eLife

Latest preprint reviews

1. Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury

   This article has 14 authors:

   1. Lilija Wehling
   2. Liam Keegan
   3. Paula Fernández-Palanca
   4. Reham Hassan
   5. Ahmed Ghallab
   6. Jennifer Schmitt
   7. Yingyue Tang
   8. Maxime Le Marois
   9. Stephanie Roessler
   10. Peter Schirmacher
   11. Ursula Kummer
   12. Jan G Hengstler
   13. Sven Sahle
   14. Kai Breuhahn

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The authors made an important extension of the canonical Hippo pathway by showing that nuclear phosphorylation of the pathway components YAP/TAZ contributes to the shuttling between different cellular compartments. The conclusions are well supported by the experimental evidence under both physiological and tissue-damaging conditions. Given the importance and developmental conserveness of the Hippo pathway, the work is of broad interest to the field of developmental and regenerative biology.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

2. Conditional and unconditional components of aversively motivated freezing, flight and darting in mice

   This article has 4 authors:

   1. Jeremy M Trott
   2. Ann N Hoffman
   3. Irina Zhuravka
   4. Michael S Fanselow

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper will be of interest to neuroscientists, learning theorists and clinicians concerned with factors influencing threat-related response selection relevant to fear vs. panic. The manuscript describes a group of well designed experiments that investigate whether flight-like behaviors reported by other investigators require associative learning in order to occur. The authors demonstrate that non-associative influences can produce strong flight behaviors, but the dataset presented does not eliminate the possibility that associative influences can drive these responses, as well.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

3. Evolution-based mathematical models significantly prolong response to abiraterone in metastatic castrate-resistant prostate cancer and identify strategies to further improve outcomes

   This article has 4 authors:

   1. Jingsong Zhang
   2. Jessica Cunningham
   3. Joel Brown
   4. Robert Gatenby

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Zhang et al use evolution-guided mathematical models to guide the timing and dosing of arbiterone treatment in castrate-resistant prostate cancer. While the sample size is limited, the implications of the study outcome are broad and compelling, and the paper importantly highlights the transformative potential of deeply interdisciplinary research.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

4. Computational modeling and quantitative physiology reveal central parameters for brassinosteroid-regulated early cell physiological processes linked to elongation growth of the Arabidopsis root

   This article has 13 authors:

   1. Ruth Großeholz
   2. Friederike Wanke
   3. Leander Rohr
   4. Nina Glöckner
   5. Luiselotte Rausch
   6. Stefan Scholl
   7. Emanuele Scacchi
   8. Amelie-Jette Spazierer
   9. Lana Shabala
   10. Sergey Shabala
   11. Karin Schumacher
   12. Ursula Kummer
   13. Klaus Harter

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study addresses the effect of brassinosteroid hormones on acidification of the apoplast. The authors characterize a novel ionic channel involved in this process as well as a gradient of H+-ATPase activity, providing evidence for a fast brassinosteroid response that has so far received little attention. A combination of computational modeling and quantitative cell physiology is used to explain the regulation of proton pumping into Arabidopsis root cell walls. The authors show that regulation of AHA proton pump activity by the activated brassinosteroid receptor complex could potentially explain the experimentally determined zonation of root cell wall pH and growth. The work will be of interest to plant biologists as well as cell biologists in general.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

5. Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors

   This article has 10 authors:

   1. Matheswaran Kandasamy
   2. Uzi Gileadi
   3. Pramila Rijal
   4. Tiong Kit Tan
   5. Lian N Lee
   6. Jili Chen
   7. Gennaro Prota
   8. Paul Klenerman
   9. Alain Townsend
   10. Vincenzo Cerundolo

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper describes an approach in which a non-replicating influenza virus expressing a cancer testis antigen is used to induce a systemic and mucosal antigen specific T cell responses. The authors find that this immune response is sufficient to reduce tumor burden following intravenous or subcutaneous tumor challenge. This paper is potentially interesting to tumor-immunity researchers.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

6. Cortical adaptation to sound reverberation

   This article has 5 authors:

   1. Aleksandar Z Ivanov
   2. Andrew J King
   3. Ben DB Willmore
   4. Kerry MM Walker
   5. Nicol S Harper

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper identifies a new adaptation phenomenon in the cortical representation of sound that could explain invariance of auditory perception to reverberations of sounds in the environment.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

7. Motor processivity and speed determine structure and dynamics of microtubule-motor assemblies

   This article has 9 authors:

   1. Rachel A Banks
   2. Vahe Galstyan
   3. Heun Jin Lee
   4. Soichi Hirokawa
   5. Athena Ierokomos
   6. Tyler D Ross
   7. Zev Bryant
   8. Matt Thomson
   9. Rob Phillips

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study investigates on how weight loss by bariatric surgery or weight-matched dietary intervention impairs breast cancer growth as well as immunotherapy. This study can potentially provide some therapeutic intervention strategies on combining vertical sleeve gastrectomy and immunotherapy in treating breast cancer.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

8. A pulse-chasable reporter processing assay for mammalian autophagic flux with HaloTag

   This article has 3 authors:

   1. Willa Wen-You Yim
   2. Hayashi Yamamoto
   3. Noboru Mizushima

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper will be of interest to researchers in the autophagy field. It provides a useful tool to accurately measure autophagy flux, providing a useful alternative to the existing assay. The key claims of the manuscript are well supported by the data, and the approaches used are thoughtful and rigorous.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

9. Drosophila gustatory projections are segregated by taste modality and connectivity

   This article has 4 authors:

   1. Stefanie Engert
   2. Gabriella R Sterne
   3. Davi D Bock
   4. Kristin Scott

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The authors reconstructed the axons of gustatory receptor neurons from the labellum in an EM volume of a whole adult Drosophila brain. The authors were able to correlate the EM data with light microscopic data in terms of the identity of neurons reconstructed, thus enabling the use of published functional data already available in terms of different taste modalities. This revealed that extensive synaptic connections are found between neurons of the same modality. This paper will be of interest to neuroscientists working in the field of circuits and behavior, especially feeding behavior.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

10. New insights into anatomical connectivity along the anterior–posterior axis of the human hippocampus using in vivo quantitative fibre tracking

    This article has 4 authors:

    1. Marshall A Dalton
    2. Arkiev D'Souza
    3. Jinglei Lv
    4. Fernando Calamante

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      The work presented herein presents a novel method to characterize hippocampal-cortical anatomical network connectivity. These important results have the potential to generate new hypotheses and influence future queries into the hippocampal-cortical system.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife