eLife

Latest preprint reviews

1. Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders

   This article has 12 authors:

   1. Thibaud Dieudonné
   2. Sara Abad Herrera
   3. Michelle Juknaviciute Laursen
   4. Maylis Lejeune
   5. Charlott Stock
   6. Kahina Slimani
   7. Christine Jaxel
   8. Joseph A Lyons
   9. Cédric Montigny
   10. Thomas Günther Pomorski
   11. Poul Nissen
   12. Guillaume Lenoir

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript reports the first high-resolution structure of the P4 flippase ATP8B1, which is associated with intrahepatic cholestatic disorder in humans. Using biochemical studies guided by the structure, the authors demonstrate ATP8B1's autoinhibition mechanism, its regulation by lipids and phosphorylation, and a plausible mechanism of disease-associated mutation. These results are an important contribution to the expanding literature in membrane protein dynamics and function.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

2. The regenerative response of cardiac interstitial cells

   This article has 10 authors:

   1. Laura Rolland
   2. Alenca Harrington
   3. Adèle Faucherre
   4. Jourdano Mancilla Abaroa
   5. Girisaran Gangatharan
   6. Laurent Gamba
   7. Dany Severac
   8. Marine Pratlong
   9. Thomas Moore-Morris
   10. Chris Jopling

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper is of interest to researchers studying cardiac regeneration and regeneration in general. Given the multiple papers characterizing interstitial cell types during mammalian cardiac injury response, this type of characterization in one of the leading regeneration model systems is overdue. The authors utilize single cell sequencing approaches to identify dynamics and key features of interstitial cell populations during zebrafish cardiac regeneration, which largely supports the claims of the paper. The data presented here have the potential to serve as a valuable reference resource for future studies, although some of the conclusions, in particular those on the function of tal1 and mmp14, are not yet sufficiently supported by data.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

3. Early lock-in of structured and specialised information flows during neural development

   This article has 4 authors:

   1. David P Shorten
   2. Viola Priesemann
   3. Michael Wibral
   4. Joseph T Lizier

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This work analyzes how meaningful connections develop in the nervous system. Studying the dissociated neuronal cultures, the authors find that the information processing connections develop after 5-10 days. The direction of the information flow is influenced by neuronal bursting properties: the early bursting neurons emerge as sources and late bursting neurons become sinks in the information flow.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

4. A guanosine tetraphosphate (ppGpp) mediated brake on photosynthesis is required for acclimation to nitrogen limitation in Arabidopsis

   This article has 13 authors:

   1. Shanna Romand
   2. Hela Abdelkefi
   3. Cécile Lecampion
   4. Mohamed Belaroussi
   5. Melanie Dussenne
   6. Brigitte Ksas
   7. Sylvie Citerne
   8. Jose Caius
   9. Stefano D'Alessandro
   10. Hatem Fakhfakh
   11. Stefano Caffarri
   12. Michel Havaux
   13. Ben Field

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript reports that ppGpp accumulation is necessary for acclimation to nitrogen starvation in a model plant Arabidopsis. The authors also showed a ppGpp-mediated downregulation of chloroplast gene transcription and a coordinated plastid-nuclear gene expression under nitrogen deficiency. This represents a solid new step in our understanding of plant responses to nitrogen-limiting conditions as well as on the role of ppGpp in plants and possibly throughout the green lineage.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife

5. Coupling of pupil- and neuronal population dynamics reveals diverse influences of arousal on cortical processing

   This article has 8 authors:

   1. Thomas Pfeffer
   2. Christian Keitel
   3. Daniel S Kluger
   4. Anne Keitel
   5. Alena Russmann
   6. Gregor Thut
   7. Tobias H Donner
   8. Joachim Gross

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The study presents novel results on spontaneous fluctuations in pupil dilation in relation to the spectral dynamics in a large sample of human participants. The study is based on MEG recordings allowing for quantifying these relations in time and space. The data provide important new insight into the temporal and spatial characteristics of pupil-linked changes in cortical states which form the basis for incorporating this insight in future clinical and cognitive neuroscience studies.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

