eLife

Latest preprint reviews

1. Epigenetic remodeling by vitamin C potentiates plasma cell differentiation

   This article has 13 authors:

   1. Heng-Yi Chen
   2. Ana Almonte-Loya
   3. Fang-Yun Lay
   4. Michael Hsu
   5. Eric Johnson
   6. Edahí González-Avalos
   7. Jieyun Yin
   8. Richard S Bruno
   9. Qin Ma
   10. Hazem E Ghoneim
   11. Daniel J Wozniak
   12. Fiona E Harrison
   13. Chan-Wang Jerry Lio

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript described a role of Vitamin C in promoting plasma cell differentiation by remodeling the epigenome via TET (Ten Eleven Translation) family proteins. Overall, most of experiments are properly executed, controlled and presented. This paper will be of interest to scientists in molecular immunologists, particularly those involved in of epigenetic mechanisms of B cell differentiation to plasma cells.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

2. Structural motifs for subtype-specific pH-sensitive gating of vertebrate otopetrin proton channels

   This article has 8 authors:

   1. Bochuan Teng
   2. Joshua P Kaplan
   3. Ziyu Liang
   4. Zachary Krieger
   5. Yu-Hsiang Tu
   6. Batuujin Burendei
   7. Andrew B Ward
   8. Emily R Liman

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The manuscript shows that OTOP proton channels are proton-gated with distinct pH sensitivities, and identifies regions on the proteins that alter pH-dependent gating. The main claims are well supported by the data. These findings are likely to be of interest to researchers studying acid/base physiology, sensory physiology, or ion channel biophysics.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

3. A viral toolbox for conditional and transneuronal gene expression in zebrafish

   This article has 10 authors:

   1. Chie Satou
   2. Rachael L Neve
   3. Hassana K Oyibo
   4. Pawel Zmarz
   5. Kuo-Hua Huang
   6. Estelle Arn Bouldoires
   7. Takuma Mori
   8. Shin-ichi Higashijima
   9. Georg B Keller
   10. Rainer W Friedrich

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript puts forward a new toolkit of viruses for manipulation and visualization of zebrafish neural circuits. The authors overcome several challenges in the field and present a set of resources likely to be of high value to the zebrafish community.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

4. The influence of biological, epidemiological, and treatment factors on the establishment and spread of drug-resistant Plasmodium falciparum

   This article has 7 authors:

   1. Thiery Masserey
   2. Tamsin Lee
   3. Monica Golumbeanu
   4. Andrew J Shattock
   5. Sherrie L Kelly
   6. Ian M Hastings
   7. Melissa A Penny

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript explores the establishment and spread of antimalarial drug-resistant P. falciparum parasites using a combination of transmission modeling and model emulation. The authors add an important component to the broader understanding by jointly considering multiple factors driving drug resistance.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

5. Proton-transporting heliorhodopsins from marine giant viruses

   This article has 12 authors:

   1. Shoko Hososhima
   2. Ritsu Mizutori
   3. Rei Abe-Yoshizumi
   4. Andrey Rozenberg
   5. Shunta Shigemura
   6. Alina Pushkarev
   7. Masae Konno
   8. Kota Katayama
   9. Keiichi Inoue
   10. Satoshi P Tsunoda
   11. Oded Béjà
   12. Hideki Kandori

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Hososhima et al. characterize a marine virus Heliorhodopsin as the first of its class to show ion transport activity. These bacteriorhodopsin homologs have been recently described and the present careful characterization of V2HeR3 represents an important step in the understanding of these interesting membrane proteins. Though the experiments are carried out carefully and the results, in general, support the conclusions, some experiments are needed and the interpretation of results needs to be clarified.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

6. Interacting rhythms enhance sensitivity of target detection in a fronto-parietal computational model of visual attention

   This article has 5 authors:

   1. Amélie Aussel
   2. Ian C Fiebelkorn
   3. Sabine Kastner
   4. Nancy J Kopell
   5. Benjamin Rafael Pittman-Polletta

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper is of interest to neuroscientists studying the interaction between working memory, decision making, cell types, and neural oscillations. It introduces a detailed model of different brain areas which interact giving rise to the complex pattern of oscillations that are observed during a visual attention task. Additionally, the model reproduces the phase-dependent behavioral performance observed experimentally during such a task. This provides a new level of precision in our understanding of how rhythmic attention works in the brain.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

7. Modeling and mechanical perturbations reveal how spatially regulated anchorage gives rise to spatially distinct mechanics across the mammalian spindle

   This article has 4 authors:

   1. Pooja Suresh
   2. Vahe Galstyan
   3. Rob Phillips
   4. Sophie Dumont

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript presents a creative, unique, and well-explained theoretical analysis of the shapes adopted by chromosome-attached microtubule bundles during manipulation with glass microneedles inside dividing cells. The overall conclusion is that the bundles are laterally anchored to other structures in the mitotic apparatus within several micrometers of their chromosome-attached ends, but relatively freer at their pole-proximal ends. This interesting work should appeal broadly to cell biologists and biophysicists.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

8. A timer gene network is spatially regulated by the terminal system in the Drosophila embryo

   This article has 3 authors:

   1. Erik Clark
   2. Margherita Battistara
   3. Matthew A Benton

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Through the use of multiplexed in situ hybridization with careful embryo staging, this manuscript represents exemplary documentation of dynamic gene expression patterns in early fly development. By comparison of these patterns in various mutant combinations, a simple logical model for specification of expression is proposed. This manuscript will be of broad significance to developmental biologists interested in embryo segmentation and gene regulatory networks underpinning patterning.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

9. Rapid encoding of task regularities in the human hippocampus guides sensorimotor timing

   This article has 5 authors:

   1. Ignacio Polti
   2. Matthias Nau
   3. Raphael Kaplan
   4. Virginie van Wassenhove
   5. Christian F Doeller

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper is of interest to scientists interested in the functions of the hippocampus, as well as those in the field of sensorimotor timing. The reported data and findings point towards the possibility that the hippocampus supports specific and generalized learning of short time intervals relevant to behavior. While the conclusions are mostly supported by the evidence, further clarification of methodology as well as additional analyses and discussion would strengthen the authors' conclusions.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

10. Large protein complex interfaces have evolved to promote cotranslational assembly

    This article has 2 authors:

    1. Mihaly Badonyi
    2. Joseph A Marsh

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      The authors use a combination of proteome-specific protein complex structures and publicly available ribosome profiling data to show that cotranslational assembly is favored by large N-terminal intermolecular interfaces. The manuscript represents an important contribution to the field of protein biosynthesis pathways by suggesting an intuitive evolutionary mechanism that can promote co-translational assembly pathways in mammalians, yeast, and bacteria.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife