eLife

Latest preprint reviews

1. Recurrent network interactions explain tectal response variability and experience-dependent behavior

   This article has 2 authors:

   1. Asaph Zylbertal
   2. Isaac H Bianco

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript uses large-scale neural imaging and network models to show how spontaneous dynamics emerge in such ensembles and how such activity influences behavior. It is a strong addition to the field for explaining many of the observed neural activity patterns and their heterogeneities.

   Reviewed by eLife

2. Integrative modeling reveals the molecular architecture of the intraflagellar transport A (IFT-A) complex

   This article has 9 authors:

   1. Caitlyn L McCafferty
   2. Ophelia Papoulas
   3. Mareike A Jordan
   4. Gabriel Hoogerbrugge
   5. Candice Nichols
   6. Gaia Pigino
   7. David W Taylor
   8. John B Wallingford
   9. Edward M Marcotte

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper will be of interest to scientists working on cilia, intraflagellar transport, and structural modeling. Using an integrative modeling approach, the paper provides a fundamental structural model for a part of the molecular machinery that is responsible for cilium assembly. However, additional approaches would improve confidence in the as yet incomplete structure model.

   Reviewed by eLife

3. High-resolution imaging of the osteogenic and angiogenic interface at the site of murine cranial bone defect repair via multiphoton microscopy

   This article has 6 authors:

   1. Kevin Schilling
   2. Yuankun Zhai
   3. Zhuang Zhou
   4. Bin Zhou
   5. Edward Brown
   6. Xinping Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors present very exciting findings on the cranial bone defect repair using cutting-edge multiphoton imaging to study the role of different vessel subtypes and related oxygen and metabolic microenvironments. The study used microscopy to visualize the oxygen distribution and energy metabolism within the defects at different time points during the process of bone healing. This allows one to understand the pathophysiological progressions of bone diseases and regeneration. It will also provide critical information to optimize the therapeutic bone healing and regeneration approach for different clinical situations.

   Reviewed by eLife

4. A role for the centrosome in regulating the rate of neuronal efferocytosis by microglia in vivo

   This article has 6 authors:

   1. Katrin Möller
   2. Max Brambach
   3. Ambra Villani
   4. Elisa Gallo
   5. Darren Gilmour
   6. Francesca Peri

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper is an important contribution to the microglia field and will be of interest to a broad readership in the fields of neurobiology, cell biology and immunology. This work describes fundamental mechanisms of efferocytosis by microglia and uses impressive imaging in zebrafish, in combination with molecular manipulations, to provide compelling data of how centrosome movements synchronize with phagocytic cup formation during microglial efferocytosis of neuronal corpses in vivo.

   Reviewed by eLife

5. Chloride-dependent mechanisms of multimodal sensory discrimination and nociceptive sensitization in Drosophila

   This article has 9 authors:

   1. Nathaniel J Himmel
   2. Akira Sakurai
   3. Atit A Patel
   4. Shatabdi Bhattacharjee
   5. Jamin M Letcher
   6. Maggie N Benson
   7. Thomas R Gray
   8. Gennady S Cymbalyuk
   9. Daniel N Cox

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper is of interest for somatosensory neurobiologists studying how polymodality is achieved in peripheral sensory neurons. The work identifies roles in cold nociception and not mechanosensation in chloride transport for a number of ion channels.

   Reviewed by eLife

6. Sugar sensation and mechanosensation in the egg-laying preference shift of Drosophila suzukii

   This article has 6 authors:

   1. Wanyue Wang
   2. Hany KM Dweck
   3. Gaëlle JS Talross
   4. Ali Zaidi
   5. Joshua M Gendron
   6. John R Carlson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Wang, Carlson, and colleagues investigate sensory adaptations in the fruit pest Drosophila suzukii, which prefers ripe over overripe fruit. This study focuses on changes in sensory pathways for sugars and food texture, which may contribute to ecological shifts. Several interesting physiological and molecular adaptations are observed in D. suzukii, but it remains unclear whether these observed changes account for behavioral changes.

