eLife

Latest preprint reviews

1. Canonical and phosphoribosyl ubiquitination coordinate to stabilize a proteinaceous structure surrounding the Legionella-containing vacuole

   This article has 3 authors:

   1. Adriana Steinbach
   2. Chetan Mokkapati
   3. Shaeri Mukherjee

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript presents a valuable and insightful contribution to the understanding of how Legionella pneumophila remodels its vacuolar niche through coordinated ubiquitination mechanisms. The identification of Rab5 as a target of both canonical and phosphoribosyl ubiquitination, and the demonstration of a detergent-resistant ubiquitin "cloud" surrounding the LCV, represent significant advances in the field. The findings are supported by rigorous experimental design, robust quantitative analyses, and clear mechanistic insight, meeting a standard of evidence that is compelling and exceeds current state-of-the-art approaches.

   Reviewed by eLife

2. A Priming Circuit Controls the Olfactory Response and Memory in Drosophila

   This article has 3 authors:

   1. He Yang
   2. Yang Jiang
   3. Samuel Kunes

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work, combining behavioural genetics and calcium imaging, provides evidence for a form of learning in Drosophila that derives solely from direct or (optogenetically induced) phantom experience of punishment or reward. Flies that experience foot-shock alone show a subsequent decrease in avoidance to all odorants, together with increased odor-evoked activation of reward-encoding dopaminergic neurons that innervate the mushroom body. Phantom reward, delivered via optogenetic activation of reward-encoding dopaminergic neurons, increases subsequent odour-avoidance. While the findings are valuable to the field, there are aspects of the work that are incomplete, and some of the conclusions and terminology are also not completely justified; three major issues include : (a) the use of the term "priming" to describe this form of learning seems inappropriate and inconsistent with the accepted definition of this term; (b) a key 1998 publication with an initial description of this behavioural phenomenon needs to be cited and presented as context; and (c) the work on reward induced increase in odor-aversion seems relatively preliminary.

   Reviewed by eLife

3. Transcriptional subtypes on immune microenvironment and predicting postoperative recurrence and metastasis in human pheochromocytoma and paraganglioma

   This article has 8 authors:

   1. Yang Liu
   2. Xu Yan
   3. Yibo Zhang
   4. Zhenfu Gao
   5. Fengrui Nan
   6. Siyu Shi
   7. Jingyun Chen
   8. Lingyu Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a valuable study describing transcriptome-based pheochromocytoma and paraganglioma (PPGL) subtypes and exploring the mutations, immune correlates and disease progression of cases in each subtype. The cohort is a reasonable size and a second cohort is included from the Cancer Genome Atlas (TCGA). One of the key premises of the study is that identification of driver mutations in PPGL is not complete and that compromises characterisation for prognostic purposes. This is a solid starting point on which to base characterisation using different methods.

   Reviewed by eLife

4. ATAD2 mediates chromatin-bound histone chaperone turnover

   This article has 14 authors:

   1. Ariadni Liakopoulou
   2. Fayçal Boussouar
   3. Daniel Perazza
   4. Sophie Barral
   5. Emeline Lambert
   6. Tao Wang
   7. Florent Chuffart
   8. Ekaterina Bourova-Flin
   9. Charlyne Gard
   10. Denis Puthier
   11. Sophie Rousseaux
   12. Christophe Arnoult
   13. André Verdel
   14. Saadi Khochbin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study explores the role of the chromatin regulator ATAD2 in mouse spermatogenesis. The data convincingly demonstrate that ATAD2 is essential for proper chromatin remodeling in haploid spermatids, influencing gene accessibility, H3.3-mediated transcription, and histone eviction. Using Atad2 knockout (KO) mice, the authors link ATAD2 to the DNA-replication-independent incorporation of sperm-specific proteins like protamines and histone H3.3. Although the findings highlight chromatin abnormalities and impaired in vitro fertilization in KO mice, natural fertility remains unaffected, suggesting possible in vivo compensatory mechanisms. Future experiments will be needed to tease out the precise molecular role of ATAD2 in spermatogenesis. This work will be of interest to the epigenetics and developmental fields.

