eLife

Latest preprint reviews

1. Development of Auditory and Spontaneous Movement Responses to Music over the First Year of Life

   This article has 8 authors:

   1. Trinh Nguyen
   2. Félix Bigand
   3. Susanne Reisner
   4. Atesh Koul
   5. Roberta Bianco
   6. Gabriela Markova
   7. Stefanie Hoehl
   8. Giacomo Novembre

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study offers important insights into the development of infants' responses to music based on the exploration of EEG neural auditory responses and video-based movement analysis. The convincing results revealed that evoked responses emerge between 3 and 12 months of age, but data analysis requires further refinement to fully complement the findings related to movement in response to music. This study will be of significant interest to developmental psychologists and neuroscientists, as well as researchers interested in music processing and in the translation of perception into action.

   Reviewed by eLife

2. Hippocampal single-cell RNA Atlas of chronic methamphetamine abuse-induced cognitive decline in mice

   This article has 6 authors:

   1. Hai Qiu
   2. Xia Yue
   3. Yuebing Huang
   4. Ziling Meng
   5. Jiahong Wang
   6. Dongfang Qiao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors proposed two hypotheses: first, that methamphetamine induces neuroinflammation, and second, that it alters neuronal stem cell differentiation. These are valuable hypotheses, and the authors provided in vivo observations of the methamphetamine response in mice. However, concerns remain regarding the interpretation of the data, and the current evidence is incomplete, requiring substantial experimental validation.

   Reviewed by eLife

3. A cortical–hippocampal communication undergoes rebalancing after new learning

   This article has 2 authors:

   1. Arron F Hall
   2. Dong V Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study investigates the neural basis of bidirectional communication between the cortex and hippocampus during learning. The evidence supporting the identification of specific circuits and functional cell types involved is convincing. However, certain aspects of the behavioral analysis and statistical interpretation remain incomplete. Overall, the work will be of interest to neuroscientists studying learning and memory.

   Reviewed by eLife

4. Unreliable homeostatic action potential broadening in cultured dissociated neurons

   This article has 16 authors:

   1. Andreas Ritzau-Jost
   2. Salil Rajayer
   3. Jana Nerlich
   4. Filip Maciag
   5. Alexandra John
   6. Michael Russier
   7. Victoria Gonzalez Sabater
   8. Luke J Steiger
   9. Jacques-Olivier Coq
   10. Jens Eilers
   11. Maren Engelhardt
   12. Juan Burrone
   13. Dominique Debanne
   14. Martin Heine
   15. Stephen M Smith
   16. Stefan Hallermann

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides compelling evidence that action potential (AP) broadening is not a universal feature of homeostatic plasticity in response to chronic activity deprivation. By leveraging state-of-the-art methods across multiple brain regions and laboratories, the authors demonstrate that AP half-width remains largely stable, challenging previous assumptions in the field. These important findings help resolve longstanding inconsistencies in the literature and significantly advance our understanding of neuronal network homeostasis.

   Reviewed by eLife

5. Glycosylated IgG antibodies contribute to the recovery of haemorrhagic fever with renal syndrome patients

   This article has 15 authors:

   1. Chuansong Quan
   2. Lu Wang
   3. Jiming Gao
   4. Yaoni Li
   5. Xiaoyu Xu
   6. Houqiang Li
   7. Zixuan Gao
   8. Wenxu Ruan
   9. Hongzhi Liu
   10. Qian Li
   11. Weijia Xing
   12. Liqiong Zhao
   13. Michael J Carr
   14. Weifeng Shi
   15. Haifeng Hou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors investigated the potential role of IgG N-glycosylation in Haemorrhagic Fever with Renal Syndrome (HFRS), which may offer significant insights for understanding molecular mechanisms and for the development of therapeutic strategies for this infectious disease. The findings are valuable to the field and the strength of evidence to support the findings is solid.

