eLife

Latest preprint reviews

1. A translational transcriptomic signature of vaccine reactogenicity for the evaluation of novel formulations

   This article has 4 authors:

   1. Jérémie Becker
   2. Maroussia Roelens
   3. Kendra Reynaud
   4. Laurent Beloeil

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study proposes a cross-species transcriptomic framework to predict vaccine reactogenicity, with implications for preclinical vaccine safety assessment. The findings show that mouse muscle transcriptomic signatures capture conserved inflammatory programs and can identify highly reactogenic formulations, with supportive but limited evidence for finer discrimination among licensed human vaccines. Overall, the work establishes a valuable foundation for translational biomarkers of reactogenicity, although the strength of evidence for broad cross-species predictive performance remains incomplete and would benefit from further validation.

   Reviewed by eLife

2. Cul5Wsb2 uses BCL2 proteins as co-receptors to target Bim for degradation

   This article has 4 authors:

   1. Wilhelm Vaysse-Zinkhöfer
   2. Enya Marie Catherine Alcindor
   3. Nicholas Garaffo
   4. David Paul Toczyski

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study presents a valuable finding on the ubiquitin-dependent regulatory loop in which proapoptotic Bim is targeted to the E3 ubiquitin ligase Cul5-Wsb2-mediated degradation through its sequestration by BCL2 proteins. The conclusions are supported by incomplete evidence and would benefit from additional experiments addressing both the mechanistic understanding and the physiological/cancer-related significance of the study.

   Reviewed by eLife

3. We couldn't get details of this article at this time:
   10.64898/2025.12.13.694159

4. We couldn't get details of this article at this time:
   10.64898/2025.12.09.693151

5. We couldn't get details of this article at this time:
   10.64898/2025.12.08.692904

6. We couldn't get details of this article at this time:
   10.1101/2025.10.23.684235

7. Developmental sleep reallocation enables metabolic adaptation in desert flies

   This article has 6 authors:

   1. Shuhao Li
   2. Milan Szuperak
   3. Ceazar Nave
   4. Si Hao Tang
   5. Jeffrey M Donlea
   6. Matthew S Kayser

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Li et al. present an important and innovative study linking developmental changes in sleep to ecological context in Drosophila mojavensis, and propose that sleep at one stage of an animal's life might anticipate needs at a future stage. The results fit well with this model, but are correlative in nature. The work is convincing, scientifically rigorous, and effectively bridges sleep biology and evolutionary ecology, opening promising new directions for the field.

   Reviewed by eLife

8. Long Wake/Short Sleep Bouts and Hyperactivity with Advanced Age in a Mouse Model of Early Onset Alzheimer’s Disease

   This article has 9 authors:

   1. Ryan K Tisdale
   2. Yu Sun
   3. Stephanie R Miller
   4. Stephanie M Lee
   5. Sunmee Park
   6. Jia Shin
   7. Giancarlo Allocca
   8. Jorge J Palop
   9. Thomas S Kilduff

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides useful insights regarding the alterations of sleep architecture in a knock-in mouse model of Alzheimer's Disease (AD). These include age-related hyperactivity that is typically associated with increased arousal, a normal homeostatic response to sleep loss, and a stronger AD-like phenotype in females. Although the analyses are robust, evidence for the proposed mechanisms underlying abnormal sleep architecture is incomplete. Overall, the study may have a focused impact for the sleep and AD fields.

   Reviewed by eLife

9. Drosophila melanogaster model of RVCL-S demonstrates age dependent disease progression

   This article has 9 authors:

   1. Elena Gracheva
   2. Abigail Matt
   3. Fei Wang
   4. Raymond Hsin
   5. Hongwu Liang
   6. Xiangping Ouyang
   7. Jimin Ding
   8. Jonathan J Miner
   9. Chao Zhou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript describing the phenotypes associated with loss and gain of RVCL-S documents important findings that have practical implications. Although the data and methods are solid and support many claims, there remain some concerns about mechanisms.

   Reviewed by eLife

10. We couldn't get details of this article at this time:
    10.1101/2025.11.26.690739