   Reviewed by eLife

7. Environmental pH signals the release of monosaccharides from cell wall in coral symbiotic alga

   This article has 10 authors:

   1. Yuu Ishii
   2. Hironori Ishii
   3. Takeshi Kuroha
   4. Ryusuke Yokoyama
   5. Ryusaku Deguchi
   6. Kazuhiko Nishitani
   7. Jun Minagawa
   8. Masakado Kawata
   9. Shunichi Takahashi
   10. Shinichiro Maruyama

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The manuscript makes a fundamental contribution to our understanding of sugar release by symbiotic dinoflagellates, and is of broad interest for the fields of ecology, marine biology, and cell biology. The experiments, which combine algal culture with targeted metabolomics, transcriptomics and the application of inhibitors, provide substantial, though not entirely complete evidence for an acidic environment mimicking conditions reported for the intracellular organelle that hosts the symbiotic algae, leading to upregulation of algal cellulases, which in turn degrade the algal cell wall and thereby releasing glucose and galactose that can be used as a source of food by the coral host. This is a new idea and could significantly contribute to our understanding of photosymbiosis.

   Reviewed by eLife

8. Fetal growth delay caused by loss of non-canonical imprinting is resolved late in pregnancy and culminates in offspring overgrowth

   This article has 16 authors:

   1. Ruby Oberin
   2. Sigrid Petautschnig
   3. Ellen G Jarred
   4. Zhipeng Qu
   5. Tesha Tsai
   6. Neil A Youngson
   7. Gabrielle Pulsoni
   8. Thi T Truong
   9. Dilini Fernando
   10. Heidi Bildsoe
   11. Rheannon O Blücher
   12. Maarten van den Buuse
   13. David K Gardner
   14. Natalie A Sims
   15. David L Adelson
   16. Patrick S Western

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Using a genetically controlled experimental setting, the authors find that the lack of Polycomb-dependent epigenetic programming in the oocyte and early embryo influences the developmental trajectory through gestation in the mouse. By showing a two-phase outcome of early growth restriction followed by enhancement, the authors address previous inconsistencies in the field. However, the link with placenta function and gene misregulation is not yet fully supported.

   Reviewed by eLife

9. Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A

   This article has 3 authors:

   1. Christopher M Hoel
   2. Lin Zhang
   3. Stephen G Brohawn

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work addresses the mechanisms of action of the transmembrane proteins TMEM87A and TMEM87B, which are thought to play a role in protein transport, but have been implicated in other processes as well, such as signaling and acting as mechanosensitive ion channels. The study represents an important advance of the understanding of this poorly characterized family of proteins. While the structure is of low resolution, it is well interpreted, and authors take good advantage of AlphaFold2 to gain insights into potential function. The work is of interest to colleagues studying transporters and ion channels.

   Reviewed by eLife

10. A cryogenic, coincident fluorescence, electron, and ion beam microscope

    This article has 16 authors:

    1. Daan B Boltje
    2. Jacob P Hoogenboom
    3. Arjen J Jakobi
    4. Grant J Jensen
    5. Caspar TH Jonker
    6. Max J Kaag
    7. Abraham J Koster
    8. Mart GF Last
    9. Cecilia de Agrela Pinto
    10. Jürgen M Plitzko
    11. Stefan Raunser
    12. Sebastian Tacke
    13. Zhexin Wang
    14. Ernest B van der Wee
    15. Roger Wepf
    16. Sander den Hoedt

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This paper is of particular interest to researchers who plan to use focused-ion beam scanning electron microscopes (FIB-SEMs) and require fluorescent data to guide the milling process. The authors describe a valuable after-market upgrade that allows fluorescent data acquisition during FIB-milling without stage repositioning. Technical details of the fluorescent module upgrade together with the sample stage redesign are compellingly documented and will enhance the implementation of this important technology.

    Reviewed by eLife