   Reviewed by eLife

6. C. elegans food choice exhibits effort discounting-like behavior

   This article has 6 authors:

   1. Jonathan RM Millet
   2. Serge Faumont
   3. Aaron B Schatz
   4. Amanda M White
   5. Kathy D Chicas-Cruz
   6. Shawn R Lockery

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work develops the C. elegans as a model organism for studying effort-based discounting by asking the worms to choose between patches of easy and hard to digest bacteria. The authors provide convincing evidence that the nematodes are effort discounting. They also provide solid evidence of involvement of dopamine in the food preference and that the finding is not restricted to lab-acclimated strains.

   Reviewed by eLife

7. The Self-Interest of Adolescents Overrules Cooperation in Social Dilemmas

   This article has 7 authors:

   1. Xiaoyan Wu
   2. Hongyu Fu
   3. Gökhan Aydogan
   4. Chunliang Feng
   5. Shaozheng Qin
   6. Yi Zeng
   7. Chao Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work investigates cooperative behaviors in adolescents using a repeated Prisoner's Dilemma game. The approach used in the study is solid. The impact of this work could be further enhanced with more rigorous modelling procedures and more modeling selection/comparison details, as well as by framing the findings in terms of the specific game-theoretic context, rather than general cooperation. Findings from this study will be of interest to developmental psychologists, economists, and social psychologists.

   Reviewed by eLife

8. Inducible, virus-free direct lineage reprogramming enhances scalable generation of human inner ear hair cell-like cells

   This article has 11 authors:

   1. Robert N Rainey
   2. Sam D Houman
   3. Louise Menendez
   4. Ryan Chang
   5. Litao Tao
   6. Helena Bugacov
   7. Andrew P McMahon
   8. Radha Kalluri
   9. John S Oghalai
   10. Andrew K Groves
   11. Neil Segil

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The findings of this important study substantially advance our understanding of the transcription factors that can induce hair cell-like cells from human pluripotent stem cells. The presented evidence supporting these findings is compelling, including rigorous characterization of the effects of hair cell induction using both single-cell RNA sequencing and electrophysiological assessments.

   Reviewed by eLife

9. Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment

   This article has 14 authors:

   1. Nicholas Tolman
   2. Taibo Li
   3. Revathi Balasubramanian
   4. Guorong Li
   5. Rebecca Pfeiffer
   6. Violet Bupp-Chickering
   7. Ruth A Kelly
   8. Marina Simón
   9. John Peregrin
   10. Christa Montgomery
   11. Bryan Jones
   12. W Daniel Stamer
   13. Jiang Qian
   14. Simon WM John

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a fundamental advancement in our understanding of trabecular meshwork cell diversity and its role in eye pressure regulation and glaucoma using multimodal single-cell analysis, spatial validation, and functional testing that go beyond the current state-of-the-art. The study demonstrates that mitochondrial dysfunction, specifically in one of three distinct cell subtypes (TM3), contributes to elevated IOP in a genetic mouse model of glaucoma carrying a mutation in the transcription factor Lmx1b. While the identification of TM3 cells as metabolically specialized is compelling, there is somewhat limited evidence linking mitochondrial dysfunction to the Lmx1b mutation in TM3 cells.

   Reviewed by eLife

10. Passive muscle forces in Drosophila are large but insufficient to support a fly’s weight

    This article has 7 authors:

    1. Ninghan Wang
    2. Helene Babski
    3. Jonathan Elliot Perdomo
    4. Sarah Beth McMahan
    5. Arun Ramakrishnan
    6. Tirthabir Biswas
    7. Vikas Bhandawat

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable study introduces a novel experimental and modeling framework to quantify passive joint torques in Drosophila, revealing that passive forces are insufficient to support body weight, contrary to prior assumptions based on larger insects. The approach is technically impressive, combining genetic silencing, kinematic tracking, and biomechanical modeling. However, the strength of evidence is incomplete, limited by concerns about the specificity of the genetic tools, simplifications in the mechanical model, and limited functional interpretation.

    Reviewed by eLife