6. Optogenetic inhibition of actomyosin reveals mechanical bistability of the mesoderm epithelium during Drosophila mesoderm invagination

   This article has 3 authors:

   1. Hanqing Guo
   2. Michael Swan
   3. Bing He

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript studies a topic of interest to developmental biologists using a combination of optogenetics, biophysical concepts, and mathematical modeling. How in plane contractile forces cause out of plane shape changes is a relevant open question, and the optogenetic tools developed in this work provide a new strategy to address the question.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

7. The oxygen sensor prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cells

   This article has 10 authors:

   1. Yousra Ajouaou
   2. Abdulkader Azouz
   3. Anaëlle Taquin
   4. Sebastien Denanglaire
   5. Hind Hussein
   6. Mohammad Krayem
   7. Fabienne Andris
   8. Muriel Moser
   9. Stanislas Goriely
   10. Oberdan Leo

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The possibility that local or systemic hypoxia regulates aspects of the immune system has attracted widespread interest over the last decade or more. Previous work has implicated regulatory T cells in at least some of these responses, and has demonstrated that over-activation of a specific hypoxia inducible factor (HIF) isoform, HIF-2alpha has the potential to driven pro-inflammatory lymphoproliferative responses characterized by defective regulatory T cells. The current work demonstrates that genetic activation of these hypoxia-signalling pathways that is restricted to the regulatory T cell lineage is sufficient to drive this type of immune activation. The work is important since it provides a focus for study of the mechanism, for which the authors make a proposal based on mis-localization of regulatory T cells. It is also important in focussing a key questions (requiring further study) as to whether physiological or pathological hypoxia, specifically affecting these cells, will drive such a response and/or whether the lymphoproliferative phenotype could be affected adversely or beneficially by agents that are being used to upregulate or downregulate hypoxia-signalling pathways in other settings.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

8. Reducing lipid bilayer stress by monounsaturated fatty acids protects renal proximal tubules in diabetes

   This article has 12 authors:

   1. Albert Pérez-Martí
   2. Suresh Ramakrishnan
   3. Jiayi Li
   4. Aurelien Dugourd
   5. Martijn R Molenaar
   6. Luigi R De La Motte
   7. Kelli Grand
   8. Anis Mansouri
   9. Mélanie Parisot
   10. Soeren S Lienkamp
   11. Julio Saez-Rodriguez
   12. Matias Simons

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study addresses the the potential effects of saturated vs. unsaturated fatty acids on kidney proximal tubule injury in diabetic kidney disease. They find that compared to saturated fatty acids, unsaturated fatty acids prevent ER stress by stimulating triacylglycerol formation.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

9. An open-source tool for automated analysis of breathing behaviors in common marmosets and rodents

   This article has 5 authors:

   1. Mitchell Bishop
   2. Maximilian Weinhold
   3. Ariana Z Turk
   4. Afuh Adeck
   5. Shahriar SheikhBahaei

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript from Bishop et al aims to quantify the hypoxic and hyperoxic ventilatory response in the marmoset, an increasingly more common primate research model. The strongest contribution of the paper is the presentation of an analysis toolkit to perform unsupervised analyses of respiratory data, which are not widely available.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

10. Invariant representation of physical stability in the human brain

    This article has 4 authors:

    1. RT Pramod
    2. Michael A Cohen
    3. Joshua B Tenenbaum
    4. Nancy Kanwisher

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      This is an intriguing study using cleverly designed stimuli to investigate the representation of physical stability in the human brain. This paper will be of interest to readers wondering when human cognition uses generalizable pattern matching similar to that used by machine learning algorithms, and when it relies on more specialized processes evolved for specific tasks. The well-crafted experiments generally support the authors' major claim.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

    Reviewed by eLife