eLife

Latest preprint reviews

1. Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis

   This article has 11 authors:

   1. Andrew Kuo
   2. Antonio Checa
   3. Colin Niaudet
   4. Bongnam Jung
   5. Zhongjie Fu
   6. Craig E Wheelock
   7. Sasha A Singh
   8. Masanori Aikawa
   9. Lois E Smith
   10. Richard L Proia
   11. Timothy Hla

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study reveals the importance of sphingolipids in endothelial cell biology. The authors have examined the role of the Sptlc1 gene in retinal injury as well as in the production of sphingolipid metabolites. These studies provide key insight into how endothelial cell production of sphingolipids alters vascular repair and systemic metabolism.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

2. Modeling osteoporosis to design and optimize pharmacological therapies comprising multiple drug types

   This article has 7 authors:

   1. David J Jörg
   2. Doris H Fuertinger
   3. Alhaji Cherif
   4. David A Bushinsky
   5. Ariella Mermelstein
   6. Jochen G Raimann
   7. Peter Kotanko

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper will be of interest to the pharmacology community with interest in available drug treatments for osteoporosis and how to optimize these. The key findings of the paper are based on in silico results and indicate that combined drug treatments may be more efficient in treatment of osteoporosis. This could have a significant impact on clinical management of osteoporosis patients.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

3. Robust group- but limited individual-level (longitudinal) reliability and insights into cross-phases response prediction of conditioned fear

   This article has 5 authors:

   1. Maren Klingelhöfer-Jens
   2. Mana R Ehlers
   3. Manuel Kuhn
   4. Vincent Keyaniyan
   5. Tina B Lonsdorf

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary

     The authors comprehensively assess the measurement properties of behavioral (skin conductance and ratings) and fMRI measures of fear conditioning (acquisition and extinction) in a sample of 107 participants, with 71 providing retest measures at 6 months. Retest reliability was generally low, whereas internal-consistency reliability was generally high. At the group level, reliability and criterion validity were generally good. Most measurements proved sensitive to modality, processing, or statistical decisions. Results are framed within a larger discussion of the role of measurement properties in individual difference research and clinical translation and will serve as an important building block towards improvement in both these areas.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

4. BIRC6 modifies risk of invasive bacterial infection in Kenyan children

   This article has 18 authors:

   1. James J Gilchrist
   2. Silvia N Kariuki
   3. James A Watson
   4. Gavin Band
   5. Sophie Uyoga
   6. Carolyne M Ndila
   7. Neema Mturi
   8. Salim Mwarumba
   9. Shebe Mohammed
   10. Moses Mosobo
   11. Kaur Alasoo
   12. Kirk A Rockett
   13. Alexander J Mentzer
   14. Dominic P Kwiatkowski
   15. Adrian VS Hill
   16. Kathryn Maitland
   17. J Anthony G Scott
   18. Thomas N Williams

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The paper presents evidence that a genetic variant in the BIRC6 gene increases the risk of invasive bacterial infection. This paper will be of interest to researchers working in areas relating to invasive bacterial infections, malaria, sepsis, and immunogenetics. While this paper presents a hypothesis for the mechanism through which the risk variant acts, larger samples carrying the variant that increases risk, only present in African populations, are needed to further investigate potential mechanisms.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

5. Novel analytical tools reveal that local synchronization of cilia coincides with tissue-scale metachronal waves in zebrafish multiciliated epithelia

   This article has 8 authors:

   1. Christa Ringers
   2. Stephan Bialonski
   3. Mert Ege
   4. Anton Solovev
   5. Jan Niklas Hansen
   6. Inyoung Jeong
   7. Benjamin M Friedrich
   8. Nathalie Jurisch-Yaksi

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This is a comprehensive, in vivo study of motile cilia dynamics, organisation and coordination in the larval zebrafish nose. The authors used a combination of highly quantitative imaging methods and transgenics to visualise the properties of multiciliated cells in this model organism - with particular emphasis on measuring the spatiotemporal coherence and organisation of cilia across the organ, and on the discovery of large-scale metachronal waves. With the aid of a computational model, the authors also explored the implications of metachronal ciliary action for fluid pumping.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

