eLife

Latest preprint reviews

1. Starvation of the bacteria Vibrio atlanticus promotes lightning group-attacks on the dinoflagellate Alexandrium pacificum

   This article has 13 authors:

   1. Jean Luc Rolland
   2. Estelle Masseret
   3. Mohamed Laabir
   4. Guillaume Tetreau
   5. Benjamin Gourbal
   6. Anne Thebault
   7. Eric Abadie
   8. Alice Rodrigues-Stien
   9. Carole Veckerlé
   10. Elodie Servanne-Meunier
   11. Delphine Destoumieux-Garzón
   12. Arnaud Lagorce
   13. Raphaël Lami

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study convincingly shows that Vibrio bacteria act as predators of ecologically significant algae that contribute to harmful blooms in the lab, as well as in their natural habitat. While the data strongly suggest that starvation may induce predation, further work is needed to fully establish this link. Similarly, the evidence for a social component in the predation process remains incomplete. This study will be very impactful to those interested in the diversity of microbial predator-prey interactions and controlling toxic algal bloom, but the paper could be strengthened by more clearly showing the degree of replication, by better defining the terms used to describe the observed behaviour, and by providing better support for starvation and collective behaviour.

   Reviewed by eLife

2. Realistic coupling enables flexible macroscopic traveling waves in the mouse cortex

   This article has 4 authors:

   1. Guanhua Sun
   2. James Hazelden
   3. Ruby Kim
   4. Daniel B Forger

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable work presents a novel computational framework for modeling macroscopic traveling waves in the mouse cortex by integrating open-source connectomic and transcriptomic data into a spiking network model. This approach allows the computational model to assign excitatory/inhibitory connections based on neurotransmitter profiles and extends simulations to the 3D domain. The authors present results that demonstrate how spatiotemporal dynamics such as slow oscillations (0.5-4 Hz) emerge and self-organize at the whole-brain scale. This study provides convincing initial insights into the structural basis of traveling waves at the whole-brain scale in the mouse.

   Reviewed by eLife

3. Neural connectome of the ctenophore statocyst

   This article has 5 authors:

   1. Kei Jokura
   2. Sanja Jasek
   3. Lara Niederhaus
   4. Pawel Burkhardt
   5. Gáspár Jékely

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental work significantly advances our understanding of gravity sensing and orientation behavior in the ctenophore, an animal of major importance in understanding the evolution of nervous systems. Through comprehensive reconstruction with volumetric electron microscopy, and time-lapse imaging of cilia motion, the authors provide compelling evidence that the aboral nerve net coordinates the activity of balancer cilia. The resemblance to the ciliomotor circuit in marine annelids provides a fascinating example of how neural circuits may convergently evolve to solve common sensorimotor challenges.

   Reviewed by eLife

4. Adrenomedullin restores the human cortical interneurons migration defects induced by hypoxia

   This article has 14 authors:

   1. Alyssa Puno
   2. Wojciech P Michno
   3. Li Li
   4. Amanda Everitt
   5. Kate McCluskey
   6. Saw Htun
   7. Dhriti Nagar
   8. Jong Bin Choi
   9. Yuqin Dai
   10. Seyeon Park
   11. Emily Gurwitz
   12. A Jeremy Willsey
   13. Fikri Birey
   14. Anca M Pasca

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors combined human assembloids, fetal brain tissue, bulk and single cell RNA sequencing, and live imaging to understand the molecular mechanisms affected by hypoxia during cortical development. The findings are very important to the neurodevelopmental field, They reveal new insights into how migration of cortical interneurons can be affected in hypoxic conditions, and provide exciting models to probe broad neurodevelopmental processes in health and disease. The evidence is compelling. The data and analyses are very rigorous and go beyond the state-of-the-art.

   Reviewed by eLife

5. Sp Transcription Factors Establish the Signaling Environment in the Neuromesodermal Progenitor Niche During Axial Elongation

   This article has 11 authors:

   1. Ravindra B Chalamalasetty
   2. Haley Tran
   3. Ryan Kelly
   4. Samuel Kuo
   5. Mark W Kennedy
   6. Moonsup Lee
   7. Sara Thomas
   8. Nikolaos Mandalos
   9. Vishal Koparde
   10. Francisco Pereira Lobo
   11. Terry P Yamaguchi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental work advances our understanding of how SP5 and SP8 promote neuromesodermal competent progenitors in murine embryos. Generally the evidence is compelling, with strong developmental genetics, transcriptomic, and genomic transcription binding surveys contributing to the strength of the data. Some of the language could be softened to avoid overinterpretation of the data, and figures and diagrams could be improved.

