eLife

Latest preprint reviews

1. Opioid suppression of an excitatory pontomedullary respiratory circuit by convergent mechanisms

   This article has 2 authors:

   1. Jordan T Bateman
   2. Erica S Levitt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Opioid-induced respiratory depression is one of the side effects of opioid drugs. Although opioid overdose deaths are highly prevalent, our knowledge of the neural circuits underlying respiratory depression in the brainstem is far from complete. The present study used a variety of sophisticated experimental techniques to convincingly reveal the identity of brainstem components that are part of the neural circuits involved in the mediation of opioid respiratory effects, together with defining potential synaptic underlying mechanisms. They focused on two regions of the brainstem, namely the Kolliker-Fuse and the preBötzinger Complex, and proposed a combination of three complementary processes at pre- and post-synaptic sites in both KF and preBötC regions to explain respiratory depression linked to opioid exposure. This study provides very important findings on the circuitry involved in opioid-induced respiratory depression, and the present results are of broad interest to the respiratory control research community, as well as medically relevant.

   Reviewed by eLife

2. Intravital imaging-based genetic screen reveals the transcriptional network governing Candida albicans filamentation during mammalian infection

   This article has 4 authors:

   1. Rohan S Wakade
   2. Laura C Ristow
   3. Melanie Wellington
   4. Damian J Krysan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Candida morphogenesis is important for virulence. This study provides important new information as to how C. albicans regulates the switch from budding to hyphal morphology. Their results identify transcription factors involved in the process of hyphal morphogenesis in the host. The results are convincing and will be interesting to scientists in the fields of medical mycology and cell biology.

   Reviewed by eLife

3. Mega-scale movie-fields in the mouse visuo-hippocampal network

   This article has 2 authors:

   1. Chinmay Purandare
   2. Mayank Mehta

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript analyzes large-scale Neuropixels recordings from visual areas and hippocampus of mice passively viewing repeated clips of a movie and reports that neurons respond with elevated firing activities to specific, continuous sequences of movie frames. The important results support a role of rodent hippocampal neurons in general episode encoding and advance understanding of visual information processing across different brain regions. The strength of evidence for the primary conclusion was found to be convincing.

   Reviewed by eLife

4. We couldn't get details of this article at this time:
   10.1101/2022.11.25.517922

5. A stable, distributed code for cue value in mouse cortex during reward learning

   This article has 5 authors:

   1. David J Ottenheimer
   2. Madelyn M Hjort
   3. Anna J Bowen
   4. Nicholas A Steinmetz
   5. Garret D Stuber

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study makes valuable observations about the representation of "value" in the mouse brain, by using a nice task design and recording from an impressive number of brain regions. The combination of state-of-the-art imaging and electrophysiology data offer solid support for the authors' conclusions. The paper will be of interest to a broad audience of neuroscientists interested in reward processing in the brain.

   Reviewed by eLife

6. Cellular and molecular dynamics in the lungs of neonatal and juvenile mice in response to E. coli

   This article has 9 authors:

   1. Sharon A McGrath-Morrow
   2. Jarrett Venezia
   3. Roland Ndeh
   4. Nigel Michki
   5. Javier Perez
   6. Benjamin David Singer
   7. Raffaello Cimbro
   8. Mark Soloski
   9. Alan L Scott

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study examines the inflammatory and immune response to live E. coli bacterial infection in neonatal and juvenile mice. Important information is described on the roles of Class II MHC and interferon responsive genes in regulating the host response to infection. This study will inform future efforts to further elucidate the impact of bacterial infections on lung development.

   Reviewed by eLife

7. Neural population dynamics of computing with synaptic modulations

   This article has 2 authors:

   1. Kyle Aitken
   2. Stefan Mihalas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a valuable study showing that fast, but transient, modifications of the synaptic efficacies, alone, can support the integration of information over time. Convincing supportive evidence is provided by showing that feed-forward networks, when equipped with such short-term synaptic modulations, can successfully perform a variety of temporal integration tasks at a performance level comparable with that of recurrent networks. These results will be of interest to both neuroscientists and researchers in machine learning.

   Reviewed by eLife

8. O-GlcNAc glycosylation orchestrates fate decision and niche function of bone marrow stromal progenitors

   This article has 11 authors:

   1. Zengdi Zhang
   2. Zan Huang
   3. Mohamed Awad
   4. Mohammed Elsalanty
   5. James Cray
   6. Lauren E Ball
   7. Jason C Maynard
   8. Alma L Burlingame
   9. Hu Zeng
   10. Kim C Mansky
   11. Hai-Bin Ruan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment:

     Bone marrow stromal cells (BMSCs) can differentiate into a variety of cell types such as osteoblasts, chondrocytes, and adipocytes. The authors of this important study provide compelling and strong evidence that ablating O-GlcNAc transferase (OGT) in BMSCs impairs bone formation but promotes marrow adiposity. The results show that the balance of osteogenic and adipogenic differentiation of BMSCs is controlled by reciprocal O-GlcNAc regulation of lineage-specifying transcription factors, and highlights the importance of an intracellular glycosylation process of specific proteins in bone formation and bone marrow adipocytes.

   Reviewed by eLife

9. Physical basis of the cell size scaling laws

   This article has 3 authors:

   1. Romain Rollin
   2. Jean-François Joanny
   3. Pierre Sens

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This theoretical work deals with the problem of homeostasis of protein density within cells, relying on the Pump and Leak model. The model makes predictions both for growing and senescent cells, which they compare to experimental data on budding yeast. The work extends previous works and makes biologically-relevant predictions, which will be of interest to both theorists and experimentalists interested in cell physiology.

   Reviewed by PREreview, eLife

10. The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging

    This article has 14 authors:

    1. Monica Sanchez-Contreras
    2. Mariya T Sweetwyne
    3. Kristine A Tsantilas
    4. Jeremy A Whitson
    5. Matthew D Campbell
    6. Brenden F Kohrn
    7. Hyeon Jeong Kim
    8. Michael J Hipp
    9. Jeanne Fredrickson
    10. Megan M Nguyen
    11. James B Hurley
    12. David J Marcinek
    13. Peter S Rabinovitch
    14. Scott R Kennedy

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      The analysis of 89,000 independent somatic mtDNA mutations provides compelling evidence that allows the authors to refute the idea that reactive oxygen species (ROS) are a main driver of mtDNA mutagenesis, although ROS effects may still be tissue-dependent. These are fundamental results with convincing evidence, and they should appeal to a broad audience. The discovery of transversion mutations (C>A/G>T and C>G/G>C), which previously were assumed to be almost nonexistent, will nevertheless require additional validation.

    Reviewed by eLife