eLife

Latest preprint reviews

1. Rapid encoding of task regularities in the human hippocampus guides sensorimotor timing

   This article has 5 authors:

   1. Ignacio Polti
   2. Matthias Nau
   3. Raphael Kaplan
   4. Virginie van Wassenhove
   5. Christian F Doeller

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper is of interest to scientists interested in the functions of the hippocampus, as well as those in the field of sensorimotor timing. The reported data and findings point towards the possibility that the hippocampus supports specific and generalized learning of short time intervals relevant to behavior. While the conclusions are mostly supported by the evidence, further clarification of methodology as well as additional analyses and discussion would strengthen the authors' conclusions.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

2. Large protein complex interfaces have evolved to promote cotranslational assembly

   This article has 2 authors:

   1. Mihaly Badonyi
   2. Joseph A Marsh

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The authors use a combination of proteome-specific protein complex structures and publicly available ribosome profiling data to show that cotranslational assembly is favored by large N-terminal intermolecular interfaces. The manuscript represents an important contribution to the field of protein biosynthesis pathways by suggesting an intuitive evolutionary mechanism that can promote co-translational assembly pathways in mammalians, yeast, and bacteria.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

3. Hierarchical architecture of dopaminergic circuits enables second-order conditioning in Drosophila

   This article has 9 authors:

   1. Daichi Yamada
   2. Daniel Bushey
   3. Feng Li
   4. Karen L Hibbard
   5. Megan Sammons
   6. Jan Funke
   7. Ashok Litwin-Kumar
   8. Toshihide Hige
   9. Yoshinori Aso

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Second order conditioning is a higher form of learning where a previously conditioned stimulus (e.g. odor A by food) is used to condition the perception of another stimulus (e.g. odor B by odor A). Yamada et al. have used the fly to identify a neural circuit in the insect mushroom body underpinning second order conditioning. This work elegantly combines neural circuit mapping, electrophysiology and modeling to put forward a mechanistic model for this highly conserved form of learning.

     This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.

   Reviewed by eLife

4. Active tactile discrimination is coupled with and modulated by the cardiac cycle

   This article has 4 authors:

   1. Alejandro Galvez-Pol
   2. Pavandeep Virdee
   3. Javier Villacampa
   4. James Kilner

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The authors measured the heartbeat and touch perception while people touched a variety of surfaces. The results indicate that people's heart rates and heartbeats vary systematically according to the type of touch performed and how difficult it was to perceive the grooved surfaces. The paradigm and the results appear very interesting though the specific analyses of choice and their presentation require some improvement to make a more convincing case.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

5. Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations

   This article has 35 authors:

   1. Fei Chen
   2. Burcu F Darst
   3. Ravi K Madduri
   4. Alex A Rodriguez
   5. Xin Sheng
   6. Christopher T Rentsch
   7. Caroline Andrews
   8. Wei Tang
   9. Adam S Kibel
   10. Anna Plym
   11. Kelly Cho
   12. Mohamed Jalloh
   13. Serigne Magueye Gueye
   14. Lamine Niang
   15. Olufemi J Ogunbiyi
   16. Olufemi Popoola
   17. Akindele O Adebiyi
   18. Oseremen I Aisuodionoe-Shadrach
   19. Hafees O Ajibola
   20. Mustapha A Jamda
   21. Olabode P Oluwole
   22. Maxwell Nwegbu
   23. Ben Adusei
   24. Sunny Mante
   25. Afua Darkwa-Abrahams
   26. James E Mensah
   27. Andrew Anthony Adjei
   28. Halimatou Diop
   29. Joseph Lachance
   30. Timothy R Rebbeck
   31. Stefan Ambs
   32. J Michael Gaziano
   33. Amy C Justice
   34. David V Conti
   35. Christopher A Haiman

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper is mainly for an audience of genetic epidemiologists interested in the evaluation and portability of polygenic scores. The authors show that a polygenic risk score to predict prostate cancer risk is very informative for individuals that are classified on three different ancestry categories. The authors show that the polygenic risk score can be used to predict the risk to develop prostate cancer as a function of age. This paper provides evidence that genetic information could be used to provide guidance to clinicians on when to perform screenings to detect prostate cancer in patients.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