   Reviewed by eLife

6. Cortical projection neurons with distinct axonal connectivity employ ribosomal complexes with distinct protein compositions

   This article has 4 authors:

   1. Tien Phuoc Tran
   2. Bogdan Budnik
   3. John E Froberg
   4. Jeffrey D Macklis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable and rigorous molecular resource, offering subtype-specific insight into the composition of ribosome-associated protein complexes in the developing cerebral cortex. The evidence is compelling in terms of data quality and is strongly supported by the results, given the rigorous technical execution. However, the findings remain primarily descriptive, as the study lacks functional validation to support mechanistic conclusions.

   Reviewed by eLife

7. Morphology and ultrastructure of pharyngeal sense organs of Drosophila larvae

   This article has 4 authors:

   1. Vincent Richter
   2. Tilman Triphan
   3. Albert Cardona
   4. Andreas S Thum

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this fundamental manuscript, Richter et al. present a thorough anatomical characterization of the Drosophila melanogaster larval pharyngeal sensory system, which is involved in taste-guided behaviors. This study fills a major gap in the larval sensory map, providing a compelling neuroanatomical foundation for future investigations into sensory circuits and behavior. The data presented here are of exceptional quality and will be of interest to the Drosophila neurobiology community.

   Reviewed by eLife

8. Human neurocomputational mechanisms of guilt-driven and shame-driven altruistic behavior

   This article has 7 authors:

   1. Ruida Zhu
   2. Huanqing Wang
   3. Chunliang Feng
   4. Linyuan Yin
   5. Ran Zhang
   6. Yi Zeng
   7. Chao Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important study on how dissociable emotions of shame and guilt emerge from cognitive processes and guide behavioral responses. The task is well designed and yields compelling behavioral, computational, and neural evidence elucidating the cognitive link between emotions and compensatory decisions. The work has broad theoretical and practical implications across a range of disciplines concerned with human behavior, including psychology, neuroscience, economics, public policy, and psychiatry.

   Reviewed by eLife

9. Criticality-driven enhancer-promoter dynamics in Drosophila chromosomes

   This article has 4 authors:

   1. Gautham Ganesh
   2. Jean-Bernard Fiche
   3. Marcelo Nöllmann
   4. Julien Mozziconacci

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript uses modeling approaches to provide mechanistic insight into the structural and dynamic properties of enhancer-promoter interactions in Drosophila. Given the interest in this field, this is a timely approach, and the results give useful insights by providing predictions about the processivity of cohesin loop extrusion in Drosophila and concluding that the compartmental interaction strength is poised near criticality in the coil-globule phase space. The evidence provided to support some of the conclusions is, however, incomplete and would be strengthened by better considering some of the caveats in the data used to constrain the models, such as the use of "homie" genetic elements in the dynamic data. There is insufficient evidence provided for the dynamics being criticality-driven, and in addition, consideration of alternative models would further strengthen the conclusions of the manuscript.

   Reviewed by eLife

10. RubyACRs Enable Red-Shifted Optogenetic Inhibition in Freely Behaving Drosophila

    This article has 9 authors:

    1. Daniel Bushey
    2. Hiroshi Shiozaki
    3. Yichun Shuai
    4. Jihong Zheng
    5. Vivek Jayaraman
    6. Jeremy P Hasseman
    7. Ilya Kolb
    8. GENIE Project Team
    9. Glenn C Turner

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This important work describes the adaptation and evaluation of two red-shifted anion channelrhodopsins (RubyACRs) for optogenetic inhibition in Drosophila. The study provides convincing evidence for the effectiveness of RubyACRs in fly neurons, including electrophysiology, calcium imaging, and behavioral analysis. With minor revisions to address potential toxicity and compatibility with 2-photon imaging, this paper and the publicly available fly lines it describes will be resources that are of value to the neuroscience community.

    Reviewed by eLife