   Reviewed by eLife

5. Altered cognitive processes shape tactile perception in autism

   This article has 4 authors:

   1. Ourania Semelidou
   2. Mathilde Tortochot-Megne Fotso
   3. Adinda Winderickx
   4. Andreas Frick

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable insights with solid evidence into altered tactile perception in a mouse model of ASD (Fmr1 mice), paralleling sensory abnormalities in Fragile X and autism. Its main strength lies in the use of a novel tactile categorization task and the careful dissection of behavioral performance across training and difficulty levels, suggesting that deficits may stem from an interaction between sensory and cognitive processes. However, while the experiments are well executed, the reported effects are subtle and sometimes non-significant. The interpretation of results may be over-extended given the nature of the data (solely behavioral) and the absence of mechanistic, causal, or computational approaches limits the strength of the broader conclusions. The work will be relevant to those interested in autism, cognition, and/or sensory processing.

   Reviewed by eLife

6. Fitting bifurcation structure, not voltage traces: A biophysically inspired derivation of reduced neuron models exemplified by potassium dynamics

   This article has 4 authors:

   1. Louisiane Lemaire
   2. Mahraz Behbood
   3. Jan-Hendrik Schleimer
   4. Susanne Schreiber

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work demonstrates an objective way to select parameter values for a quadratic integrate-and-fire model so that its bifurcation diagram matches a specific target diagram, generated from the Wang-Buzsaki model. The method is useful for the field and is presented with convincing evidence. The method is currently limited in its ability to be applied to data, but improves our mathematical tools to treat a rarely studied type of bifurcation.

   Reviewed by eLife

7. Executive resources shape the impact of language predictability across the adult lifespan

   This article has 6 authors:

   1. Merle Marie Schuckart
   2. Sandra Martin
   3. Sarah Tune
   4. Lea-Maria Schmitt
   5. Gesa Hartwigsen
   6. Jonas Obleser

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding on whether executive resources mediate the impact of language predictability in reading in the context of aging. The evidence is solid in the investigation of prediction in reading, with one caveat that the text materials used could be biased against the aging population. The work will be of interest to cognitive neuroscientists working on reading, language comprehension, and executive control.

   Reviewed by eLife

8. Ptbp1 is not required for retinal neurogenesis and cell fate specification

   This article has 5 authors:

   1. Haley Appel
   2. Rogger P Carmen-Orozco
   3. Clayton P Santiago
   4. Thanh Hoang
   5. Seth Blackshaw

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study used a conditional knockout mouse line to remove Ptbp1 in retinal progenitors and demonstrated that its deletion has no effect on retinal neurogenesis or cell fate specification, thereby challenging the prevailing view of Ptbp1 as a master regulator of neuronal fate. The data are convincing, supported by transcriptomic analysis, histology, and proliferation assays. This study is important, and the broader implications for other CNS regions warrant further investigation.

   Reviewed by eLife

9. Intrinsic and circuit mechanisms of predictive coding in a grid cell network model

   This article has 2 authors:

   1. Inayath Shaikh
   2. Collins Assisi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study presents a mechanistic model of predictive coding by medial entorhinal cortex grid cells, implemented with biologically detailed conductance-based neurons. The evidence supporting the emergence of this coding scheme from specific membrane currents and the anatomical connectivity among inhibitory neurons is solid. However, the justification for the choice of connectivity patterns and other network parameters remains somewhat incomplete. This work will be of interest to neuroscientists working on spatial navigation, circuit dynamics, and neuronal coding.

   Reviewed by eLife

10. An updated catalogue of split-GAL4 driver lines for descending neurons in Drosophila melanogaster

    This article has 12 authors:

    1. Jessica L Zung
    2. Shigehiro Namiki
    3. Geoffrey W Meissner
    4. Han SJ Cheong
    5. Marta Costa
    6. Katharina Eichler
    7. Tomke Stürner
    8. Gregory SXE Jefferis
    9. Claire Managan
    10. FlyLight Project Team
    11. Wyatt Korff
    12. Gwyneth M Card

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      Complementing previous work (Namiki et al, 2018), this study provides an important resource for the Drosophila community as it reports 500 lines targeting descending neurons (DN), in addition to compiling 306 existing DN lines from the literature. The compelling work characterizes 146 DNs and makes a critical link with the DNs identified in Electron microscopy (EM). The lines in this paper will be of interest to Drosophila neuroscientists who will be able to use the reported genetic drivers for further functional characterization of DNs and circuit mapping in conjunction with existing EM datasets.

    Reviewed by eLife