eLife

Latest preprint reviews

1. Domain-adaptive matching bridges synthetic and in vivo neural dynamics for neural circuit connectivity inference

   This article has 10 authors:

   1. Kaiwen Sheng
   2. Shanghang Zhang
   3. Shenjian Zhang
   4. Yutao He
   5. Maxime Beau
   6. Peng Qu
   7. Xiaofei Liu
   8. Youhui Zhang
   9. Lei Ma
   10. Kai Du

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This article reports an algorithm for inferring the presence of synaptic connection between neurons based on naturally occurring spiking activity of a neuronal network. One key improvement is to combine self-supervised and synthetic approaches to learn to focus on features that generalize to the conditions of the observed network. This valuable contribution is currently supported by incomplete evidence.

   Reviewed by eLife

2. Improved inference of latent neural states from calcium imaging data

   This article has 4 authors:

   1. Stephen Keeley
   2. David Zoltowski
   3. Adam Charles
   4. Jonathan Pillow

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study provides a practical computational framework for inferring latent neural states directly from calcium fluorescence recordings, bypassing the traditional need for a separate spike deconvolution step. The evidence supporting the method is solid, featuring rigorous validation across multiple latent variable model families (including HMM, GPFA, and LFADS) using both simulated and experimental data. However, the assessment of the method's generality would be further strengthened by application to a broader range of experimental datasets, such as recordings from different brain regions or using different calcium indicators.

   Reviewed by eLife

3. We couldn't get details of this article at this time:
   10.1101/2025.10.10.681724

4. We couldn't get details of this article at this time:
   10.1101/2025.07.28.667217

5. We couldn't get details of this article at this time:
   10.1101/2024.10.31.621367

6. Activation of the Spx redox sensor counters cysteine-driven Fe(II) depletion under disulfide stress

   This article has 9 authors:

   1. Abigail G Hall
   2. Abdulelah A Alqarzaee
   3. Aliyah J Collins
   4. Sasmita Panda
   5. Svetlana Romanova
   6. Sujata S Chaudhari
   7. Andrew J Monteith
   8. Dorte Frees
   9. Vinai C Thomas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study provides new insights into how Staphylococcus aureus adapts to disulfide stress through the redox-sensitive regulator Spx, which coordinates nutrient uptake, cysteine import, redox homeostasis, and bacterial growth. While the authors present compelling evidence supporting the central role of Spx in managing disulfide stress, several aspects require further clarification. In particular, the precise mechanisms regulating cysteine uptake and the proposed link between disulfide stress responses and iron limitation would benefit from additional explanation and experimental or conceptual justification.

   Reviewed by eLife

7. RiboTRAP-seq identifies spatially distinct functions for the anterior and posterior intestine in immune and metabolic regulation in C. elegans

   This article has 3 authors:

   1. Chung-Chih Liu
   2. Nicolas Seban
   3. Supriya Srinivasan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this valuable study, the authors performed cell-specific ribosome pulldown to identify gene expression (translatome) differences in the anterior (NT1) vs middle & posterior (NT2-9) cells of the C. elegans intestine, under fed, starved, or refeeding conditions. The data generated will be very helpful to the C. elegans community, and the evidence supporting the conclusions of the study is assessed to be solid. Some methodological caveats remain and are discussed.

   Reviewed by eLife

8. We couldn't get details of this article at this time:
   10.1101/2025.06.27.661748

9. Human spinal cord organoids reveal cell intercalation as a conserved mechanism for secondary neurulation

   This article has 9 authors:

   1. José Blanco-Ameijeiras
   2. Yara El Majzoub
   3. Mar García-Valero
   4. Mariana M Faustino
   5. Elena Rebollo
   6. Javier Macho-Rendón
   7. Jorge Corbacho
   8. Juan Ramón Martínez-Morales
   9. Elisa Martí

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable human stem cell-derived organoid model that captures key morphological and cellular features of spinal cord development and provides evidence for a YAP-dependent mechanism of lumen formation relevant to secondary neurulation. Overall, the evidence is convincing, using strong and validated approaches consistent with the current state of the art, including systematic protocol optimisation across multiple cell lines and quantitative analysis of tissue architecture. However, some claims regarding precise anterior-posterior and dorsoventral spinal cord identity, as well as several novelty claims, are at times overstated and would benefit from more direct validation and more careful positioning. The work will be of interest to developmental biologists and researchers studying neural tube defects.

   Reviewed by eLife

10. Patient-specific iPSC models of neural tube defects identify underlying deficiencies in neuroepithelial cell shape regulation and differentiation

    This article has 8 authors:

    1. Ioakeim Ampartzidis
    2. Elliott M Thompson
    3. Yashica Gupta
    4. Andrea Krstevski
    5. Nicola Elvassore
    6. Eirini Maniou
    7. Paolo de Coppi
    8. Gabriel L Galea

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      The authors used genetic mutations in VANGL2 to study cell morphological changes during differentiation of hPSCs and understand the mechanisms underlying neural tube closure defects. The findings are important as they establish a quantitative, reproducible 2D human iPSC-to-neural-progenitor platform for analyzing cell-shape dynamics during differentiation. The convincing evidence provided, combined with the relative simplicity of the model and its tractability as a patient-specific and reverse genetic platform, make it attractive.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons