eLife

Latest preprint reviews

1. Doubling dolutegravir dosage reduces the viral reservoir in ART-treated people with HIV

   This article has 16 authors:

   1. Céline Fombellida-Lopez
   2. Aurelija Valaitienė
   3. Lee Winchester
   4. Nathalie Maes
   5. Patricia Dellot
   6. Céline Vanwinge
   7. Aurélie Ladang
   8. Etienne Cavalier
   9. Fabrice Susin
   10. Dolores Vaira
   11. Marie-Pierre Hayette
   12. Catherine Reenaers
   13. Michel Moutschen
   14. Courtney V Fletcher
   15. Alexander O Pasternak
   16. Gilles Darcis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable clinical trial compares the impact of dolutegravir intensification on longitudinal measures of total HIV DNA and day 84 measures of intact HIV DNA. The trial was well-designed, and the paper is easy to read and provides hypothesis generation-level evidence that treatment intensification might decrease intact HIV DNA level in some people after 3 months. The findings are solid, with significant limitations being that study endpoints and hypotheses were not precisely defined prior to the trial, and that effect size is limited and inconsistent across trial participants.

   Reviewed by eLife

2. Species biology and demographic history determines species vulnerability to climate change in tropical island endemic birds

   This article has 6 authors:

   1. Ratnesh Karjee
   2. Vikram Iyer
   3. Durbadal Chatterjee
   4. Rajasri Ray
   5. Kritika M Garg
   6. Balaji Chattopadhyay

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Tropical single-island endemic bird populations are particularly vulnerable to climate change. The authors investigate genetic evidence of how such species dealt with climate changes in the past as a possible predictor for how they will respond to change in the future, which could provide an important example for the fields of conservation genetics and island biogeography. The authors' integration of genomics and habitat modeling is commendable, but we find that the support for their conclusions is incomplete: at times, the results presented appear to contradict each other, the authors do not fully account for key variables, and the limited taxonomic scope may cause problematic biases for the conclusions.

   Reviewed by eLife

3. Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

   This article has 6 authors:

   1. Sarah M Chang
   2. Muhammad Bin Munim
   3. Sonia E Trojan
   4. Anna Shevzov-Zebrun
   5. Keene L Abbott
   6. Matthew G Vander Heiden

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable findings on the relationship between nutrient availability and NAD/NADH levels, which in turn regulate biomass production in cancer cells. The authors provide solid evidence to support their claims, offering insight into why it is difficult to predict which nutrients limit cancer cell growth: both cell type and nutrient availability together determine the oxidative capacity that constrains the synthesis of various metabolic intermediates. The manuscript will be of interest to researchers working in cancer and cell metabolism.

   Reviewed by eLife

4. Epidermal resident memory T cell fitness requires antigen encounter in the skin

   This article has 17 authors:

   1. Eric S Weiss
   2. Toshiro Hirai
   3. Haiyue Li
   4. Andrew Liu
   5. Shannon Baker
   6. Ian Magill
   7. Jacob Gillis
   8. Youran R Zhang
   9. Torben Ramcke
   10. Kazuo Kurihara
   11. The ImmGen Consortium OpenSource T cell Project
   12. David Masopust
   13. Niroshana Anandasabapathy
   14. Harinder Singh
   15. David Zemmour
   16. Laura K Mackay
   17. Daniel H Kaplan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript advances the prior finding that antigen recognition in the skill helps establish skin resident memory in CD8 T cells by elucidating the role of TGFBR3 in regulating CD8+ TRM skin persistence upon topical antigen exposure. Key novelty of the your work lies in generation and use of the CD8+ T cell-specific TGFBR3 knockout model, which allows them to demonstrate the role of TGFBR3 in fine tuning the degree of CD8+ T cell skin persistence and that TGFBR3 expression is promoted by CD8+ TRM encountering their cognate antigen upon initial skin entry. This is an important finding and is supported by convincing evidence. There are concerns about the use of FTY720 and the need to establish active TGFbeta limiting conditions to further test this working model.

