eLife

Latest preprint reviews

1. The layered costs and benefits of translational redundancy

   This article has 4 authors:

   1. Parth K Raval
   2. Wing Yui Ngan
   3. Jenna Gallie
   4. Deepa Agashe

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors investigate the cost and benefits of maintaining seemingly redundant multiple copies of the translation machinery components. The authors demonstrate that while redundant multiple copies are beneficial in a nutrient-rich environment, maintaining these extra copies is costly and deleterious in a nutrient-poor environment. This explains why copy numbers of translation machinery genes are under selection according to the environmental niche an organism occupies. The work is very important and the findings exciting and supported by compelling evidence. In particular, the fitness gain upon deletion of translation genes in poor conditions is an insightful observation.

   Reviewed by eLife

2. Nucleotide-level linkage of transcriptional elongation and polyadenylation

   This article has 6 authors:

   1. Joseph V Geisberg
   2. Zarmik Moqtaderi
   3. Nova Fong
   4. Benjamin Erickson
   5. David L Bentley
   6. Kevin Struhl

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Giesberg and colleagues provide evidence both in yeast and human cells that fast elongation speeds of RNA polymerases result in a "downstream-shifted" poly(A) profile while the opposite is true for slower speeds of elongating polymerases. GC content of sequences downstream of poly(A) clusters influences the cluster profiles by affecting elongation and thus allowing more time for the 3'-cleavage complex to find the poly(A) site and form the transcript terminus. Although the findings presented in this manuscript are not surprising, they are new and contribute a missing piece to our knowledge of how the transcription machinery determines which poly(A) site to utilize at the end of genes.

   Reviewed by eLife

3. Kindlin-2 inhibits TNF/NF-κB-Caspase 8 pathway in hepatocytes to maintain liver development and function

   This article has 13 authors:

   1. Huanqing Gao
   2. Yiming Zhong
   3. Liang Zhou
   4. Sixiong Lin
   5. Xiaoting Hou
   6. Zhen Ding
   7. Yan Li
   8. Qing Yao
   9. Huiling Cao
   10. Xuenong Zou
   11. Di Chen
   12. Xiaochun Bai
   13. Guozhi Xiao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     As shown by the authors, the focal adhesion protein, kindlin-2, plays an essential role in liver development in that its genetic inactivation leads to severe fibrosis and death in young mice. This lethality is attributed to increased liver inflammation and cell death. This work will be of interest to readers studying mechanisms of liver development and pathological fibrosis.

   Reviewed by eLife

4. Quantifying decision-making in dynamic, continuously evolving environments

   This article has 5 authors:

   1. Maria Ruesseler
   2. Lilian Aline Weber
   3. Tom Rhys Marshall
   4. Jill O'Reilly
   5. Laurence Tudor Hunt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors use a clever experimental design and approach to tackle an important set of questions in the field of decision-making. From this work, the authors have a number of intriguing results. However, questions remain regarding the extent to which a number of alternative models and interpretations, not considered in the paper, could account for the observed effects.

   Reviewed by eLife

5. Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver

   This article has 15 authors:

   1. Abby Sarkar
   2. Yinhua Jin
   3. Brian C DeFelice
   4. Catriona Y Logan
   5. Yan Yang
   6. Teni Anbarchian
   7. Peng Wu
   8. Maurizio Morri
   9. Norma F Neff
   10. Huy Nguyen
   11. Eric Rulifson
   12. Matthew Fish
   13. Avi Gurion Kaye
   14. Azalia M Martínez Jaimes
   15. Roel Nusse

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors report that, in the murine liver, intermittent fasting alters the homeostatic regenerative programme. This has fundamental implications for the use of murine models to study liver regeneration and cancer and highlights through a series of solid mechanistic studies the role of FGF/Wnt signalling interactions in modulating fasted associated regeneration. It opens up further questions as to why this occurs, how this is beneficial to adapting to a fasting state, and the potential for translation.

   Reviewed by eLife

6. EHD2 overexpression promotes tumorigenesis and metastasis in triple-negative breast cancer by regulating store-operated calcium entry

   This article has 17 authors:

   1. Haitao Luan
   2. Timothy A Bielecki
   3. Bhopal C Mohapatra
   4. Namista Islam
   5. Insha Mushtaq
   6. Aaqib M Bhat
   7. Sameer Mirza
   8. Sukanya Chakraborty
   9. Mohsin Raza
   10. Matthew D Storck
   11. Michael S Toss
   12. Jane L Meza
   13. Wallace B Thoreson
   14. Donald W Coulter
   15. Emad A Rakha
   16. Vimla Band
   17. Hamid Band

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study, supported by reasonably solid evidence, will be of interest to breast cancer researchers. The finding that EHD2 promotes tumor growth and impacts store-operated calcium entry (SOCE) adds to our understanding of breast cancer cell physiology. If supported by further research, the study provides a rationale for using SOCE inhibitors in a subset of breast cancers, with high expression of EHD2 serving as a potential predictive biomarker for using SOCE inhibitors.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2022.08.20.504604

8. Cryo-EM structures of an LRRC8 chimera with native functional properties reveal heptameric assembly

   This article has 5 authors:

   1. Hirohide Takahashi
   2. Toshiki Yamada
   3. Jerod S Denton
   4. Kevin Strange
   5. Erkan Karakas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper, which provides useful information on the assembly of volume-regulated anions channels formed by LRRC8 proteins, will be of interest scientists in the field of ion channels. The authors report the structure of a LRRC8C-LRRC8A chimera with native functional properties as a heptameric complex with a lipid-filled pore. This is very interesting and well-presented work, but the evidence supporting the physiological relevance of the heptameric assembly and the hypothesized role of lipids is still incomplete.

   Reviewed by eLife

9. Reevaluation of Piezo1 as a gut RNA sensor

   This article has 7 authors:

   1. Alec R Nickolls
   2. Gabrielle S O'Brien
   3. Sarah Shnayder
   4. Yunxiao Zhang
   5. Maximilian Nagel
   6. Ardem Patapoutian
   7. Alexander T Chesler

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study that resolves a controversy about a proposed molecular linkage between the fields of mechanobiology and RNA signaling. While prior research had claimed that a specific mechanosensitive ion channel in the gut responds to a specific fecal RNA, this study provides compelling evidence that the mechanosensitive ion channel does not respond to the RNA.

   Reviewed by eLife

10. A striatal circuit balances learned fear in the presence and absence of sensory cues

    This article has 3 authors:

    1. Michael Kintscher
    2. Olexiy Kochubey
    3. Ralf Schneggenburger

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This paper will interest neuroscientists working in the field(s) of basal ganglia, amygdala, and fear learning. Overall this is an important study that examines the contribution of an understudied brain region to fear conditioning in male subjects. Some conclusions will benefit from additional verification and evaluation of the specificity of the findings to the amygdala-striatal transition zone relative to adjacent regions.

    Reviewed by eLife