eLife

Latest preprint reviews

1. Cell-cycle-resolved Hi-C reveals unexpected plasticity of A/B compartments across interphase

   This article has 7 authors:

   1. Linda Choubani
   2. Hisashi Miura
   3. Takako Ichinose
   4. Asami Oji
   5. Saori Takahashi
   6. Rory T Cerbus
   7. Ichiro Hiratani

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript provides valuable insight into how genome organization changes as cells progress through the cell cycle after mitotic exit, identifying two sharp genome remodeling events at G1-S and to a lesser extent, at S-G2 transitions. The conclusions are supported by solid, rigorous data, including sequencing and orthogonal imaging data. The use of sorted unsynchronized cells rather than cells treated with drugs is a particular strength.

   Reviewed by eLife

2. Jam2 Signaling Functions Downstream of Hand2 To Initiate The Formation Of Organ-Specific Vascular Progenitors In Zebrafish

   This article has 7 authors:

   1. Martyna Griciunaite
   2. Julius Martinkus
   3. Sanjeeva Metikala
   4. Ricardo DeMoya
   5. Suman Gurung
   6. Diandra Rufin Florat
   7. Saulius Sumanas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study addresses the question of how organ-specific blood vessels form during different stages of development, and how specific genes may regulate these processes. New genetic tools were developed to label distinct endothelial cell populations and track them over time in different mutant backgrounds. The results are solid; however, additional data quantification, lineage tracing, and cell autonomy experiments would further strengthen the conclusions.

   Reviewed by eLife

3. AT-HOOK-MOTIF NUCLEAR LOCALIZED 15 extends plant longevity by binding at poorly accessible, epigenetic mark-depleted chromatin that surrounds transcribed regions

   This article has 3 authors:

   1. Thalia Luden
   2. Jihed Chouaref
   3. Remko Offringa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents an important study into the molecular function of AT-HOOK MOTIF NUCLEAR LOCALIZED 15 (AHL15), a member of the AHL protein family, identifying it as a potential regulator of three-dimensional gene-loop organization within transcribed gene bodies. The authors support this claim with compelling genome-wide evidence, integrating AHL15 binding profiles with transcriptional and chromatin accessibility changes, as well as demonstrating overlap with genes known to form loops across transcribed regions. The evidence supporting the claims of the authors is solid. Collectively, these findings will be of broad interest to biologists seeking to understand the core regulatory mechanisms underlying gene expression.

   Reviewed by eLife

4. We couldn't get details of this article at this time:
   10.1101/2023.09.11.557269

5. Energy Landscape Analysis Reveals Thalamic Modulation of Brain State Transitions During Movie Watching

   This article has 9 authors:

   1. Qiuyi Liu
   2. Lili Sun
   3. Xinyi Zhao
   4. Wenbin Qu
   5. Jiaqi Zhou
   6. Ziang Wang
   7. Kaizhou Li
   8. Huiting Lei
   9. Xia Liang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study investigated the dynamics of human cortical network activity with functional magnetic resonance imaging during movie watching and studied the modulation of these dynamics by subcortical areas using an energy landscape mapping method. The authors identified a set of brain states defined at the level of canonical functional networks, quantified how the brain transitions between these states, and related transition probabilities to inter-subject correlations in evoked brain activity. A major emphasis of the work concerns the role of the thalamus, which shows transition-linked activity changes and dynamic connectivity patterns, including differential involvement of parvalbumin- and calbindin-associated thalamic subdivisions. The analytical strategy developed in this study is applicable to other task- and resting-state fMRI data and would be useful for many researchers in the field; however, the evidence supporting the overall conclusions remains incomplete due to limitations associated with fMRI data preprocessing, analysis, and cross-validation.

   Reviewed by eLife

6. We couldn't get details of this article at this time:
   10.1101/2025.07.31.667981

7. Identifying tissue states by spatial protein patterns related to chemotherapy response in triple-negative breast cancer

   This article has 11 authors:

   1. Luciana M Luque
   2. Mohammad Asif Khan
   3. Giuseppe Torrisi
   4. Tessa D Green
   5. David Hardman
   6. Claudia Owczarek
   7. Tom A Phillips
   8. Debora S Marks
   9. Maddy Parsons
   10. Chris Sander
   11. Linus J Schumacher

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important work implementing data mining methods on IMC data to discover spatial protein patterns related to the triple-negative breast cancer patients' chemotherapy response. The evidence supporting the claims of the authors is solid, although more detailed methodology clarification and validation are needed. While the accuracy of the methods is not very high, the work shows potential for translational application.

   Reviewed by eLife

8. We couldn't get details of this article at this time:
   10.1101/2025.06.25.661618

9. We couldn't get details of this article at this time:
   10.1101/2025.07.29.667240

10. We couldn't get details of this article at this time:
    10.1101/2025.07.28.666781