   Reviewed by eLife

5. Predicting human decision-making across task conditions via individuality transfer

   This article has 1 author:

   1. Hiroshi Higashi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This revised paper provides a valuable and novel neural network-based framework for parameterizing individual differences and predicting individual decision-making across task conditions. The methods and analyses are solid yet could benefit from further validation of the superiority of the proposed framework against other baseline models. With these concerns addressed, this study would offer a proof-of-concept neural network approach to scientists working on the generalization of cognitive skills across contexts.

   Reviewed by eLife

6. When do measured representational distances reflect the neural representational geometry?

   This article has 2 authors:

   1. Veronica Bossio Botero
   2. Nikolaus Kriegeskorte

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript makes important contributions to the methodology commonly used to assess representational structures in human and animal brain activity recorded using various techniques (especially fMRI). The evidence in the form of mathematical analysis and simulations is solid. The impact of this contribution could be improved by extending the simulations to assess the effects of violations of explicit and implicit assumptions.

   Reviewed by eLife

7. Perinatal environmental enrichment affects murine neonates’ brain structure before their active engagement with environment

   This article has 7 authors:

   1. Malte S Kaller
   2. Clémence Ligneul
   3. Rylan Allemang-Grand
   4. Tie Yuan Zhang
   5. Jacob Ellegood
   6. Michael Meaney
   7. Jason P Lerch

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important study that combines replications of findings and novel detailed MRI investigations to assess the impact of environmental enrichment and maternal behavior on mice brain structure at different stages of development. The results and evidence supporting the conclusions are convincing, but in detail, the interpretation is challenging, in particular due to inter-individual and inter-litter variability. The extent to which maternal care mediates the impact of enrichment on brain development during the perinatal period also remains unclear because behavior was observed only during short periods, and the performed analyses are still incomplete. This study will nevertheless be of significant interest to neuroscientists and researchers interested in neurodevelopment in relation to environmental factors because of its in-depth use of MRI to study brain plasticity in mice.

   Reviewed by eLife

8. Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain

   This article has 8 authors:

   1. Cassandra C Taber
   2. Wenguang He
   3. Geneviève MC Gasmi-Seabrook
   4. Mia Hubert
   5. Fraser G Ferens
   6. Mitsuhiko Ikura
   7. Jeffrey E Lee
   8. Michael Ohh

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this valuable study, Taber et al. used a battery of biophysical and structural approaches to characterize the impact of erythrocytosis-related mutations in prolyl hydroxylase domain protein 2 (PHD2). The authors show that PHD2 mutant proteins are destabilized, thus supporting the tenet that dysregulation of PHD2/hypoxia induced factor (HIF) axis underpins erythrocytosis, while providing solid evidence that N-terminal ODD prolyl hydroxylation of HIF is indispensable for these phenotypes. These findings were found to be of interest for researchers focusing on oxygen sensing in homeostasis and pathological states.

   Reviewed by eLife

9. FMRP Regulates Neuronal RNA Granules Containing Stalled Ribosomes, Not Where Ribosomes Stall

   This article has 7 authors:

   1. Jewel T-Y Li
   2. Mehdi Amiri
   3. Senthilkumar Kailasam
   4. Jingyu Sun
   5. Nahum Sonenberg
   6. Joaquin Ortega
   7. Wayne S Sossin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Based on several lines of interesting data, the authors conclude that FMRP, though associated with stalled ribosomes, does not determine the position on the mRNAs at which ribosomes stall. Although this conclusion would be valuable if clearly established, the current set of data are incomplete and it is unclear if the methodologies applied in this paper are fully adequate to address this gap.

   Reviewed by eLife

10. Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity

    This article has 9 authors:

    1. Hannah Neiswender
    2. Jessica E Pride
    3. Rajalakshmi Veeranan-Karmegam
    4. Phylicia Allen
    5. Grace Neiswender
    6. Avneesh Prabakar
    7. Caili Hao
    8. Xingjun Fan
    9. Graydon B Gonsalvez

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      In their study, Neiswender et al. provide important insights into how BicD2 variants linked to spinal muscular atrophy alter dynein activity and cargo specificity. The authors present convincing evidence that disease-associated mutations lead to interactome changes, supported by additional validation of the BicD2/HOPS complex and discussion of their functional implications. This well-executed study offers invaluable datasets and a strong foundation for future exploration of disease mechanisms.

    Reviewed by eLife