.02.680041

8. We couldn't get details of this article at this time:
   10.1101/2025.09.12.675753

9. We couldn't get details of this article at this time:
   10.1101/2025.09.10.675311

10. We couldn't get details of this article at this time:
    10.1101/2025.09.07.674776