Latest preprint reviews

  1. Microbiota impact Drosophila ageing via Acetobacter, Tachykinin, and TkR99D

    This article has 7 authors:
    1. Diana Marcu
    2. David R Sannino
    3. Anthony J Dornan
    4. Rita Ibrahim
    5. Atharv Kapoor
    6. Miriam Wood
    7. Adam J Dobson
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study demonstrates that in Drosophila melanogaster, tachykinin (Tk) expression is regulated by the microbiota. The authors present convincing evidence that axenic flies raised with no microbiota are longer-lived than conventionally reared animals, and that Tk expression and Tk receptors in the nervous system are required for this effect. They further test individual bacterial strains for their role in these effects and connect the effect to loss of lipid stores and suggest that FOXO may be involved in the phenotype, results that are of interest to the fields of environmental perception, host microbiome interactions, and geroscience.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    This article has 9 evaluationsAppears in 2 listsLatest version Latest activity
  2. Adaptation of endothelial cells to microenvironment topographical cues through lysyl oxidase like-2-mediated basement membrane scaffolding

    This article has 17 authors:
    1. Marion F Marchand
    2. Noémie Brassard-Jollive
    3. Claire Leclech
    4. Jorge Barrasa-Fano
    5. Yoann Atlas
    6. Claudia Umana-Diaz
    7. Apeksha Shapeti
    8. Corinne Ardidie-Robouant
    9. Tristan Piolot
    10. Sabrina Martin
    11. Philippe Mailly
    12. Christophe Guilluy
    13. Abdul I Bakarat
    14. Catherine Monnot
    15. Hans Van Oosterwyck
    16. Stéphane Germain
    17. Laurent Muller
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents important findings describing the early assembly of vascular basement membrane and how vascular cells switch from responding to cues provided by the external environment to those provided by self-assembled basement membrane. The evidence supporting the claims of the authors is convincing, with state-of-the-art microscopy and several different culture conditions examined. The work will be of interest to cell biologists studying the ECM, vascular development, as well as medical scientists focused on diseases that depend on vascular growth.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Loss of the s2U tRNA modification induces antibiotic tolerance and is linked to changes in ribosomal protein expression

    This article has 5 authors:
    1. Katherine L Cotten
    2. Abigail McShane
    3. Peter C Dedon
    4. Thomas J Begley
    5. Kimberly M Davis
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This fundamental work examines how tRNA modifications influence antibiotic tolerance, providing novel insights that may have therapeutic uses. The evidence supporting the conclusions is convincing. Strengths of the manuscript include the mechanism of tRNA modification influencing antibiotic tolerance and the precise measurement techniques used throughout. Further analysis of growth rate impacts and specific identification of the proteins responsible for the effect would further strengthen the manuscript.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
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