6. Polygenic adaptation after a sudden change in environment

   This article has 2 authors:

   1. Laura Katharine Hayward
   2. Guy Sella

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper is an impressive and deep look at a very important problem: understanding the genetic underpinnings of evolution acting on a quantitative trait. The authors analytically study the response to an abrupt shift in phenotypic optimum, in terms of both phenotype and genetic basis (how various alleles/loci contribute to this response). The basic assumptions are classic, but the methods and findings are new (especially finite population effects) and well supported by clear analytical approximations and extensive simulation checks. The main finding is that the relative contribution of large vs moderate effect alleles changes substantially and predictably over a long-term period after the shift, even though the phenotypic changes are already undetectable over this period.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

7. Taste quality and hunger interactions in a feeding sensorimotor circuit

   This article has 5 authors:

   1. Philip K Shiu
   2. Gabriella R Sterne
   3. Stefanie Engert
   4. Barry J Dickson
   5. Kristin Scott

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript contributes to a circuit-based understanding of how sweet and bitter tastes are integrated with hunger state to drive feeding initiation in Drosophila. Anatomical, behavioral, and neuronal activity data support a multi-step pathway from sensory input to motor output. This manuscript, thus, contributes to our understanding of how multiple sensory cues are integrated with an internal state to reach a behavioral decision.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

8. Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery

   This article has 22 authors:

   1. Laura M Sipe
   2. Mehdi Chaib
   3. Emily B Korba
   4. Heejoon Jo
   5. Mary Camille Lovely
   6. Brittany R Counts
   7. Ubaid Tanveer
   8. Jeremiah R Holt
   9. Jared C Clements
   10. Neena A John
   11. Deidre Daria
   12. Tony N Marion
   13. Margaret S Bohm
   14. Radhika Sekhri
   15. Ajeeth K Pingili
   16. Bin Teng
   17. James A Carson
   18. D Neil Hayes
   19. Matthew J Davis
   20. Katherine L Cook
   21. Joseph F Pierre
   22. Liza Makowski

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study investigates on how weight loss by bariatric surgery or weight-matched dietary intervention impairs breast cancer growth as well as immunotherapy. This study can potentially provide some therapeutic intervention strategies on combining vertical sleeve gastrectomy and immunotherapy in treating breast cancer.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

9. Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits

   This article has 16 authors:

   1. Ziru Li
   2. Emily Bowers
   3. Junxiong Zhu
   4. Hui Yu
   5. Julie Hardij
   6. Devika P Bagchi
   7. Hiroyuki Mori
   8. Kenneth T Lewis
   9. Katrina Granger
   10. Rebecca L Schill
   11. Steven M Romanelli
   12. Simin Abrishami
   13. Kurt D Hankenson
   14. Kanakadurga Singer
   15. Clifford J Rosen
   16. Ormond A MacDougald

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This is an exemplary manuscript describing the creation of a novel mouse model to study bone marrow adipocytes. The authors demonstrate that these cells play a critical role in the pathophysiology of myeloid cell lineage regeneration as well as the maintenance of bone mass and hematopoietic progenitors during times of limited energy (e.g. caloric restriction).

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

10. Successor-like representation guides the prediction of future events in human visual cortex and hippocampus

    This article has 3 authors:

    1. Matthias Ekman
    2. Sarah Kusch
    3. Floris P de Lange

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      In this paper, Ekman and colleagues present novel evidence, using a visual sequence task in fMRI, that the early visual cortex (V1) and the hippocampus both represent perceptual sequences in the form of a predictive "successor" representation, where the current state is represented in terms of its future (successor) states in a temporally discounted fashion. In both brain structures, there was evidence for upcoming, but not preceding steps in the sequence, and these results were found only in the temporal but not spatial domain. This study suggests that the hippocampus and V1 represent temporally structured information in a predictive, future-oriented manner.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

    Reviewed by eLife