eLife

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1. We couldn't get details of this article at this time:
   10.1101/2025.08.13.670061

2. We couldn't get details of this article at this time:
   10.1101/2025.11.19.689239

3. Structural basis for the folding of PINK1 by the HSP90–CDC37 chaperone complex

   This article has 8 authors:

   1. Kei Okatsu
   2. Hayato Yamamoto
   3. Akinori Okamoto
   4. Shinya H Goto
   5. Yumiko Nishimoto
   6. Yukihiko Sugita
   7. Takeshi Noda
   8. Shuya Fukai

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a high-quality cryo-EM structure of the human kinase PINK1 in complex with the HSP90-CDC37 chaperone complex, capturing a partially folded intermediate in which the C-lobe and C-terminal extension are structured while the N-lobe remains unfolded and engaged by the HSP90 clamp. The structural data are broadly consistent with a recently published structure of the same complex, providing useful insight into early steps of PINK1 maturation and highlighting residues linked to familial Parkinson's disease. However, the mechanistic conclusions remain incomplete because the manuscript does not experimentally validate key hypotheses raised by the structure, including the functional roles of the C-lobe interface, the HPNI motif, the C-terminal extension, or the proposed competition between HSP90 and TOM20.

   Reviewed by eLife

4. We couldn't get details of this article at this time:
   10.1101/2025.06.17.660072

5. We couldn't get details of this article at this time:
   10.1101/2025.07.31.667882

6. Ventral Hippocampal Temporoammonic and Schaffer Collateral Pathways Differentially Control Fear- and Anxiety-Related Behaviors

   This article has 6 authors:

   1. Maltesh Kambali
   2. Muxiao Wang
   3. Rajasekar Nagarajan
   4. Jinrui Lyu
   5. Howard Gritton
   6. Uwe Rudolph

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Kambali et al use optogenetic manipulations to examine whether the ventral hippocampal Schaffer collateral (vCA3-to-vCA1) and temporoammonic (EC-to-vCA1) pathways regulate anxiety- and fear-related behaviors in mice. They find that both pathways regulate the expression of fear (freezing) responses to a context and auditory conditioned stimulus paired with foot shock (trace conditioning protocol), but only the Schaffer collateral pathway regulates the expression of anxiety-related behaviors in the elevated plus maze, open field test, and Vogel conflict test. Overall, the study is valuable: it detects bidirectional effects of optogenetic excitation and inhibition in both pathways. However, the strength of the evidence in support of its main claims is incomplete.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2025.11.29.690828

8. Cytoplasmatic polyadenylation of mRNA by TENT5A is critical for enamel mineralization

   This article has 15 authors:

   1. Goretti Aranaz-Novaliches
   2. Olga Gewartowska
   3. Frantisek Spoutil
   4. Seweryn Mroczek
   5. Pavel Talacko
   6. Karel Harant
   7. Ana-Matilde Augusto-Vale
   8. Irena Krejzova
   9. Carlos Eduardo Madureira Trufen
   10. Pawel Krawczyk
   11. Ales Benda
   12. Vendula Novosadová
   13. Radislav Sedlacek
   14. Andrzej Dziembowski
   15. Jan Prochazka

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study reports an important and novel finding that TENT5A, an enzyme involved in fine-tuning poly(A) tail length on selected mRNAs, is required for proper enamel mineralization in mice. The evidence supporting the authors' conclusion that reduced expression of enamel matrix proteins (EMPs) in TENT5A-deficient mice results from shortened poly(A) tails remains incomplete, as TENT5A may possess additional functions independent of post-transcriptional regulation that are not addressed in the current study.

   Reviewed by eLife

9. We couldn't get details of this article at this time:
   10.1101/2025.10.02.680173

10. Opposite and complementary roles of the two calcium thresholds for inducing LTP and LTD in models of striatal projection neurons

    This article has 1 author:

    1. Daniel Trpevski

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This computational study constitutes an extension to prior work on biophysical calcium-based synaptic plasticity rules with metaplasticity, investigating how single neurons can learn to perform non-linear pattern classification. This important work presents a significantly simpler solution to the studied problem with potentially broad applicability, there is however incomplete evidence to support the core conclusions.

    Reviewed by eLife