6. The giant staphylococcal protein Embp facilitates colonization of surfaces through Velcro-like attachment to fibrillated fibronectin

   This article has 9 authors:

   1. Nasar Khan
   2. Hüsnü Aslan
   3. Henning Büttner
   4. Holger Rohde
   5. Thaddeus Wayne Golbek
   6. Steven Joop Roeters
   7. Sander Woutersen
   8. Tobias Weidner
   9. Rikke Louise Meyer

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Staphylococcus epidermidis is a commensal that colonizes corneocytes of humans and other mammals. Colonization is crucial for many aspects of health including the development of our immune system and protection against invading pathogens. Embp is a long protein encoded by S. epidermidis on the cell surface that coats implanted foreign devices and host fibronectin, but this study shows that Embp does not bind to fibronectin in its soluble form, instead requiring surface binding to expose other epitopes to bind host fibronectin. This study uses atomic force microscopy to demonstrate these specific molecular interactions and their likely relevance to host-microbe interactions with prospects for pharmaceutical interventions.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

7. Overcoming the cytoplasmic retention of GDOWN1 modulates global transcription and facilitates stress adaptation

   This article has 9 authors:

   1. Zhanwu Zhu
   2. Jingjing Liu
   3. Huan Feng
   4. Yanning Zhang
   5. Ruiqi Huang
   6. Qiaochu Pan
   7. Jing Nan
   8. Ruidong Miao
   9. Bo Cheng

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study identifies two distinct nuclear export elements and a strong cytoplasmic anchoring sequence that restrict transcription factor GDOWN1 to the cytoplasm in normal conditions. The authors identify stress conditions that override this normal control to promote GDOWN1 nuclear localization as part of a protective response. This study will be of interest to the transcriptional regulation field.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

8. A single nucleotide variant in the PPARγ-homolog Eip75B affects fecundity in Drosophila

   This article has 4 authors:

   1. Katja M Hoedjes
   2. Hristina Kostic
   3. Thomas Flatt
   4. Laurent Keller

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Hoedjes et al. examine how a single nucleotide variant in a regulatory region upstream of the Eip75B gene influences key aspects of life history in Drosophila, using RNAi knockdowns, inbred lines and CRISPR/Cas9 allele replacement at the endogenous locus. This study represents one of the very few examples in animals where the effect of a naturally segregating single nucleotide variant on a complex trait is carefully quantified.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

9. Single-cell glycomics analysis by CyTOF-Lec reveals glycan features defining cells differentially susceptible to HIV

   This article has 7 authors:

   1. Tongcui Ma
   2. Matthew McGregor
   3. Leila Giron
   4. Guorui Xie
   5. Ashley F George
   6. Mohamed Abdel-Mohsen
   7. Nadia R Roan

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study applies a new novel method of single cell detection to biologically relevant systems to try to understand whether glycans on the surface of CD4+T cells impact HIV susceptibility. They find that cells expressing higher levels of fucose and sialic acid are more likely to be infected with to HIV than those with low levels. The findings point to glycans as a biomarker and potential determinant for HIV cells susceptibility and open the door to new avenues for studies the interplay between cell surface glycans and viral infections.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

10. Human hippocampal responses to network intracranial stimulation vary with theta phase

    This article has 4 authors:

    1. Sarah M Lurie
    2. James E Kragel
    3. Stephan U Schuele
    4. Joel L Voss

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      This project has substantial potential for better explaining the physiological basis of how to best use electrical stimulation on the cortical surface to modulate the hippocampal memory system. This would be an important task translationally and practically because it could lead to methods for modulating activity in deep brain structures noninvasively. However, in its current form the paper has weaknesses that make the results hard to trust and interpret. In its current form, it is not clear if the data clearly support the paper's strong conclusions.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

    Reviewed by eLife