eLife

Latest preprint reviews

1. Eco-evolutionary dynamics of clonal multicellular life cycles

   This article has 3 authors:

   1. Vanessa Ress
   2. Arne Traulsen
   3. Yuriy Pichugin

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript models the evolution of simple multicellular life cycles using evolutionary game theory. The authors discuss natural selection between different life cycles by modeling growth, fragmentation, and interactions between propagules, discovering conditions for selection of a single life cycle or coexistence of multiple ones. Overall, the model is biologically intuitive, the results are rigorous, and the implications for the evolution of multicellularity are interesting.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

2. Adiposity may confound the association between vitamin D and disease risk – a lifecourse Mendelian randomization study

   This article has 3 authors:

   1. Tom G Richardson
   2. Grace M Power
   3. George Davey Smith

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript is of broad interest to readers in the fields of vitamin D and obesity. It utilises a Mendelian randomization framework to separate the genetically predicted effects of adiposity at two timepoints in the lifecourse, childhood and adulthood. The key claims of the manuscript are well supported by the data. Higher childhood body size had a direct effect on lower vitamin D levels in early life, while in midlife, childhood body size impacted on adult obesity to result in lower vitamin D levels.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

3. Glutamine metabolism modulates chondrocyte inflammatory response

   This article has 10 authors:

   1. Manoj Arra
   2. Gaurav Swarnkar
   3. Naga Suresh Adapala
   4. Syeda Kanwal Naqvi
   5. Lei Cai
   6. Muhammad Farooq Rai
   7. Srikanth Singamaneni
   8. Gabriel Mbalaviele
   9. Robert Brophy
   10. Yousef Abu-Amer

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript focuses on identifying how metabolism can influence the response of cartilage cells to inflammation. This has relevance to the painful disease known as osteoarthritis. Modulation of cell metabolism in the right direction can serve to protect joint cartilage from the negative effects of inflammation which causes onset and disease progression.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

4. Automated systematic evaluation of cryo-EM specimens with SmartScope

   This article has 6 authors:

   1. Jonathan Bouvette
   2. Qinwen Huang
   3. Amanda A Riccio
   4. William C Copeland
   5. Alberto Bartesaghi
   6. Mario J Borgnia

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Bouvette et al. describe a new software for fully automated cryo-EM sample screening and data acquisition, making use of deep-learning-based algorithms for the detection of regions and objects of interest. This is the first example of software for fully automated grid screening, which is of great interest to the cryo-EM community, to free skilled researchers and engineers from a serious of tedious tasks, so that they can devote more time to method development or finding answers to interesting biological and medical questions.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

5. Experience-driven rate modulation is reinstated during hippocampal replay

   This article has 5 authors:

   1. Margot Tirole
   2. Marta Huelin Gorriz
   3. Masahiro Takigawa
   4. Lilia Kukovska
   5. Daniel Bendor

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     We all have had days where there were multiple distinct memorable experiences that we successfully remember as distinct. This paper for the first time focuses on the important question of whether the resting/sleeping hippocampus maintains a clear distinction between replays of different environments and finds that in fact, replays of different tracks are distinct in the sense that both the right sets of neurons are coactive AND their firing rates in replay reflect their firing rates during experiences.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

6. TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons

   This article has 5 authors:

   1. Wendy Wing Sze Yue
   2. Lin Yuan
   3. Joao M Braz
   4. Allan I Basbaum
   5. David Julius

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The manuscript by Yue et al describes studies investigating the role of sensory neuron versus arteriole expression of Trpv1 in body temperature control. This is a detail about the contribution of different cells which has significance because of the reported on-target side-effect of hyperthermia by Trpv1-antagonists. The study shows that the effects on body temperature are predominantly produced through sensory neurons. From these studies it is speculated that the actions of Trpv1 might be pharmacologically modified to permit dissociation of the effects on neurogenic inflammation and the undesirable effects on body temperature.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. All reviewers agreed to share their names with the authors.)

   Reviewed by eLife

7. A neutrophil–B-cell axis impacts tissue damage control in a mouse model of intraabdominal bacterial infection via Cxcr4

   This article has 19 authors:

   1. Riem Gawish
   2. Barbara Maier
   3. Georg Obermayer
   4. Martin L Watzenboeck
   5. Anna-Dorothea Gorki
   6. Federica Quattrone
   7. Asma Farhat
   8. Karin Lakovits
   9. Anastasiya Hladik
   10. Ana Korosec
   11. Arman Alimohammadi
   12. Ildiko Mesteri
   13. Felicitas Oberndorfer
   14. Fiona Oakley
   15. John Brain
   16. Louis Boon
   17. Irene Lang
   18. Christoph J Binder
   19. Sylvia Knapp

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This experiment investigated the link between the role of B lymphocytes to neutrophils for the achievement of LPS tolerance. The authors found that B cells can modulate the tissue-damaging properties of neutrophil leukocytes by influencing neutrophil Cxcr4 signaling in a mouse model of bacterial sepsis.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

8. Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells

   This article has 5 authors:

   1. Joseph Wayne M Fowler
   2. Rong Zhang
   3. Bo Tao
   4. Nabil E Boutagy
   5. William C Sessa

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study shows a direct link between inflammation and cholesterol metabolism in endothelial cells. Specifically, the authors show a pathway by which the major inflammatory factor, NF kappa B, activates a gene called STARD10, which, in turn, leads to the activation of the cholesterol biosynthetic pathway. The study, therefore, provides important insights into the inter-relationship between cholesterol metabolism and inflammation at the molecular level.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

9. Wide-ranging consequences of priority effects governed by an overarching factor

   This article has 15 authors:

   1. Callie R Chappell
   2. Manpreet K Dhami
   3. Mark C Bitter
   4. Lucas Czech
   5. Sur Herrera Paredes
   6. Fatoumata Binta Barrie
   7. Yadira Calderón
   8. Katherine Eritano
   9. Lexi-Ann Golden
   10. Daria Hekmat-Scafe
   11. Veronica Hsu
   12. Clara Kieschnick
   13. Shyamala Malladi
   14. Nicole Rush
   15. Tadashi Fukami

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript identifies pH as a common factor that underlies eco-evolutionary dynamics related to priority effects, which play an important role in community assembly. Using multiple lines of evidence, the data support the overall conclusions of the manuscript that pH-mediated priority effects in the nectar microbiome are the drivers of alternative community states. This manuscript will be of broad interest to readers in ecology and evolutionary biology.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

10. Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using competing inert hydroxymethylene diphosphonate

    This article has 14 authors:

    1. Hiroko Okawa
    2. Takeru Kondo
    3. Akishige Hokugo
    4. Philip Cherian
    5. Jesus J Campagna
    6. Nicholas A Lentini
    7. Eric C Sung
    8. Samantha Chiang
    9. Yi-Ling Lin
    10. Frank H Ebetino
    11. Varghese John
    12. Shuting Sun
    13. Charles E McKenna
    14. Ichiro Nishimura

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      The manuscript shows that bisphosphonate-related osteonecrosis of the jaw, a rare complication of osteoporosis treatment, was prevented in mice using a novel treatment which works by reversing the associated oral inflammation. The work in this manuscript has the potential to be impactful if limitations are addressed. It will be of interest to investigators in the bone and dental fields who conduct pre-clinical research.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife